陳濤

講授課程:

研究生學位課《高等生物反應工程》

研究生選修課《代謝工程》

本科生專業實驗課《基因工程技術實驗》

本科生專業課《基因工程操作原理》

學術兼職:

國際代謝工程學會(IMES)會員，中國微生物學會會員；

國家自然科學基金評審人，教育部學位與研究生教育評估網評專家；

國際期刊Frontiers in Bioengineering and Biotechnology的審稿編輯

Metabolic Engineeing, Biotechnology for Biofuels，Bioresource Technology，ACS Synthetic Biology,Biotechnology and Bioengineering, Micirobial Cell Factories， Journal of Biotechnology，Biotechnology Journal，Current Microbiology、生物工程學報，化工學報、化學進展等國內外學術期刊審稿人。學術成就:

2010年，天津大學研究生數字化教學平台課程建設三等獎2011年，大學生創新實踐活動優秀指導教師

2013年，天津大學化工學院青年教師講課賽二等獎

2013年，寶舜獎教金

2014年，天津大學青年教師講課賽三等獎

2015年，本科畢業設計優秀指導教師

科研項目:

國家自然科學基金面上項目：枯草芽孢桿菌基因組最小化的研究

973子課題：生物基材料合成途徑的DNA模塊設計與組裝

973子課題：代謝網路與調控網路構建分析與模擬設計

天津市科委基金：枯草芽孢桿菌生產2,3-丁二醇的代謝工程研究

國家自然科學基金青年基金：基於高產核黃素枯草芽孢桿菌全基因組突變分析的逆向代謝工程研究

國家自然科學基金面上項目：枯草芽孢桿菌基因組微氧代謝木糖機理及產乙偶姻代謝工程研究

國家自然科學基金面上項目：大腸桿菌微氧產3-羥基丙酸代謝工程研究

主要論著

2017

1．Y Mao, J Fu, R Tao, C Huang, Z Wang*, YJ Tang, T Chen*, X Zhao. Systematic metabolic engineering of Corynebacterium glutamicum for industrial-level production of optically pure D-(-)-Acetoin. Green Chemistry，2017,19, 5691-5702.

2. G Huo, Y Zhu, Q Liu, R Tao, N Diao, Z Wang, T Chen*. Metabolic engineering of an E. coli ndh knockout strain for PHB production from mixed glucose‐xylose feedstock.Journal of Chemical Technology and Biotechnology.2017, 92(10):2739-2745.

3．Q Yuan, T Huang, P Li, T Hao, F Li, H Ma*, Z Wang*, X Zhao, T Chen*, I. Goryanin. Pathway-Consensus Approach to Metabolic Network Reconstruction for Pseudomonas putida KT2440 by Systematic Comparison of Published Models. PloS one,2017, 12 (1), e0169437.

4. Y Zhang, P Kang, S Liu, Y Zhao, Z Wang, T Chen*. glyA gene knock-out in Escherichia coli enhances L-serine production without glycine addition., Biotechnology and Bioprocess Engineering. 2017, 22 (4), 390-396.

5. T Liu, YY Yu, T Chen, WN Chen. A synthetic microbial consortium of shewanella and bacillus for enhanced generation of bioelectricity. Biotechnology and bioengineering.2017, 114 (3), 526-532.

6. Z Li, J Meng, W Wang, Z Wang, M Li, T Chen, CJ Liu. The room temperature electron reduction for the preparation of silver nanoparticles on cotton with high antimicrobial activity. Carbohydrate Polymers.2017, 161, 270-276.

7．Y Zou, T Chen, L Feng, S Zhang, D Xing, Z Wang*. Enhancement of 5-aminolevulinic acid production by metabolic engineering of the glycine biosynthesis pathway in Corynebacterium glutamicum. Biotechnology Letters, 2017, 39(9):1369-1374.

