共找到28條詞條名為李文輝的結果 展開
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- 太原理工大學教授
李文輝
北京生命科學研究所研究員
李文輝，男，北京生命科學研究所研究員。
2017年9月30日，當選2017年北京學者。
2020年11月12日，李文輝憑藉其在推動乙肝科研和治療方面做出的傑出貢獻，榮獲全球乙肝研究和治療領域最高獎——巴魯克·布隆伯格獎
大事件
1971
出生
1971年，出生於甘肅省。
2001
在哈佛大學進行分子病毒學研究
2001年末至2004年，在哈佛大學醫學院微生物學和分子遺傳學系作為博士後繼續分子病毒學研究。
2007
聘任為北京生命科學研究所研究員
2007年下半年，李文輝回國加入北京生命科學研究所，並被聘任為研究員。
2012
他的團隊成功地發現了HBV和HDV的功能性受體
2012年，他的團隊成功地發現了HBV和HDV的功能性受體——主要在肝臟中表達的牛磺膽酸鈉共轉運蛋白（NTCP）。
2020-11-12
獲得巴魯克·布隆伯格獎
2020年11月12日，李文輝憑藉其在推動乙肝科研和治療方面做出的傑出貢獻，榮獲全球乙肝研究和治療領域最高獎——巴魯克·布隆伯格獎。
Education教育經歷
| 1994 | 蘭州醫學院 醫學學士學位 |
LanzhouMedical College (School of Medicine, Lanzhou University) Bachelor Degree of Medicine | |
| 1997 | 蘭州生物製品研究所 免疫學碩士學位 |
Lanzhou Institute of Biological Products M.S. in Immunology | |
| 2001 | 中國協和醫科大學 中國醫學科學院 基礎醫學研究所 病原生物學博士學位 |
Instituteof BasicMedical Sciences PekingUnion Medical College & Chinese Academyof Medical Sciences Ph.D. in Pathogenic Biology |
工作經歷Professional Experience
| 2007- | 北京生命科學研究所 研究員 |
Assistant Investigator, National Institute of Biological Sciences, Beijing | |
| 2004-2007 | 哈佛大學醫學院Instructor |
| HarvardMedical School, Boston | |
| 2001-2004 | 哈佛大學醫學院 博士后 |
| Postdoctoral Fellow, Harvard Medical School, Boston | |
| 1997-1998 | 蘭州生物製品研究所 研究助理 |
| Research Assistant, Lanzhou Institute of Biological Products, Lanzhou |
研究概述Research Description
本實驗室的主要研究興趣為囊膜病毒侵入細胞及相關過程的分子機制。病毒侵入細胞起始於與細胞表面受體的結合。圍繞這一過程，我們希望探索：病毒細胞受體分子的識別；病毒受體是如何介導病毒感染的；其它胞內因子是如何參與病毒侵入的；病毒蛋白是如何進行免疫逃逸的；如何有效地抑制病毒的感染，等。我們綜合運用病毒學，生物化學，化學生物學等多學科方法，以回答上述問題。這些研究將有利於深化對於病毒基本生物學，及病毒與感染宿主相互作用的認識與理解，並且有助於開發有效的抗病毒製劑及新型疫苗。
乙型肝炎是危害人類健康的嚴重傳染病，是導致肝硬化、肝癌的重要病因。我們最近成功地發現並確認了人類乙型肝炎病毒，及其密切相關的丁型肝炎病毒感染肝細胞所必需的功能受體分子是肝細胞膜上的鈉離子-牛磺膽酸-協同轉運蛋白（NTCP）。這一重要發現為進一步深入研究乙肝病毒及相關致病機制打開了新的大門，並為研發新的藥物和治療手段提供了可能。
Our lab tries to understand the entry mechanisms of enveloped viruses. Regardless of the type of enveloped virus, the initial step of viral entry always involves the interactions between the viral envelope protein(s) and viral receptor(s) on host cells. The questions that we are mostly interested in are: what is the specific cellular receptor for a virus? How does the receptor contribute to viral entry? How does the viral entry protein evade the host immune response? How can viral infection be inhibited by entry inhibitor or host immunity. We seek to identify the receptors and elucidate the entry processes of viral pathogens important to human health. Knowledge of viral entry mechanisms will deepen our understanding of basic biology of viruses and their host cells, and offer new opportunities to develop more efficient inhibitors against the infections and new generation of viral vaccines.
