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宋楊
西南大學教授
2001年和2006年於武漢大學獲得學士和博士學位,2006-2008年美國愛荷華大學博士后研究員,2008年擔任西南大學教授,博士生導師至今。2009年入選教育部新世紀優秀人才計劃。2009-2010年美國愛荷華大學高級訪問學者。2012-2013年美國佛羅里達大學高級訪問學者。2016年獲得國家基金委優秀青年基金。主持國家基金委、科技部、教育部和重慶市等基金,發表SCI論文60餘篇,包括PNAS、Chem Res Toxicol 、J Org Chem、Free Radical Bio Med、Toxicological Sciences和Toxicology等。
2008.12-至今 西南大學,藥學院,教授,博士生導師;
2012.08-2013.02 美國佛羅里達大學,化學學院,高級訪問學者;
2009.10-2010.03 美國愛荷華大學,醫學院,高級訪問學者;
2006.10-2008.12 美國愛荷華大學,公共衛生學院/醫學院雙聘,博士后;
2001.09-2006.10 武漢大學,化學與分子科學學院,博士;
1997.09-2001.07 武漢大學,化學與分子科學學院,學士。
主要社會兼職:
(2).國家基金委、科技部、教育部、人事部和重慶市等項目評審專家。
(3). Chem Res Toxicol、Food Chem Toxicol、Environ Sci Technol、J Hazard Mater、J Appl Toxicol和Free Radical Bio Med 等國際期刊審稿人。
本課題組研究興趣如下:
1、研究小分子對信號通路的影響,包括炎症、腫瘤轉移和侵襲、自噬和程序性細胞死亡等;
2、研究氧化應激相關生理過程及藥物干預,包括神經退行性疾病、肝損傷等;
3、功能納米材料的構建、細胞行為及其生理學意義。
(1). 國家自然科學基金委優秀青年基金(NSFC-21622704):環境毒理與健康效應,2017.01-2019.12,主持
(2). 國家自然科學基金(NSFC-21477098):多氯聯苯醌引起的氧化應激相關信號轉導與神經毒性作用機制及抗氧化劑干預,2015.01-2018.12,主持。
(3). 國家自然科學基金(NSFC-20907037):尋找多氯聯苯代謝途徑中缺失的一環,2010.01-2012.12,主持。
(4). 教育部新世紀優秀人才支持計劃(NCET-10-0660):2010.01-2012.12,主持。
(5). 科技部重大新葯創製科技重大專項子項目(2010ZX09401-306-2-19):抗腫瘤葯巰環磷醯胺的臨床前研究,2010.01-2012.12,主持。
(6). 教育部留學回國人員科研啟動基金(2011[508]):由多氯聯苯及其衍生物引發的自由基及其毒性關係研究,2011.08-2014.07,主持。
(7). 重慶市自然科學基金(CSTC-2009BB5005):具有雙重功能的抗腫瘤活化前葯的設計,合成及生物活性研究,2009.03-2012.02,主持。
(8). 中央高校基本科研業務費團隊項目(XDJK2016A004):抗氧化策略干預炎症過程,2016.01-2017.12,主持。
(9). 中央高校基本科研業務費重大項目(XDJK2014A020):植物來源多酚類化合物防治阿爾茨海默病的分子機制及藥用基礎,2014.03-2017.02,主持。
(10). 中央高校基本科研業務費重點項目(XDJK2010B008):基於氨肽酶的抗體導向抗腫瘤前葯的設計與評價,2010.11-2013.10,主持。
(11). 西南大學博士基金(SWUB2008077):共價鍵交聯G-四鏈體抑制端粒酶的藥物小分子研究,2009.01-2011.12,主持。
(12). 科技部重大新葯創製科技重大專項(2010ZX09401-306-1-4):重慶創新藥物質量控制工程技術研究中心,2010.01~2012.12,參與。
(13). 國家重點基礎研究發展計劃(973計劃)(2012CB720600):基於核酸的重大疾病診斷新策略和新技術研究,2012.01-2016.08,參與。
(14). 國家自然科學基金重點項目(NSFC-21035005):長程共振能量轉移及其在生物醫藥分析中的應用,2011.01-2014.12,參與。
(15). 中央高校基本科研業務費(XDJK2009C083):基於多色熒光量子點的多腫瘤標誌物的同時免疫分析2009.11-2012.10,參與。
(16). 重慶市自然科學基金(CSTC2010BB113):多色熒光量子點標記探針高靈敏同時檢測食品中的多種殘留抗生素,2010.10-2013.09,參與。
1. Yang Song, Brett A. Wagner, Jordan R. Witmer, Hans-Joachim Lehmler, Garry R. Buettner*, Nonenzymatic displacement of chlorine and formation of free radicals upon the reaction of glutathione with PCB quinones, Proceedings of the National Academy of Sciences of the United States of America, 2009, 106, 9725–9730.