8. A Kalantari, T Chen, B Ji, IA Stancik, V Ravikumar, D Franjevic, C. Saulou-Bérion, A. Goelzer, and Ivan Mijakovic..Conversion of glycerol to 3-hydroxypropanoic acid by genetically engineered Bacillus subtilis. Frontiers in microbiology.2017, 8:638

2016

1.J Fu, G Huo, L Feng, Y Mao, Z Wang*, H Ma, T Chen*, X Zhao. Metabolic engineering of Bacillus subtilis for chiral pure meso-2, 3-butanediol production.Biotechnology for biofuels. 2016.9:90

2.Lili Feng, Ya Zhang, Jing Fu, Tao Chen, Xueming Zhao,Zhiwen Wang *,Metabolic engineering of Corynebacterium glutamicum for efficient production of 5-aminolevulinic acid. Biotechnology and Bioengineering.2016.113(6):1284-1293.

3.Y Li, X Zhu, X Zhang, J Fu, Z Wang, T Chen*, X Zhao. Characterization of genome-reduced Bacillus subtilis strains and their application for the production of guanosine and thymidine. Microbial cell factories. 2016.15:94.

4.Bo Zhang, Xin-li Li, Fu Jing, Ning Li, Zhiwen Wang*,Ya-jie Tang, Tao Chen*.Production of Acetoin through Simultaneous Utilization of Glucose, Xylose, and Arabinose by Engineered Bacillus subtilis. PloS one. 2016,11 (7), e0159298.

5.JH Yu, LW Zhu, ST Xia, HM Li, YL Tang, XH Liang, T Chen, YJ Tang*.Combinatorial optimization of CO2 transport and fixation to improve succinate production by promoter engineering. Biotechnology & Bioengineering. 2016,113(7):1531-1541.

6.S Liu, P Kang, Z Cui, Z Wang, T Chen*. Increased riboflavin production by knockout of 6-phosphofructokinase I and blocking the Entner–Doudoroff pathway in Escherichia coli.Biotechnology letters. 2016.38(8):1307-1314.

7.Qinglong Meng, Yanfei Zhang, Xiaozhi Ju, Chunling Ma, Hongwu Ma*, Jiuzhou Chen, Ping Zheng, Jibin Sun, Jun Zhu, Yanhe Ma, Xueming Zhao, Tao Chen*.Production of 5-aminolevulinic acid by cell free multi-enzyme catalysis. Journal of Biotechnology. 2016;226:8–13.

8.Xiaoyan Yang, Qianqian Yuan, Yangyang Zheng, Hongwu Ma*, Tao Chen, Xueming ZhaoAn engineered non-oxidative glycolysis pathway for acetone production in Escherichia coli. Biotechnology Letters. 2016, 38(8):1359-1365.

9.X Wang, G Wang, X Li, J Fu, T Chen, Z Wang*, X Zhao. Directed evolution of adenylosuccinate synthetase from Bacillus subtilis and its application in metabolic engineering. Journal of biotechnology. 2016.231:115-121.

10.J Meng, B Wang, D Liu, T Chen, Z Wang*, X Zhao. High-yield anaerobic succinate production by strategically regulating multiple metabolic pathways based on stoichiometric maximum in Escherichia coli. Microbial Cell Factories. 2016;15:141.

11.余君涵，馬雯雯，王智文，陳濤，趙學明。人工合成啟動子文庫研究進展。微生物學通報. 2016;43(1):198-204.

12.徐志博，林振泉，陳濤。大腸桿菌中核黃素的生物合成途徑改造及生產。化學工業與工程. 2016;33(2):114-119.

2015

1.Yifan Li; Zhenquan Lin; Can Huang; Yan Zhang; Zhiwen Wang; Chen Tao*, Xueming Zhao.Metabolic engineering of Escherichia coli using CRISPR-Cas9 meditated genome editing. Metabolic Engineering. 2015,31:13-21.27.

2. Zhang, Bo;Li, Ning;Wang, Zhiwen;Tang, Ya-Jie;Chen, Tao*Zhao, Xueming, Inverse metabolic engineering of Bacillus subtilis for xylose utilization based on adaptive evolution and whole-genome sequencing, Applied Microbiology and Biotechnology, 99(2), pp 885-896, 2015/2/1.

