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金大勇

南方科技大學講席教授

金大勇,2007年6月於澳大利亞麥考瑞大學獲博士學位。曾先後任職於麥考瑞大學悉尼科技大學,並於2017年晉陞為悉尼科技大學傑出教授。現為南方科技大學生物醫學工程系講席教授。

人物經歷


教育經歷

2007年-2008年 博士后 澳大利亞麥考瑞大學,物理系
2003年-2007年 博士學習 澳大利亞麥考瑞大學, 物理系
1998年-2002年 本科學習 遼寧師範大學,物理系

工作經歷

2019年-至今:南方科技大學
2017-2022: 澳大利亞悉尼科技大學,傑出教授,生物醫學材料及儀器研究所所長
2015-2017 澳大利亞悉尼科技大學,教授,生物醫學材料及儀器研究所所長,澳大利亞國家可集成生物醫療儀器與技術轉化基地所長
2014-2015 澳大利亞麥考瑞大學,化學及分子生物學系,副教授,澳洲基金委國家納米生物光子學重點實驗中心首席科學家
2013-2014 澳大利亞麥考瑞大學,化學及分子生物學系,高級講師助理教授,澳洲基金委傑出青年 Future Fellowship
2010-2013 澳大利亞麥考瑞大學,物理系,講師助理, 澳洲基金委研究員 (ARC APD Fellow) 先進細胞儀實驗室主任
2009-2010 澳大利亞麥考瑞大學,物理系,講師
2008-2009 澳大利亞麥考瑞大學,物理系,獨立研究員

主要成就


研究領域

金大勇的研究工作涉及物理、工程和跨學科領域,專業涵蓋了生物醫學光子學、納米技術、發光材料、顯微鏡方法學、生物醫療診斷等。作為項目團隊負責人,金大勇在悉尼科技大學建立了澳大利亞可集成生物醫療儀器與技術轉化港、中澳科技部聯合資助的攜帶型體外診斷技術聯合研究中心,以及悉尼科技大學-南方科技大學生物醫學材料和器件聯合研究中心。他組建的悉尼科技大學生物醫學材料及儀器研究所旨在將最前沿的光子學和先進材料轉化為顛覆性的生物技術。

學術論文

2019
1. Wen, S.; Zhou J.; Schuck P.J†.; Suh Y.D†.; Schmidt T†.; Jin, D†, 2019, Future and challenges for hybrid upconversion nanosystems, Nature Photonics, DOI:10.1038/s41566-019-0528-x.
2. Karl Zhanghao, Xingye Chen, Wenhui Liu, Meiqi Li, Yiqiong Liu, Yiming Wang, Sha Luo, Xiao Wang, Chunyan Shan, Hao Xie, Juntao Gao, Xiaowei Chen, Dayong Jin, Xiangdong Li, Yan Zhang, Qionghai Dai, Peng Xi, Super-resolution imaging of fluorescent dipoles via polarized structured illumination microscopy, Nature Communications, DOI: 10.1038/s41467-019-12681-w
3. Gu, Y.; Guo, Z.; Yuan, W.; Kong, M.; Liu, Y.; Liu, Y.; Gao, Y.; Feng, W.; Wang, F.; Zhou, J.; Jin, D†; Li, F. †, 2019, High-sensitivity imaging of time-domain near-infrared light transducer, Nature Photonics, DOI:10.1038/s41566-019-0437-z.
4. Ren, W.; Lin, G.; Clarke, C.; Zhou, J.; Jin, D†, 2019, Optical Nanomaterials and Enabling Technologies for High-Security-Level Anticounterfeiting, Advanced Materials, 10.1002/adma.201901430.
5. Xu, J.; Gulzar, A.; Yang, P.; Bi, H.; Yang, D.; Gai, S.; He, F.; Lin, J.; Xing, B.; Jin, D†, 2019, Recent advances in near-infrared emitting lanthanide-doped nanoconstructs: Mechanism, design and application for bioimaging, Coordination Chemistry Reviews, 381, 104-134.
6. Wei, Y.; Xing, G.; Liu, K.; Li, G.; Dang, P.; Liang, S.; Liu, M.; Cheng, Z.; Jin, D†; Lin, J. †, 2019, New strategy for designing orangish-red-emitting phosphor via oxygen-vacancy-induced electronic localization, Light: Science & Applications, 8, 15.
7. Wang, L.; Cui, D.; Ren, L.; Zhou, J.; Wang, F.; Casillas, G.; Xu, X.; Peleckis, G.; Hao, W.; Ye, J.; Dou, S. X.; Jin, D†; Du, Y. †, 2019, Boosting NIR-driven photocatalytic water splitting by constructing 2D/3D epitaxial heterostructures, Journal of Materials Chemistry A, 7, 13629-13634.
