蔡超

蔡超，博士，副教授。中國海洋大學“青年英才工程”計劃資助獲得者。

2007年畢業於山東大學，並先後獲得學士、碩士學位；2011年畢業於中國科學院生態環境研究中心，獲博士學位；2011至2014年在美國倫斯勒理工學院（RPI）化學生物學系Robert J. Linhardt教授課題組從事博士后研究工作；2014年底經中國海洋大學“青年英才工程”計劃引進在醫藥學院工作。主要從事活性寡糖及天然小分子的合成研究工作，完成十二糖分子MMP及天然小分子(-)-Cleistenolide的全合成工作；應用化學酶法合成系列超低分子量肝素寡糖化合物；針對過硫酸化的糖胺聚糖進行結構解析等研究。在Chem. Rev.，Nat. Chem. Biol.，Org. Lett.，Anal. Chem.，J. Org. Chem.等國際學術期刊發表論文20餘篇。

研究方向及內容：

1.糖胺聚糖（如肝素、硫酸軟骨素等）寡糖分子的化學及酶法合成工作；

2.糖胺聚糖的結構修飾、模擬物及簇合物的構建及活性評價工作；

3.海洋來源多糖及寡糖的化學修飾及結構鑒定工作；

4.海洋來源天然小分子的化學合成（輔以糖分子為手性模板）工作。

代表性論文和專利：

1. Dimitrievska S., Cai C., Weyers A.,et al. Click-coated, heparinized, decellularized vascular grafts.Acta Biomaterialia2015,13, 177–187.

2. Farrán A., Cai C., Sandoval M.,et al.Green solvents in carbohydrate chemistry: from raw materials to fine chemicals. Chem. Rev.2015,115, 6811–6853.

3. Cai C., Dickinson D. M., Li L.,et al. Fluorous-assisted chemoenzymatic synthesis of heparan sulfate oligosaccharides.Org. Lett.2014,16, 2240–2243.

4. Xu Y., Cai C., Chandarajoti K.,et al.Homogeneous low molecular weight heparins with reversible anti-coagulant activity.Nat. Chem. Biol. 2014,10, 248–250.

5. Li G., Cai C., Li L.,et al.A new method to detect contaminants in heparin using radical depolymerization and liquid chromatography-mass spectrometry.Anal. Chem. 2014,86, 326–330.

6. Ucakturk E., Cai C., Li L.,et al. Capillary electrophoresis for total glycosaminoglycan analysis.Anal. Bioanal. Chem.2014,406, 4617–4626.

7. Cai C., Li L., Harvey C., Liu J., Linhardt R. J. Towards the chemoenzymatic synthesis of heparan sulfate oligosaccharides: Oxidative cleavage of p-nitrophenyl group with ceric ammonium salts.Tetrahedron Lett. 2013,54, 4471-4474.

8. Cai C., Edgar K., Liu J., Linhardt R. J. Preparation and application of a “clickable” acceptor for enzymatic synthesis of heparin oligosaccharides.Carbohydr. Res.2013,372, 30-34.

9. Chang Y., Cai C., Li L.,et al. Ultrasensitive detection and quantification of acidic disaccharides using capillary electrophoresis and quantum dot-based fluorescence resonance energy transfer.Anal. Chem. 2013,85, 9356–9362.

10. Cai C., Solakyildirim K., Yang B., Beaudet J. M., Weyers A., Linhardt R. J., Zhang F. Semi-synthesis of Chondroitin Sulfate-E from Chondroitin Sulfate-A.Carbohydr. Polym.2011,87, 822-829.

11. Cai C.,Liu J., Du Y. and Linhardt R. J.Stereoselective Total Synthesis of (−)-Cleistenolide.J. Org. Chem. 2010,75, 5754-5756.

12. Wei G., Cai C., Du Y. Highly Efficient and Versatile Synthesis of Some Important Precursors from 1,6-Anhydrous-β-D-glucopyranose as a Green Starting Material.Chin. J. Chem, 2009,27, 1589-1592.

13. Wei G., Zhang L., Cai C., Cheng S., Du Y. Selective Cleavage of Sugar Anomeric O-acyl Groups Using

FeCl·6HO.Tetrahedron Lett.2008,49, 5488-5491.