Hepatitis B virus (HBV) infection and its associated cirrhosis and hepatocellular carcinoma cause about one million deaths annually. The molecular mechanisms by which HBV and its satellite virus Hepatitis D virus (HDV) infect human liver have been elusive. By taking state-of-the-art affinity purification approach, we recently identified sodium taurocholate cotransporting polypeptide (NTCP), a liver bile acid transporter, as a specific receptor for HBV and HDV. NTCP binds to a critical receptor binding region of viral envelope L protein and contributes substantially to the efficiency of HBV and HDV infections. This finding advances our understanding of the HBV and HDV infection and may lead to new strategies for prevention and treatment of these viral infections and associated diseases.
發表文章Publications
| 1. | Li W, Sui J, Huang IC, Kuhn JH, Radoshitzky SR, Marasco WA, Choe H, Farzan M.The S proteins of human coronavirus NL63 and severe acute respiratory syndrome coronavirus bind overlapping regions of ACE2. Virology. 2007; doi:10.1016/j.virol.2007.04.035 |
| 2. | Radoshitzky SR, Abraham J, Spiropoulou CF, Kuhn JH, Nguyen D, Li W, Nagel J, Schmidt PJ, Nunberg JH, Andrews NC, Farzan M, Choe H. Transferrin receptor 1 is a cellular receptor for New World haemorrhagic fever arenaviruses. Nature. 2007;446(7131):92-6. |
| 3. | Kuhn JH, Li W, Radoshitzky SR, Choe H, Farzan M. Severe acute respiratory syndrome coronavirus entry as a target of antiviral therapies. Antiviral Therapy. 2007, 12:639-650 review |
| 4. | Li F, Berardi M, Li W, Farzan M, Dormitzer PR, Harrison SC. Conformational states of the severe acute respiratory syndrome coronavirus spike protein ectodomain. J Virol. 2006, 80(14): 6794-800. |
| 5. | He Y, Li J, Li W, Lustigman S, Farzan M, Jiang S. Cross-neutralization of human and palm civet severe acute respiratory syndrome coronaviruses by antibodies targeting the receptor-binding domain of spike protein. J Immunol. 2006,176(10):6085-92. |
| 6. | Li W, Wong SK, Li F, Kuhn JH, Huang IC, Choe H, Farzan M. Animal origins of the severe acute respiratory syndrome coronavirus: insight from ACE2-S-protein interactions. J Virol. 2006,80(9):4211-9 review |
| 7. | Kuhn JH, Radoshitzky SR, Guth AC, Warfield KL, Li W, Vincent MJ, Towner JS, Nichol ST, Bavari S, Choe H, Aman MJ, Farzan M. Conserved receptor-binding domains of Lake Victoria marburgvirus and Zaire ebolavirus bind a common receptor. J Biol Chem. 2006,281(23):15951-8. |
| 8. | Huang IC, Bosch BJ, Li F, Li W, Lee KH, Ghiran S, Vasilieva N, Dermody TS, Harrison SC, Dormitzer PR, Farzan M, Rottier PJ, Choe H. SARS coronavirus, but not human coronavirus NL63, utilizes cathepsin L to infect ACE2-expressing cells. J Biol Chem. 2006,281(6):3198-203. |
| 9. | Zhang L, Zhang F, Yu W, He T, Yu J, Yi CE, Ba L, Li W, Farzan M, Chen Z, Yuen KY, Ho D. Antibody responses against SARS coronavirus are correlated with disease outcome of infected individuals.J Med Virol. 2006,78(1):1-8. |
| 10. | Li F, Li W, Farzan M, Harrison SC. Structure of SARS coronavirus spike receptor-binding domain complexed with receptor. Science. 2005,309(5742):1864-8. Comments in science. 2005, 16; 309 (5742) :1822-3. |
| 11. | Sui J, Li W, Roberts A, Matthews LJ, Murakami A, Vogel L, Wong SK, Subbarao K, Farzan M, Marasco WA. Evaluation of human monoclonal antibody 80R for immunoprophylaxis of severe acute respiratory syndrome by an animal study, epitope mapping, and analysis of spike variants.J Virol. 2005,79(10):5900-6. |
