白鋼

1990年畢業於瀋陽藥科大學，1993年赴日本留學，1998年獲藥學博士學位。 2000年作為南開大學引進人才回國在生命科學學院任教。2000年任微生物學系主任，2004年任生命科學學院副院長。主要社會兼職有：全國高等醫藥院校規劃教材編委，中國天然藥物雜誌編委，天津市微生物學會理事。

長期從事藥學及免疫學相關研究，在生物技術製藥，中藥現代化等領域積累了豐富的經驗。

曾先後主持和承擔“863”項目“a-糖苷酶抑制性降糖中藥復方的研究與開發”和“基於結構基因（蛋白）組的藥物分子設計”；國家“十五”重點攻關“林業重大病蟲害預警及控制技術研究”；國家自然科學基金“假單胞菌TS-1138轉化ATC合成L-半胱氨酸代謝途徑的研究”；天津市重點攻關“基因工程α-2b干擾素新型純化工藝及製劑研究”；天津市重點基金“中藥超靈敏感度免疫學分析法的研究”、“治療哮喘天然藥物的開發及分子機理研究”和“L-半胱氨酸高轉化率菌株的構建及代謝調控理論研究”等多項科研項目，發表相關國內外學術論文70餘篇, 其中SCI收錄論文22篇，此外還申請發明專利多項。

1. Yuanyuan Hou, Xuelin Cao, Linyi Dong, Liqiang Wang, Binfeng Cheng, Qian Shi, Xiaodong Luo,* Gang Bai*. Bioactivity-based liquid chromatography-coupled electrospray ionization tandem ion trap/time of flight mass spectrometry for β2AR agonist identification in alkaloidal extract of Alstonia scholaris. Journal of Chromatography A.2012; 1227:203-9;

2. Lin-Yi DONG, Yun-hui ZHANG, Xuelin CAO1, Bin-Feng CHENG, Yuan-Yuan HOU, Jing WANG, Gang BA*, Guo-An LUO*. Rapid and Global Identification of Potentially Bioactive Crude Extracts from Chinese Medicinal Formula Chuanbeipipa Dropping Pills. Lat. Am. J. Pharm.2012; 31 (1): 18-26;

3. Liqiang Wang, Jiamin Peng, Binfeng Cheng, Jie Gao, Min Jiang, Gang Bai, Yuanyuan Hou*. Carboxymethylcellulose sodium improves the pharmacodynamics of 1-deoxynojirimycin by changing its absorption characteristics and pharmacokinetics in rats. Pharmazie, 2012; 67(2):168-73;

4. J. Du, J. J. Duan, Q. Zhang, J. Hou, F. Bai, N. Chen, and G. Bai. Enzymatic Synthesis of L_tryptophan from D,L-2-amino-Δ2-thiazoline-4-carboxylic Acid and Indole by Pseudomonas sp. TS1138 L-2-amino-Δ2-thiazoline-4-carboxylic Acid Hydrolase, S-carbamyl-L-cysteine Amidohydrolase and Escherichia coli L-Tryptophanase. Applied Biochemistry and Microbiology, 2012; 48(2), 159-166;

5. Limei Ren, Xiaohong Qin, Xiaofang Cao, LeleWang, Fang Bai, Gang Bai*, Yuequan Shen*; Structural insight into substrate specificity of human intestinal maltase-glucoamylase. Protein & Cell, 2011; 2(10):827-36;

6. Xiaohong Qin, Limei Ren, Xue Yang, Fang Bai, Gang Bai*, Yuanquan Shen*; Structures of human pancreatic alpha- amylase in complex with acarviostatins: Implications for drug design against Type II Diabetes. Journal of Structural Biology, 2011;174(1):196-202;

7. Limei Ren, Xiaofang Cao, Peng Geng, Fang Bai*, Gang Bai; Study of the inhibition of two human maltase- glucoamylases catalytic domains by different α-glucosidase inhibitors. Carbohydr Res. 2011; 346(17), 2688-92;

8. Meng Peng, Guo Yuanqiang, Zhang Qi, Hou Jie, Bai Fang,* Geng Peng, Bai Gang. A novel amino-oligosaccharide isolated from the culture of Streptomyces strain PW638 is a potent inhibitor of α-amylase. Carbohydr Res. 2011; 346 (13):1898-902;

9. Hao Huang, Lanxin Ji, Shengyou Song, Jing Wang, Na Wei, Min Jiang, Gang Bai*, Guoan Luo*; Identification of the major constituents in Xuebijing Injection by HPLC-ESI-MS. Phytochemical Analysis 2011;22(4):330-8;

