張貴生

1982,09－1986,07吉林大學化學系，有機化學專業理學學士學位。

1986,09－1989,07吉林大學理論化學研究所、物理化學專業理學碩士學位。導師：裘祖文教授。

1989.07－1992.07，任河南師範大學化學系，助教。

1992.07－1994.11，任河南師範大學化學系，講師。

1994.11－1999.11，任河南師範大學化學系，副教授。

1999.09－至今，任河南師範大學化學與環境科學學院，教授。

1999.09－2002.07，任北京大學藥學院，天然藥物與仿生藥物國家重點實驗室,藥物化學專業理學博士學位。導師：張禮和院士。

2003.01―07，任美國俄亥俄州立大學生物學院生物化學系，博士后研究員。07―2006.01美國俄亥俄州立大學生物學院生物化學系，高級研究員。

2006.01―至今，任河南師範大學化學與環境科學學院，教授、河南省特聘教授、博士生導師。

研究方向

1、含糖藥物的新葯設計與合成。

2、有機合成化學，綠色有機合成。

3、藥物研發及藥物生產新工藝研究。

科研項目

國家教育部“長江學者和創新團隊發展計劃”：“創新藥物及醫藥材料的設計與合成”2011-2013。

國家自然科學基金項目（20672031）：“稀有糖及蒽環類抗生素簡單結構類似物的合成及抗腫瘤活性研究”2007,1-2009,12。

國家自然科學基金項目(20872029)：“新型蒽環類抗腫瘤先導物的水溶性糖基衍生物的合成及藥物活性研究”2009,1-2011,12。

河南省傑出青年基金項目（084100510002）：“新型蒽環類抗癌藥物的合成及藥物活性研究”2008,1-2010,12。

河南省高校科技創新研究團隊支持計劃(2008IRTSTHN002)：“藥物分子設計、合成及活性研究”2008,1-2010,12.

河南省高校新世紀優秀人才支持計劃（2006HANCET-06）：“含糖結構的抗腫瘤、抗病毒藥物的設計、合成與生物活性研究”。2007-2009。

書籍

1.WenlanChen,GuishengZhang,LizhiZhu,LanyanFang,XianhuaCao,JamesKedenburg,JieShen,DuxinSun,andPengGeorgeWang，UncommonSugarsandTheirConjugatestoNaturalProducts.《FrontiersinModernCarbohydrateChemistry》,Chapter2,2007,pp15-33;ACSSymposiumSeries,Volume960.PublicationDate(Print):March13,2007(Chapter)DOI:10.1021/bk-2007--0960 ch002.

論文

1.LingjunLi,RanLi,AnlianZhu,GuishengZhang,LiheZhang,CuBr-NCS-mediatedazide-alkynecycloaddition:mildandeffientsynthesisof5-bromo-1,4-disubstituted-1,2,3-triazoles,Synlett,2011,6,874-878.

2.XiaoyunDang,QingfengLiu,FenglingCui,LixiaQin,GuishengZhang*,XiaojunYao,JuanDu,Animprovedsyntheticapproachto7-[3-amino-4-O-(α-l-mycarosyl)-2,3,6-trideoxy-α-l-lyxo-hexopyranosyl]daunorubicinoneanditsinteractionwithhumanserumalbumin.CarbohydrateResearch,2011,346,949-955.

3.JianpingLi,JikuanJiu,HuijuanLi,GuishengZhang,Anefficientthree-componentone-potpreparationof1,4-dihydropyridinescontainingnovelsubstitutedpyrazoleundersulfamicacidcatalysis.Chin.J.Chem.,2011,29,511-514.

4.YanLu,JuanLv,GuishengZhang,GongkeWang,QingfengLiu,InteractionofananthracyclinedisaccharidewithctDNA:Investigationbyspectroscopictechniqueandmodelingstudies.SpectrochimicaActaPartA,2010,75,1511-1515.

5.XiaopengZhang,HuanzhiJingandGuishengZhang,Selenium-catalyzedoxidativecarbonylationofanilineandalcoholstoN-phenylcarbamates.Synth.Commun.,2010,40,1614-1624.

6.YanLu,QingqinFeng,FenglingCui,WeiweiXing,GuishengZhang,*XiaojunYao.Interactionof3`-azido-3`-deaminodaunorubicinwithhumanserumalbumin:Investigationbyfluorescencespectroscopyandmolecularmodelingmethods.Bioorg.Med.Chem.,2010,20(23),6899-6904.

7.HaimingGuo,ZhijieMao,ARKIVOC,2010(ix)300-307.HongyingNiu,DongchaoWang,GuishengZhangandGuirongQu,Improvedone-potsynthesisof6-methylpurinesundermicrowaveirradiation.

