李根喜

1996～2000年為副教授，2001年為教授，2002年為博導，其中，1998～2000年分別在德國慕尼黑大學生物系、日本東北大學藥學部、美國哈佛大學醫學院生化與分子藥學系作訪問學者。1999年任生化系系主任。主要從事蛋白質電子傳遞、界面行為及其與生物小分子、納米材料相互作用的研究。2008～2011年任上海大學生命科學學院院長。兼任中國生物化學與分子生物學會蛋白質專業委員會常務委員、副秘書長，中國儀器儀錶學會化學感測器專業委員會委員。

2009年獲得“國家傑出青年科學基金”。科研成果“蛋白質和酶的電荷傳遞及界面行為與電化學分析法的研究”在1999年1月獲教育部科技進步三等獎。

擔任編委的主要期刊

1. International Journal of Molecular Sciences副主編 2005.5-2006.2；國際顧問編委

2006.3～

2. American Journal of Biochemistry and Biotechnology地區編委2005.1 ～

3. Asian Chemistry Letters國際顧問編委2004. 1 ～

4. 中國生物化學與分子生物學報編委2004. 1 ～

5. Biochemistry and Molecular Biology Education編委 2008.1 ～

1. Genxi Li, “Protein-based Voltammetric Sensors”; in “Encyclopedia of Sensors”, Edited by Craig A. Grimes, Elizabeth C. Dickey and Michael V. Pishko, American Scientific Publisher, 2006, Volume 8, pp. 301-314.

2. Genxi Li, “Protein-based biosensors using nanomaterials”; in “Nanotechnologies for Life Sciences”, Edited by Challa Kumar, Wiley-VCH, 2006, volume 8, “Nanomaterials for Biosensors”, 2007, pp. 278-310.

本小組主要是採用電化學方法，並結合其他一些生物學、化學手段，通過對電極表面進行功能修飾，對蛋白質等生物大分子進行分子改造，以研究生物分子的電子傳遞和界面行為，並對分子識別機制、信號傳遞過程、生物感測技術、信息分子功能等熱點問題進行探討，對蛋白質功能和結構研究的新途徑進行探索，建立生物分子測定的新方法、新技術，發展新型生物感測器件，以期對單分子、單細胞和生物活體進行實時、無創傷研究。

近期正致力於以下方面課題的研究：

1. 蛋白質的電子傳遞、電化學及界面行為。

2.蛋白質功能與結構的電化學研究。

3.納米生物學。

4.分子識別、組裝及相互作用。

5.新型第三代生物感測器的研製。

6.生物信號分子研究及相關信號傳導機制探索。

1 Nandi Zhou, Jing Wang, Ting Chen, Zhiguo Yu, Genxi Li

Enlargement of gold nanoparticles on the surface of self-assembled monolayer modified

electrode: A mode in biosensor design

Anal. Chem, 2006, 78, 5227～5230

2 Yinxi Huang, Lei Liu, Chang Shi, Junyi Huang, and Genxi Li

Electrochemical interrogation of the effect of Ca2+ on cardiolipin-cytochrome c interaction

Biochimica et Biophysica Acta - General Subjects, 2006, 1760: 1827～1830

3 Hui Zhou, Lei Liu, Kun Yin, Shanli Liu, Genxi Li

Electrochemical investigation on the catalytic ability of tyrosinase with the effect of nano titanium dioxide

Electrochem. Comm., 2006, 8: 1168～1172

4 Xiaofeng Zheng, Anyue Chen, Tomonori Hoshi, Jun-ichi Anzai, Genxi Li

Electrochemical studies of (―)-epigallocatechin gallate and its interaction with DNA

Anal Bioanal Chem, 2006, 386: 1913～1919

5 Rongwu Yang, Xinjian Liu, Zhiqiang Zhu, Shanli Liu, Genxi Li

Enhanced electron transfer and catalytic activity of cyanocobalamin with β-cyclodextrin

Sensor Lett, 2006, 4: 416～418

6 Rongwu Yang, Ge Gao, Ting Liu, Shanli Liu, Genxi Li

Enhanced ability of hemoglobin to carry oxygen by salidroside

Electrochem. Comm., 2007, 9: 94～96

7 Guifang Chen, Jing Zhao, Xinjian Liu, Ge Gao, Junyi Huang, Genxi Li

Electrochemical sensing DNA damage with nano- titanium dioxide and repair with a medicinal herb species resveratrol

Journal of Biotechnology, 2007, 127: 653～656

8 Xiaoli Zhu, Ishida Yuri, Xin Gan, Iwao Suzuki, and Genxi Li

Electrochemical study of the effect of nano zinc oxide on microperoxidase and its application to more sensitive hydrogen peroxide biosensor preparation

