崔紫寧
崔紫寧
崔紫寧,男,1981年10月出生,內蒙古人,理學博士,青年教授,碩士生導師。主要從事糖化學及含雜環有機分子的設計合成以及生物活性研究工作。至今發表論文40餘篇,申請中國發明專利12項,獲得授權5項。主持國家自然科學基金2項,參與973項目1項,主持日本振興會(JSPS)項目1項,主持和參與省部級項目10餘項。入選2015年“珠江科技新星”,同年入選我校省級“千百十人才培養工程”重點培養。所在研究團隊入選華南農業大學“十佳科研團隊”。
2004.09-2010.06 中國農業大學理學院應用化學系 碩博連讀
2008.10-2009.09 日本千葉大學 聯合培養博士
2008.06-2008.07 中國科學院研究生院 研究生暑期學校學習
2000.09-2004.07 中國農業大學國家化學理科基地班 本科
2016.09-至今 華南農業大學群體微生物研究中心
廣東省微生物信號與作物病蟲害防控重點實驗室 青年教授
2013.09-2016.06 華南農業大學農學院植物病理系
廣東省微生物信號與作物病蟲害防控重點實驗室 副研究員
2012.04-2013.08日本千葉大學JST博士后研究員
2012.08-2012.11 北京大學 訪問學者
2010.08-2012.07 日本千葉大學JSPS外籍特別研究員
1. 國家自然科學基金(31570122):病原細菌多胺信號轉導系統抑製劑的設計與合成。2016年1月-2019年12月,項目主持人。
3.廣東省公益研究與能力建設專項(2014A020210019):以拓撲異構酶II為靶點的新型氧雜蒽酮糖基綴合物的合成及構效關係研究。2015年1月-2017年12月,項目主持人。
4.廣東省普通高校特色創新項目(自然科學)(2014KTSCX031):糖綴合物作為植物抗病誘導劑的設計合成及其作用機制研究。2015年1月-2017年12月,項目主持人。
5.廣州市“珠江科技新星”專項(201506010029):基於細菌群體感應信號分子的抑製劑設計與合成及作物病害防控。2015年4月-2018年3月,項目主持人。
6. 華南農業大學校長科學基金(4200-K13014):含呋喃環2, 5-二取代-1, 3, 4-噻二唑類化合物的合成、生物活性及構效關係研究。2014年1月-2016年12月,項目主持人。
8. 廣東省普通高校國家級重大培育項目(自然科學類)(2014GKXM019):微生物群體感應通訊系統與病害防控基礎研究。2015年1月-2017年12月,主要成員。
9. 廣東省公益研究與能力建設專項(2016A020217014):馬鈴薯三糖熊果酸衍生物作為新型H5N1進入抑製劑的構效關係及生物學研究。2016年4月-2018年12月,主要成員。
10.廣東省公益研究與能力建設專項(2015A020209133):柑橘潰瘍病防控的新型殺菌增效劑研究。2016年1月-2018年12月,主要成員。
已結題項目:
13.國家自然科學基金(21102173):糖基修飾水楊酸衍生物的合成及其抗病誘導活性研究。2012年1月-2014年12月,項目主持人。
14.Molecular design, synthesis and bioactivity evaluation of novel glycosyl hydrazines. From the Japan Society for the Promotion of Science, Grant No. P10100, from Aug./2010 to Jul./2012,項目主持人。
15. 中國農業大學研究生科研創新專項—優秀學位論文研究項目:糖基修飾的Schiff鹼類衍生物的設計合成與生物活性研究。2009年12月-2010年5月,項目主持人。
16. 國家自然科學基金(20802089):基於EcR/USP結構的新型IGRs先導化合物的生物合理設計。2009年1月-2011年12月,主要成員。
1.Song, Gaopeng; Li, Sumei; Lei, Zhiwei; Li, Yibin; Li, Junhua; Liao, Yixian; Cui, Zi-Ning. Synthesis and biological evaluation of acylated oligorhamnoside derivatives structurally related to mezzettiaside-6 with cytotoxic activity.Org. Biomol. Chem., 2016, 14(28), 6691-6702(cover paper).
2.Li, Ya-Sheng; Tian, Hao; Zhao, Dongsheng; Hu, De-Kun; Jin Hongwei; Song, Gaopeng*; Cui, Zi-Ning*. Synthesis and Bioactivity of Pyrazole and TriazoleDerivatives as Potential PDE4 Inhibitors.Bioorg. Med. Chem. Lett., 2016, 26(15), 3632-3635.