8.ZhiguoHu,*XiaoshanFan,GuishengZhang，Synthesisandcharacterizationofglucose-graftedbiodegradableamphiphilicglycopolymersP(AGE-glucose)-b-PLA.Carbohydr.Polym.,2010,79,119-124.

9.LingjunLi,JiuxiaWang,GuishengZhang*,QingfengLiu,Amildcopper-mediatedGlaser-typecouplingreactionunderthenovelCuI/NBS/DIPEApromotingsystem，TetrahedronLett.,2009,50,4033.

10.FenglingCui,XiaoduoKong,LixiaQin,GuishengZhang*,QingfengLiu,BeileiLei,XiaojunYao，Specificinteractionof4′-O-(a-l-Cladinosyl)daunorubicinwithhumanserumalbumin:ThebindingsiteIIonHSAmolecularusingspectroscopyandmodeling，J.Photochem.Photobio.B,2009,95(3),162-169.

11.FenglingCui,LixiaQin,GuishengZhang,*XiaojunYao,BeileiLei,StudyoftheInteractionofAglyconofDaunorubicinwithHumanSerumAlbuminbySpectroscopyandModeling,MacromolBiosci,2008,8,1079-1089.

12.FenglingCui,LixiaQin,GuishengZhang,*QingfengLiu,XiaojunYao,BeileiLei,Interactionofanthracyclinedisaccharidewithhumanserumalbumin:Investigationbyfluorescencespectroscopictechniqueandmodelingstudies,J.Pharma.Biomed.Anal.,2008,48,1029-1036.

13.FenglingCui,LixiaQin,GuishengZhang,*XiaobingLiu,XiaojunYao,BeileiLei,Aconciseapproachto1,11-didechloro-6-methyl-4`-O-demethylrebeccamycinanditsbindingtohumanserumalbumin:Fluorescencespectroscopyandmolecularmodelingmethod,Bioorg.Med.Chem.,2008,16,7615-7621.

14.LingjunLi,GuishengZhang,*AnlianZhuandLiheZhang,Aconvenientpreparationof5-Iodo-1,4-disubstituted-1,2,3-triazole:multi-componentone-potreactionofazideandalkynemediatedbyCuI-NBS,J.Org.Chem.,2008,73(9),3630-3633.

15.LeiShi,GuishengZhang*andFengPan,Fe2(SO4)3·xH2O-catalyzedper-O-acetylationofsugarscompatiblewithacid-labileprotectinggroupsadoptedincarbohydratechemistry,Tetrahedron,2008,64,2572-2575.

16.FenglingCui,LixiaQin,GuishengZhang,XiaojunYao,JuanDu,Bindingofdaunorubicintohumanserumalbuminusingmolecularmodelinganditsanalyticalapplication.Int.J.Biol.Macromol.,2008,42,221-228.

17.GuishengZhang*,QingfengLiu,LeiShi,JiuxiaWang,Ferricsulfatehydrate-catalyzedO-glycosylationusingglycolswithorwithoutmicrowaveirradiation,Tetrahedron,2008,64,339-344.

18.GuishengZhangandQingfengLiu.Ferricsulphatehydrate-catalyzed,microwave-assistedsynthesisof2,3-unsaturatedO-glycosidesviatheFerrierreaction.Synth.Commun.,2007,37,3485-3492.

19.GuishengZhang,*LeiShi,QingfengLiu,J.Wang,L.LiandX.Liu.Adivergentstrategyforconstructingasugarlibrarycontaining2,6-dideoxysugarsanduncommonsugarswith4-substitution.Tetrahedron,2007,63,9705-9711.

20.G.Zhang,L.Shi,Q.Liu,X.Liu,L.LiandJ.Wang,Adivergentapproachto3-azido-2,3,6-trideoxy-L-hexosesfromrhamnal,TetrahedronLett.,2007,48,3413-3416

21.D.Lu,J.Nadas,G.Zhang,W.Johnson,J.L.Zweier,A.J.Cardounel,F.A.Villamena,andP.G.Wang,4-Aryl-1,3,2-oxathiazolylium-5-olatesaspH-ControlledNO-Donors:TheNextGenerationofS-Nitrosothiols,J.Am.Chem.Soc.,2007,129(17),5503-5514.

22.R.F.Battisti,Y.Zhong,L.Fang,S.Gibbs,J.Shen,J.Nadas,G.ZhangandD.Sun,ModifyingthesugarmoietiesofdaunorubicinovercomesP-gp-mediatedmultidrugresistance.MolecularPharmaceutics,2007,4(1),140-153.