10. Qian Shi, Yuanyuan Hou, Yang Yang, Gang Bai*; Protective effect of glycyrrhizin against beta2-adrenergic receptor agonist-induced receptor internalization and cell apoptosis. Biol. Pharm. Bull. 2011;34(5):609-17;

11. Jie Hou, Qi Zhang, Xia Li, Yu Tang, Fang Bai, Qian Shi, Mei-rong Cao, Cui-hong Yang, De-ling Kong, Gang Bai*, Synthesis of novel folate conjugated fluorescent nanoparticles for tumor imaging. J Biomed Mater Res A. 2011;99(4):684-9;

12. Bai F, Xu H, Zhang Q, Qi X, Mou R, Bai G*, Qiao M*. Functional characterization of pfm in protein secretion and lung infection of Pseudomonas aeruginosa. Can J Microbiol. 2011; 57(10):829-37;

13. Tang Yu, Zhang Qi, Wang Long, Pan PengWei, Bai Gang*; Preparation of cellulose magnetic microspheres with "the smallest critical size" and their application for microbial immunocapture. Langmuir 2010, 26(13): 11266-71;

14. Yang Yang, Shi Qian, Liu Ze, Li RuoJie, Pan PengWei, Hou YuanYuan, Lu WanGe, Bai Gang*; The synergistic anti-asthmatic effects of glycyrrhizin and salbutamol. Acta Pharmacologica Sinica2010; 31(4):443-449;

15. Jing Wang, Na Wei, Hongzhi Zhao, Hao Huang, Min Jiang, Gang Bai*, Guoan Luo; Global Chemome Study by LC Coupled with DAD and ESI–Q–TOF MS of a Composite Traditional Chinese Medicine Qishenyiqi Dropping Pills. Chromatographia2010, 72, 431–440;

16. Gao Zhihui, Tang Yu, Chen Jiaqi, Bai Ru, Zhang Qi, Hou Yuanyuan, Lu Yaxin, Bai Gang*: A novel DPP-IV-resistant analog of glucagon-like peptide-1 (GLP-1): KGLP-1 alone or in combination with long-acting PLGA microspheres. Peptides.2009; 30 (10):1874-1881;

17. Gao Zhihui, Zhang Qi, Cao Yu, Pan Pengwei, Bai Fang, Bai Gang: Preparation of novel magnetic cellulose microspheres via cellulose binding domain-streptavidin linkage and use for mRNA isolation from eukaryotic cells and tissues. Journal of Chromatography A.2009; 216 (45): 7670-7676;

18. Zong Wei, Yang Yang, Peilin Zhang, Rosemary Andrianakos, Kouichi Hasegawa, Jungmook Lyu, Xi Chen, Gang Bai, Chunming Liu, Martin Pera, Wange Lu. Klf4 interacts directly with Oct4 and Sox2 to promote reprogramming. Stem Cells. 2009; 27(12):2969-2978;

19. Wang Bin, Wang Shuai, Zhang Zhenxing, Yang Pin, Tian Ye, Wang Peng, Zhang Qi, Bai Gang. Alkynyl-modified Naphthalimide: Synthesis, crystal structure and fluorescence spectrum source. Chinese Journal of Structural Chemistry. 2009; 28(8): 1008-1012;

20. Geng Peng, Gang Bai*, Xiansheng Meng, Fang Bai, Guoan Luo: Screening for metabolites of acarviostatin family aminooligosaccharides in rats using ultraperformance liquid chromatography coupled with electrospray ionization tandem mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis2009; 50 (5) 917–923;

21. Qian Shi, Ze liu, Yang Yang, Peng Geng, Yuanyuan Zhu, Qi zhang, Bai Gang徠* : Identification of anti-asthmatic compounds in Pericarpium citri reticulatae and evaluation of their synergistic effects. Acta Pharmacologica Sinica2009; 30(5):567-575;

22. Zhihui Gao, Gang Bai,* Jiaqi Chen, Qi Zhang, Pengwei Pan, Peng Geng and Fang Bai: Development, Characterization, and Evaluation of a Fusion Protein of a Novel Glucagon-like Peptide-1 (GLP-1) Analogue and Human Serum Albumin inPichia pastoris.Biosci. Biotechnol. Biochem.2009;73(3):688-694;

