陳雷

2011.3-2015.2. 慶北大學農業生命科學學院，應用生命科學專業農學博士 (Ph. D.)

2009.3-2011.2. 慶北大學農業生命科學學院，應用生命科學專業農學碩士 (M.S.E.)

2015.08-至今 福建農林大學 副教授待遇

2015.3-2015.6 慶北大學生命研究所 博士后研究員

2009.3 – 2015.3 韓國政府獎學金

2014.12. 優秀博士論文發表獎(top 1%)

2011-2015年 博士在讀期間任學科助教，指導並完成41名本科畢業論文，並擔任天然產物成分析/統計學的雙語（英語和韓語）教學工作。

2009-2015年 近5年來前後主持/參與韓國農業發展廳、慶尚北道農業科技部科研課題11項，從事天然產物活性因子的分離純化及其功能評價和功能保健食品的開發。

• Food Research International (8)

• Journal of Separation Science (3)

• Natural Product Research (4),

• International Journal of Food Properties (4)

• Medicinal Chemistry Research (5)

• Journal of the Science of Food and Agriculture (1)

• Phytomedicine (3)

食藥品的功能成分生理活性和安全性的檢測：

單體化合物的活性分析有助於解析和認識功能性活性組分。目前的研究工作主要從活性←結構特徵→作用機 理兩個方向著手，系統探究功能性成分活性的構效機制。博士期間做了大量的不同溶液提取物和單體的體內外抗氧化、抗炎（LPS-誘導炎症巨噬細胞和小鼠）、抗癌（癌細胞實驗）、抗糖尿（體外和STZ-誘導小鼠實驗）活性比較，對活性物質的抗病機理以及信號通路分析具有比較好的研究基礎。

計算化學生物學

以分子模擬、生物信息學和化學信息學為手段，研究重要生物大分子的功能和機制，研究有機小分子和生物大分子相互作用的基本理論，發展和完善計算機輔助藥物設計方法。運用計算機輔助藥物設計方法並結合必要的化學和生物實驗手段，尋找和設計可以有效調節重大疾病靶標分子功能的有機小分子化合物。

主要論文發表情況(含in press階段)

1. Chen L., Kang Y.H. Antioxidant and Enzyme Inhibitory Activities of Plebeian Herba (Salvia plebeia R. Br.) under Different Cultivation Conditions. Journal of Agricultural and Food Chemistry (Impact Factor: 3.38), 2014, 62: 2190-2197.(JCR二區，第一作者)

2. Chen L., Kang Y.H., Suh J.K. Roasting processed oriental melon (Cucumis melo L. var. makuwa Makino) seed influenced the triglyceride profile and the inhibitory potential against key enzymes relevant for hyperglycemia. Food Research International (Impact Factor: 2.818): 2014, 56: 236-242.(JCR二區，第一作者)

3. Chen L., Hwang J.E., Choi B. et al. Antioxidant capacities and cytostatic effect of Korean red pepper (Capsicum annuum L): a screening and in vitro study. Journal of the Korean Society for Applied Biological Chemistry. 2014, 57: 43-52. (JCR四區，第一作者)

4. Chen L., Kang Y.H. Hypoglycaemic activity of oriental melon (cucumis melo l. var. makuwa makino) seeds and its active compounds. The Plant Resources Society of Korea. 2014, 27, 622-628（SSCI, Korea, 第一作者）

5. Chen L.,Kang Y.H. Antioxidant Activities of Agrimonia pilosa Ledeb: In Vitro Comparative Activities of Its Different Fractions. Korean J. Plant Res, 2014, 27(6): 642-649.（SSCI, Korea, 第一作者）

6. Chen L., Kang Y.H. Anti-inflammatory and antioxidant activities of red pepper (Capsicum annuum L.) stalk extracts: Comparison of pericarp and placenta extracts. Journal of Functional Foods (Impact Factor: 4.48), 2013, 5: 1724-1731.(JCR二區，第一作者)