8. Mi, C.; Zhou, J. †; Wang, F.; Jin, D., 2019, Thermally enhanced NIR–NIR anti-Stokes emission in rare earth doped nanocrystals, Nanoscale, 10.1039/C9NR03041G.
9. Ding, B.; Shao, S.; Jiang, F.; Dang, P.; Sun, C.; Huang, S.; Ma, P. a.; Jin, D.; Kheraif, A. A. A.; Lin, J. †, 2019, MnO2-Disguised Upconversion Hybrid Nanocomposite: An Ideal Architecture for Tumor Microenvironment-Triggered UCL/MR Bioimaging and Enhanced Chemodynamic Therapy, Chemistry of Materials, 31, 2651-2660.
10. Zhou, Y.; Chen, Y.; He, H.; Liao, J.; Duong, H. T. T.; Parviz, M. †; Jin, D. †, 2019, A homogeneous DNA assay by recovering inhibited emission of rare earth ions-doped upconversion nanoparticles, Journal of Rare Earths, 37, 11-18.
2018
11. Zhou, J.; Wen, S.; Liao, J.; Clarke, C.; Tawfik, S. A.; Ren, W.; Mi, C.; Wang, F.; Jin, D†, 2018, Activation of the surface dark-layer to enhance upconversion in a thermal field, Nature Photonics, 12, 154-158.
12. Chen, C.; Wang, F.; Wen, S.; Su, Q. P.; Wu, M. C. L.; Liu, Y.; Wang, B.; Li, D.; Shan, X.; Kianinia, M.; Aharonovich, I.; Toth, M.; Jackson, S. P.; Xi, P.; Jin, D†, 2018, Multi-photon near-infrared emission saturation nanoscopy using upconversion nanoparticles, Nature Communications, 9, 3290.
13. Wen, S.; Zhou, J.; Zheng, K.; Bednarkiewicz, A.; Liu, X.; Jin, D†, 2018, Advances in highly doped upconversion nanoparticles, Nature Communications, 9, 2415.
14. Jin, D†; Xi, P.; Wang, B.; Zhang, L.; Enderlein, J.; Van Oijen, A. M., 2018, Nanoparticles for super-resolution microscopy and single-molecule tracking, Nature Methods, 15, 415-423.
15. Wang, F.; Wen, S.; He, H.; Wang, B.; Zhou, Z.; Shimoni, O.; Jin, D. †, 2018, Microscopic inspection and tracking of single upconversion nanoparticles in living cells, Light: Science and Applications, 7.
16. Zhou, J.; Leaño, J. L.; Liu, Z.; Jin, D. †; Wong, K. L. †; Liu, R. S. †; Bünzli, J. C. G. †, 2018, Impact of Lanthanide Nanomaterials on Photonic Devices and Smart Applications, Small, 14.
17. Teng, B.; Han, Y.; Zhang, X.; Xiao, H.; Yu, C.; Li, H.; Cheng, Z.; Jin, D.; Wong, K. L.; Ma, P.; Lin, J., 2018, Phenanthriplatin(iv) conjugated multifunctional up-converting nanoparticles for drug delivery and biomedical imaging, Journal of Materials Chemistry B, 6, 5059-5068.
18. Sun, Y.; Zhang, W.; Wang, B.; Xu, X.; Chou, J.; Shimoni, O.; Ung, A. T.; Jin, D. †, 2018, A supramolecular self-assembly strategy for upconversion nanoparticle bioconjugation, Chemical Communications, 54, 3851-3854.
19. Shang, Y.; Bao, G.; Zhou, J.; Wong, K.; Yang, C.; Jin, D., 2018, Lanthanide-Doped Upconversion Luminescent Materials for Point of Care Diagnosis, Journal of the Chinese Rare Earth Society, 36, 129-146.
20. Ren, W.; Zhou, Y.; Wen, S.; He, H.; Lin, G.; Liu, D.; Jin, D., 2018, DNA-mediated anisotropic silica coating of upconversion nanoparticles, Chemical Communications, 54, 7183-7186.
21. Ren, W.; Wen, S.; Tawfik, S. A.; Su, Q. P.; Lin, G.; Ju, L. A.; Ford, M. J.; Ghodke, H.; Van Oijen, A. M.; Jin, D., 2018, Anisotropic functionalization of upconversion nanoparticles, Chemical Science, 9, 4352-4358.
