鄧小燕

學習經歷

1/1986-10/1991年生物醫學工程專業博士。

加拿大麥吉爾大學(McGill University)，化學工程系及臨床研究所。

12/1982年生物力學專業碩士。

成都科技大學，工程力學系。

10/1975年畢業文憑。

武漢華中理工大學，火電站專業。

工作經歷

2001—現在北京航空航天大學生物工程系教授。

7/1995--11/2000加拿大魁北克拉瓦爾大學生物材料研究所研究員。

加拿大魁北克拉瓦爾大學醫學院外科系科研教授。

11/1991--6/1995加拿大魁北克拉瓦爾大學生物材料研究所博士后。

1/1983—6/1985成都科技大學（現四川大學）。

工程力學系生物力學教研室助教。

1978–9/1980四川省環境保護研究所助理工程師。

10/1975--1978西南核反應堆研究設計院反應堆操縱員。

主要學術

計算力學學報編委；中國生物物理學會生物流變學專業委員會委員。

計算力學學報’編委；‘醫用生物力學’編委；‘生物醫學工程雜誌’編委；中國生物醫學工程學會理事；中國生物物理學會生物力學及生物流變學專業委員會委員；中國力學學會及生物醫學工程學會生物力學專業委員會副主任；國家自然科學基金委員會數理學部第十屆評審專家；國家自然科學基金委員會生命學部第十一屆評審專家。目前主持國家自然科學基金重點項目一項、面上兩項等。

生物醫學工程，生物力學，血流動力學及心血管介入器械

生物力學，血流動力學及心血管介入器械

1. Deng X.Y. (1983) Investigation on electrochemical measurement of wall shear stresses in the flow field of cardiac valve prostheses. Proceedings of the Second Asian Congress of Fluid Mechanics, Beijing, China. (EI檢索)

2. Kang, Z.H. and Deng X.Y.　Swirling jet rate sensor and its flow field (1985)　In: Fluid Control and Measurement, edited by M. Harada, Pergamon Press, Oxford, England, pp. 599-609.(EI檢索)

3. Deng, X.Y., King, M. and Guidoin, R. (1993) Localization of atherogenesis at arterial junctions - Modeling the release rate of low density lipoproteins (LDL) and its breakdown products accumulated in blood vessel walls.　American Society for Artificial Internal Organs (ASAIO) Journal 39: 489-495.

4. Chakfé, N., Marois, Y., Guidoin, R., Deng, X.Y., Marois, M., Roy, R. and Douville, Y. (1993) Biocompatibility and biofunctionality of a gelatin impregnated polyester arterial prosthesis. Polymer and Polymer Composites, 1, 229-251. (EI檢索)

5. Deng, X.Y., Marois, Y., King, W. M. and Guidoin, R. (1994) Uptake of 3H-7-cholesterol along the arterial wall at an area of stenosis.　ASAIO Journal 40: 186-191. (EI檢索)

6. Dadgar, L., Deng, X.Y., King, M., Marois, Y.,　Martin, L. and Guidoin, R. (1994) Longitudinal forces acting on a knitted polyester arterial prosthesis when implanted as a thoracic aorta substitute in the dog. J. Invest. Surg. 7: 377-391.

7. Deng, X.Y., Marois, Y., How, T., Merhi, Y., King, W. M. and Guidoin, R. (1995) Luminal surface concentration of lipoprotein (LDL) and its effect on the wall uptake of cholesterol by canine carotid arteries. J. Vasc. Surg. 21: 135-145. (SCI檢索)

8. Deng, X.Y., King, W. M. and Guidoin, R. (1995) Localized atherogenesis at arterial junctions-Concentration distribution of low density lipoproteins (LDL) at the luminal surface in the region of disturbed flow. ASAIO Journal, 41: 58-67. (EI檢索)

9. King, M., Marois, Y., Guidoin, R., Ukpabi, P., Deng, X.Y., Martin, L., Paris, E. and Douville, Y. (1995) Evaluating the Dialine® vascular prosthesis knitted from an alternative source of polyester yarns. J. Biomed. Mater. Res. 29: 595-610. (EI, SCI檢索)