3.Wang Xiaoyue, Wang Baiyun, Wang Zhiwen*, Chen Tao, Zhao Xueming. The research progress of protein directed evolution. Prog. Biochem. Biophys. 2015,42(2):123-131.

4.Ma, Wenwen;Wang, Xiaoyue;Mao, Yufeng;Wang, Zhiwen*;Chen, Tao;Zhao, Xueming, Development of a markerless gene replacement system in Corynebacterium glutamicumusing upp as a counter-selection marker., Biotechnology Letters,. 2015.37(3):609-617.

5.Zhibo Xu, Zhenquan Lin, ZhiwenWang, Tao Chen*. Improvement of the riboflavin production by engineering the precursors biosynthesis pathways inEscherichia coli.Chinese Journal of Chemical Engineering. 2015,23(11):1834-1839.

6.Zhenquan Lin, Yan Zhang, Qianqian Yuan, Qiaojie Liu, Yifan Li, Zhiwen Wang, Hongwu Ma*, Tao Chen*, Xueming Zhao. Metabolic engineering ofEscherichia colifor poly(3-hydroxybutyrate) production via threonine bypass.Microbial Cell Factories,2015,14:185.

7.QinglongMeng,YanfeiZhang,ChunlingMa,HongwuMa*,XuemingZhao,TaoChen.Purification and functional characterization of thermostable 5-aminolevulinic acid synthases.Biotechnology Letters,2015, 37(11):2247-2253.

8.王永成，陳濤，石婷，王智文*,趙學明。嘌呤核苷及其衍生物的代謝工程，中國生物工程雜誌,2015,35（5）：87-95.

9.劉曉霏，付晶，霍廣鑫，章博，王智文，陳濤*，生物法製備平台化合物乙偶姻的最新研究進展，中國生物工程雜誌,2015,35（10）：91-99.

10.朱旭軍，李一凡，李楊，付晶，王智文，陳濤*.陳濤枯草芽孢桿菌無標記遺傳操作技術研究進展2015, 42(12): 2440−2447.

11.李思夢；李曉靜；陳濤*,代謝工程方法改造大腸桿菌生產胸苷，生物工程學報, 31:01期, pp 105-114, 2015.

12.趙學明，陳濤，王智文，《代謝工程》，高等教育出版社，北京，2015.

2014

1 Qiaojie Liu; Zhenquan Lin; Yan Zhang; Yifan Li; Zhiwen Wang; Tao Chen*, Improved poly(3-hydroxybutyrate) production in Escherichia coli by inactivation of cytochrome bd-II oxidase or/and NDH-II dehydrogenase in low efficient respiratory chains., Journal of Biotechnology, 192 Pt A卷, pp 170-176, 2014/12/20.

2. Yan Zhang,Zhenquan Lin,Qiaojie Liu,Yifan Li,Zhiwen Wang,Hongwu Ma,Tao Chen*,Xueming Zhao.Engineering of Serine-Deamination pathway, Entner-Doudoroff pathway and pyruvate dehydrogenase complex to improve poly(3-hydroxybutyrate) production in Escherichia coli.Microbial Cell Factories.2014, 13(1):172.

3 Ning Li; Bo Zhang; Zhiwen Wang; Ya-Jie Tang; Tao Chen*; Xueming Zhao, Engineering Escherichia coli for fumaric acid production from glycerol., Bioresour Technol, 174C卷, pp 81-87, 2014/10/7.

4. Fu, Jing; Wang, Zhiwen; Chen, Tao*; Liu, Weixi; Shi, Ting; Wang, Guanglu; Tang, Ya-jie; Zhao, Xueming, NADH plays the vital role for chiral pure D-(-)-2,3-butanediol production in Bacillus subtilis under limited oxygen conditions., Biotechnology and Bioengineering, 111(10), pp 2126-2131, 2014/10.

5. Ma, Xianghui; Zhang, Xinbo; Wang, Baiyun; Mao, Yufeng; Wang, Zhiwen*; Chen, Tao*; Zhao, Xueming, Engineering microorganisms based on molecular evolutionary analysis: a succinate production case study., Evolutionary Applications, 7(8), pp 913-920, 2014/9.

