劉琳

劉琳1980年生於安徽省合肥市。2001年和2006年在中國科學技術大學獲得學士和博士學位。2006年至2010年在美國國立衛生研究院（NIH）進行博士后訪問研究。現任中科院植物所研究員，擔任“光合作用的生物化學”研究組組長。已發表SCI期刊論文24篇，其中以第一或通訊作者發表論文14篇。劉琳研究員在博士後期間，解析了天然免疫的模式識別受體TLR3與雙鏈RNA的複合物結構，闡明了TLR3識別雙鏈RNA的結構基礎。研究成果發表於 Science (2008)，已被引用470餘次，併入選美國高校《細胞與分子生物學》教材（2010，Wiley，6th Edition）和《細胞》教材（2011，Jones & Bartlett）。

主要研究方向：

（1）光合色素代謝的分子基礎；（2）金屬蛋白的結構與功能；（3）蛋白-核酸的相互作用。

研究項目：

（1）面上項目31370759 “植物5-氨基乙醯丙酸合成中GluTR及其調控蛋白的結構基礎”；（2）面上項目31670794 “植物葉黃質合成中細胞色素P450酶的結構與機理研究”。

主要發表文章：

2016

Dong W,Wang J,Niu G,Zhao S,Liu L*. Crystal structure of the zinc-boundHhoAprotease from Synechocystis sp. PCC 6803. FEBS Lett., 2016, 590(19): 3435-3442.

Zhao S, Wang X, Niu G, Dong W, Wang J, Fang Y, Lin Y, Liu L*. Structural basis for copper/silver binding by metallochaperone CopM. Acta Crystallogr. D Struct. Biol., 2016, 72(9): 997-1005.

Wang X, Liu L*. Crystal structure and catalytic mechanism of 7-hydroxymethyl chlorophyll a reductase. J. Biol. Chem., 2016, 291(25): 13349-13359.

Fang Y, Zhao S, Zhang F, Zhao A, Zhang W, Zhang M, Liu L*. The Arabidopsis glutamyl-tRNA reductase (GluTR) forms a ternary complex with FLU and GluTR-binding protein. Sci. Rep., 2016, 6: 19756.

2011-2015

Chen X, Pu H, Fang Y, Wang X, Zhao S, Lin Y, Zhang M, Dai H, Gong W*, Liu L*. Crystal structure of the catalytic subunit of magnesium chelatase. Nat. Plants, 2015, 1(9): 15125.

Chen X, Pu H, Wang X, Long W, Lin R, Liu L*. Crystal structures of GUN4 in complex with porphyrins. Mol. Plant., 2015, 8(7): 1125-1127.

Zhang M, Zhang F, Fang Y, Chen X, Chen Y, Zhang W, Dai H, Lin R, Liu L*. The non-canonical tetratricopeptide-repeat (TPR) domain of Fluorescent (FLU) mediates complex formation with glutamyl-tRNA reductase. J. Biol. Chem., 2015, 290(28): 17559-17565.

Feng J, Zhao S, Chen X, Wang W, Dong W, Chen J, Shen JR, Liu L*, Kuang T*. Biochemical and structural study of Arabidopsis hexokinase 1. Acta Crystallogr. D Biol. Crystallogr., 2015, 71(2): 367-375.

Chen X, Wang X, Feng J, Chen Y, Fang Y, Zhao S, Zhao A, Zhang M, Liu L*. Structural insights into the catalytic mechanism of Synechocystis magnesium protoporphyrin IX O-methyltransferase (ChlM). J. Biol. Chem., 2014, 289(37): 25690-25698.

Zhao A, Fang Y, Chen X, Zhao S, Dong W, Lin Y, Gong W, Liu L*. Crystal structure of Arabidopsis glutamyl-tRNA reductase in complex with its stimulator protein. Proc. Natl. Acad. Sci. USA, 2014, 111(18): 6630-6635.

Sun W, Gao F, Fan H, Shan X, Sun R, Liu L*, Gong W*. The structures of Arabidopsis Deg5 and Deg8 reveal new insights into HtrA proteases. Acta Crystallogr. D Biol. Crystallogr., 2013, 69(5): 830-837.

Sun R, Fan H, Gao F, Lin Y, Zhang L, Gong W*, Liu L*. Crystal structure of Arabidopsis Deg2 protein reveals an internal PDZ ligand locking the hexameric resting state. J. Biol. Chem., 2012, 287(44): 37564-37569.

2010年以前

Liu L, Botos I, Wang Y, Leonard JN, Shiloach J, Segal DM, Davies DR*. Structural basis of toll-like receptor 3 signaling with double-stranded RNA. Science, 2008, 320(5874): 379-381.

Wang M, Liu L, Wang Y, Wei Z, Zhang P, Li Y, Jiang X, Xu H, Gong W*. Crystal structure of homoserine O-acetyltransferase from Leptospira interrogans. Biochem. Biophys. Res. Commun., 2007, 363(4): 1050-1056.

Liu L, Wei Z, Wang Y, Wan M, Cheng Z, Gong W*. Crystal structure of human coactosin-like protein. J. Mol. Biol., 2004, 344(2): 317-323.

Liu L, Wang Y, Zhang P, Cheng Z, Wan M, Zhou Z, Gong W*. Expression, purification and preliminary crystallographic studies of human coactosin-like protein. Acta Cryst. D Biol. Crystallogr., 2004, 60(9): 1651-1653.