王大勇

2000-09--2003-07瀋陽藥科大學藥理學專業博士

1990-03--1995-01瀋陽藥科大學英語藥學專業學士

2013-04--今海南大學農學院生物技術系

2012-05--2013-04美國伊利諾依大學農業、消費者及環境科學學院動物科學系 專家 (Research Specialist)

2010-03--2012-05美國伊利諾依大學 分子及細胞生物學院 分子及整合生理學系 研究員 (Research Scientist)

2007-07--2010-02 美國伊利諾依大學 分子及細胞生物學院 分子及整合生理學系 博士后（Postdoctoral Research Associate）

2007-04--2007-06日本名古屋大學醫學部 傑出中心（Center of Excellency， COE）研究員

2004-10--2007-03 日本（原）公定書協會駐名古屋大學附屬醫院藥劑部研究員（Research Resident）

2002-04--2007-06 日本名古屋大學大學院神經精神藥理學系 外國人研究員

1995-08-2000-08 哈葯集團生物工程有限公司

高級生物化學、生物技術製藥、神經生物學

Keap1潛在磷酸化位點及調控信號研究（引進人才科研啟動基金資助項目）

1. Dayong Wang, Qin Fu, Yuan Zhou, Qian Shi, Benedict Igwe, Elena V. Wisely, Salvatore Oddo, Yang K. Xiang. Amyloid β activates adrenergic receptor to induce intracellular signaling pathways for tau pathology. Journal of Biological Chemistry.2013, 288: 10298-10307.

2. Ruijie Liu, Dayong Wang, Steven Hizon, Qin Fu, Qian Shi, Yang K. Xiang. Palmitoylation regulates intracellular trafficking of β2 adrenergic receptor/arrestin/phosphodiesterase 4D complexes in cardiomyocytes. Plos ONE. 2012, 7(8):1-13.

3. Dayong Wang, Eunice Yuen, Yuan Zhou, Yan Zhen, Yang K. Xiang. Amyloid beta peptide-(1-42) induces internalization and degradation of beta2 adrenergic receptors in prefrontal cortical neurons. Journal of Biological Chemistry. 2011, 286(36):31852-63.

4. Dayong Wang, Yang K. Xiang.Chapter 10: β-adrenergic receptor, amyloid Abeta, and Alzheimer’s disease.Current Topics in Membranes: Advances in Adrenergic Receptor Biology. 2011, 67: 205-229.

5. Dayong Wang, G. Govindaiah, Ruijie Liu, Vania De Arcangelis, Charles Lee Cox, Yang K. Xiang. Binding of Amyloid βpeptide to β2adrenergic receptor induces PKA dependent AMPA receptor hyperactivity. The FASEB Journal.2010, 24(9):3511-21.

6. Yukihiro Noda, Akihiro Mouri, Yu Ando, Yukari Waki, Shin-nosuke Yamada, Akira Yoshimi, Kiyofumi Yamada, Norio Ozaki, Dayong Wang, Toshitaka Nabeshima. Galantamine ameliorates the impairment of recognition memory in mice repeatedly treated with methamphetamine: involvement of allosteric potentiation of nicotinic acetylcholine receptors and dopaminergic-ERK1/2 systems. The International Journal of Neuropsychopharmacology. 2010, 13(10):1343-54.

7. Hiroko Tsunekawa, Yukihiro Noda, Masayuki Miyazaki, Fumio Yoneda, Toshitaka Nabeshima, Dayong Wang.Effects of (R)-(-)-1-(benzofuran-2-yl)-2-propylaminopentane hydrochloride [(-)-BPAP] in animal models of mood disorders.Behavioural Brain Research. 2007, 189(1): 107-116.

8. Dayong Wang, Yukihiro Noda, Hiroko Tsunekawa, Yuan Zhou, Masayuki Miyazaki, Koji Senzaki, Toshitaka Nabeshima. Role of N-Methyl-D-aspartate receptors in antidepressant-like effects of σ1 receptor agonist 1-(3,4-Dimethoxyphenethyl)-4-(3-phenylpropyl)piperazine dihydrochloride(SA-4503) in olfactory bulbectomized rats. Journal of Pharmacology and Experimental Therapeutics. 2007, 322(3): 1305-1314.

9. Dayong Wang, Yukihiro Noda, Yuan Zhou, Atsumi Nitta, Hiroshi Furukawa, Toshitaka Nabeshima. Synergistic effect of combined treatment with risperidone and galantamine on phencyclidine-induced impairment of latent visuospatial learning and memory: role of nAChR activation-dependent increase of dopamine D1 receptor-mediated neurotransmission. Neuropharmacology. 2007,53(3):379-89.