10. Dadgar, L., Downs, A. R. Deng, X.Y., Marois, Y., King, M. and Guidoin, R. (1995) Longitudinal forces acting at side-to-end and end-to-side anastomoses when a knitted polyester arterial prosthesis is implanted in the dog. J. Invest. Surg. 8: 163-178. (SCI檢索)

11. Ukpabi, P., Marois, Y., King, M., Deng, X.Y., Martin, L., Laroche, G., Douville, Y. and Guidoin, R. (1995) The GelweaveR polyester arterial prosthesis. Can. J. Surg. 38: 322-331. (SCI檢索)

12. Marois, Y., Chakfé, N., Deng, X.Y., King, M.W., Marois, M. and Guidoin, R. (1995) Carbodiimide cross-linked gelatin, a new coating for porous polyester arterial prosthesis. Biomaterials 16: 1131-1139. (EI, SCI檢索)

13. Deng, X.Y., Stroman, P.W. and Guidoin, R. (1996) Theoretical modelling of the release rate of low-density lipoprotein and their breakdown products at arterial stenoses. Clinical and Investigative Medicine 19: 83-91. (SCI檢索)

14. Deng, X.Y., Marois, Y., Guidoin, R., Merhi, Y., Stroman, P., King, M. and Douville, Y. (1996) Efficiency of external wrap to reduce lipid infiltration into venous grafts: in vitro evaluation. Artificial Organs 20: 1208-1214. (SCI檢索)

15. Karino, T. and Deng, X. Y. and Naiki, T. (1995) Flow-dependent concentration polarization of lipoproteins at the blood-endothelium boundary. Proceedings of the 1995 Bioengineering Conference, Beaver Creek, Colorado, USA, pp. 13-14. (EI檢索)

16. Guidoin, R., Marois, Y., Deng, X.Y., Chakfé, N., Marois, M., Roy, R., King, M., and Douville, Y. (1996) Can collagen-impregnated polyester arterial prostheses be recommended as blood conduits of small diameter? ASAIO Journal 42: 974-983. (EI, SCI檢索)

17. Ghalichi, F., Deng, X. Y., Marois, Y., De Champlain, A. and Guidoin, R. (1996) Hemodynamic performance of polyester protein-impregnated arterial prostheses after implantation: A plea for faster resorption of the coating. Proceedings of The Canadian Medical and Biological Engineering Society Conference, Charlottetown, Prince Edward Island, Canada, pp. 68-69.

18. Dadgar, L., Marois, Y., Deng, X.Y. and Guidoin, R. (1997) Arterial wall mechanical characteristics after treatment with collagenase: an in vitro aneurysm model. Clinical and Investigative Medicine 20: 25-34 (SCI檢索).

19. Yang, M., Deng, X.Y., Zhang, Z., Julien, M., Pelletier, F., Desaulniers, D., Cossette, R., Teijeira, F., Laroche, G. and Guidoin, R. (1997) Are intraaortic balloons suitable for reuse? A survey study of 127 used intraaortic balloons. Artificial Organs 21: 121-130. (SCI檢索)

20. Guidoin, R., King, M., Marois, Y., Ukpabi, P.,　Deng, X.Y., Zhang, Z., Yang, C., Badour, B., Laroche, G. and Martin, L. (1997) Polyester arterial prostheses: Recent developments from the Czech Republic and Poland. ASAIO Journal 43: 69-83. (EI, SCI檢索)

21. Guidoin, R., Deng, X.Y., and Marois, Y. (1997) Failure modes and performance of synthetic, autologous and endovascular grafts.　ASAIO Journal 43: 239-241. (EI, SCI檢索)

22. Marois, Y., Guidoin, R., Deng, X.Y., King, M., Martin, L. and Roy, R. (1997) The Dialine II, A new collagen-impregnated warp-knitted polyester arterial prosthesis. Ann. Vasc. Surg. 11: 133-140. (SCI檢索)

23. Yang, M., Deng, X.Y., Laroche, G., Hahn, C., King, M. and Guidoin, R. (1997) A capillary method to measure water transmission through polyurethane membranes. ASAIO Journal. 43: 890-896. (EI, SCI檢索)

