張海林

2000年起任職於西奈山醫學中心生理與生物物理系。

2001年10月以特殊人才受聘於河北醫科大學。

研究領域

內向整流鉀離子通道的結構與功能

信號傳導的分子機制

離子通道功能的調節

分子生理學，分子藥理學及神經生物學

論文

1. Peng LY, Mirshahi T., Zhang HL., Hirsch J. and Logothetis DE (2003) Critical Determinants of the G Protein g Subunits in the Gbg Stimulation of G Protein-actiated Inwardly Rectifying Potassium (GIRK) Channel Actiity. J Biol Chem 278 (50), 50203–50211,

2. Chan KW, Zhang HL and Logothetis1 DL (2003) N-terminal transmembrane domain of the SUR controls trafficking and gating of Kir6 channel subunits. The EMBO Journal, 22 (15) 3833-3843

3. Zhang H., Craciun LC, Mirshahi T, Rohács T, Lopes CMB, Jin T, and Logothetis DE. (2003) PIP2 Actiates KCNQ Channels, and Its Hydrolysis Underlies Receptor-Mediated Inhibition of M Currents. Neuron， 37（6）, 963-975

4. Lopes C M.B., Zhang H., Rohacs T, Jin T, Yang, J. and Logothetis D.E. (2002) Alterations in Consered Kir Channel-PIP2 Interactions Underlie Channelopathies. Neuron, 34, 933–944

5. Perez CA., Huang L., Rong M., Kozak JA., Zhang H., Max M. and Margolskee RF. (2002). A transient receptor potential channel expressed in taste receptor cells. Nature Neurosci. 5(11):1169-76.

6. Mirshahi T, Mittal , Zhang H, Linder ME, Logothetis DE. (2002) Distinct sites on G protein beta gamma subunits regulate different effector functions. J Biol Chem 277(39):36345-50.

7. He C, Yan X, Zhang H, Mirshahi T, Jin T, Huang A, Logothetis DE (2002) Identification of critical residues controlling G protein-gated inwardly rectifying K(+) channel actiity through interactions with the beta gamma subunits of G proteins. J Biol Chem 277:6088-96

8. Mirshahi T, Robillard L, Zhang H, Hebert TE, Logothetis DE (2002) Gbeta residues that do not interact with Galpha underlie agonist-independent actiity of K+ channels. J Biol Chem 277(9):7348-55

9. Rohac T., Lopes CMB., Mirshahi T., Jin T., Zhang H. & Logothetis DE. (2001). Assay pf phosphatidylinositol biphosphate regulation of potassium channels. In G protein pathways, part C: Effector mechanism. Methods in Enzymology, 345-357

10. Hughes TE, Zhang, HL, Logothetis DE, Berlot CH (2001). isualization of a functional Gaq-green fluorescent protein fusion in liing cells: Association with the plasma membrane is disrupted by mutational actiation and by elimination of palmitoylation sites, but not by actiation mediated by receptors or AlF4- . J Biol Chem, 276:4227-4235.

11. Kobrinsky E, Mirshahi T, Zhang H, Jin T, Logothetis DE (2000). Receptor-mediated hydrolysis of plasma membrane messenger PIP2 leads to K+-current desensitization. Nature Cell Biology, 2:507-14.

12. Zhang,HL., He C., Yan XX, Mirshahi T and Logothetis DE. (1999) Actiation of inwardly rectifying K+ channels by distinct PtdIns(4,5)P2 interactions. Nature Cell Biology, 1:183-188

13. He, C., Zhang, HL., Mirshahi, T. and Logothetis, D. (1999). Specific Gbg Interaction With a K+ Channel Distinguish Between Basal and Agonist-induced Currents. J. Bio. Chem, 274:12517-12524

14. Logothetis, E.D. & Zhang, HL. (1999) Gating of G protein-sensitie inwardly rectifying K+ channels through phosphatidylinositol 4,5-bisphosphate-dependent mechanism. J. Physiol. London, 520, 630

15. Zhang, H-L., T. B. Bolton, A. E. Piekarska & G. A. McPherson (1998). The electrophysiological effects of tetraphenylphosphonium and tetraphylboron on ascular somooth muscle. Eur. J. Pharmacol, 347(1), 119-23

16. Zhang, H-L & Bolton, T. B. (1996) ATP-sensitie potassium channels and their modulation by nucleotides and potassium channel openers in ascular smooth muscle cells. In: Smooth muscle excitation. Eds: Bolton T. B. & Tomita, T. Academic Press Limited. Chapter 12, pp 139-154

17. Zhang, H-L. & Bolton, T. B. (1996). Two types of ATP-sensitie potassium channels in rat portal ein smooth muscle cells. Br. J. Pharmacol. 118, 105-114

18. Zhang, H-L. & Bolton, T. B. (1995). Effects of UK-84149 on oltage-actiated calcium currents of single smooth muscle cells from guinea-pig and rabbit jejunum and rabbit coronary. Br. J. Pharmacol., 114, 1657-1665

19. Zhang, H-L. & Bolton, T. B. (1995). Actiation by Intracellular GDP, metabolic inhibition and pinacidil of a glibenclamide-sensitie K-channel in smoothmuscle cells of rat mesenteric artery. Br. J. Pharmacol., 114, 662-672

20. Beech, D.J., Zhang, H., Nakao, K. & Bolton, T.B. (1993). Single channel and whole-cell K-currents eoked by lecromakalim in smooth muscle cells from the rabbit portal ein. Br. J. Pharmacol., 110, 583-590.

21. Beech, D.J., Zhang, H., Nakao, K. & Bolton, T.B. (1993). K channel actiation by nucleotide diphosphates and its inhibition by glibenclamide in ascular smooth muscle cells. Br. J. Pharmacol., 110, 573-582

著作

A text book of fundamental medical pharmacology (英文)，編委，吉林科學技術出版社， 2004

課題

1. 國家傑出青年科學基金 (30325038), 2004.1-2007.12

2. 美國國家衛生研究院NIH Fogarty 國際合作項目(1 R03 TW006020-01A1): Protein Kinase C-dependent inhibition of Kir channels, 2003.4-2006.4，

3. 科技部基礎研究重大項目前期研究專項(2003CCA00300):細胞膜磷脂對離子通道功能的調節及其生理學意義, 2003.12-2005.12

4. 國家自然科學基金項目(30270361): 膜磷脂PIP2對M電流及KCNQ電流的調節作用. 2003.1-2005.12，

5. 河北省自然科學基金項目。磷脂醯肌醇二磷酸對M電流的調節及生理學意義（303464），2003.1-2005.12

6. 國家自然科學基金項目(30240001): 老年大鼠M電流的研究. 2002.1---2002.12,

7. 教育部科學技術研究重點項目(02016): pH調節內向整流鉀離子通道功能的分子機制, 2002.1-2003.12