22. Lin, G.; Baker, M. A. B.; Hong, M.; Jin, D., 2018, The Quest for Optical Multiplexing in Bio-discoveries, Chem, 4, 997-1021.
23. He, H.; Liu, B.; Wen, S.; Liao, J.; Lin, G.; Zhou, J.; Jin, D., 2018, Quantitative Lateral Flow Strip Sensor Using Highly Doped Upconversion Nanoparticles, Analytical Chemistry, 90, 12356-12360.
24. He, H.; Howard, C. B.; Chen, Y.; Wen, S.; Lin, G.; Zhou, J.; Thurecht, K. J.; Jin, D., 2018, Bispecific Antibody-Functionalized Upconversion Nanoprobe, Analytical Chemistry, 90, 3024-3029.
25. Guan, M.; Zhou, Z.; Mei, L.; Zheng, H.; Ren, W.; Wang, L.; Du, Y.; Jin, D.; Zhou, J. †, 2018, Direct cation exchange of surface ligand capped upconversion nanocrystals to produce strong luminescence, Chemical Communications, 54, 9587-9590.
26. Gai, S.; Yang, G.; Yang, P.; He, F.; Lin, J.; Jin, D.; Xing, B., 2018, Recent advances in functional nanomaterials for light–triggered cancer therapy, Nano Today, 19, 146-187.
27. Duong, H. T. T.; Chen, Y.; Tawfik, S. A.; Wen, S.; Parviz, M.; Shimoni, O.; Ab, Jin, D. †, 2018, Systematic investigation of functional ligands for colloidal stable upconversion nanoparticles, RSC Advances, 8, 4842-4849.
28. Clarke, C.; Liu, D.; Wang, F.; Liu, Y.; Chen, C.; Ton-That, C.; Xu, X.; Jin, D. †, 2018, Large-scale dewetting assembly of gold nanoparticles for plasmonic enhanced upconversion nanoparticles, Nanoscale, 10, 6270-6276.
29. Chen, Y.; Duong, H. T. T.; Wen, S.; Mi, C.; Zhou, Y.; Shimoni, O.; Valenzuela, S. M.; Jin, D. †, 2018, Exonuclease III-Assisted Upconversion Resonance Energy Transfer in a Wash-Free Suspension DNA Assay, Analytical Chemistry, 90, 663-668.
30. Bao, G.; Zha, S.; Liu, Z.; Fung, Y. H.; Chan, C. F.; Li, H.; Chu, P. H.; Jin, D.; Tanner, P. A.; Wong, K. L., 2018, Reversible and Sensitive Hg2+Detection by a Cell-Permeable Ytterbium Complex, Inorganic Chemistry, 57, 120-128.
31. Bao, G.; Wong, K. L.; Jin, D.; Tanner, P. A., 2018, A stoichiometric terbium-europium dyad molecular thermometer: energy transfer properties, Light: Science and Applications, 7.
2017
32. Liu, Y.; Lu, Y.; Yang, X.; Zheng, X.; Wen, S.; Wang, F.; Vidal, X.; Zhao, J.; Liu, D.; Zhou, Z.; Ma, C.; Zhou, J.; Piper, J. A.; Xi, P.; Jin D†, 2017, Amplified stimulated emission in upconversion nanoparticles for super-resolution nanoscopy, Nature, 543, 229-233.
33. Ma, C.; Xu, X.; Wang, F.; Zhou, Z.; Liu, D.; Zhao, J.; Guan, M.; Lang, C. I.; Jin, D. †, 2017, Optimal Sensitizer Concentration in Single Upconversion Nanocrystals, Nano Letters, 17, 2858-2864.
34. Zou, R.; Huang, J.; Shi, J.; Huang, L.; Zhang, X.; Wong, K. L.; Zhang, H.; Jin, D.; Wang, J.; Su, Q., 2017, Silica shell-assisted synthetic route for mono-disperse persistent nanophosphors with enhanced in vivo recharged near-infrared persistent luminescence, Nano Research, 10, 2070-2082.
35. Xu, X.; Clarke, C.; Ma, C.; Casillas, G.; Das, M.; Guan, M.; Liu, D.; Wang, L.; Tadich, A.; Du, Y.; Ton-That, C.; Jin, D. †, 2017, Depth-profiling of Yb3+sensitizer ions in NaYF4 upconversion nanoparticles, Nanoscale, 9, 7719-7726.
36. Xie, J.; Xie, X.; Mi, C.; Gao, Z.; Pan, Y.; Fan, Q.; Su, H.; Jin, D.; Huang, L.; Huang, W., 2017, Controlled Synthesis, Evolution Mechanisms, and Luminescent Properties of ScFx:Ln (x = 2.76, 3) Nanocrystals, Chemistry of Materials, 29, 9758-9766.