24. Deng, X.Y, Marois, Y, Guidoin, R. (1998) Fluid Filtration Across the Arterial Wall under Flow Conditions: Is Wall Shear Rate Another Factor Affecting Filtration Rate? Annals of New York Academy of Sciences 858: 105-115. (SCI檢索)

25. Fatouraee, N. Deng, X.Y., De Champlain, A. and Guidoin, R. (1998) Concentration polarization in the arterial system. Annals of New York Academy of Sciences 858: 137-146. (SCI)

26. Ghalichi, F., Deng, X.Y., De Champlain, A., Douville, Y., King, M. and Guidoin, R. (1998) Low Reynolds number turbulence modeling of blood flow in arterial stenoses. Biorheology 35: 281-294. (SCI檢索)

27. Ghalichi, F., Deng, X.Y., Marois, Y., De Champlain, A., King, M and Guidoin, R. (1998) Theoretical prediction on hemodynamic performance of polyester protein-impregnated arterial prostheses after implantation: A plea for faster resorption of the coating. ASAIO Journal 45: 18-24. (EI, SCI檢索)

28. Marois, Y., Zhang, Z., Vert, M., Deng, X.Y., Lenz, R. and Guidoin, R. (1999) Effect of sterization on the physical and structural characteristics of polyhydroxyoctanoate (PHO). Journal of Biomaterials Science: Polymer Edition 10: 469-482.(SCI檢索)

29. Marois, Y., Zhang, Z., Vert, M., Deng, X.Y., Lenz, R. and Guidoin, R. (1999) Hydrolytic and enzymatic incubation of polyhydroxyoctanoate (PHO): A short-term in vitro study of a degradable bacterial polyester.　Journal of Biomaterials Science: Polymer Edition 10: 483-499 (SCI檢索).

30. Deng, X.Y., Marinov, G., Marois, Y. and Guidoin, R. (1999) Mechanical characteristics of the canine thoracic duct: What are the driving forces of the lymph flow? Biorheology 36, 391-399. (SCI檢索)

31. Marois, Y., Zhang, Z., Vert, M., Deng, X.Y., Lenz, R. and Guidoin, R. (2000). Mechanism and rate of degradation of polyhydroxyoctanoate films in aqueous media: A long-term in vitro study.　Journal of Biomedical Materials Research 49, 216-224. (EI, SCI檢索)

32. Deng X.Y. and Guidoin R. (2000) Alternative blood conduits: could the porosity of synthetic prostheses be the key to long-term biofunctionality?　Medical & Biological Engineering & Computing 38, 219-225. (EI, SCI檢索)

33. Wang, G.X., Cai, S.X., Deng X.Y., Ouyang, K., Xie, G.M. and Guidoin R (2000) Secretory response of endothelin-1 in cultured human　glomerular microvascular endothelial cells to shear stress. Biorheology 37, 291-299. (SCI檢索)

34. Wang, G.X., Deng X.Y. and Guidoin R (2002) Concentration polarization of macromolecules in canine carotid arteries and its implication for the localization of atherogenesis. Journal of Biomechanics (付印).

35. Deng X.Y. and Wang, G.X. (2002) 動脈系統中致動脈粥樣性脂質的濃度極化現象。 《中國科學》(中英文版) (付印).

36. Deng X.Y. (2002) 動脈狹窄內低密度脂蛋白傳輸的數值研究：LDL的濃度極化現象。《計算力學》 (付印).

著述

1. Guidoin, R., King, M., Deng, X.Y., Paris, E. and Douville, Y. (1992) Les protheses arterielles en polyester: Une fibre unique pour des modèles variés. In: Les Substituts Arteriels, Edited by Edouard Kieffer, AERCV, Paris,　pp. 3-51.

2. Paris, E., King, M., Guidion, R., Delorme, J., Deng, X.Y., and Douville, Y. (1994) Innovations and deviations in therapeutic vascular devices. In: Polymeric Materials for Biomedical Applications. Edited by Severian Dumitriu. Marcel Dekker Inc. (New York), pp.245-275.

