鍾波

學習經歷

2001.9－2005.6 中國地質大學外國語學院 英語專業 學士

2003.2－2005.6 武漢大學生命科學學院 生物科學專業 學士

2005.9－2010.6 武漢大學生命科學學院 細胞生物學 博士導師：舒紅兵 院士

主要工作經歷與任職情況 2010.3－現在 武漢大學生命科學學院，病毒學國家重點實驗室 教授、博導 中組部青年

主要社會兼職：

中國細胞生物學會青年委員會委員

中國免疫學會青年委員會委員

JBC，Acta Biochim Biophys Sin，Immunologic Research等雜誌應邀審稿人

要研究領域及興趣

本實驗室主要從事抗病毒天然免疫信號轉導、炎性細胞因子介導的炎症反應與腫瘤發生的分子機理的研究。我們主要以表達克隆、酵母雙雜交以及蛋白質組學等多種手段，篩選參與調控抗病毒天然免疫以及炎症反應過程的蛋白，並通過基因敲除、轉基因小鼠以及動物疾病模型研究這些蛋白在調控病毒感染、自身免疫性疾病以及腫瘤發生等過程中的功能與機制。

獲獎與榮譽 2014 入選中組部第五批青年 2012 “全國百篇優秀博士論文”獲得者，中國 2012 美國免疫學家學會“Abstract Award”，美國 2010 應邀參加第60屆“諾貝爾獲獎者大會”，德國 2009 吳瑞獎，吳瑞基金會，美國

主持課題項目： 1 國家自然科學基金面上項目：2014.01-2017.12 2 國家重大基礎研究計劃子項目（973）：2014.01-2018.12 3 教育部優秀博士論文獲得者基金：2014.01-2017.12 4 中組部青年項目：2015.01-2017.12 5 病毒學國家重點實驗室研究骨幹:2014.01-

代表性論文

1. Lin D, Zhang M, Zhang MX, Ren YJ, Zhao Q, Jin J, Pan Z, Wu M, Shu HB, Dong C,Zhong B*. Induction of USP25 by viral infection promotes innate antiviral responses by mediating the stabilization of TRAF3 and TRAF6.Proc Natl Acad Sci U S A. 2015 2015 Aug 24. pii: 201509968. [Epub ahead of print]. (* corresponding author)

2.Wei J, Lian H,Zhong B, Shu HB. Parafibromin is a component of IFNγ-triggered signaling pathways that facilitates JAK1/2-mediated tyrosine phosphorylation of STAT1.J Immunol.2015 Jul 31. pii: 1501111. [Epub ahead of print]

3.Deng T, Lin D, Zhang M, Zhao Q, Li W,Zhong B, Deng Y, Fu X. Differential expression of bone morphogenetic protein 5 in human lung squamous cell carcinoma and adenocarcinoma.Acta Biochim Biophys Sin.2015 47(7):557-63.

4.Lin D,Zhong B*. Regulation of cellular innate antiviral signaling by ubiquitin modification.Acta Biochim Biophys Sin.2015 47(3):149-155. (* corresponding author)

5.Liu X, Chen X,Zhong B, Wang A, Wang X, Chu F, Nurieva RI, Yan X, Chen P, van der Flier LG, Nakatsukasa H, Neelapu SS, Chen W, Clevers H, Tian Q, Qi H, Wei L, Dong C. Transcription factor achaete-scute homologue 2 initiates follicular T-helper-cell development.Nature. 2014, 507(7493):513-8.

6.Luo WW, Lian H,Zhong B, Shu HB, Li S. Krüppel-like factor 4 negatively regulates cellular antiviral immune response.Cell Mol Immunol. 2014 Dec 22.

7.Zhou Q, Lin H, Wang S, Wang S, Ran Y, Liu Y, Ye W, Xiong X,Zhong B, Shu HB, Wang YY. The ER-associated protein ZDHHC1 is a positive regulator of DNA virus-triggered, MITA/STING-dependent innate immune signaling.Cell Host Microbe.2014, 16(4):450-6.

8. Qin Y, Zhou MT, Hu MM, Hu YH, Zhang J, Guo L,Zhong B, Shu HB. RNF26 temporally regulates virus-triggered type I interferon induction by two distinct mechanisms.PLoS Pathog.2014, 10(9):e1004358.

9.Lei CQ, Zhang Y, Li M, Jiang LQ,Zhong B, Kim YH, Shu HB. ECSIT Bridges RIG-I-Like Receptors to VISA in Signaling Events of Innate Antiviral Responses.J Innate Immun.2015, 7(2):153-64.

10.Zhang Y, Lei CQ, Hu YH, Xia T, Li M,Zhong B, Shu HB. Krüppel-like factor 6 is a co-activator of NF-κB that mediates p65-dependent transcription of selected downstream genes.J Biol Chem.2014, 289(18):12876-85.

11.Hu MM, Yang Q, Zhang J, Liu SM, Zhang Y, Lin H, Huang ZF, Wang YY, Zhang XD,Zhong B, Shu HB. TRIM38 inhibits TNFα- and IL-1β-triggered NF-κB activation by mediating lysosome-dependent degradation of TAB2/3.Proc Natl Acad Sci U S A.2014, 111(4):1509-14.

12.Lei CQ, Zhang Y, Xia T, Jiang LQ,Zhong B, Shu HB. FoxO1 negatively regulates cellular antiviral response by promoting degradation of IRF3. (2013).J Biol Chem.288, 12596-604.

