孫寶林

1986年牡丹江師範學院學士；

1989年中科院遺傳所碩士；

1999年密歇根州立大學博士。

重要致病細菌群體感應與生物膜發育及致病機理；細菌非編碼小RNA調控的細胞行為。詳情請見實驗室主頁sunlab點ustc點edu點cn。

主要在研課題:

1. 中國科學院“百人計劃”專項，2004.01–2007.12，資助金額：270萬。

2. 國家“十一五”科技重大專項“艾滋病和病毒性肝炎等重大傳染病防治”子課題“結核病靶標研究”，2008.10–2011.05，資助金額：315萬。

3. 中國科學院知識創新工程“結核分枝桿菌致病機制、快速診斷和新型藥物研究”，2009.6–2011.05，資助金額：60萬。

4. 國家自然科學基金“金黃色葡萄球菌非編碼小RNA的功能解析”，2010.01–2012.12，資助金額：40萬。

5. 國家自然科學基金“金黃色葡萄球菌KdpDE二元信號轉導系統對致病性的調控研究”，2011.01–2013.12，資助金額：34萬。

近期論文：

Xiong, M., Y. Bao, X. Yang, Y. Wang, B. Sun, and J. Wang (2012). Lipase-sensitive polymeric triple-layered nanogel for "on-demand" drug delivery.J. Am. Chem. Soc. 134:4355-4362.

Xue, T., Y. You, F. Shang, and B. Sun (2012). Rot and Agr system modulate fibrinogen-binding ability mainly by regulatingclfB expression inStaphylococcus aureus NCTC8325.Med. Microbiol. Immunol. 201:81-92.

Xue, T., Y. You, D. Hong, H. Sun, and B. Sun (2011). TheStaphylococcus aureus KdpDE two-component system couples extracellular K sensing and Agr signaling to infection programming.Infect. Immun.79:2154-2167.

Zhao, L., T. Xue, F. Shang, H. Sun, and B. Sun (2010).Staphylococcus aureus AI-2 quorum sensing associates with the KdpDE two-component system to regulate capsular polysaccharide synthesis and virulence.Infect. Immun.78:3506-3515.

Tao, L., X. Wu, and B. Sun (2010). Alternative sigma factor σ modulates prophage integration and excision inStaphylococcus aureus.PLoS Pathog.6:e1000888.

Shang, F., T. Xue, H. Sun, L. Xing, S. Zhang, Z. Yang, L. Zhang, and B. Sun (2009). TheStaphylococcus aureus GGDEF domain-containing protein, GdpS, influences protein A gene expression in a cyclic diguanylic acid-independent manner.Infect. Immun. 77:2849-2856.

Huang, J., B. Sun, and X. Zhang (2010).Shewanella xiamenensis sp. nov., isolated from coastal sea sediment.Int. J. Syst. Evol. Microbiol. 60:1585-1589.

Huang, J., B. Sun, and X. Zhang (2010). Electricity generation at high ionic strength in microbial fuel cell by a newly isolatedShewanella marisflavi EP1.Appl. Microbiol. Biotechnol. 85:1141-1149.

Xue, T., L. Zhao, H. Sun, X. Zhou, and B. Sun (2009). LsrR binding-site recognition and regulatory characteristics inEscherichia coli AI-2 quorum sensing.Cell Res.19:1258-1268.

Wu, C. and B. Sun (2009). Identification of novel esterase from metagenomic library of Yangtze River.J. Microbiol. Biotechnol. 19:187-193.

Chu, X., H. He, C. Guo, and B. Sun (2008). Identification of two novel esterases from a marine metagenomic library derived from South China Sea.Appl. Microbiol. Biotechnol.80:615-625.

Zhou, X., X. Meng, and B. Sun (2008). An EAL domain protein and cyclic AMP contribute to the interaction between the two quorum sensing systems inEscherichia coli.Cell Res. 18:937-948.

Ju, X., L. Zhao, and B. Sun (2007). Nitrogen fixation by reductively dechlorinating bacteria.Environ. Microbiol. 9:1078-1083.

Sun, B., B. M. Griffin, H. L. Ayala-del-Río, S. A. Hashsham, and J. M. Tiedje (2002). Microbial dehalorespiration with 1,1,1-trichloroethane.Science298:1023-1025.

Sun, B., J. R. Cole, and J. M. Tiedje (2001).Desulfomonile limimaris sp. nov., an anaerobic dehalogenating bacterium from marine sediments.Int. J. Syst. Evol. Microbiol.51:365-371.

Sun, B., J. R. Cole, R. A. Sanford, and J. M. Tiedje (2000). Isolation and characterization ofDesulfovibrio dechloracetivorans sp. nov., a marine dechlorinating bacterium growing by coupling the oxidation of acetate to the reductive dechlorination of 2-chlorophenol.Appl. Environ. Microbiol. 66:2408-2413.