楊曉明

楊曉明：出生年月1982年1月，山西人，理學博士。西南大學藥學院副教授。

教育及工作經歷

2010-至今西南大學藥學院

2007-2009四川大學-美國普渡大學生物化學系 理學博士

2004-2007四川大學化學學院 碩博連讀

2000-2004四川大學化學學院 理學學士

研究方向

(1)藥物分析方法學研究：熒光納米材料合成方法的探索，材料的表徵及其在藥物分析、疾病標誌物檢測中的應用。

(2)免疫分析方法學研究：結合新型熒游標記材料，構建免疫分析方法及其在藥物分析、食品安全、環境衛生中小分子檢測中的應用。

(3)探究潛在腫瘤標誌物Plk1及相關蛋白激酶在癌細胞信號通路中功能的研究：細胞增殖與調控，細胞信號轉導。

近年來發表學術論文

1. Dan Zhong, Hong Miao, Kuncheng Yang,Xiaoming Yang*. Carbon dots originated from carnation for fluorescent and colorimetric pH sensing.Materials Letters,2016, 166:89-92. (SCI, IF=2.489)

2. Lan Wang, Hong Miao, Dan Zhong andXiaoming Yang*. Synthesis of dopamine-mediated Cu nanoclusters for sensing and fluorescent coding.Analytical Methods,2016, 8:40-44. (SCI, IF=1.821)

3. Hong Miao, Dan Zhong, Zinan Zhou,Xiaoming Yang*. Papain-templated Cu nanoclusters: assaying and exhibiting dramatic antibacterial activity cooperating with HO.Nanoscale,2015, 7:19066-19072. (SCI, IF=7.394)

4. Shanshan Zhu, Yan Zhuo, Hong Miao, Dan Zhong,Xiaoming Yang*. Detection of mercury(II) by DNA templated gold nanoclusters based on forming thymidine-Hg-thymidine duplexes.Luminescence,2015, 30:631-636. (SCI, IF=1.518)

5. Dan Zhong, Yan Zhuo, Yuanjiao Feng,Xiaoming Yang*. Employing carbon dots modified with vancomycin for assaying Gram-positive bacteria like Staphylococcus aureus.Biosensors and Bioelectronics,2015, 74:546-553. (SCI, IF=6.409)

6. Yawen Luo, Hong Miao,Xiaoming Yang*. Glutathione-stabilized Cu nanoclusters as fluorescent probes for sensing pH and vitamin B1.Talanta,2015, 144:488-495. (SCI, IF=3.545)

7. Yan Zhuo, Dan Zhong, Hong Miao,Xiaoming Yang*. Reduced carbon dots employed for synthesizing metal nanoclusters and nanoparticles.RSC Advances,2015, 5:32669-32674. (SCI, IF=3.84)

8. Yuanjiao Feng, Dan Zhong, Hong Miao,Xiaoming Yang*. Carbon dots derived from rose flowers for tetracycline sensing.Talanta,2015, 140:128-133. (SCI, IF=3.545)

9. Yan Zhuo, Hong Miao, Dan Zhong, Shanshan Zhu,Xiaoming Yang*. One-step synthesis of high quantum-yield and excitation-independent emission carbon dots for cell imaging.Materials Letters,2015, 139:197-200. (SCI, IF=2.489)

10.Xiaoming Yang*, Yan Zhuo, Shanshan Zhu, Yawen Luo, Yuanjiao Feng and Yan Xu. Selectively assaying CEA based on a creative strategy of gold nanoparticles enhancing silver nanoclusters’ fluorescence.Biosensors and Bioelectronics,2015, 64:345-351. (SCI, IF=6.409)

11.Xiaoming Yang*, Yuanjiao Feng, Shanshan Zhu, Yawen Luo, Yan Zhuo and Yao Dou. One-step synthesis and applications of fluorescent Cu nanoclusters stabilized by L-Cysteine in aqueous solution.Analytica Chimica Acta,2014, 847:49-54. (SCI, IF=4.513)

12.Xiaoming Yang*, Yawen Luo, Yan Zhuo, Yuanjiao Feng and Shanshan Zhu. Novel synthesis of gold nanoclusters templated with L-tyrosine for selective analyzing tyrosinase.Analytica Chimica Acta,2014, 840:87-92. (SCI, IF=4.513)

13.Xiaoming Yang*, Yan Zhuo, Shanshan Zhu, Yawen Luo, Yuanjiao Feng and Yao Dou. Novel and green synthesis of high-fluorescent carbon dots originated from honey for sensing and imaging.Biosensors and Bioelectronics,2014, 60:292-298. (SCI, IF=6.409)

14. Yan Xu,Xiaoming Yang*, Shanshan Zhu and Yao Dou. Selectively fluorescent sensing of Cu based on Lysine-functionalized gold nanoclusters.Colloids and Surfaces A: Physicochemical and Engineering Aspects,2014, 450: 115-120. (SCI, IF=2.752)