13.Zhong B, Liu XK, Wang XH, Liu XD, Li HX, Darnay BR, Lin X, Sun SC and Dong C. Ubiquitin-specific Protease 25 regulates TLR4-dependent innate immune response through deubiquitination of TRAF3. (2013).Sci Signal. 6, ra35.

14.Liu XK#, Li HX#,Zhong B#, Blonska M, Gorjestani S, Yan M, Tian Q, Zhang DE, Lin X and Dong C. USP18 inhibits NF-κB and NFAT activation during Th17 differentiation by deubiquitinating the TAK1-TAB1 complex. (2013).J Exp Med.210, 1575-90. (#Co-first authors)

15.Zhong B, Liu XK, Wang XH, Chang SH, Liu XD, Wang AB, Reynolds JM, and Dong C. Negative regulation of IL-17-mediated signaling and inflammation by the ubiquitin-specific protease USP25. (2012).Nat Immunol.13, 1110-17.

16.Liu XD, Yan X,Zhong B, Nurieva RI, Wang A, Wang X, Martin-Orozco N, Wang Y, Chang SH, Esplugues E, Flavell RA, Tian Q, Dong C. Bcl6 expression specifies the T follicular helper cell program in vivo. (2012).J Exp Med.209:1841-52.

17.Xu T#, Wang X#,Zhong B, Nurieva RI, Ding S, Dong C. Ursolic acid suppresses interleukin-17 (IL-17) production by selectively antagonizing the function of RORgamma t protein. (2011).J Biol Chem.286, 22707-10.

18.Lei CQ,Zhong B, Zhang Y, Zhang J, Wang S and Shu HB. Glycogen synthase kinase 3β regulates IRF3 transcription factor-mediated antiviral response via activation of the kinase TBK1. (2010).Immunity. 33, 878-89.

19.Zhong B, Zhang Y, Tan B, Liu TT, Wang YY and Shu HB. The E3 ubiquitin ligase RNF5 targets virus-induced signaling adaptor for ubiquitination and degradation. (2010).J Immunol.184, 6249-6255.

20.Zhong B, Wang YY and Shu HB. Regulation of virus-triggered type I interferon signaling by cellular and viral proteins. (2010).Frontier in Biology5, 12-31.

21.Zhong B,Zhang L, Lei CQ, Li Y., Mao AP, Yang Y, Wang YY, Zhang XL and Shu HB. The ubiquitin ligase RNF5 regulates antiviral responses by mediating degradation of the adaptor protein MITA. (2009).Immunity30, 397-407.

22.Zhong B, Yang Y, Li S, Wang YY, Li Y, Diao FC, Lei CQ, He X, Zhang L, Tien, P and Shu HB. The adapter protein MITA links virus-sensing receptors to IRF3 transcription factor activation. (2008).Immunity29, 538–550.

23.Zhong B, Tien P and Shu HB. Innate immune responses: crosstalk of signaling and regulation of gene transcription. (2006).Virology352, 14-21.

24.Wang YY, Liu LJ,Zhong B, Liu TT, Li Y, Yang Y, Ran Y, Li S, Tien P and Shu HB. WDR5 is essential for assembly of the VISA-associated signaling complex and virus-triggered IRF3 and NF-kB activation. (2010).Proc Natl Acad Sci U S A.107, 815-820.

25.Mao AP, Li S,Zhong B, Li Y, Yan J, Li Q and Shu HB. Virus-triggered ubiquitination of TRAF3 by cIAP1/2 at the mitochondria is essential for induction of IFN-b and cellular antiviral response. (2010).J Biol Chem.285, 9470-9476.

26.Chen R, Zhang L,Zhong B, Tan B, Liu Y and Shu HB. Ubiquitin-specific protease 17 is involved in virus-triggered type I interferon signaling. (2010).Cell Res.20: 802-11.

27.Li S, Zheng H, Mao AP,Zhong B, Li Y, Liu Y, Gao Y, Ran Y, Tien P and Shu HB. Regulation of virus-triggered signaling by OTUB1- and OTUB2-mediated deubiquitination of TRAF3 and TRAF6. (2010).J Biol Chem.285, 4291-4297.

28.Li Y, Li C, Xue P,Zhong B, Mao AP, Ran Y, Chen H, Wang YY, Yang FQ and Shu HB. ISG56 is a negative regulator of virus-triggered signaling and cellular antiviral response. (2009).Proc Natl Acad Sci U S A.106, 7945-50.

29.Daio FC, Li S, Tian Y, Zhang M, Xu LG, Zhang Y, Wang RP, Zhai Z,Zhong B, Tien P and Shu HB. Negative regulation of MDA5- but not RIG-I-mediated innate antiviral signaling by the dihydroxya. (2007).Proc Natl Acad Sci U S A.104, 11706-11711.

30.Tian Y#, Zhang Y#,Zhong B, Wang YY, Diao FC, Wang RP, Zhang M, Chen DY, Zhai Z and Shu HB. RBCK1 negatively regulates tumor necrosis factor- and interleukin-1-triggered NF-kappaB activation by targeting TAB2/3 for degradation. (2007).J Biol Chem. 282, 16776-11782. (#Co-first authors).

31.張煜，鍾波，楊艷，舒紅兵. TLRs與RLRs介導的細胞抗病毒反應信號轉導及其調節機制. (2009).細胞生物學雜誌31, 453-468.

32.鍾波，舒紅兵. 天然免疫模式識別受體與樹突狀細胞的發現和意義——2011年諾貝爾生理學或醫學獎成果和相關研究.生命科學(2011). 23, 1147-1161.