3.Wang, Chao; Liu, Xiaoling; Wang, Jing; Cui, Zining; Zhang, Lian-Hui*. Design and characterization of a polyamine derivative inhibiting the expression of type III secretion system inPseudomonas aeruginosa.Sci. Rep., 2016, 6, 30949.
4.Fan, Susu; Tian, Fang; Li, Jianyu; Chen, Huamin; Yang, Fenghuan; Hutchins, William; Yuan, Xiaochen; Yang, Cui Zi-Ning, Ching-Hong Yang*; He, Chenyang. Identification of phenolic compounds that suppress the virulence ofXanthomonas oryzaeon riceviathe type III secretion system.Mol. Plant Pathol., 2016, DOI: 10.1111/mpp.12415.
5.Zhou, Jia-Nuan; Zhang, Hai-Bao; Lv, Ming-Fa; Chen, Yu-Fan; Liao, Li-Sheng; Cheng, Ying-Ying; Liu, Shi-Yin; Chen, Shao-Hua; He, Fei; Cui Zi-Ning; Jiang, Zi-De; Chang, Changqing*; Zhang, Lian-Hui*. SlyA regulates phytotoxin production and virulence inDickeya zeaeEC1.Mol. Plant Pathol., 2016, DOI: 10.1111/mpp.12376.
6.Liu, Chunhui; Cui, Zi-Ning*; Yan, Xiaojing; Qi, Zhiqiu; Ji,Mingshan; Li, Xinghai*. Synthesis, Fungicidal Activity and Mode of Action of 4-Phenyl-6-trifluoromethyl-2- aminopyrimidines againstBotrytis cinerea.Molecules, 2016, 21(7), 828.
7.Song, Gao-Peng, Hu, De-Kun, Tian, Hao, Li, Ya-Sheng, Cao, Yun-Shen; Jin, Hong-Wei; Cui, Zi-Ning*. Synthesis and Larvicidal Activity of Novel Thenoylhydrazide Derivatives.Sci. Rep., 2016, 6, 22977.
8.Song, Gaopeng; Li, Jianzuo; Tian, Hao; Li, Yasheng; Hu, Dekun; Li, Ying; Cui, Zi-Ning*. Synthesis and Antitumor Activity of NovelN-Benzoyl-N'-substituted Pyrimidinyl (Thio)semicarbazideDerivatives.Lett. Drug Des. Discov., 2016, 13(4), 329-334.
9.Cui, Zi-Ning*; Li, Ya-Sheng; Hu, De-Kun; Tian, Hao; Jiang, Jia-Zhen; Wang,Yuan; Yan,Xiao-Jing. Synthesis and fungicidal activity of novel 2,5-disubstituted-1,3,4- thiadiazole derivatives containing 5-phenyl-2-furan,Sci. Rep., 2016, 6, 20204.
10. Song, Gaopeng; Zhao, Dongsheng; Hu, Dekun; Li, Yasheng; Jin, Hongwei; Cui, Zi-Ning*. Design, Synthesis and Biological Evaluation of Novel Tetrahydroisoquinoline Derivatives as Potential PDE4 Inhibitors,Bioorg. Med. Chem. Lett., 2015, 25(20), 4610-4614.
11.Song, Gao-peng; Li, Su-mei; Si, Hong-zong; Li, Yi-bin; Li, Ya-sheng; Fan, Ji-hong; Liang, Qian-qian; He, Hui-bing; Ye, Han-ming; Cui, Zi-Ning*. Synthesis and Bioactivity of Novel Xanthone and Thioxanthone L-Rhamnopyranosides,RSC Adv., 2015, 5(45), 36092-36103.
12.Li, Chengkun; Jiang, Lin; Wang, Yue; Wan, Fuxian; Zhang, Peizhi; Li, Ying; Cui, Zi-Ning*. Design, Synthesis and Biological Activities ofN-(Substituted benzoyl)-N′-(5-methoxyl-2- methylsulfanylpyrimidin-4-amino) (thio) Ureas,Chin. J. Org. Chem., 2014, 34(11), 2296-2303.
13.Cui, Zining*; Ito, Jun; Dohi, Hirofumi; Amemiya, Yoshimiki; Nishida, Yoshihiro. Molecular Design and Synthesis of Novel Salicyl Glycoconjugatesas Elicitors against Plant Diseases,PLOSOne, 2014, 9(9), e108338.
14.Cui, Zining*; Li, Xinghai; Tian, Fang; Yan, Xiaojing. Synthesis and Bioactivity of 5-Substituted-2-furoyl Diacylhydazide Derivatives with Aliphatic Chain,Int. J. Mol. Sci.,2014, 15(5), 8941-8958.