6. Wang Baiyun; Wang Xiaoyue; Wang Zhiwen*; Chen Tao; Zhao Xueming, Redox Cofactor Metabolic Engineering with Escherichia coli, Progress in Chemistry, 26(9), pp 1609-1618, 2014/9.

7. Lin, Zhenquan; Xu, Zhibo; Li, Yifan; Wang, Zhiwen*; Chen, Tao*; Zhao, Xueming, Metabolic engineering of Escherichia coli for the production of riboflavin, Microbial Cell Factories, 13卷, 2014/7/16.2014, 13:104

8. Shi, Ting; Wang, Yongcheng; Wang, Zhiwen*; Wang, Guanglu; Liu, Dingyu; Fu, Jing; Chen, Tao; Zhao, Xueming, Deregulation of purine pathway in Bacillus subtilis and its use in riboflavin biosynthesis, Microbial Cell Factories, 13:101, 2014/7/15.

9.Wang, Guanglu; Bai, Ling; Wang, Zhiwen*; Shi, Ting; Chen, Tao; Zhao, Xueming, Enhancement of riboflavin production by deregulating gluconeogenesis in Bacillus subtilis., World Journal of Microbiology and Biotechnology, 30(6), pp 1893-1900, 2014/6.

10.賈慧慧；李曉靜；陳濤*；趙學明, 微生物發酵法生產L-絲氨酸及L-半胱氨酸研究進展, 中國生物工程雜誌, 05期, pp 100-106, 2014/5/15.

11. Yang, Jiangang; Wang, Zhiwen; Zhu, Nianqing; Wang, Baiyun; Chen, Tao*; Zhao, Xueming, Metabolic engineering of Escherichia coli and in silico comparing of carboxylation pathways for high succinate productivity under aerobic conditions, Microbiological Research, 169(5–6), pp 432-440, 2014/5.

12.馬紅武；劉會娟；朱年青；陳濤*, 代謝工程方法改造谷氨酸棒狀桿菌生產乙偶姻, 天津大學學報(自然科學與工程技術版), 11期, pp 967-972, 2014/4.

13. Zhu, Nianqing; Xia, Huihua; Yang, Jiangang; Zhao, Xueming; Chen, Tao*, Improved succinate production in Corynebacterium glutamicum by engineering glyoxylate pathway and succinate export system, Biotechnology Letters, 36(3), pp 553-560, 2014/3.

14. 李桂瑩；張新波；王智文*；石婷；陳濤；趙學明, 逆向代謝工程的最新研究進展, 生物工程學報, 08期, pp 1151-1163, 2014/3.

15. Tao Chen; Nianqing Zhu; Huihua Xia, Aerobic production of succinate from arabinose by metabolically engineered Corynebacterium glutamicum, Bioresource Technology, 151(5–6), pp 411-414, 2014/1.

16. 夏慧華；尹國民；朱年青；陳濤*, 谷氨酸棒桿菌生產琥珀酸的代謝工程研究進展, 微生物學通報, 05期, pp 943-949, 2014

2013

1.Hao, Tong;Han, Binbin;Ma, Hongwu;Fu, Jing;Wang, Hui;Wang, Zhiwen;Tang, Bincai; Chen, Tao*;Zhao, Xueming*, 2013, In silico metabolic engineering of Bacillus subtilis for improved production of riboflavin, Egl-237, (R,R)-2,3-butanediol and isobutanol, Molecular Biosystems, 9(8), pp 2034-2044 (SCI, IF=3.350(2012))

2.Zhu, Nianqing;Xia, Huihua;Wang, Zhiwen;Zhao, Xueming;Chen, Tao*, 2013, Engineering of Acetate Recycling and Citrate Synthase to Improve Aerobic Succinate Production in Corynebacterium glutamicum, PLos One, 8(4), (SCI, IF=3.730(2012)