37. Teng, B.; Ma, P.; Yu, C.; Zhang, X.; Feng, Q.; Wen, L.; Li, C.; Cheng, Z.; Jin, D.; Lin, J., 2017, Upconversion nanoparticles loaded with eIF4E siRNA and platinum(IV) prodrug to sensitize platinum based chemotherapy for laryngeal cancer and bioimaging, Journal of Materials Chemistry B, 5, 307-317.
38. Marciniak, L.; Pilch, A.; Arabasz, S.; Jin, D.; Bednarkiewicz, A., 2017, Heterogeneously Nd3+doped single nanoparticles for NIR-induced heat conversion, luminescence, and thermometry, Nanoscale, 9, 8288-8297.
39. Fu, L.; Morsch, M.; Shi, B.; Wang, G.; Lee, A.; Radford, R.; Lu, Y.; Jin, D.; Chung, R., 2017, A versatile upconversion surface evaluation platform for bio-nano surface selection for the nervous system, Nanoscale, 9, 13683-13692.
40. Deng, K.; Li, C.; Huang, S.; Xing, B.; Jin, D.; Zeng, Q.; Hou, Z.; Lin, J., 2017, Recent Progress in Near Infrared Light Triggered Photodynamic Therapy, Small, 13.
2016
41. Liu, D.; Xu, X.; Du, Y.; Qin, X.; Zhang, Y.; Ma, C.; Wen, S.; Ren, W.; Goldys, E. M.; Piper, J. A.; Dou, S.; Liu, X.; Jin, D. †, 2016, Three-dimensional controlled growth of monodisperse sub-50 nm heterogeneous nanocrystals, Nature Communications, 7.
42. Zheng, X.; Zhu, X.; Lu, Y.; Zhao, J.; Feng, W.; Jia, G.; Wang, F.; Li, F.; Jin, D. †, 2016, High-Contrast Visualization of Upconversion Luminescence in Mice Using Time-Gating Approach, Analytical Chemistry, 88, 3449-3454.
43. Zheng, X.; Lu, Y.; Zhao, J.; Zhang, Y.; Ren, W.; Liu, D.; Lu, J.; Piper, J. A.; Leif, R. C.; Liu, X.; Jin, D. †, 2016, High-Precision Pinpointing of Luminescent Targets in Encoder-Assisted Scanning Microscopy Allowing High-Speed Quantitative Analysis, Analytical Chemistry, 88, 1312-1319.
44. Zhao, J.; Zheng, X.; Schartner, E. P.; Ionescu, P.; Zhang, R.; Nguyen, T. L.; Jin, D.; Ebendorff-Heidepriem, H., 2016, Upconversion Nanocrystal-Doped Glass: A New Paradigm for Photonic Materials, Advanced Optical Materials, 4, 1507-1517.
45. Sayyadi, N.; Justiniano, I.; Connally, R. E.; Zhang, R.; Shi, B.; Kautto, L.; Everest-Dass, A. V.; Yuan, J.; Walsh, B. J.; Jin, D.; Willows, R. D.; Piper, J. A.; Packer, N. H., 2016, Sensitive Time-Gated Immunoluminescence Detection of Prostate Cancer Cells Using a TEGylated Europium Ligand, Analytical Chemistry, 88, 9564-9571.
46. Ma, C.; Xu, X.; Wang, F.; Zhou, Z.; Wen, S.; Liu, D.; Fang, J.; Lang, C. I.; Jin, D. †, 2016, Probing the Interior Crystal Quality in the Development of More Efficient and Smaller Upconversion Nanoparticles, Journal of Physical Chemistry Letters, 7, 3252-3258.
47. Liu, D.; Xu, X.; Wang, F.; Zhou, J.; Mi, C.; Zhang, L.; Lu, Y.; Ma, C.; Goldys, E.; Lin, J.; Jin, D. †, 2016, Emission stability and reversibility of upconversion nanocrystals, Journal of Materials Chemistry C, 4, 9227-9234.
48. Liu, B.; Li, C.; Xie, Z.; Hou, Z.; Cheng, Z.; Jin, D.; Lin, J., 2016, 808 nm photocontrolled UCL imaging guided chemo/photothermal synergistic therapy with single UCNPs-CuS@PAA nanocomposite, Dalton Transactions, 45, 13061-13069.
