李靜

姓名：李靜

性別：女

職稱：南開大學藥學院副教授

學科方向：藥物化學生物學

招生方向：微生物與生物藥學

教師簡介

2007年7月畢業於山東農業大學，獲博士學位，期間在山東大學從事干擾素β的糖基化研究。同年到南開大學工作，講授本科生的《藥用植物學》和研究生的《課題申請與項目管理》。

研究方向為：糖苷酶代謝異常及其相關疾病的藥物開發。

目前主持一項國家自徠然科學基金：糖基化信號途徑中OGA的雙催化功能及調節機制（No. 31000371），參加973子課題研究和國家新葯創製重大專項等多項國家課題，發表文章11篇，其中SCI收載論文9篇。

1. Jing Li, Min Chen, Xian-Wei Liu, Hou-Cheng Zhang, Fa Fu Shen and George Peng Wang*. Transient expression of an active human interferon-beta in lettuce. Scientia Horticulturae, 2007, 112(3): 258-265.

2. Lianwen Zhang, Feifei Ren, Jing Li, Xiaofeng Ma, and Peng Wang*. A Modified Coupled Enzyme Method for O-linked GlcNAc Transferase Activity Assay. Biological Procedures Online, 2009, 11:170-183.

3. Yan-ling Liu , Yun-fei Cai, Zhong-juan Zhao, Jun-feng Wang, Jing Li, Guang-min Xia, Feng-ning Xiang*. Cloning and Functional Analysis of a β-Amyrin Synthase Gene Associated with Oleanolic Acid Biosynthesis in Gentiana straminea MAXIM. Biological & Pharmaceutical Bulletin, 2009, 32(5): 818-824.

4. Jing Li, Cai-luan Huang, Lian-wen Zhang, Lin Lin, Zhong-hua Li, Peng Wang*. Isoforms of Human O-GlcNAcase Show Distinct Catalytic Efficiencies. Biochemistry (Moscow), 2010, 75(7): 938-943.

5. Rui Shen, Shuai Wang, Xiaofeng Ma, Junyang Xian, Jing Li, Lianwen Zhang, and Peng Wang*. An Easy Colorimetric Assay for Glycosyltransferases. Biochemistry (Moscow), 2010, 75(7): 944-950.

6. Tiehai Li, Lina Guo, Yan Zhang, Jiajia Wang, Zhonghua Li, Lin Lin, Zhenxing Zhang , Lei Li, Jianping Lin, Wei Zhao*, Jing Li*and Peng George Wang*. Design and synthesis of O-GlcNAcase inhibitors via Click Chemistry and biological evaluations. Carbohydrate Research, 2011, 346:1083-1092.

7. Tiehai Li, Lina Guo, Zhonghua Li, Jiajia Wang, Jing Li*, Wei Zhao*. O-GlcNAcase Inhibitors. Progress in Chemistry, 2011, 8: 75-82.

8. Tiehai Li, Lina Guo, Yan Zhang, Jiajia Wang, Zhenxing Zhang, Jing Li, Wenpeng Zhang, Jianping Lin,Wei Zhao* and Peng George Wang *. Structure-activity relationships in a series of C2-substituted gluco-configured tetrahydroimidazo- pyridines as β-glucosidase inhibitors. Bioorganic & Medicinal Chemistry, 2011, (19): 2136–2144.

9. Jing Li, Zhonghua Li, Tiehai Li, Lin Lin, Yan Zhang, Lina Guo, Yan Xu, Wei Zhao* and Peng Wang*. Identification of a Specific Inhibitor of nOGA –a Caspase-3 Cleaved O-GlcNAcase Variant during Apoptosis. Biochemistry (Moscow), 2012, 77(2): 194-200.

10. 林霖，李國超，李中華，徐䶮，田高飛，李靜，劉艷玲. O-GlcNAcase抗原片段的選擇、優化表達和多克隆抗體的製備。生物工程學報, 2011(8): 1183-1190. (核心)

11. 李靜，朱元元，郭遠強，王燕銘. 開放式教學在藥用植物學與生藥學實驗教學中的應用. 藥學教育，2009,25(5): 48-50.