15.Cui, Zining*; Su, Hang; Jiang, Jiazhen; Yang, Xinling; Nishida, Yoshihiro. Design, Synthesis and Bioactivity ofN-Glycosyl-N'-(5-substitutedphenyl-2-furoyl) Hydrazide Derivatives,Int. J. Mol. Sci.,2014, 15(4), 6741-6756
16.Cui, Zining*; Liang, Zhibin; Tian, Fang; Liu, Shiyin; Yan, Xiaojing. Synthesis and Bioactivity of Novel Pyridazin-3(2H)-one Derivatives Containing 5-Phenyl-2-furan (I),Chin. J. Pestic. Sci., 2014, 16(3), 252-258.
17.Cui, Zining*; Tian, Fang; Liang, Zhibin; Liu, Shiyin; Yan, Xiaojing. Synthesis and Bioactivity of Novel Pyridazin-3(2H)-one Derivatives Containing 5-Phenyl-2-furan (II),Chin. J. Pestic. Sci., 2014, 16(4), 394-399.
18.Cui, Zining*; Li, Xing-Hai; Nishida, Yoshihiro. Synthesis and Bioactivity of Novel Carvacrol and Thymol Derivatives Containing 5-Phenyl-2-furan,Lett. Drug Des. Discov., 2014, 11(7), 877-885.
19.Li, Xing-Hai; Pan, Qiang; Cui, Zi-Ning*; Ji, Ming-Shan; Qi, Zhi-Qiu. Synthesis and Fungicidal Activity of N-(2,4,5-trichlorophenyl)-2-Oxo- and 2-Hydroxycycloalkylsulfon amides,Lett. Drug Des. Discov., 2013, 10(4), 353-359.
20.Li,Xing-Hai;Cui,Zi-Ning(first co-author);Chen,Xiao-Yuan;Wu,De-Cai;Qi, Zhi-Qiu;Ji, Ming-Shan. Synthesis of 2-Acyloxycyclohexylsulfonamides and Evaluation on Their Fungicidal Activity,Int. J. Mol. Sci., 2013, 14(11), 22544-22557.
21.Cui, Zi-Ning; Shi, Yan-Xia; Zhang, Li; Ling, Yun; Li, Bao-Ju; Nishida, Yoshihiro; Yang, Xin-Ling. Synthesis and Fungicidal Activity of Novel 2, 5-Disubstituted-1, 3, 4-oxadiazole Derivatives,J. Agric. Food Chem., 2012, 60(47), 11649−11656.
22.Cui, Zi-Ning; Shi, Yan-Xia; Cui, Jing-Rong; Ling, Yun; Li, Bao-Ju; Yang, Xin-Ling. Synthesis and Bioactivities of Novel Pyrazole and Triazole Derivatives Containing 5-Phenyl-2-Furan.Chem. Biol. Drug Des., 2012, 79(1), 121-127.
23.Cui, Zi-Ning; Yang, Xin-Ling; Shi, Yan-Xia; Uzawa, Hirotaka; Cui, Jing-Rong; Dohi, Hirofumi; Nishida, Yoshihiro. Molecular design, synthesis and bioactivity of glycosyl hydrazine and hydrazone derivatives: Notable effects of the sugar moiety.Bioorg. Med. Chem. Lett., 2011, 21(23), 7193-7196.
24.Cui, Zi-Ning; Zhang, Li; Huang, Juan; Yang, Xin-Ling; Ling, Yun. Synthesis and Bioactivity of NovelN,N′-Diacylhydrazine Derivatives Containing Furan(III).Chin. J. Chem., 2010, 28(7), 1257-1266.
25.Cui, Zi-Ning; Zhang, Li; Huang, Juan; Ling, Yun; Yang, Xin-Ling. Synthesis, Insecticidal Activity and 3D-QSAR Studies on Diacylhydrazine Derivatives Containing Furan.Chin. J. Org. Chem., 2010, 30(10), 1482-1491.
26.Cui, Zi-Ning; Ling, Yun; Li, Bao-Ju; Li, Yong-Qiang; Rui, Chang-Hui; Cui, Jing-Rong; Shi, Yan-Xia; Yang, Xin-Ling.Synthesis and Bioactivity ofN-benzoyl-N'-[5-(2'- substituted phenyl)-2-furoyl] semicarbazide Derivatives.Molecules, 2010, 15(6), 4267-4282.