3. Deng, X.Y. and Guidoin, R. (1998) Engineering data on human arteries, veins and lymphatic vessels. In: Handbook of Biomaterials Properties.　Edited by Black, J. and Hastings, G.W., Chapman&Hall, London, pp. 81-105

論文摘要

1. Deng, X. Y. and Karino, T. (1986) Flow patterns at venous junctions and their implication in the pathogenesis of venous thrombosis. Biorheology 23, 222. (SCI 檢索)

2. Deng, X. Y. and Karino, T. (1988)　Mass transfer to and from the vessel wall distal to a sudden tubular expansion. World Congress on Medical Physics and Biomedical Engineering, San Antonio, Texas, USA.

3. Deng, X. Y. and Karino, T. (1988)　Fluid dynamics and mass transfer to and from the vessel wall in the models of arterial stenoses. World Congress on Medical Physics and Biomedical Engineering, San Antonio, Texas, USA.

4. Deng, X. Y. and Karino, T. (1989) Theoretical study on flow and mass transfer to and from the vessel wall in an axisymmetric arterial stenosis. Biorheology 26, 597.

5. Deng, X. Y. and Karino, T. (1989)　Effects of steady laminar recirculation flows on mass transfer from a flowing fluid to a semi-permeable vessel wall. Biorheology 26, 604.

6. Karino T. and Deng X. (1990) Lipoprotein concentration at the blood-endothelium boundary and its implications for the pathogenesis of vascular diseases. J. Japanese College of Angiology 30, 710.

7. Deng, X. Y., King, M. and Guidoin, R. (1993)　Localized atherogenesis at arterial junctions - Modeling the effect of flow disturbances on the transfer of low density lipoproteins (LDL). The 39th Annual Meeting of ASAIO, New Orleans, USA, p. 119.

8. Deng, X. Y., King, M. and Guidoin, R. (1993)　Localized atherogenesis at arterial junctions - Modeling the effect of flow disturbances on the transfer of low density lipoproteins (LDL). The 39th Annual Meeting of ASAIO, New Orleans, USA, p. 119.

9. Ukpabi, P., King, M., Deng, X. Y., Marois, Y., Martin, L. and Guidoin, R. (1993)　Biofunctionality and biostability of new polyester vascular prostheses.　The 14th Annual Canadian Biomaterials Society Conference, Hamilton, Canada, p. 1.

10. Guidoin, R., Marois, Y., King , M., Ukpabi, P., Deng, X. Y., Martin, L., Laroche, G., Douville, Y. and Awad, J. (1994) The Gel Weave polyester arterial prosthesis. The 40th Annual Meeting of ASAIO, San Francisco, USA, p. 18.

11. Dadgar, L., Deng, X. Y.,　and Guidoin, R. (1994) Flow induced wall vibration: a mechanical factor which could cause the formation of anastomotic false aneurysms. The 15th Annunal Canadian Biomaterials Society Conference, Quebec, Canada, p. 35.

12. Deng, X. Y., Marois, Y., Guidoin, R., King, W. M. and Douville, Y. (1994)　Effect of pressure on filtration property and 3H-cholesterol uptake rate of blood vessel walls by blood vessel walls. The 15th Annual Canadian Biomaterials Society Conference, Quebec, Canada, p. 39.

13. Marois, Y., Deng, X. Y., King, M. and Guidoin, R. (1995) In vitro and in vivo characterization of a new polyester arterial prosthesis sealed with irradiated collagen. ASAIO Journal (Suppl): p. 110.

14. Deng, X. Y., Marois, Y., Guidoin, R., Merhi, Y., Stroman, P., King, M. and Douville Y. (1995) Rigid external support can prevent vein grafts from atherosclerosis by reducing lipid infiltration. Artificial Organs, 19: p. 1062.

15. Yang, M., Deng, X. Y., Julien, M., Zhang, Z., Desaulniers, D. and Guidoin, R. (1995) Physical and chemical characterization of used polyurethane intraaortic balloon: a survey study of 127 used intraaortic balloons. Artificial Organs, 19: p. 1048.