2. Zixuan Liu, Qiong Shi, Xiufang Song, Yuxin Wang, Yawen Wang, Erqun Song, Yang Song*, Activating Transcription Factor 4 (ATF4)-ATF3-C/EBP Homologous Protein (CHOP) Cascade Shows an Essential Role in the ER Stress-Induced Sensitization of Tetrachlorobenzoquinone- Challenged PC12 Cells to ROS-Mediated Apoptosis via Death Receptor 5 (DR5) Signaling, Chemical Research in Toxicology, 2016, 29, 1510-1518.
3. Chuanyang Su, Qiong Shi, Xiufang Song, Juanli Fu, Zixuan Liu, Yawen Wang, Yuxin Wang, Xiaomin Xia, Erqun Song*, Yang Song*, Tetrachlorobenzoquinone induces Nrf2 activation via rapid Bach1 nuclear export/ubiquitination and JNK-P62 signaling, Toxicology, 2016, 363, 48-57.
4. Juanli Fu, Qiong Shi, Xiufang Song, Zixuan Liu, Yawen Wang, Yuxin Wang, Erqun Song, Yang Song*, Tetrachlorobenzoquinone exerts neurological pro-inflammatory activity by promoting HMGB1 release, which induces TLR4 clustering within the lipid raft, Toxicological Sciences, 2016,153, 303-315.
5. Qiong Shi, Xiufang Song, Zixuan Liu, Yawen Wang, Yuxin Wang, Juanli Fu, Chuanyang Su, Xiaomin Xia, Erqun Song, Yang Song*, Quinones Derived from Polychlorinated Biphenyls Induce ROS-Dependent Autophagy by Evoking an Autophagic Flux and Inhibition of mTOR/p70S6k, Chemical Research in Toxicology, 2016, 29, 1160-1171.
6. Xiaomin Xia, Qiong Shi, Xiufang Song, Juanli Fu, Zixuan Liu, Yawen Wang, Yuxin Wang, Chuanyang Su, Erqun Song, Yang Song*, Tetrachlorobenzoquinone stimulates NLRP3 inflammasome-mediated post-translational activation and secretion of IL-1β in endothelial HUVEC cell line, Chemical Research in Toxicology, 2016, 29, 421-429.
7. Xiufang Song, Lingrui Li, Qiong Shi, Hans-Joachim Lehmler*, Juanli Fu, Chuanyang Su, Xiaomin Xia, Erqun Song, Yang Song*, Polychlorinated biphenyl quinone metabolite promotes p53-dependent DNA damage checkpoint activation, S-phase cycle arrest and extrinsic apoptosis in human liver hepatocellular carcinoma HepG2 Cells, Chemical Research in Toxicology, 2015, 28, 2160-2169.
8. Xiaomin Xia, Juanli Fu, Xiufang Song, Qiong Shi, Chuanyang Su, Erqun Song, Yang Song*, Neohesperidin dihydrochalcone down-regulates MyD88-dependent and -independent signaling by inhibiting endotoxin-induced trafficking of TLR4 to lipid rafts, Free Radical Biology and Medicine, 2015, 89, 522-532
9. Demei Xu, Chuanyang Su, Xiufang Song, Qiong Shi, Juanli Fu, Lihua Hu, Xiaomin Xia, Erqun Song, Yang Song*, Polychlorinated Biphenyl Quinone Induces Endoplasmic Reticulum Stress, Unfolded Protein Response, and Calcium Release, Chemical Research in Toxicology, 2015, 28,1326-1337.
10. Hui Dong, Qiong Shi, Xiufang Song, Juanli Fu, Lihua Hu, Demei Xu, Chuanyang Su, Xiaomin Xia, Erqun Song, Yang Song*, Polychlorinated biphenyl quinone induces oxidative DNA damage and repair responses: The activations of NHEJ, BER and NER via ATM-p53 signaling axis, Toxicology and Applied Pharmacology, 2015, 286, 10-16.
11. Juanli Fu, Qiong Shi, Xiufang Song, Xiaomin Xia, Chuanyang Su, Zixuan Liu, Erqun Song, Yang Song*, Tetrachlorobenzoquinone exhibits neurotoxicity by inducing inflammatory responses through ROS-mediated IKK/IκB/NF-κB signaling, Environmental Toxicology and Pharmacology, 2016, 41, 241-250
12. Qiong Shi, Xiufang Song, Juanli Fu, Chuanyang Su, Xiaomin Xia, Erqun Song, Yang Song*, Artificial sweetener neohesperidin dihydrochalcone showed antioxidative, anti-inflammatory and anti-apoptosis effects against paraquat-induced liver injury in mice, International Immunopharmacology, 2015, 29, 722-729.