| 12. | Li W, Zhang C, Sui J, Kuhn JH, Moore MJ, Luo S, Wong SK, Huang IC, Xu K, Vasilieva N, Murakami A, He Y, Marasco WA, Guan Y, Choe H, Farzan M. Receptor and viral determinants of SARS-coronavirus adaptation to human ACE2. EMBO J. 2005,24(8):1634-43. |
| 13. | Sui J, Li W, Murakami A, Tamin A, Matthews LJ, Wong SK, Moore MJ, Tallarico AS, Olurinde M, Choe H, Anderson LJ, Bellini WJ, Farzan M, Marasco WA. Potent neutralization of severe acute respiratory syndrome (SARS) coronavirus by a human mAb to S1 protein that blocks receptor association. Proc Natl Acad Sci U S A. 2004 ,101(8):2536-41. |
| 14. | WongSK, Li W, Moore MJ, Choe H, Farzan M.A 193-amino acid fragment of the SARS coronavirus S protein efficiently binds angiotensin-converting enzyme 2. J Biol Chem. 2004, 279(5):3197-201. |
| 15. | Moore MJ, Dorfman T, Li W, Wong SK, Li Y, Kuhn JH, Coderre J, Vasilieva N, Han Z, Greenough TC, Farzan M, Choe H. Retroviruses pseudotyped with the severe acute respiratory syndrome coronavirus spike protein efficiently infect cells expressing angiotensin-converting enzyme 2. J Virol. 2004;78(19):10628-35. |
| 16. | Li W, Moore MJ, Vasilieva N, Sui J, Wong SK, Berne MA, Somasundaran M, Sullivan JL, Luzuriaga K, Greenough TC, Choe H, Farzan M. Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus. Nature. 2003, 426 (6965) :450-4. Comment in Cell. 2003,115(6):652-3 |
| 17. | Choe H, Li W, Wright PL, Vasilieva N, Venturi M, Huang CC, Grundner C, Dorfman T, Zwick MB, Wang L, Rosenberg ES, Kwong PD,Burton DR, Robinson JE, Sodroski JG, Farzan M.Tyrosine sulfation of human antibodies contributes to recognition of the CCR5 binding region of HIV-1 gp120. Cell. 2003,114(2):161-70. Comment in Cell. 2003,114(2):147-8. |
| 18. | Farzan M, Chung S, Li W, Vasilieva N, Wright PL, Schnitzler CE, Marchione RJ, Gerard C, Gerard NP, Sodroski J, Choe H. Tyrosine-sulfated peptides functionally reconstitute a CCR5 variant lacking a critical amino-terminal region. J Biol Chem. 2002, 277(43):40397-402. |
| 19. | Li W, Zhang Y, Sui J, Wang S. Combined immunization of DNA vaccine and replication-defective recombinant adenovirus bearing rabies glycoprotein gene induces immune response against rabies virus. Chinese Journal of Microbiology and Immunology,2002, 22(4): 403-406 |
| 20. | Sui J,Li W, Jiang X, He Y, Song Z. Highly Efficient Expression and Functional Studies of An Anti-KG1a Cell scFv 5C1 derived from Phage Display Antibody Library. Chinese Journal of Microbiology and Immunology. 2001, 21(4) : 437~441 |
| 21. | Li W, Zhang Y, Wang S, Liu L. Immune response of mice against replication-defective recombinant adenovirus containing glycoprotein gene of rabies 3aG strain. Chinese Journal of Experimental and Clinical Virology, 2001, 15(1):35-39 |
| 22. | Li W, Wang S, Zhang Y, Liu L. Construction of cloned recombinant adenovirus genome by homologous recombination in Escherichia coli. Chinese Journal of Biochemistry and Molecular Biology, 2000, 16(3):346-351 |
| 23. | Shen X, Xie Y, Li W . Construction of recombinant HBV preS2 -S Pichia pastoris. Progress in Microbiology and Immunology, 1999,27(1):14-18 |
2017年9月30日，當選2017年北京學者。
2020年11月12日，榮獲全球乙肝研究和治療領域最高獎——巴魯克•布隆伯格獎。
妻子：隋建華，北京生命科學研究所研究員，生物製品中心和抗體中心主任。
