張紀岩

從1995年起，主要從事炎症調控信號轉導機制的研究。2003年5月至2005年12月赴美國芝加哥大學Ben-May癌症研究所做博士后。2006年晉陞為副研究員。2010年晉陞為研究員。在揭示炎症信號通路異常活化、促進細胞存活分子機制的同時，在國內外率先系統研究具有免疫抑制、抗炎作用的第二信使環磷酸腺苷 (cAMP) 對炎症信號通路p38途徑、JNK途徑的滅活機制，並提出了抗炎分子設計的新策略，對於改善炎症性疾病缺乏有效治療手段的臨床困境具有重要意義。共發表SCI收錄文章30餘篇，累計IF超過200，主要發現和觀點被Cell等國際權威雜誌評述和他引超過300次。第一 (或共同第一) 作者和通訊 (或共同通訊) 作者SCI收錄文章23篇，其中IF>5文章11篇。獲中國科協第四屆中國青年女科學家獎 (2007)，入選北京市科技新星計劃 (A類，2007)，當選總後勤部“科技新星” (2008)，入選軍隊高層次科技創新拔尖人才 (2012)。

1.Guo Y, Wang W, Wang J, Feng J, Wang Q, Jin J, Lv M, Li X, Li Y, Ma Y*, Shen B*,Zhang J*. Receptor for activated C kinase 1 promotes hepatocellular carcinoma growth by enhancing mitogen-activated protein kinase kinase 7 activity.Hepatology2013; 57: 140-51.

2.Wang J, Tang R, Lv M, Wang Q, Zhang X, Guo Y, Chang H, Qiao C, Xiao H, Li X, Li Y, Shen B*,Zhang J*. Defective anchoring of JNK1 in the cytoplasm by MKK7 in Jurkat cells is associated with resistance to Fas-mediated apoptosis.Mol Biol Cell 2011; 22: 117-27.

3. Zhang J*, Zhu N, Wang Q, Wang J, Ma Y, Qiao C, Li Y, Li X, Su B, Shen B*. MEKK3 over-expression contributes to the hyper-responsiveness of IL-12-overproducing cells and CD4+ T conventional cells in NOD mice.J Immunol2010; 185: 3554-63.

4.Cui J, Wang Q, Wang J, Lv M, Zhu N, Li Y, Feng J*, Shen B,Zhang J*. Basal c-Jun NH2-terminal protein kinase activity is essential for survival and proliferation of T-cell acute lymphoblastic leukemia cells.Mol Cancer Ther 2009; 8: 3214-22.

5. Zhang J*, Wang Q, Zhu N, Yu M, Shen B, Xiang J, Lin A. Cyclic AMP inhibits JNK activation by CREB-mediated induction of c-FLIP and MKP-1, thereby antagonizing UV-induced apoptosis.Cell Death Differ 2008; 15: 1654-62.

6. Zhang J*, Shen B, Lin A. Novel strategies for inhibition of the p38 MAPK pathway.Trends Pharmacol Sci 2007; 28: 286-95.

7. Zhang J, Bui TN, Xiang J, Lin A*. cAMP inhibits p38 activation via CREB-induced Dynein light chain.Mol Cell Biol 2006; 26：1223-34.

8. Zhang J, Liu J, Yu C, Lin A. BAD Ser128 is not phosphorylated by c-Jun NH2-terminal kinase for promoting apoptosis.Cancer Res 2005; 65: 8372-8.

9.Yu C#, Minemoto Y#,Zhang J#, Liu J#, Tang F, Bui TN, Xiang J, Lin A. JNK suppresses apoptosis via phosphorylation of the proapoptotic Bcl-2 family protein BAD.Mol Cell 2004; 13: 329-40.(#Equal contribution)

10.Wang J, Tang R, Lv M,Zhang J*, Shen B*. Selective unresponsiveness to the inhibition of p38 MAPK activation by cAMP helps L929 fibroblastoma cells escape TNF-a-induced cell death.Mol Cancer2010; 9:6.

11. Wang Q, Feng J, Wang J, Zhang X, Zhang D, Zhu T, Wang W, Wang X, Jin J, Cao J, Li X, Peng H, Li Y*, Shen B,Zhang J*.Disruption of TAB1/p38α interaction using a cell-permeable peptide limits myocardial ischemia/reperfusion injury.Mol Ther. 2013 Sep;21(9):1668-77.