15.Xiaoming Yang*, Yawen Luo, Shanshan Zhu, Yuanjiao Feng, Yan Zhuo and Yao Dou. One-pot synthesis of high fluorescent carbon nanoparticles and their applications as probes for detection of tetracyclines.Biosensors and Bioelectronics,2014, 56: 6-11.(SCI, IF=6.409)

16.Xiaoming Yang*, Shanshan Zhu, Yao Dou, Yan Zhuo, Yawen Luo and Yuanjiao Feng. Novel and remarkable enhanced-fluorescence system based on gold nanoclusters for detection of tetracycline.Talanta,2014, 122: 36-42. (SCI, IF=3.545)

17.Xiaoming Yang*, Lei Yang, Yao Dou and Shanshan Zhu. Synthesis of highly fluorescent lysine-stabilized Au nanoclusters for sensitive and selective detection of Cu ion.Journal of Materials Chemistry C,2013, 6748-6751. (SCI, IF=4.696)

18.Xiaoming Yang*, Yao Dou and Shanshan Zhu. Highly sensitive detection of superoxide dismutase based on an immunoassay with surface-enhanced fluorescence.Analyst,2013, 138:3246-3252. (SCI, IF=4.107)

19. Yao Dou andXiaoming Yang*. Novel high-sensitive fluorenscent detection of deoxyribonuclease I based on DNA-templated gold/silver nanoclusters.Analytica Chimica Acta,2013, 784:53-58. (SCI, IF=4.513)

20. Yao Dou,Xiaoming Yang*, Zhongde Liu and Shanshan Zhu. Homocysteine-functionalized silver nanoparticles for selective sensing of Cu ions and Lidocaine hydrochloride.Colloids and Surfaces A: Physicochemical and Engineering Aspects,2013, 423:20-26. (SCI, IF=2.752)

21.Xiaoming Yang*, Hongchang Li, Anping Deng and Xiaoqi Liu. Plk1 phosphorylation of topors is involved in its degradation.Molecular Biology Reports,2010, 37:3023-3028. (SCI, IF=2.024)

22.Xiaoming Yang, Hongchang Li, Zinan Zhou, Wen-Hong Wang, Anping Deng, Ourania Andrisani and Xiaoqi Liu*. Plk1-mediated phosphorylation of topors regulates P53 stability.Journal of Biological Chemistry,2009, 284:18558-18592. (SCI, IF=4.573)

23.Xiaoming Yang, Hongchang Li, Shawn Liu, Anping Deng and Xiaoqi Liu*. CDC2-mediated phosphorylation of CLIP-170 is essential for its inhibition of centrosome reduplication.Journal of Biological Chemistry,2009, 284:28775-28782. (SCI, IF=4.573)

24. Jiabin Tang,Xiaoming Yang and Xiaoqi Liu*. Phophorylation of PLK1 at Ser-326 regulates its functions during mitotic progression.Oncogene,2008, 27:6635-6645. (SCI, IF=8.559)

25. Zhao-Qiu Wu,Xiaoming Yang , Gregory Weber and Xiaoqi Liu*. PLK1 Phosphorylation of TRF1 is essential for its binding to telomers.Journal of Biological Chemistry,2008, 283:25503-25513. (SCI, IF=4.573)

26. Hongchang Li, X Shawn Liu,Xiaoming Yang,Bing Song, Yun Wang and Xiaoqi Liu*. Polo-like kinase 1 Phosphorylation of p150Glued facilitates nuclear envelope breakdown during prophase.Proc. Natl. Acad. Sci. U.S.A.2010, 107(33):14633-14638. (SCI, IF=9.809)

27. Hongchang Li, X Shawn Liu,Xiaoming Yang,Yingmin Wang, Yun Wang, Jerrold R Turner and Xiaoqi Liu*. Phosphorylation of CLIP-170 by PLK1 and CK2 promotes timely formation of kinetochore-microtubule attachments.EMBO J.2010, 29:2953-2965. (SCI, IF=10.740)

28. Xiaoling Qi,Xiaoming Yang, Bin Wang, Hong Yang and Anping Deng*. Development of a broad selective molecularly imprinted polymers based solid phase extraction of contraceptive drug levonorgestrel from water samples.Intern. J. Environm. Anal. Chem.2012, 92,268-278. (SCI, IF=1.24)

29. Weiwei Xing, Li He, Hong Yang, Chengjun Sun, Dawei Li,Xiaoming Yang, Yuan Li and Anping Deng*. Development of a sensitive and group-specific polyclonal antibody-based enzyme-linked immunosorbent assay (ELISA) for detection of malachite green and leucomalachite green in water and fish samples.2009, 89:2165-2173. (SCI, IF=1.879)