23.ChangshengZhang,ChristophAlbermann,XunFu,NoelR.Peters,JohnD.Chisholm,GuishengZhang,EricJ.Gilbert,PengGeorgeWang,DavidL.VanVrankenandJonS.Thorson*,RebG-andRebM-catalyzedindolocarbazolediversification.ChemBioChem,2006,7,795-804.

24.G.Zhang,L.Fang,L.Zhu,Y.Zhong,P.G.Wang,D.Sun,Synthesesandbiologicalactivitiesof3-azidodisaccharideanaloguesofdaunorubicinagainstdrug-resistantleukemia.J.Med.Chem.,2006,49(5),1792-1799.

25.L.Fang,G.Zhang(co-firstauthor),C.Li,X.Zheng,L.Zhu,J.J.Xiao,G.Szakacs,J.Nadas,K.K.Chan,P.G.Wang,D.Sun,DiscoveryofadaunorubicinanaloguethatexhibitspotentantitumoractivityandovercomesP-gp-mediateddrugresistance.J.Med.Chem.,2006,49(3),932-941.

26.Zhang,G.;Fang,L.;Zhu,L.;Sun,D.;Wang,P.G.,Synthesesandbiologicalactivityofbisdaunorubicins.Bioorg.Med.Chem.,2006,14(2),426-434.

27.Li,L.;Zhu,L.;Zhang,X.;Zhang*,G.;Qu,G.,Convenienttetrahydropyranylationofalcoholsandphenolsbycatalyticferricsulfatehydrate(Fe2(SO4)3·xH2O).Can.J.Chem.,2005,83(8),1120-1123.

28.Zhang,G.;Shen,J.;Cheng,H.;Zhu,L.;Fang,L.;Luo,S.;Muller,M.T.;Lee,G.E.;Wei,L.;Du,Y.;Sun,D.;Wang,P.G.,Synthesesandbiologicalactivitiesofrebeccamycinanalogswithuncommonsugars.J.Med.Chem.,2005,48(7),2600-2611.

29.Ye,X.-S.;Sun,F.;Liu,M.;Li,Q.;Wang,Y.;Zhang,G.;Zhang,L.-H.;Zhang,X.-L.,Syntheticiminosugarderivativesasnewpotentialimmunosuppressiveagents.J.Med.Chem.,2005,48(11),3688-3691.

30.Luo,S.;Zhu,L.;Talukdar,A.;Zhang,G.;Mi,X.;Cheng,J.-P.;Wang,P.G.,Recentadvancesinrareearth-metaltriflatecatalyzedorganicsynthesisingreenmedia.Mini-ReviewsinOrganicChemistry,2005,2(2),177-202.

31.Zhu,L.;Talukdar,A.;Zhang,G.;Kedenburg,J.P.;Wang,P.G.,ADivergentsynthesisofuncommonsugarsfromfuranaldehyde.Synlett,2005,10,1547-1550.

32.Zhang,G.;Fang,L.;Zhu,L.;Aimiuwu,J.E.;Shen,J.;H.,C.;Muller,M.T.;Lee,G.E.;Sun,D.;Wang,P.G.,SynthesesandBiologicalActivitiesofDisaccharideDaunorubicins.J.Med.Chem.,2005,48,5269-5278.

33.Zhu,L.;Cao,X.;Chen,W.;Zhang,G.;Sun,D.;Wang,P.G.,Synthesesandbiologicalactivitiesofdaunorubicinanalogswithuncommonsugars.Bioorg.Med.Chem.,2005,13,6382-6387.

專利

1.Multidrugresistanceanticanceranthracyclines.USPatent20060276418A1。

2.Multidrugresistanceanticanceranthracyclines.PCT/US2006/018630；WO2006124720A1。

3.多重耐葯抗癌藥蒽環類，200680016329.0

4.一種用於化學反應過程中的新型分水器,ZL201020181503.0,

5.一種簡單、高效、合成4-取代惡唑烷酮衍生物的方法,201010264733.8,。

6具有抗癌活性的蝴蝶黴素類似物及合成方法,201010569632.1。

7具有抗癌活性的蒽環類抗生素簡單結構類似物及製備方法,201010569901.4。

8具有抗癌活性的3'-疊氮基表阿黴素的合成,201110023054.6。

9(S)-2-羥烷基-1,4-二羥基-9,10-蒽醌與糖基綴合物的合成及抗腫瘤活性201110023502.2。

主講課程《有機合成化學》《糖及核苷化學》《有機藥物化學》等。