49. Hou, Z.; Deng, K.; Li, C.; Deng, X.; Lian, H.; Cheng, Z.; Jin, D.; Lin, J., 2016, 808 nm Light-triggered and hyaluronic acid-targeted dual-photosensitizers nanoplatform by fully utilizing Nd3+-sensitized upconversion emission with enhanced anti-tumor efficacy, Biomaterials, 101, 32-46.
50. He, F.; Li, C.; Zhang, X.; Chen, Y.; Deng, X.; Liu, B.; Hou, Z.; Huang, S.; Jin, D.; Lin, J., 2016, Optimization of upconversion luminescence of Nd3+-sensitized BaGdF5-based nanostructures and their application in dual-modality imaging and drug delivery, Dalton Transactions, 45, 1708-1716.
2015
51. Zhou, B.; Shi, B.; Jin, D. †; Liu, X. †, 2015, Controlling upconversion nanocrystals for emerging applications, Nature Nanotechnology, 10, 924-936.
52. Yang, M.; Liang, Y.; Gui, Q.; Zhao, B.; Jin, D.; Lin, M.; Yan, L.; You, H.; Dai, L.; Liu, Y., 2015, Multifunctional luminescent nanomaterials from NaLa(MoO 4) 2:Eu 3+ /Tb 3+ with tunable decay lifetimes, emission colors, and enhanced cell viability, Scientific Reports, 5.
53. Song, B.; Ye, Z.; Yang, Y.; Ma, H.; Zheng, X.; Jin, D.; Yuan, J., 2015, Background-free in-vivo imaging of Vitamin C using time-gateable responsive probe, Scientific Reports, 5.
54. Lu, J.; Chen, Y.; Liu, D.; Ren, W.; Lu, Y.; Shi, Y.; Piper, J.; Paulsen, I.; Jin, D., 2015, One-Step Protein Conjugation to Upconversion Nanoparticles, Analytical Chemistry, 87, 10406-10413.
2014
55. Lu, Y.; Zhao, J.; Zhang, R.; Liu, Y.; Liu, D.; Goldys, E. M.; Yang, X.; Xi, P.; Sunna, A.; Lu, J.; Shi, Y.; Leif, R. C.; Huo, Y.; Shen, J.; Piper, J. A.; Robinson, J. P.; Jin, D. †, 2014, Tunable lifetime multiplexing using luminescent nanocrystals, Nature Photonics, 8, 32-36.
56. Lu, Y.; Lu, J.; Zhao, J.; Cusido, J.; Raymo, F. M.; Yuan, J.; Yang, S.; Leif, R. C.; Huo, Y.; Piper, J. A.; Paul Robinson, J.; Goldys, E. M.; Jin, D. †, 2014, On-the-fly decoding luminescence lifetimes in the microsecond region for lanthanide-encoded suspension arrays, Nature Communications, 5.
57. Zhang, Y.; Zhang, L.; Deng, R.; Tian, J.; Zong, Y.; Jin, D.; Liu, X. †, 2014, Multicolor barcoding in a single upconversion crystal, Journal of the American Chemical Society, 136, 4893-4896.
58. Zhang, L.; Zheng, X.; Deng, W.; Lu, Y.; Lechevallier, S.; Ye, Z.; Goldys, E. M.; Dawes, J. M.; Piper, J. A.; Yuan, J.; Verelst, M.; Jin, D. †, 2014, Practical implementation, characterization and applications of a multi-colour time-gated luminescence microscope, Scientific Reports, 4.
59. Ye, Z.; Zhang, R.; Song, B.; Dai, Z.; Jin, D.; Goldys, E. M.; Yuan, J., 2014, Development of a functional ruthenium(II) complex for probing hypochlorous acid in living cells, Dalton Transactions, 43, 8414-8420.
60. Zhao, J.; Lu, Z.; Yin, Y.; McRae, C.; Piper, J. A.; Dawes, J. M.; Jin, D. †; Goldys, E. M., 2013, Upconversion luminescence with tunable lifetime in NaYF4:Yb,Er nanocrystals: Role of nanocrystal size, Nanoscale, 5, 944-952.
2013
61. Zhao, J.; Jin, D. †; Schartner, E. P.; Lu, Y.; Liu, Y.; Zvyagin, A. V.; Zhang, L.; Dawes, J. M.; Xi, P.; Piper, J. A.; Goldys, E. M.; Monro, T. M., 2013, Single-nanocrystal sensitivity achieved by enhanced upconversion luminescence, Nature Nanotechnology, 8, 729-734.
62. Zhang, L.; McKay, A.; Jin, D. †, 2013, High-throughput 3-dimensional time-resolved spectroscopy: Simultaneous characterisation of luminescence properties in spectral and temporal domains, RSC Advances, 3, 8670-8673.