23. Lihua Huai, Ning Chen, Wenbo Yang, Gang Bai: Metabolic Control Analysis of L-Cysteine Producing Strain TS1138 ofPseudomonas sp. Biochemistry (Moscow).2009;74(3):355-361;

24. Geng Peng, Gang Bai*, Shi Qian, Zhang Lei, Gao Zhihui, Zhang Qi: Taxonomy of the Streptomyces strain ZG0656 that produces acarviostatin alpha-amylase inhibitors and analysis of their effects on blood glucose levels in mammalian systems. Journal of Applied Microbiology2009;106 (2) 525–533

25. Peng Geng, Xiansheng Meng, Gang Bai,* Guoan Luo: Luo, Guoan: Profiling of acarviostatin family secondary metabolites secreted byStreptomyces coelicoflavus ZG0656 using ultraperformance liquid chromatography coupled with electrospray ionization mass spectrometry (UPLC/ESI-MS). Analytical Chemistry2008;80(19):7554-61;

26. GangBai,* Yang Yang, Qian Shi, Ze Liu, Qi Zhang, Yuan-yuan Zhu: Identification of higenamine in Radix Aconiti Lateralis Preparata as a beta2-adrenergic receptor agonist.Acta Pharmacologica Sinica. 2008;29(10):1187-1194;

27. Qi Zhang, Gang Bai,* Jiaqi Chen, Wang Tian, Yu Cao, Pengwei Pan, Chao Wang: Identification of antiviral mimetic peptides with interferon α-2b like activity from a random peptide library using a novel functional bio-panning method. Acta Pharmacologica Sinica. 2008; 29(5):634-640 ;

28. Peng Geng, Feng Qiu, Yuanyuan Zhu, Gang Bai*: Four acarviosine-containing oligosaccharides isolated from the culture ofStreptomyces coelicoflavus ZG0656 as potent α-amylase inhibitors. Carbohydrate Research. 2008; (343): 882–892;

29. Geng Peng, Gang Bai*: Two novel aminooligosaccharides isolated from the culture of Streptomyces coelicoflavus ZG0656 as potent α-amylase inhibitors. Carbohydrate Research. 2008; (343): 470-476;

30. Jiaqi Chen, Gang Bai,* Yu Cao, Zhihui Gao, Yuanyuan Zhu, Wenbo Yang : One-step purification of a fusion protein of glucagon-like peptide-1 and human serum albumin expressed in pichia pastoris by an immunomagnetic separation technique..Biosci. Biotechnol. Biochem.2007;71 (11), 2655–2662;

31. Yu Cao, Wang Tian, Shenyan Gao, Wenbo Yang, Gang Bai*: Immobilization Staphylococcal_Protein A on magnetic cellulose microspheres for IgG affinity purification. Artificial Cells Blood Substitutes and Immobilization Biotechnology.2007;35(5):467-480;

32. Peng Geng, Yang Yang, Zhihui Gao, Yangsheng Yu, Qian Shi, Gang Bai*: Combined effect of total alkaloids from Feculae bombycis and natural flavonoids on diabetes. Journal of Pharmacy and Pharmacology. 2007;59(8): 1145-50;

33. Qi Zhang, Gang Bai,* Jiaqi Chen, Yangsheng Yu , Wang Tian, Wen-bo Yang: Use of an Enhanced Green Fluorescence Protein linked to a Single Chain Fragment Variable Antibody to LocalizeBursaphelenchus xylophilus Cellulase. Biosci. Biotechnol. Biochem.2007;71 (6), 1514-1520;

34. Yangsheng Yu, Gang Bai,* Chunqin Liu, Yu Cao, Peng Geng, Wenbo Yang: One-step elimination of L-cysteine desulfhydrase from crude enzyme extracts ofPseudomonas sp. TS1138 using an immunomagnetic affinity matrix improves the enzymatic production of L-cysteine. Journal of Chromatography B. 2007; 853 (6) :247–253 ;

35. Yu Cao, Qi Zhang, Chao Wang, Yuanyuan Zhu, Gang Bai*: Preparation of novel immunomagnetic cellulose microspheres via CBD-protein A linkage and its use for the isolation of interferon alpha-2b. Journal of Chromatography A. 2007; 1149: 228–235;

36. Jiaqi Chen, Gang Bai,* Yang Yang, Peng Geng, Yu Cao, Yanyan Zhu：Identifying glucagon-like peptide-1 mimetics using a novel functional reporter gene high-throughput screen assay. Peptides. 2007 28(4):928-34;