10. Dayong Wang, Yukihiro Noda, Yuan Zhou, Akihiro Mouri, Hiroyuki Mizoguchi, Atsumi Nitta, Weiduo Chen, Toshitaka Nabeshima. The allosteric potentiation of nicotinic acetylcholine receptors by galantamine ameliorates the cognitive dysfunction in beta amyloid25-35i.c.v.-injected mice: involvement of dopaminergic systems.Neuropsychopharmacology. 2007, 32(6): 1261-1271.

11. Dayong Wang, Yukihiro Noda, Yuan Zhou, Atsumi Nitta, Hiroshi Furukawa, Toshitaka Nabeshima. Synergistic effect of galantamine with risperidone on impairment of social interaction in phencyclidine-treated mice as a schizophrenic animal model. Neuropharmacology. 2007, 52(4):1179-87.

12. Dayong Wang, Yukihiro Noda, Hiroko Tsunekawa, Yuan Zhou, Masayuki Miyazaki, Koji Senzaki, Toshitaka Nabeshima. Behavioural and neurochemical features of olfactory bulbectomizedrats resembling depression with comorbid anxiety. Behavioural Brain Research. 2007, 178(2):262-73.

13. 王大勇, 於慶海, 周園, Yukihiro Noda, Toshitaka Nabeshima. 現代免疫佐劑研究. 《中國免疫學雜誌》. 2006, 22(2):189-192.

14. Li-Bo Zou, Akihiro Mouri, Nobuhisa Iwata, Takaomi C. Saido, Dayong Wang, Min-Wei Wang, Hiroyuki Mizoguchi, Yukihiro Noda and Toshitaka Nabeshima. Inhibition of neprilysin by infusion of thiorphan into the hippocampus causes an accumulation of amyloid {beta} and impairment of learning and memory. Journal of Pharmacology and Experimental Therapeutics. 2006, 317(1):334-40.

15. Dayong Wang, Yukihiro Noda, Toshitaka Nabeshima. Features of olfactory bulbectomized rat model of depression and effects of sigma1 receptor agonist. Japanese Journal of Molecular Psychiatry. 2006, 6(2): 81-84.

16. Akihiro Mouri, Li-Bo Zou, Nobuhisa Iwata, Takaomi C. Saido, Dayong Wang,Min-Wei Wang, Yukihiro Noda and Toshitaka Nabeshima. Inhibition of neprilysin by thiorphan (i.c.v.) causes an accumulation of amyloid beta and impairment of learning and memory. Behavioral Brain Research. 2006,168(1):83-91.

17. Takeshi Enomoto, Yukihiro Noda, Akihiro Mouri, Eun-Joo Shin, Dayong Wang, Rina Murai, Kazuo Hotta, Hiroshi Furukawa, Atsumi Nitta, Hyoung-Chun Kim, and Toshitaka Nabeshima. Long-Lasting Impairment of Associative Learning Is Correlated with a Dysfunction of N-Methyl-D-aspartate- Extracellular Signaling-Regulated Kinase Signaling in Mice after Withdrawal from Repeated Administration of Phencyclidine.Molecular Pharmacology. 2005,68:1765-1774.

18. Hiroko Tsunekawa, Yukihiro Noda, Dayong Wang, Hiroyuki Mouri, Toshitaka Nabeshima. Selegiline potentiates effects of donepezil on cognitive impairment induced by amyloid beta (25-35). Bulletin of the Japanese Society for Neurochemistry. 2005, 44: 182.

19. Dayong Wang, Yukihiro Noda, Yuan Zhou, Atsumi Nitta, Toshitaka Nabeshima and Qinghai Yu. Effects of sodium houtuyfonate on phosphorylation of CaMK II, CREB and ERK 1/2 and expression of c-Fos in macrophages. International Immunopharmacology. 2004, 8: 1083-1088.

20. Tsunekawa Hiroko, Yukihiro Noda, Dayong Wang, Toshitaka Nabeshima. Antidepressive effect of(R)-(-)-1-(benzofuran-2-yl)-2-propylaminopentane hydrochloride [(-)-BPAP] in animal models of stress disorders. Journal of Pharmacological Science. 2004, 94 (suppl.): 225P.

21. Dayong Wang, Qinghai Yu, Peggy Eikstadt, Darcy Hammond, Yun Feng, and Na Chen. Studies on adjuvaticity of sodium houttuyfonate and its mechanism. International Immunopharmacology. 2002, 10:1411-1418.

22. Dayong Wang, Qinghai Yu, Yun Feng, and Na Chen. Adjuvanticity of sodium houttuyfonate. Indian Journal of Pharmacology. 2002, 34(5):363-364.

（1）獲（原）美國NARSAD青年研究員獎，主持完成相關項目；

（2）主持完成美國伊利諾依州公共衛生部阿爾茨海默病研究基金項目；

（3）美國伊利諾依大學分子及整合生理學系年度學術論壇一等獎；

（4）日本上原紀念生命科學獎學金