63. Song, Z.; Anissimov, Y. G.; Zhao, J.; Nechaev, A. V.; Nadort, A.; Jin, D.; Prow, T. W.; Roberts, M. S.; Zvyagin, A. V., 2013, Background free imaging of upconversion nanoparticle distribution in human skin, BIOMEDO, 18.
64. Zhang, W.; Zhang, R.; Zhang, J.; Ye, Z.; Jin, D.; Yuan, J., 2012, Photoluminescent and electrochemiluminescent dual-signaling probe for bio-thiols based on a ruthenium(II) complex, Analytica Chimica Acta, 740, 80-87.
65. Zhang, R.; Ye, Z.; Yin, Y.; Wang, G.; Jin, D.; Yuan, J.; Piper, J. A., 2012, Developing red-emissive ruthenium(II) complex-based luminescent probes for cellular imaging, Bioconjugate Chemistry, 23, 725-733.
66. Zhang, L.; Wang, Y.; Ye, Z.; Jin, D.; Yuan, J., 2012, New class of tetradentate β-diketonate-europium complexes that can be covalently bound to proteins for time-gated fluorometric application, Bioconjugate Chemistry, 23, 1244-1251.
67. Tian, L.; Dai, Z.; Zhang, L.; Zhang, R.; Ye, Z.; Wu, J.; Jin, D.; Yuan, J., 2012, Preparation and time-gated luminescence bioimaging applications of long wavelength-excited silica-encapsulated europium nanoparticles, Nanoscale, 4, 3551-3557.
68. Schartner, E. P.; Jin, D.; Ebendorff-Heidepriem, H.; Piper, J. A.; Lu, Z.; Monro, T. M., 2012, Lanthanide upconversion within microstructured optical fibers: Improved detection limits for sensing and the demonstration of a new tool for nanocrystal characterization, Nanoscale, 4, 7448-7451.
69. Lu, Y.; Xi, P.; Piper, J. A.; Huo, Y.; Jin, D. †, 2012, Time-gated orthogonal scanning automated microscopy (OSAM) for high-speed cell detection and analysis, Scientific Reports, 2.
70. Lu, J.; Martin, J.; Lu, Y.; Zhao, J.; Yuan, J.; Ostrowski, M.; Paulsen, I.; Piper, J. A.; Jin, D. †, 2012, Resolving low-expression cell surface antigens by time-gated orthogonal scanning automated microscopy, Analytical Chemistry, 84, 9674-9678.
71. Calander, N.; Jin, D.; Goldys, E. M., 2012, Taking plasmonic core-shell nanoparticles toward laser threshold, Journal of Physical Chemistry C, 116, 7546-7551.
72. Lu, Y.; Jin, D.; Leif, R. C.; Deng, W.; Piper, J. A.; Yuan, J.; Duan, Y.; Huo, Y., 2011, Automated detection of rare-event pathogens through time-gated luminescence scanning microscopy, Cytometry Part A, 79 A, 349-355.
73. Jin, D. †; Piper, J. A., 2011, Time-gated luminescence microscopy allowing direct visual inspection of lanthanide-stained microorganisms in background-free condition, Analytical Chemistry, 83, 2294-2300.
74. Jin, D. †, 2011, Demonstration of true-color high-contrast microorganism imaging for terbium bioprobes, Cytometry Part A, 79 A, 392-397.
75. Deng, W.; Sudheendra, L.; Zhao, J.; Fu, J.; Jin, D.; Kennedy, I. M.; Goldys, E. M., 2011, Upconversion in NaYF4:Yb, Er nanoparticles amplified by metal nanostructures, Nanotechnology, 22.
76. Deng, W.; Jin, D. †; Drozdowicz-Tomsia, K.; Yuan, J.; Wu, J.; Goldys, E. M., 2011, Ultrabright Eu-doped plasmonic Ag@SiO2 nanostructures: Time-gated bioprobes with single particle sensitivity and negligible background, Advanced Materials, 23, 4649-4654.
77. Jiang, L.; Wu, J.; Guilan, W.; Ye, Z.; Zhang, W.; Jin, D.; Yuan, J.; Piper, J., 2010, Development of a visible-light-sensitized europium complex for time-resolved fluorometric application, Analytical Chemistry, 82, 2529-2535.
78. Jiang, H.; Wang, G.; Zhang, W.; Liu, X.; Ye, Z.; Jin, D.; Yuan, J.; Liu, Z., 2010, Preparation and time-resolved luminescence bioassay application of multicolor luminescent lanthanide nanoparticles, Journal of Fluorescence, 20, 321-328.