16. Deng, X. Y., Guidoin, R. and Marois, Y. (1996) The static properties of the canine thoracic duct. The 5th World Biomaterials Congress Vol. II, p. 382. (EI檢索)

17. Yang, M., Deng, X. Y., Guidoin, R. (1996) Water permeability of polyurethane membranes. The 5th World Biomaterials Congress Vol. II, p. 820. (EI檢索)

18. Deng, X. Y., Karino, T. and Guidoin, R. (1996) Particle adhesion to a semi-permeable wall exposed to flow disturbance: Simulation of the transport of blood components. Haemostasis Vol. 26, Abstact 218.

19. Marois, Y., Vert, M., Zhang, Z.,　Deng, X. Y., Lenz, R. and Guidoin, R. (1996) Degradability of polyhydroxyoctanoate films: An hydrolytic or enzymatic process. International Symposium on Bacteria Polyhydroxyalkanoates, Section 9/03. Davos, Switzerland.

20. Karino, T. and Deng, X. Y. (1997) The effects of recirculation flows on mass transfer from a vessel wall to a flowing fluid. International Journal of Cardiovascular Medicine and Science, Vol. 1, p. 128. (First International Interdisciplinary Conference on Cardiovascular Medicine, Surgery, Science, and Mechanics.　Washington, DC, USA, June 6-9, 1997)

21. Fatouraee, N., Deng, X. Y., De Champlain, A. and Guidoin, R. (1997) LDL transport from flowing blood to the arterial wall under pulsatile flow conditions. International Journal of Cardiovascular Medicine and Science, Vol. 1, p. 130. (First International Interdisciplinary Conference on Cardiovascular Medicine, Surgery, Science, and Mechanics.　Washington, DC, USA, June 6-9, 1997)

22. Fatouraee, N.,　Deng, X. Y., De Champlain, A. and Guidoin, R. (1997) Numerical simulation of low density lipoprotein transport from flowing blood to the arterial wall under pulsatile flow conditions. The first International Symposium on Advanced Biomaterials.　Montreal, Canada, October 2-5, 1997, p. 12.

23. Fatouraee, N.,　Deng, X. Y., De Champlain, A. and Guidoin, R. (1997) Numerical simulation of blood flow and lipid transport in human carotid artery. Annals of Biomedical Engineering, vol. 25 (Supp. 1), p.s-26. (1997 Annual Fall Meeting of Biomedical Engineering Society, San Diego, California, USA, October 2-5, 1997.)

24. Deng, X.Y, Marois, Y, Guidoin, R. Fluid Filtration Across the Arterial Wall under Flow Conditions: Is Wall Shear Rate Another Factor Affecting Filtration Rate? Biotransport-98, International Symposium of Heat and Mass Transfer in Biological and Medical Engineering, Kusadasi, Turkey, June 8 – 12, 1998.

25. Fatouraee, N., Deng, X.Y., De Champlain, A. and Guidoin, R. Concentration polarization in the arterial system. Biotransport-98, International Symposium of Heat and Mass Transfer in Biological and Medical Engineering, Kusadasi, Turkey, June 8 – 12, 1998.

26. Deng, X.Y, Guidoin, R., Marois, Y. Fluid Filtration Across the Arterial Wall under Flow Conditions. Abstracts of the 11th Conference of the European Society of Biomechanics, J. of Biomechanics, 31 (Suppl. 1), p. 142, Toulouse, France, 8-11 July, 1998.

27. Ghalichi, F., Deng, X.Y., De Champlain, A., Douville, Y. and Guidoin, R. Low Reynolds number turbulence modeling of blood flow in arterial stenoses. Abstracts of the Third World Congress of Biomechanics, Sapporo, Japan, Auguest 2-8, 1998, pp. 412.

28. Fatouraee, N., Deng, X.Y., De Champlain, A. and Guidoin, R. Numerical simulation of lipid transport through arterial stenoses. (Abstract) 1999 ASME Bioengineering Conference, Big Sky, Montana, (USA), June 16-20, 1999. (EI檢索)

29. Deng, X.Y., Fatouraee, N. and Guidoin R Concentration polarization of atherogenic lipids and its implication in the localization of atherosclerosis. (Abstract) European Medical & Biological Engineering Conference EMBEC'99, Vienna (Austria), Nov. 04 - 07, 1999.

