胡先明

1981年11月：獲武漢大學化學系理學碩士；

1995年12月：在荷蘭格羅寧根大學化學系獲博士學位，師從R.M.Kellogg教授。

1996年2月：回國。

Hu Xianming (Prof. Dr.) was graduated from the university in 1978, he continued to study as graduate student until 1981 when he obtained a master degree of science from the Chemistry Department of Wuhan University. He joined the Professor R. M. Kellogg's group in 1992 and got his Ph.D. degree in Groningen University of the Netherlands in 1995. Then he came back to Wuhan University of China in February of 1996.

學術兼職 / Committee and Broad Memberships

1. 中國化學會永久會員，湖北省化學化工學會理事；

2. 中國藥學會高級會員，藥物化學專業委員會委員；

3. 湖北省藥學會常務理事，副理事長，藥物化學專業委員會主任委員。

1)手性合成與手性拆分、手性分離分析技術；

(2)藥物合成化學、天然產物化學及其藥劑學研究。

（3）承擔委託合成藥物及天然藥物研究和開發項目，承接藥物、中間體及精細化學品合成服務項目。

（1）環丙烷類抗癲癇和抗驚厥藥物及其抗病毒作用研究

（2）大環內酯類抗生素的設計與合成

（3）胺基甾體及甾類神經肌肉阻斷劑的設計與合成

（4）黃酮類抗病毒藥物的設計與合成

（5）茯苓活性多糖抗腫瘤凍乾粉針劑的研製

（6）基於茯苓多糖的新型藥用輔料的開發

（7）其它企業委託課題和外包服務

2009年

1.Qifeng Zhu, Yuanhu Pan, Zaixu Xu, Ruimin Li, Guofu Qiu, Wenjin Xu, Xianbing Ke, Lamei Wu, Xianming Hu*, Synthesis and potential anticonvulsant activity of new N-3-substituted 5, 5-cyclopropane spirohydantoins, European Journal of Medicinal Chemistry, 2009, 44, 296-302.

2.Xiao Ju Zhoua, Yi Mu Yib, Jing Wanb, Xian Ming Hua,* Preparation and body distribution of freeze-dried powder of ursolic acid phospholipid nanoparticles, Drug Development and Industrial Pharmacy, 2009 , 35(3), 305 – 310.

3.Xiao Ju Zhou, Yan Hu, Yanping Tian, Xian Ming Hu*, Effect of N-trimethyl chitosan enhancing the dissolution properties of the lipophilic drug cyclosporin A, Carbohydrate Polymers, 2009, 76（2），285-290.

4.Xianbing Ke, Hao Hu, Keda Zhang, Wenjin Xu, Qifeng Zhu, Lamei Wu, and Xianming Hu*, Significant Steroids: Effective and General Synthesis of 4α- and 4β-Amino-5α-Androstanes, Chemical Communications，2009，1037-1039.

5.Yan Hu, Xiaoju Zhou, Yong Lu, Chengyang Hu, Xianming Hu*, Novel Biodegradable Hydrogels based on Pachyman and its Derivatives for Drug Delivery, International Journal of Pharmaceutics, 2009, 371, 89–98.

6.Xianbing Ke, Hao Hu, Dingshan Zhou, Wenjin Xu, Qifeng Zhu, N. Pulla Reddy, Xianming Hu*, A Facile and General Synthesis of 2β-Aminosteroids, Synthesis, 2009, 8, 1255-1260.

7.Wenjin Xu, Jun Zhang, Hao Guo, Qifeng Zhu and Xianming Hu*, The Influence of Substituents on the Hydroxyl-Bearing Carbon in the Aza-Payne Rearrangement of Aziridinemethanols, Letters in Organic Chemistry, 2009, 6, 412-415.

8.Yuling Xiao, Qifeng Zhu, Wenjin Xu, Lamei Wu, Shucai Liang, Xianming Hu*. Preparation and characterization of a novel pachyman-based pharmaceutical aid II. A pH-sensitive, biodegradable and biocompatible hydrogel for controlled release of protein drugs, Carbohydrate Polymers, (2009) , 77(3), 612-620.

9.Wenjin Xu, Hao Guo, Jun Zhang, Qifeng Zhu, Xianming Hu,*.Asymmetric reduction of acetophenone using a,a-disubstituted aziridinemethanols and borane. Journal of Molecular Catalysis A: Chemical，(2009), 300(1-2), 25-28.

2010年

1.Zhongyuan Wu, Yong Lu, Ming Luo, Xianran He, Yuling Xiao, Jin Yang, Yuanhu Pan, Guofu Qiu, Hao Guo, Hao Hu, Dingshan Zhou and Xianming Hu,Synthesis and antibacterial activity of 3-O-carbamoyl derivatives of 6,11-di-O-methylerythromycin A: A novel class of acylides, European Journal of Medicinal Chemistry, 2010, 45(9): 3636-3644.

2.Xianran He, Guanpeng Qiu, Jin Yang, Yuling Xiao, Zhongyuan Wu, Guofu Qiu, Xianming Hu. Synthesis and anticonvulsant activity of new 6-methyl-1-substituted-4, 6-diazaspiro[2.4]heptane-5, 7-diones. European Journal of Medicinal Chemistry, 2010, 45(9): 3818-3830.

3.Zhongyuan Wu, Yong Lu, Ming Luo, Xianran He, Yuling Xiao, Jin Yang, Yuanhu Pan, Guofu Qiu, Yinya Xu, Wenhong Huang, Ping Long, Ruimin Li and Xianming Hu. Synthesis and antibacterial activity of novel 4″-carbamates of 6,11-di-O-methylerythromycin A. The Journal of Antibiotics, 2010, 63(7):343-350.

4.Jin Yang, Yuling Xiao, Xianran He, Zhongyuan Wu, Guofu Qiu, Xianming, Hu, Aesculetin-induced apoptosis through ROS-mediated mitochondrial dysfunction pathway in human cervical cancer cells. J. Asian Nat. Prod. Res., 2010, 12(3): 185– 193.

5.Xianran He, Min Zhong, Tao Zhang, Wen Wu, Yuling Xiao, Jin Yang, Zhongyuan Wu, Yuanhu Pan, Guofu Qiu, Xianming Hu*. Synthesis and anticonvulsant activity of N-3-arylamide substituted 5,5-cyclopropanespirohydantoin derivatives. European Journal of Medicinal Chemistry, 45 (2010) 5870-5877

（1）胡先明，柯賢炳，胡昊，2α,3α-環氧-16α-溴-5α-雄甾-17-酮的合成方法，申請號200710052447.3 申請日 07.06.11。ZL 2007 1 0052447.3

（2）胡先明，朱齊鳳，5-環丙烷螺環乙內醯脲衍生物的製備方法及藥物應用，申請號：200810047026.6

（3）胡先明 柯賢炳 胡昊，3α-羥基-2β-胺基-5α-雄甾-17-酮化合物的合成方法，申請日：2009.01.15；申請號：200910060520.0

（4）胡先明，肖玉玲，段小六，周小菊，劉華華，活性羧甲基茯苓多糖及其生產工藝和應用，申請號200910273267.7

（5）胡先明，吳仲元，魯勇，羅明，4“-取代的6, 11-二-氧-甲基紅黴素A的衍生物。申請號：201010188983.8

（6）胡先明，吳仲元，魯勇，羅明，3-氧-取代的6, 11-二-氧-甲基紅黴素A的衍生物。申請號：201010195098.2

（7）胡先明，賀賢然，N-3-芳醯胺-5-環丙烷螺環乙內醯脲衍生物及其製備方法和應用。申請號：201010196044.8