79. Deng, W.; Jin, D.; Drozdowicz-Tomsia, K.; Yuan, J.; Goldys, E. M., 2010, Europium chelate (BHHCT-Eu3+) and its metal nanostructure enhanced luminescence applied to bioassays and time-gated bioimaging, Langmuir, 26, 10036-10043.
80. Wu, J.; Ye, Z.; Wang, G.; Jin, D.; Yuan, J.; Guan, Y.; Piper, J., 2009, Visible-light-sensitized highly luminescent europium nanoparticles: Preparation and application for time-gated luminescence bioimaging, Journal of Materials Chemistry, 19, 1258-1264.
81. Song, C.; Ye, Z.; Wang, G.; Jin, D.; Yuan, J.; Guan, Y.; Piper, J., 2009, Preparation and time-gated luminescence bioimaging application of ruthenium complex covalently bound silica nanoparticles, Talanta, 79, 103-108.
82. Leif, R. C.; Yang, S.; Jin, D.; Piper, J.; Vallarino, L. M.; Williams, J. W.; Zucker, R. M., 2009, Calibration beads containing luminescent lanthanide ion complexes, BIOMEDO, 14.
83. Jin, D. †; Piper, J. A.; Leif, R. C.; Yang, S.; Ferrari, B. C.; Yuan, J.; Wang, G.; Vallarino, L. M.; Williams, J. W., 2009, Time-gated flow cytometry: An ultra-high selectivity method to recover ultra-rare-event μ-targets in high-background biosamples, BIOMEDO, 14.
84. Deng, W.; Drozdowicz-Tomsia, K.; Jin, D.; Goldys, E. M., 2009, Enhanced flow cytometry-based bead immunoassays using metal nanostructures, Analytical Chemistry, 81, 7248-7255.
85. Wu, J.; Wang, G.; Jin, D.; Yuan, J.; Guan, Y.; Piper, J., 2008, Luminescent europium nanoparticles with a wide excitation range from UV to visible light for biolabeling and time-gated luminescence bioimaging, Chemical Communications, 365-367.
86. Jin, D. †; Connally, R.; Piper, J., 2007, Practical time-gated luminescence flow cytometry. I: Concepts, Cytometry Part A, 71, 783-796.
87. Jin, D. †; Connally, R.; Piper, J., 2007, Practical time-gated luminescence flow cytometry. II: Experimental evaluation using UV LED excitation, Cytometry Part A, 71, 797-808.
88. Jin, D. †; Connally, R.; Piper, J., 2006, Long-lived visible luminescence of UV LEDs and impact on LED excited time-resolved fluorescence applications, Journal of Physics D: Applied Physics, 39, 461-465.
89. Connally, R.; Jin, D. †; Piper, J., 2006, High intensity solid-state UV source for time-gated luminescence microscopy, Cytometry Part A, 69, 1020-1027.
