劉聰

劉聰，男，中科科學院上海有機化學研究所研究員，課題組長

1998-2002 吉林大學 學士 Jilin University B.S.

2002-2008 北京大學 博士 Peking University Ph.D

2008-至今 美國加州大學洛杉磯分校＆霍華德休斯醫學院 博士后 UCLA&HHMI Postdoc

1.與神經退行性疾病如老年痴呆症、帕金森症，亨廷頓氏病相關的蛋白質的錯誤摺疊，異常積聚，和澱粉樣化的分子機理研究。

2.基於重要生物靶點分子結構的小分子藥物先導物的設計，篩選和優化。主要針對老年痴呆症和帕金森症相關的致病蛋白多聚體及澱粉樣纖維的分子結構，進行小分子及多肽化合物的合理設計，篩選，及基於此先導物的機理和功能研究。

3.基於澱粉樣多肽的具有新功能的新材料設計，開發和應用。

2012 IUCr青年科學家國際旅行資助獎 國際晶體學會蛋白晶體學新方法會議

2012 ADDF 傑出青年科學家獎 第六屆神經退行性疾病藥物開發年會

2007 傑出牆報獎 第六屆國際蛋白科學會議

1.Jiang L*, Liu C*, Leibly D, Landau M, Zhao ML, Hughes M, Eisenberg D. Structure-based discovery of fiber-binding compounds that reduce the cytotoxicity of amyloid beta.eLife 2013;2:300857.

2. Gu L, Liu C, Guo Z. Structural insights into Aβ42 oligomers using site-directed spin

labeling. The Journal of Biological Chemistry, 2013, June 28, 288, 18673-1868.

3.Liu C*, Zhao ML*, Jiang L*., Cheng PN., Park JY, Sawaya M, Pensalfini A, Gou DW, Berk DW, Glabe C, Nowick, J and Eisenberg D. Out‐of‐register β‐sheets suggest a pathway to toxic amyloid aggregations. Proc. Nat. Acad. Sci. USA, 2012 Dec 18;109(51):20913-8

4.Cheng PN*, Liu C*, Zhao ML, Eisenberg D and Nowick J. Macrocyclic β‐sheet mimics that antagonize protein aggregation and reduce amyloid toxicity. Nature Chemistry,2012,doi:10.1038/nchem.1433.

5.Stroud JC*, Liu C*, Teng PK and Eisenberg D. Toxic fibrillar oligomers of amyloid‐βhave cross‐βstructure. Proc. Nat. Acad. Sci. USA., 2012, May 15;109(20):7717.

6.Laganowsky A, Liu C, Sawaya MR, Whitelegge JP, Park J, Zhao M, Pensalfini A, Soriaga AB, Landau M, Teng PK, Cascio D, Glabe C and Eisenberg D. Atomic view of a toxic amyloid small oligomer. Science., 2012, Mar 9;335(6073):1228‐31.

7.Liu C*, Sawaya MR*, Cheng PN, Zheng J, Nowick JS and Eisenberg D. Characteristics of amyloid‐related oligomers revealed by crystal structures of macrocyclic β‐sheet mimics. J. Am. Chem. Soc., 2011, May 4;133(17):6736‐44.

8.Zheng J, Liu C, Sawaya MR, Vadla B, Khan S, Woods RJ, Eisenberg D, Goux WJ and Nowick JS. Macrocyclic β‐sheet peptides that inhibit the aggregation of a tau‐protein‐derived hexapeptide. J. Am. Chem. Soc., 2011, Mar 9;133(9):3144‐57(2011).

9.Liu, C, Sawaya, M.R. and Eisenberg, D. β2-microglobulin forms three-dimensional domain-swapped amyloid fibrils with disulfide linkages. Nat. Struct. Mol. Biol., 2011, Jan;18(1):49‐55.

10.Liu C*, Li D*, Liang YH, Li LF and Su XD. Ring‐opening mechanism revealed by crystal structures of NagB and its ES intermediate complex. J. Mol. Biol., 2008, 379.

11. Li D*, Liu C*, Liang YH, Li LF and Su XD. Crystal structure of B. subtilis YjcG characterizing the YjcG‐like group of 2H phosphoesterase superfamily. Proteins: Structure, Function, and Bioinformatics, 2008, 72, 1071.

(* Authors contributed equally)