13. Lihua Hu, Chuanyang Su, Xiufang Song, Qiong Shi, Juanli Fu, Xiaomin Xia, Demei Xu, Erqun Song, Yang Song*, Tetrachlorobenzoquinone triggers the cleavage of Bid and promotes the cross-talk of extrinsic and intrinsic apoptotic signalings in PC12 cells, NeuroToxicology, 2015, 49, 149–157.
14. Chuanyang Su, Xiaomin Xia, Qiong Shi, Xiufang Song, Juanli Fu, Congxue Xiao, Hongjun Chen, Bin Lu, Zhiyin Sun, Shanmei Wu, Siyu Yang, Xuegang Li, Xiaoli Ye, Erqun Song, Yang Song*, Neohesperidin Dihydrochalcone versus CCl-Induced Hepatic Injury through Different Mechanisms: The Implication of Free Radical Scavenging and Nrf2 Activation, Journal of Agricultural and Food Chemistry, 2015, 63, 5468-5475.
15. Hui Dong, Qiong Shi, Xiufang Song, Juanli Fu, Lihua Hu, Demei Xu, Chuanyang Su, Xiaomin Xia, Erqun Song, Yang Song*, Polychlorinated biphenyl quinone induces oxidative DNA damage and repair responses: The activations of NHEJ, BER and NER via ATM-p53 signaling axis, Toxicology and Applied Pharmacology, 2015, 286, 10-16.
16. Pu Zhang, Shan Feng, Huiyuan Bai, Panying Zeng, Feng Chen, Chengxiang Wu, Yi Peng, Qin Zhang, Qiuyao Zhang, Qichao Ye, Qiang Xue, Xiaoyu Xu, Erqun Song, Yang Song*, Polychlorinated biphenyl quinone induces endothelial barrier dysregulation by setting the crosstalk between VE-cadherin, focal adhesion and MAPK signaling, American Journal of Physiology-Heart and Circulatory Physiology, 2015, 308, H1205-1214.
17. Chuanyang Su, Pu Zhang, Xiufang Song, Qiong Shi, Juanli Fu, Xiaomin Xia, Huiyuan Bai, Lihua Hu, Demei Xu, Erqun Song, Yang Song*, Tetrachlorobenzoquinone activates Nrf2 signaling by Keap1 cross-Linking and ubiquitin translocation but not Keap1-cullin3 complex dissociation, Chemical Research in Toxicology, 2015, 28,765-774.
18. Demei Xu, Lihua Hu, Chuanyang Su, Xiaomin Xia, Pu Zhang, Juanli Fu, Wenchao Wang, Duo Xu, Hong Du, Qiuling Hu, Erqun Song, Yang Song*, Tetrachloro-p-benzoquinone induces hepatic oxidative damage and inflammatory response, but not apoptosis in mouse: The prevention of curcumin, Toxicology and Applied Pharmacology, 2014, 280, 305-313.
19. Xiaomin Xia, Chuanyang Su, Juanli Fu, Pu Zhang, Xiaoji Jiang, Demei Xu, Lihua Hu, Erqun Song*, Yang Song*, Role of α-lipoic acid in LPS/D-GalN induced fulminant hepatic failure in mice: Studies on oxidative stress, inflammation and apoptosis, International Immunopharmacology, 2014, 22, 293-302.
20. Demei Xu, Lingrui Li, Lichao Liu, Hui Dong, Qin Deng, Xiaojia Yang, Erqun Song, Yang Song*, Polychlorinated biphenyl quinone induces mitochondrial-mediated and caspase-dependent apoptosis in HepG2 cells, Environmental Toxicology, 2015, 30, 1063-1072.
1. 宋爾群,宋楊,磁編碼的熒光-磁性多功能納米複合物及其製備方法,中國專利,專利號ZL201310344477.7.
2. 宋楊,宋爾群,李程,提取綠原酸的方法,中國專利,專利號ZL201210453316.7.
3. 宋楊,宋爾群,李效堯,一種對乙醯氨基酚—磷醯氮芥抗腫瘤藥物及其製備方法,中國專利,專利號ZL201110434041.8.
4. 宋楊,宋爾群,李效堯,環磷醯胺類衍生物及作為抗腫瘤藥物的用途,中國專利,專利號ZL20111 0424586.0.
(1).教育部新世紀優秀人才支持計劃,2009;
(2).西南大學成才基金,2010;
(3). Scoups“尋找青年科學之星”,2012;
(4).西南大學優秀共產黨員,2012;
(5).國家基金委優秀青年基金,2016。