27.Cui, Zi-Ning; Li, Ying; Ling, Yun; Huang, Juan; Cui, Jing-Rong; Wang, Rui-Qing; Yang, Xin-Ling. New Class of Potent Antitumor Acylhydrazone Derivatives Containing Furan.Eur. J. Med. Chem., 2010, 45(12), 5576-5584.
28.Zhang, Li; Cui, Zi-Ning; Yin, Bin; Yang, Guang-Fu; Ling, Yun; Yang, Xin-Ling. QSAR and 3D-QSAR Studies of the Diacyl-hydrazine Derivatives Containing Furan Ring Based on the Density Functional Theory.Sci. China: Chem.,2010, 53(6), 1322-1331.
29.Cui, Zi-Ning; Ma, Yong-Qiang; Ling, Yun; Yang, Xin-Ling*. Crystal Structure of Hexa-m2-chloro-m4-oxo- tetrakis [(1, 4-dioxane-kO) copper(II)].Analytical Sciences-X-ray Structure Analysis Online, 2009, 25(7), 79-80.
30.Cui, Zi-Ning; Huang, Juan; Li, Ying; Ling, Yun; Yang, Xin-Ling*; Chen, Fu-Heng. Synthesis and Bioactivity of NovelN,N′-Diacylhydrazine Derivatives Containing Furan(I).Chin. J. Chem., 2008, 26(5), 916-922.
31.Cui, Zi-Ning; Zhang, Li; Huang, Juan; Li, Ying; Ling, Yun; Yang, Xin-Ling*. 3D-QSAR Studies on Diacylurea Derivatives Containing Furan Moiety.Acta Chim. Sinica, 2008, 66(12), 1417-1423.
32.Cui, Zi-Ning; Wang, Zhen; Li, Ying; Zhou, Xin-Yu; Ling, Yun; Yang, Xin-Ling*. Synthesis and Insecticidal Activity of Diacylhydrazine Containing Furan.Chin. J. Org. Chem., 2007, 27(10):1300-1304.
33.Cui, Zi-Ning; Yang, Lin; Li, Xi-Chen; Wang, Zhen; Yang, Xin-Ling. Progress in the Study on the Synthesis and the Activities as Insect Growth Regulators of 2, 5-Disubstituted 1, 3, 4- Oxadiazoles.Chin. J. Org. Chem., 2006, 26(12), 1647-1656.
1.崔紫寧,陳昱帆,程瑩瑩,周佳暖,劉詩胤,陳少華。含呋喃環2,5-二取代-1,3,4-噻二唑類化合物在製備致病疫黴菌抑菌劑中的應用,中國發明專利。ZL 201310631983.4, 2016-3-30。
2.崔紫寧,程瑩瑩,劉詩胤,陳昱帆,周佳暖,陳少華。一種含呋喃環2, 5-二取代-1, 3, 4-噻二唑類化合物及其製備方法和應用,中國發明專利。ZL 201310629477.1, 2015-10-28。
3.崔紫寧,周佳暖,劉詩胤,程瑩瑩,陳少華。一種苯基取代噻吩甲醯肼類化合物及其製備方法和應用,中國發明專利。ZL 201310574554.8, 2015-06-17。
4.楊新玲,崔紫寧,凌雲,徐炎,張元新。N-5-取代苯基-2-呋喃甲醯基類化合物及其製備方法與應用,中國發明專利。ZL 201110100774.8, 2014-08-20。
5.楊新玲,李映,凌雲,崔紫寧,胡君,苗宏建,陳馥衡。一種取代苯甲醯胺基甲酸甲酯類化合物及其製備方法與應用,中國發明專利。ZL 200710303669.8, 2009-12-16。
6.崔紫寧,胡德坤,田浩,李亞勝,宋高鵬,劉星宇。N’-5-(取代苯基)-2-呋喃甲醯基-5-丙基-1H-吡唑-3-甲酸乙酯類化合物及其製備方法與應用。2016,201610383248.X (審查中)
7.崔紫寧,田浩,胡德坤,李亞勝,宋高鵬,劉星宇。S-(5-取代-1,3,4-噻二唑)-(5-取代苯基)-2-呋喃硫代甲酸酯類化合物及其製備方法與應用。2016,201610382784.8
(審查中)
9.陳少華,廖立勝,崔紫寧,周佳暖,賀飛。一種高效降解農藥的方法。2015,11pp,CN 104548470 A,20150429(審查中)
11.楊新玲,崔紫寧,凌雲,黃娟,張莉,陳馥衡。一類具有抗腫瘤活性的苯甲醯腙類化合物, 中國發明專利。2009, 10pp. CN 101402620 A, 20090408(審查中)