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劉嵐
中山大學海洋學院教授
1998年,獲中山大學高分子研究所博士研究生學位;現任中山大學海洋學院教授,博士研究生導師,海洋微生物功能分子廣東省高校重點實驗室副主任,南海資源開發與保護協同創新中心PI。
1998年,獲中山大學高分子研究所博士研究生學位;現任中山大學海洋學院教授,博士研究生導師,海洋微生物功能分子廣東省高校重點實驗室副主任。2003-2004年美國弗吉尼亞大學訪問學者。研究方向主要為海洋天然產物的發現及應用。先後主持和承擔了863計劃項目,國家自然科學基金,國家海洋公益性行業專項等10餘項課題。在Tetrahedron、Organic Letter、J. Chromatogr、Planta Medica.、Mar. Drugs等雜誌發表論文60餘篇,獲授權專利發明10餘項。
1. 國家自然科學基金:南海紅樹林真菌抗腫瘤活性代謝產物研究
2. 國家自然科學基金:用分子烙印技術分離手性藥物對映體的研究
3. 國家公益性行業(海洋)專項:海洋微生物小分子化合物資源庫構建及葯源活性物質的篩選應用(子課題)
4. 高校科研基本業務費項目:南海紅樹林真菌BL321活性次生代謝產物的分離和結構改造
5. 廣東省自然科學基金:纖維素類手性固定相分離藥物對映體的研究
1.New Lasiodiplodins from mangrove endophytic fungus Lasiodiplodia sp 318#. Natural product research, 2017, 31(3): 326-332.
2. Lasiodiplodins from mangrove endophytic fungus Lasiodiplodia sp 318#. Natural product research, 2016, 30(7): 755-760.
3. A new Secondary metabolites of the crinoid (Comanthina schlegeli) associated fungus Alternaria brassicae 93. Natural product research, 2016, 30(20): 2305-2310.
4.Six New Polyketide Decalin Compounds from Mangrove Endophytic Fungus Penicillium aurantiogriseum 328#. Marine Drugs, 2015, 13(10): 6306-6318.
5. A New Terminal Cyano Group-containing Benzodiazepine Alkaloid from the Mangrove Endophytic FungusPenicillium sp. Natural product research, 2015, 10(9): 1549-1551.
6. Meroterpenes and azaphilones from marinemangrove endophytic fungus Penicillium 303# Fitoterapia, 97(9), 241-246, 2014.
7. Alterporriol-type dimers from the mangroveendophytic fungus, Alternaria sp. (SK11), and their MptpB
inhibitions. Marine Drugs, 12(5), 2953-2969, 2014
8. Loddigesiinols G-J: alpha-glucosidaseinhibitors from Dendrobium loddigesii. Molecules, 19(6), 8544-8555, 2014.
9. Studies on the Synthesis of Derivatives ofMarine-Derived Bostrycin and Their Structure-Activity Relationshipagainst Tumor Cells, Marine Drugs, 10(4), 932-952, 2012.
10. Four eremophilane sesquiterpenes from themangrove endophytic fungus Xylaria sp. Bl321. Marine Drugs, 10:340-348,2011.
11. Metabolites of Mangrove Fungus Xylaria sp.(BL321) from the South China Sea,Planta Medica. 2012, 78(2):172-176.
12. Synthesis and cytotoxicevaluation of eremophilane sesquiterpene S6-2 derivatives. Chem. Pharm. Bull,59(9): 1186-1189 ,2011.
13. Structural elucidation and NMR assignments offour aromatic lactones from a mangrove endophytic fungus (No. GX4-1B). MagneticResonance in Chemistry, 48(6):496-499,2010.
14. 3,3'-Functionalized octahydro BINOL: a facilesynthesis and its high enantioselectivity in the alkyne addition to aldehydes. Tetrahedron,2004, 60(34):7427-7430.