30. Deng, X.Y., Fatouraee, N. and Guidoin R. Concentration polarization of atherogenic lipids and its implication in the localization of atherosclerosis. (Abstract) European Medical & Biological Engineering Conference EMBEC'99, Vienna (Austria), Nov. 04 - 07, 1999.

31. Wang G. X., Guidoin R., Deng X. Y. An in vitro experimental study on concentration polarization of macromolecules in canine carotid arteries . Proceedings of the 5th Asian Symposium on Biomedical Materials, Hong Kong, December 9-12, 2001, p. 34.

And more...

譯著

<日>岡小天著　心血管血液流變學　第八章　北京計量出版社（1984）

1993年全美人工器官年會青年科學家論文獎（美國新奧爾良）。

1989年第7屆國際生物流變學學術大會優秀學生論文獎(法國蘭西)。

1986年--1991年加拿大麥吉爾大學博士生獎學金。

2005年重慶市自然科學三等獎“動脈系統中致動脈粥樣性脂質的濃度極化現象”證書號：ZR050300801，第一獲獎人，2005/3/3。

科研：

主持完成了美國Whitaker Foundation科學基金課題”Flow-dependent luminal surface concentration of atherogenic lipoproteins: Role of hemodynamic factors in atherosclerosis”。

主持完成了拉瓦爾大學醫學研究中心的課題”Hemodynamics and anastomotic intimal hyperplasia”。

作為主要合作者，參與了多項由加拿大和魁北克政府醫學科學基金組織資助的科研課題。

“Coeur Artificiel”Foundation, Geneva, Switzerland課題”Design and development of a totally implantable artificial heart”。主要參加人（負責人工心臟的血流動力學研究）。

國家自然科學基金:“血流動力學與動脈循環系統物質傳輸的相關性研究”（批准號：10172027，2002.1-2004.12），主持人，24萬人民幣。

國家自然科學基金:“動脈旁路搭橋術后血管內膜增生及血流流場相關性研究”（批准號：30270360，2003.1-2005.12），主持人，經費20.0萬人民幣。

重慶市教委：“小口徑人造血管漩流導引器的研製”（2004.1-2006.12）主持人，經費：滾動支助，第一年10.0萬人民幣(批准號030001)。

重慶大學生物力學與組織工程教育部重點實驗室開放基金會（2003.1-2003.12），主持人，經費5.0萬人民幣

重慶大學科研啟動經費：“動脈旁路或再造手術后血管內膜增生的血流動力學成因”（2003.7-2006.6）主持人，經費20.0萬人民幣。

重慶大學“電動人工全心的研製”種子經費，主持人，經費30.0萬人民幣。

重慶市科委“電動人工全心預研”主持人，經費15.0萬人民幣(CSTC.2004ac3031)

國家重點基礎研究計劃（973計劃）：轉基因高等動物的創建與高級腦功能分析（2003CB716600）二級子課題：轉基因載體構建及模式動物大腦基因表達的研究（2003CB716601）主要負責人，經費50.0萬人民幣

國家科技部‘新型抗血栓和再狹窄血管內支架的研製’（批准號:2004DFA064002004.12-2009.12）,第二主持人，經費80萬

國家自然科學基金:“胚胎滋養層細胞在子宮脈管系統逆血流遷移的血流動力學研究”（批准號：10572017，2006.1-2008.12），主持人，經費36.0萬人民幣。

國家自然科學基金:“動脈系統中脂質的濃度極化與脂質在血管內皮層中沉積的相關性研究”（批准號：30670517，2007.1-2009.12），主持人，經費30.0萬人民幣。

國家自然科學基金:“動脈系統中的旋動流現象-它對血小板運動、粘附和物質（LDL）輸運的影響及其在臨床中的應用”（批准號：10632010，2007.1-2010.12），主持人，經費190.0萬人民幣。

1993年全美人工器官年會青年科學家論文獎（美國新奧爾良）。

1989年第7屆國際生物流變學學術大會優秀學生論文獎(法國蘭西)。