田見暉
動物遺傳育種與繁殖專業博士
中國畜牧獸醫學會動物繁殖學分會秘書長兼副理事長
畜禽育種國家工程實驗室副主任
農業部動物遺傳育種與繁殖學科群副主任
國家“十二五”農業與農村科技發展規劃專家組成員
國家“十一五”、“十二五”“863”計劃“動物分子與細胞工程育種”重大專項首席專家
揭示了雌性體外胚胎X染色體失活不足,導致體外受精動物性別失衡的機制,發明體外胚胎髮育的視黃酸校正技術,解決了長期以來雌性體外胚胎死亡的難題。發現了C型鈉肽mRNA降解啟動哺乳動物卵子減數分裂恢復的機制。揭示了牛卵泡中C型鈉肽阻滯卵子減數分裂的獨特路徑,開發C型鈉肽卵子核-質同步成熟技術,攻克了卵子體外成熟質量差的技術瓶頸。開發了家畜高效、精準排卵控制技術和相關藥物,推動了中國生豬“批次化”生產大規模產業應用。
主持及承擔科研項目
支撐計劃課題,2011BAD19B01,家畜胚胎保存與性控雙犢誘導技術研究,2011.01-2013.12
863課題,2008AA101004,家畜精子快速低損傷分離技術研究與應用,2008.01-2011.12
863課題,2008AA101003,家畜卵泡高效誘導發育技術研究與應用,2008.01-2011.12
支撐計劃課題,2006BAD14B08,畜禽良種資源高效繁殖和生殖健康關鍵技術研究,2006.11-2008.12
教育部人才項目特聘教授(2015年);高層次人才支持計劃領軍人才(2018年);教育部新世紀優秀人才(2014年);教育部技術發明一等獎(2019年);大北農科技獎一等獎(2019年);中國農學會“中國農業農村重大新技術新產品新裝備——十大新產品”(2020年);國家技術發明獎二等獎(2020年).
獲省部級科技獎勵4項。
Gao S, Wang Z, Di K, Chang G, Tao L, An L, Wu F, Liu Y, Wu Z, Li X, Gao S,Tian J*. Melatonin improves the reprogramming ef?ciency of murine induced pluripotent stem cells using a secondary inducible system. J Pineal Res. 2013; 55: 31-39. (IF: 7.30)
Pang Y., An L, Wang P, Yu Y, Yin Q, Wang X, Zhang X., Zhang Q., Yang M, Guo. M, Wu Z,Tian J*. Treatment of porcine donor cells and reconstructed embryos with the antioxidant melatonin enhances cloning efficiency. J Pineal Res. 2013; 54: 389-397. (IF: 7.30)
Nie J, An L, Miao K, Hou Z, Yu Y, Tan K, Sui L, He S, Liu Q, Xing L, Wu ZH, Tian JH.* Comparative analysis of dynamic proteomic profiles between in vivo and in vitro produced mouse embryos during post-implantation period. J Proteome Res. 2013; 12: 3843-3856 (IF: 5.22)
Xu X, Ma W, Zhu Y, Wang C, Wang B, An N, An L, Liu Y, Wu Z, Tian J*. The microtubule-associated protein ASPM regulates spindle assembly and meiotic progression in mouse oocytes. PLoS One. 2012; 7, e49303. (IF:4.24)
Ma W, An L, Wu Z, Wang X, Guo M, Miao K, Ma W,Tian J*. Efficient and safe recipient preparation for transplantation of mouse spermatogonial stem cells: pretreating testes with heat shock. Biol Reprod. 2011; 85: 670-6677. (IF:4.14)
Cheng W, An L, Wu Z, Zhu Y, Liu J, Gao H, Li X, Zheng S, Chen D, Tian J*. Effects of disulfide bond reducing agents on sperm chromatin structural integrity and developmental competence of in vitro matured oocytes after intracytoplasmic sperm injection in pigs. Reproduction. 2009: 137:633-643. (IF: 3.50)
An, L., Pang, Y.W., Gao, H.M., Tao, L., Miao, K., Wu, Z.H. & Tian, J.H.* Heterologous expression of C. elegans fat-1 decreases the n-6/n-3 fatty acid ratio and inhibits adipogenesis in 3T3-L1 cells. Biochem Biophys Res Commun. 2012: 428, 405-10.
Xia, C., Xia, W., Yang, S., An, L., Li, X., Wu, Z., Zhang, J., Wang, Z. & Tian, J* Effect of antioxidant supplementation on function and fertility of sex-sorted boar spermatozoa. Anim Reprod Sci. 2012: 136, 108-14.
Cheng, W.M., Wu, Z.H., Zhang, X., Zhu, Y.B., Pang, Y.W., Guo, M., Wang, D. & Tian, J.H.* Effects of different activation regimens on pronuclear formation and developmental competence of in vitro-matured porcine oocytes after intracytoplasmic sperm injection. Reprod Domest Anim. 2012: 47, 609-14 ()
Miao, K., Guo, M., An, L., Xu, X.L., Wu, H., Wang, D., Wu, Z.H. &Tian, J.H* A new method to efficiently produce transgenic embryos and mice from low-titer lentiviral vectors. Transgenic Res. 2011: 20, 357-63 ().
An, L., Wu, Z.H., Wu, Y.F., Zhang, X.L., Liu, X., Zhu, Y.B., Cheng, W.M., Gao, H.M., Guo, M. & Tian, J.H.* Fertility in single-ovulating and superovulated dairy heifers after insemination with low dose sex-sorted sperm. Reprod Domest Anim 2010: 45, e344-50
Cheng, W.M., Sun, X.L., An, L., Zhu, S.E., Li, X.H., Li, Y. & Tian, J.H.* Effect of different parthenogenetic activation methods on the developmental competence of in vitro matured porcine oocytes. Anim Biotechnol 2007: 18, 131-41.
Tian, J.H.*, Wu, Z.H., Liu, L., Cai, Y., Zeng, S.M., Zhu, S.E., Liu, G.S., Li, Y. & Wu, C.X Effects of oocyte activation and sperm preparation on the development of porcineembryos derived from in vitro-matured oocytes and intracytoplasmic sperm injection.. Theriogenology 2006: 66, 439-48
動物繁殖理論與生物技術,主編,養殖領域研究生教學用書,中國農業出版社,2010。
動物生殖生理學,副主編,全國高等農業院校教學指導委員會推薦研究生教學用書,中國農業出版社,北京,2006。