伍貽康

教　育：

1982.1 畢業於南京藥學院葯化系本科(獲理學學士)

1982.2—1986.9 中科院上海藥物所研究生( 1985.1獲理學碩士後繼續攻博 )

1986.10—1991.9 瑞典哥德堡大學有機系研究生( 獲Ph.D. ) 工作經歷

1991.9—1994.11 瑞典哥德堡大學有機系研究助理

1994.12—1997.10 中科院上海有機所三維葯研中心( 副研究員1995. 4 )

1997.10 調入生命有機化學國家重點實驗室

1994年回國至今在中國科學院上海有機化學研究所工作。現為研究員/博士生導師，兼任中國化學會 <<有機化學>>雜誌的副主編及<<中國化學>>和<<化學學報>>編委。2000年獲國家傑出青年基金。

研究方向

具顯著生物活性的天然及非天然複雜分子的不對稱合成及作用機制研究，不對稱合成方法學研究。

先後從事的研究領域包括人工模擬轉氨酶，分子內碳負離子與羥基間的氫鍵作用，昆蟲信息素及小分子合成砌塊，青蒿素與亞鐵離子作用機理，多種天然產物及其類似物的全合成等。

著作

發表論文

Some of the publications in recent years：

(1) Wu, Y.—K. “How Might Qinghaosu (Artemisinin) and Related Compounds Kill the Intraerythrocytic Malaria Parasite? — A Chemist’s View ”, Acc. Chem. Res. 2002, 35(5), 255—259.

(2) Wu, Y.—K.; Shen, X.; Tang, C.—J.; Chen, Z.—L.; Hu, Q.; Shi, W. “Synthesis of Natural Fragrant Molecules cis—3—Methyl—4—Decanolide and Aerangis Lactone. General Enantioselective Routes to b,g—cis—Disubstituted g—Lactones and g, d—cis—Disubstituted d—Lactones ”, J. Org. Chem. 2002, 67(11), 3802—3810.

(3) Wu, Y.—K.; Shen, X.; Huang, J.—H.; Tang, C.—J.; Liu, H.—H.; Hu, Q. "Preferential Hydrolysis of Benzylic/Allylic Dithianes and Dithiolanes Using o—Iodoxybenzoic Acid (IBX) in DMSO Containing Traces of Water", Tetrahedron. Lett. 2002, 43(36), 6443 — 6445.

(4) Wu, Y.—K.; Huang, J.—H.; Shen, X.; Hu, Q.; Tang, C.—J.; Li, L. "Facile Cleavage of Triethylsilyl (TES) Ethers Using ortho—Iodoxybenzoic Acid (IBX) without Affecting tert—Butyldimethylsilyl (TBS) Ethers", Org. Lett. 2002, 4(13), 2141—2144.

(5) Wu, Y.—K.; Shen, X., “Preparation of Tributylborane from Butyllithium and Boron trifluoride Etherate”, Synth. Commun. 2001, 31(19), 2939—2942.

(6) Wu, Y.—K.; Li, Y.; Wu, Y.—L. “Tandem Hemiketal Formation—Intramolecular Friedel—Crafts Alkylation. A Facile Route to the Hetero—Atom Substituted Benzene—Fused Bicyclo[3.3.1]nonanes”, Helv. Chim. Acta 2001, 84(1), 163—171.

(7) Wu, Y.—K.; Shen, X. “A high—yielding low—cost facile synthesis of chiral auxiliaries 2—oxazolidinones”, Tetrahedron: Asymmetry 2000, 11(21), 4359—4363.

(8) Shao, H.—W.; Wu, Y.—K.; Li, R.—X. “A Highly Practical Method for Monobenzylation of Amino Acids”, Synth. Commun. 2000, 30(11), 1911—1915.

(9) Shen, X.; Wu, Y.—L.; Wu, Y.—K. “Enantioselective Synthesis of Ethyl 4,5,7,8,9—Penta—O—acetyl—2,6—anhydro—3—deoxy—D—erythro—L—gluca—nononate: a 2—Monodeoxygenated Derivative of ‘2—keto—3—deoxy—D—glycero—D—galacto—nononic Acid’ ”, Helv. Chim. Acta 2000, 83(5), 943—953.

(10) Zeng, B.—B.; Wu, Y.—K.; Wu, Y.—L. ; Li, Y.; Chen, X.—G., “Enantiopure Simple Analogues of Annonaceous Acetogenins with Remarkable Selective Cytotoxicity towards Tumor Cell Lines”, Angew. Chem. Int. Ed. 2000, 39(11), 1934—1937.

(11) Hu, T.—S.; Wu, Y.—L.; and Wu, Y.—K. “The First Total Synthesis of Annonacin, the Most Typical Monotetrahydrofuran Annonaceous Acetogenins”, Org. Lett. 2000, 2(7), 887—889.

(12) Wang, D.—Y.; Wu, Y.—K.; Wu, Y.—L.; Li, Y.; Shan, F. “Synthesis, iron(II)—induced cleavage and in vivo antimalarial efficacy of 10—(2—hydroxy—1—naphthyl)—deoxoqinghaosu (—deoxoartemisinin)”,

J. Chem. Soc., Perkin Trans. 1. 1999, 1827—1832.

(13) Wu, Y.—K.; Yue, Z.—Y.; Wu Y.—L., “Interaction of qinghaosu (artemisinin) with cysteine sulfurhydryl mediated by traces of non—heme iron”, Angew. Chem. Int. Ed. 1999, 38(17), 2580—2582.

(14) Fan, J.—F.; Wu, Y.—K.; Wu, Y.—L., “First examples of Friedel—Crafts alkylation using ketals as alkylating agents: an expeditious access to the benzo—8—oxabicyclo[3.2.1]octane ring system”, J. Chem. Soc., Perkin Trans. 1., 1999, 1189—1192.

(15) Zhu, Q.; Fan, K.—Y.; Ma, H.—W.; Qiao, L.—X.; Wu, Y.—L.; Wu, Y.—K., "Radical—Mediated Diastereoselective Construction of A Chiral Synthon for Synthesis of Dolabellanes" , Org. Lett. 1999, 1, 757—759.

(16) Yu, Q.; Wu, Y.—K.; Ding, H.; Wu, Y.—L., “The first total synthesis of 4—deoxyannomontacin”, J. Chem. Soc., Perkin Trans. 1., 1999, 1183—1188.

(17) Wu, W.—M.; Wu, Y.—K.; Wu, Y.—L.; Yao, Z.—J.; Zhou, C.—M.; Li, Y.; Shan, F. “Unifided Mechanistic Framework for the Fe(II)—Induced Cleavage of Qinghaosu and Derivatives/Analogues. The First Spin—Trapping Evidence for the Previously Postulated Secondary C—4 Radical”, J. Am. Chem. Soc. 1998, 120(14), 3316—3325.

(18) Wu, Y.—K.; Ahlberg, P. “A Synthetic Study towards (5R*,6S*)—(2—Indenyl)spiro[4,5]decan—2—one”, Acta Chem. Scand. 1995, 49, 364—374.

(19) Wu, Y.—K.; Ahlberg, P., “Preparation of 4,4—Dimethoxybutyl Iodide from 1,4—Butanediol via the Corresponding Tosylate”, J. Org. Chem. 1994, 59, 5076—5077.

(20) Wu, Y.—K.; Ohlsson, E., “A Modified Synthesis of (±)—(E)—7Methyl—1,6—dioxaspiro[4,5]decane”, Acta Chem. Scand. 1993, 47, 422—424..