3.劉維喜；付晶；章博；陳濤*, 2013, 微生物木糖代謝途徑改造製備生物基化學品, 生物工程學報, (08), pp 1161-1172

4.鄭宗寶；趙美娜；陳濤*；趙學明, 2013, 基於重組策略的一體化生物加工過程最新進展, 生物工程學報, (10), pp 1354-1362

5.顧群；李一凡；陳濤*, 2013, 合成生物系統的組合優化, 生物工程學報, (08), pp 1064-1074

6.湯彬彩；郝彤；袁倩倩；陳濤；馬紅武*, 2013, 一種基於代謝網路分析最小化基因組的方法及其在大腸桿菌中的應用, 生物工程學報, (08), pp 1173-1184

7.Li, Yifan;Gu, Qun;Lin, Zhenquan;Wang, Zhiwen;Chen, Tao*;Zhao, Xueming, 2013, Multiplex Iterative Plasnnid Engineering for Combinatorial Optimization of Metabolic Pathways and Diversification of Protein Coding Sequences, ACS Synthetic Biology, 2(11), pp 651-661 (SCI, IF=(2012))

8.Li-Wen Zhu;Xiao-Hong Li;Lei Zhang;Hong-Mei Li;Jian-Hua Liu;Zhan-Peng Yuan;Tao Chen;Ya-Jie Tang*, 2013, Activation of glyoxylate pathway without the activation of its related gene in succinate-producing engineered Escherichia coli, Metabolic Engineering, 20(4), pp 9-19 (EI, SCI, IF=6.859(2012))

9.Shi, Ting;Wang, Guanglu;Wang, Zhiwen*;Fu, Jing;Chen, Tao;Zhao, Xueming, 2013, Establishment of a Markerless Mutation Delivery System in Bacillus subtilis Stimulated by a Double-Strand Break in the Chromosome, PLos One, 8(11), (SCI, IF=3.730(2012))

10.Li, Ning;Zhang, Bo;Chen, Tao*;Wang, Zhiwen;Tang, Ya-jie;Zhao, Xueming, 2013, Directed pathway evolution of the glyoxylate shunt in Escherichia coli for improved aerobic succinate production from glycerol, Journal of Industrial Microbiology and Biotechnology, 40(12), pp 1461-1475 (SCI, IF=2.321(2012))

11.Liu, Rui-Sang; Zhou, Huan;Li, Hong-Mei;Yuan, Zhan-Peng;Chen, Tao;Tang, Ya-Jie*, 2013, Metabolism of L-methionine linked to the biosynthesis of volatile organic sulfur-containing compounds during the submerged fermentation of Tuber melanosporum, Applied Microbiology and Biotechnology, 97(23), pp 9981-9992 (EI, SCI, IF=3.689(2012))

12.Tao Chen*;Weixi Liu;Jing Fu;Bo Zhang;Ya-jie Tang, 2013, Engineering Bacillus subtilis for acetoin production from glucose and xylose mixtures, Journal of Biotechnology, 168(4), pp 499-505 (EI, SCI, IF=3.183(2012))

2012

1.Zheng, Zongbao; Chen, Tao*;Zhao, Meina;Wang, Zhiwen;Zhao, Xueming, 2012, Engineering Escherichia coli for succinate production from hemicellulose via consolidated bioprocessing, Microbial Cell Factories, 11, (EI, SCI, IF=3.5520(2011),

2.Wang, Qingzhao;Chen, Tao; Zhao, Xueming;Chamu, Jauhleene, 2012, Metabolic engineering of thermophilic Bacillus licheniformis for chiral pure D-2,3-butanediol production, Biotechnology and Bioengineering, 109(7), pp 1610-1621 (SCI, IF=3.9460(2011)

3.Wang, Meng;Fu, Jing; Zhang, Xueyu;Chen, Tao*, 2012, Metabolic engineering of Bacillus subtilis for enhanced production of acetoin, Biotechnology Letters, 34(10), pp 1877-1885 (EI, SCI, IF=1.853(2012)

4.付晶；王萌；劉維喜；陳濤*；FuJingWangMengLiuWeixiChenTao(KeyLaborato, 2012, Latest Advances of Microbial Production of 2,3-Butanediol, Progress in Chemistry, 24(11), pp 2268-2276 (SCI, IF=0.670(2012)).