Biosensors and Bioelectronics, 2007, 22: 1600～1604

9 Jing Chen, Guifang Chen, Dong Li, Jianbo Jia, Genxi Li

Electroanalysis of ethanol with a glass carbon electrode co-modified with liver tissue homogenate and carbon nanotubes

Electroanalysis, 2007, 19: 813～815

10 Jing Wang, Zhiqiang Liang, Lihua Wang, Chunhai Fan, Genxi Li

Electron transfer reactivity and catalytical activity of structurally rigidized hemoglobin

Sensors and Actuators B, 2007, 125: 17～21

11 Jing Zhao, Xiaofeng Zheng, Xin Zhang, Junyi Huang, and Genxi Li

Electrochemical Studies of camptothecin and its interaction with human serum albumin

International Journal of Molecular Sciences, 2007, 8: 42～50

12 Han Xiao, Jing Wang, Guifang Chen, and Genxi Li

Electrochemical sensing of self-disassociation of PKA upon activation by cAMP

Langmuir, 2007, 23: 3506～3508

13 Han Xiao, Hui Zhou, Guifang Chen, Shanli Liu, Genxi Li

Electrochemical studies of inducible nitric oxide synthase modulated by binding of calmodulin in Ca2+-free and -bound forms

Journal of Proteome Research, 2007, 6: 1426～1429

14 Guifang Chen, Xiang Ma, Xin Zhang, Junyi Huang, Genxi Li

An electrochemical study of myoglobin entrapped in three kinds of films

Sensor Lett, 2007, 5: 463～466

15 Lei Liu, Xiaoli Zhu, Dongmei Zhang, Junyi Huang, and Genxi Li

An electrochemical method to detect folate receptor positive tumor cells

Electrochem. Comm., 2007, 9: 2547～2550

16 Jing Wang, Nandi Zhou, Zhiqiang Zhu, Junyi Huang, Genxi Li

Detection of flavonoids and assay of their antioxidant activity based on enlargement of gold nanoparticles

Anal Bioanal Chem, 2007, 388: 1199～1205

17 Xiaoli Zhu, Qianlu Yang, Junyi Huang, Iwao Suzuki, Genxi Li

Colorimetric study of the interaction between gold nanoparticles and a series of amino acids

J. Nanosci. Nanotechnol., 2008, 8: 353～357

18 Xiaoli Zhu, Wenjun Zhang, Han Xiao, Junyi Huang, and Genxi Li

Electrochemical study of a hemin-DNA complex and its activity as a ligand binder

Electrochimica Acta, 2008, 53: 4407～4413

19 Junyi Huang, Dongmei Zhang, Wei Xing, Xiang Ma, Yanxia Yin, Qun Wei, Genxi Li

An approach to assay the enzymatic activity of calcineurin and the inhibitory

effect of zinc ion

Anal. Biochem., 2008, 375: 385～387

20 Guifang Chen, Xiang Ma, Fanben Meng, Genxi Li

The electron transfer reactivity of kaempferol and its interaction with amino acid residues

Bioelectrochemistry, 2008, 72: 169～173

21 Guifang Chen, Xiaoli Zhu, Fanben Meng, Zhiguo Yu, and Genxi Li

Apoferritin as a bionanomaterial to facilitate the electron transfer reactivity of hemoglobin and the catalytic activity towards hydrogen peroxide

Bioelectrochemistry, 2008, 72: 77～80

22 Han Xiao, Ting Liu, Nandi Zhou, Zhiguo Yu, and Genxi Li

Electron transfer reactivity and catalytic activity of choline oxidase in

Didodecyldimethylammonium bromide film and its application for sensitive

choline monitoring

Sensor Lett., 2008, 6: 209～212

23 Jing Zhao, Wenying Meng, Peng Miao, Zhiguo Yu, Genxi Li

Photodynamic effect of hypericin on the conformation and catalytic activity of hemoglobin

Int. J. Mol. Sci., 2008, 9: 145～153

24 Xiaoqiang Liang, Guifang Chen, Xin Zhang, Shanli Liu, Genxi Li

Study of UVA irradiation on hemoglobin in the presence of NADH

Journal of Photochemistry and Photobiology B: Biology, 2008, 90: 53～56

25 Junyi Huang, Lin Chen, Xin Zhang, Shanli Liu, Genxi Li

Electrochemical studies of ion-channel behavior of annexin V in phosphatidylcholine

bilayer membranes

Electrochem. Comm., 2008, 10: 451～454