7. Chen L., Kang Y.H. In vitro inhibitory effect of oriental melon (Cucumis melo L. var. makuwa Makino) seed on key enzyme linked to type 2 diabetes: Assessment of anti-diabetic potential of functional food. Journal of Functional Foods (Impact Factor: 4.48) 2013, 5(2): 981-986.(JCR二區，第一作者)

8.Chen L., Kang Y. H. In vitro inhibitory potential against key enzymes relevant for hyperglycemia and hypertension of red pepper (Capsicum annuum L.) including pericarp, placenta, and stalk. Journal of Food Biochemistry (Impact Factor: 1.155), 2013, 38: 300-306. (JCR四區，第一作者)

9.Chen L., Hwang J.E., Gu K.M. et al. Comparative study of antioxidant effects of five Korean varieties red pepper (Capsicum Annuum. L) extracts from various parts including placenta, stalk, and pericarp. Food Science and Biotechnology (Impact Factor: 1.449), 2012, 21: 715-721. (JCR四區，第一作者).

10.Chen L., Kang Y.H. Effect of roasting on anti-inflammatory activity of oriental melon (Cucumis melo l. Var. Makuwa) seeds. International Conference on Agriculture Science and Environment Engineering (EI).

11.Chen L., Kang Y.H. Identification and characterization of major α-glucosidase inhibitors from Agrimonia pilosa Ledeb. Chemistry & Biodiversity (in press, impact factor: 1.95). (JCR四區，第一作者)

12. Huang Q.,Chen L.* et al., 2015 Phenolic compounds ameliorate the glucose uptake in HepG2 Cells Insulin Resistance via activating AMPK. Journal of Functional Foods. 2015, 19, 487-494. (JCR二區，通訊作者)

13. Teng H.,Chen L.*. Compounds from Agrimonia pilosa Ledeb modulating glycogen synthesis and enhancing glucose consumption in insulin-resistance HepG2 cells. Food and Function (in press, impact factor: 2.91). (JCR二區，第一作者)

14. Teng H.,Chen L.*. "α-Glucosidase and α-amylase inhibitors from seed oil: a review of liposoluble substance to treat diabetes. Critical Reviews in Food Science and Nutrition (accepted, impact factor: 5.54). (JCR一區，第一作者)

15.Chen L., Yu R.H., Ni X., Yanbo K. Z., Szkudelski T., Fan J., Makarova E., Xu B.B., Xiao J. Natural polyphenols in the treatment of type 2 diabetes: Human studies and clinical trial. Current Medicinal Chemistry (impact factor: 3.82). Invited Paper. (JCR二區，第一作者)

16.Chen L., Teng H., Huang Q., Wang J., Lin Q. et al., Microwave-assisted Extraction of Oil, Fatty Acids from Raspberry Seed and Antioxidant Analysis: Evaluation of cytoprotective effect in HepG2 cells. Food Chemistry (in press, impact factor: 3.39). (JCR二區，第一作者)

17.Chen L., Teng H., Lee W.Y., Song. H.B. Ultrasonic-assisted extraction of raspberry seed oil and evaluation of its physicochemical properties, fatty acid compositions and antioxidant activities. Plosone, (in press, impact factor: 3.39). (JCR三區，第一作者)

18. Teng H.,Chen L., Lee W.Y. Mathematical Modeling of Thin-layer Drying Kinetics of Blue-berried Honeysuckle (Lonicera caerulea var. Venulosa). Journal of the Korean Society for Applied Biological Chemistry. (2nd reversion submitted, impact factor: 0.69). (JCR四區，第二作者)

19.Chen L., Teng H., Xiao J.* Agrimonolide from Agrimonia pilosa suppresses inflammatory responses through down-regulation of COX-2/iNOS and inactivation of NF-κB in lipopolysaccharide- stimulated macrophages. Phytomedicine. Impact factor: 3.04 ((JCR二區，第一作者)

20.Chen L., Teng H., Xiao J.* Structural modifications of flavonoids required for efficient anti-inflammatory activity: Update on Structure-Activity Relationship Critical Reviews in Food Science and Nutrition (submitted, impact factor: 5.5