90. Bao, G.; Jin, D., 2019, Nanoparticles give mice infrared vision, Nature Photonics, 13, 304-305.
91. Zhou, J.; Jin, D., 2018, Triplet state brightens upconversion, Nature Photonics, 12, 378-379.
92. Lin, G.; Jin, D., 2018, Taking upconversion to lase in microcavity, Nature Nanotechnology, 13, 534-536.
93. Jin, D., 2016, View from. UPCON 2016: Bright future for upconversion, Nature Photonics, 10, 567-569.

人物事件


今年5月,澳大利亞研究理事會(ARC)公布了五個獲准成為國家重點研究基地的科研團隊名單,悉尼科技大學教授金大勇團隊位列其中。這個集合了兩所大學、六家企業研究資源的團隊,成為了澳大利亞首個醫療儀器和生物技術方面的國家重點研發基地。
金大勇把這次申請的成功歸功於合作帶來的資源整合。對於他來說,科研合作一直能帶來好運氣,包括今年1月發表在《自然—通訊》雜誌上的論文,也包括去年8月他獲得的澳大利亞科學最高榮譽尤里卡獎。
雖然自身科研能力也足夠硬,但金大勇一直對他的團隊強調說:“我們可能不是最好的科學家,但要做最好的合作者。”
2015年8月26日晚,澳大利亞悉尼市政廳燈光絢麗,科研精英、政界要員、社會名流集聚一堂,參加尤里卡獎的頒獎晚宴。在澳大利亞,尤里卡獎是家喻戶曉的科學最高獎勵,其頒獎晚宴常被稱為“澳大利亞科學界的奧斯卡頒獎禮”。
當晚的重頭壓軸好戲是尤里卡交叉學科創新獎的角逐。最終,剛剛從麥考瑞大學調任到悉尼科技大學的金大勇和他的兩位合作夥伴獲得這項殊榮。這個團隊以其所研發的上轉換SuperDots技術的突破和它在疾病早期診斷、生物靶向醫療、防偽數據存儲和納米光學等領域的廣泛應用,贏得了評委和觀眾的青睞。
與金大勇共同獲獎的合作夥伴之一是彼時剛剛調任南澳大學科研副校長的Tanya Monro,這位金大勇的老朋友,也是剛剛公布的國家重點研究基地的合作力量之一。“其實,真正好的合作夥伴尋找起來並不是特別容易。”金大勇說,“首先要投脾氣,要有共同的目標和理念。我一直說,要先做朋友,再做合作者。”
金大勇的研究以光學儀器及其應用為特色,此次成功申請的國家重點研究基地主要做生物技術和醫療儀器研究。“原來,糖尿病患者測血糖需要去醫院,但現在有可攜帶的小型血糖儀,在手指頭扎一下就可以檢測血糖高低。再比如,現在的智能手機能測你的心律、心跳,市場上流行的可穿戴醫療儀器,能檢測你走了多少步、睡眠質量如何等。如今,隨著老齡化加重,醫院的壓力越來越大,醫療診斷的小型化、家庭化是大趨勢。我們所做的就是這個方向。”金大勇介紹說,新的研究基地主攻方向就是要把最新的科研技術集成到醫療診斷檢測儀器上。“包括癌症的診斷檢測,比如前列腺癌可以通過尿樣來檢測。還有在西方現在對吸毒駕車有檢測需求,但現在測量的準確率和可攜帶性都達不到要求。做這樣的研究需要我們團隊與其他科研力量和企業有更大範圍的合作,采眾家之所長,將技術整合到醫療檢測儀器的研發上。”
以應用為導向的研究理念加重了金大勇與外界和產業界合作的需要。這種理念來源於他的學習和研究經歷。
2003 年7月,金大勇放棄了在中國科學院上海光學精密機械研究所碩士研究生的學習機會,來到澳大利亞與妻子Lisa團聚,並師從時任麥考瑞大學科研副校長的教授Jim Piper攻讀博士學位。
Jim Piper是澳大利亞知名的激光物理學家,他的研究團隊承擔過悉尼奧運會和雅典奧運會火炬核心部件的製作。他也鼓勵金大勇做更多實用性的科學研究。當時,金大勇很看好生物醫學儀器的前景,於是決定將新型流式細胞儀的開發和研製作為他的博士課題。
2006年7月,他以一項時間分辨流式細胞儀的國際專利和三篇學術文章順利畢業並留校,2008年拿到了麥考瑞大學研究員的稱號和資助,開始創辦先進細胞儀實驗室。2010 年,金大勇拿到了澳大利亞自然科學基金委的研究員項目和國際合作獎,帶領他的四名博士學生致力於開發時間分辨技術,來實現“大海撈針式”的早期診斷技術和光學編碼技術。
2013年初,金大勇被學校晉陞為高級講師,不到一年破格晉陞為副教授。他成功得到了兩筆大型的公司合作資助,讓他得以和三家公司一起合作,開發癌症的早期診斷技術和傳染病DNA的快速檢測技術。2014年,金大勇獲得主持了一項大型儀器項目,並取得了澳大利亞基金委的未來科學基金。他和Tanya Monro聯合發起了納米生物光子學實驗室,成功獲批3800萬澳元的長達七年的資助。2015年初,金大勇接受了悉尼科技大學首席教授的聘書和高達800多萬澳元的科研啟動經費,組建新的交叉學科研究團隊——生物醫療材料和儀器研究所。
“我們團隊研究的學科跨度很大,從物理光學到化學材料,再到細胞生物學。說實話,每次做跨學科研究的過程都很痛苦,但我們覺得很有意思,能學到新的東西。”金大勇說。
今年1月,金大勇團隊的一項重要成果發表在《自然—通訊》雜誌上,這項成果解決了多功能納米探針材料的可控、可重複和高效率合成的技術難題,為新型材料製備提供了新的發展空間和思路。論文發表后,很多人問金大勇,為何一直以光學儀器及其應用研究為特色的他,短時間內會在材料合成領域取得突破?金大勇總是回答:“我們跨領域速度快,其實是因為學得快,建立合作比較快,我們常常通過合作來轉型。”
多年科研的經驗讓金大勇清楚地認識到,他的團隊適合做交叉學科研究,適合與產業、與國際進行合作。“我把這個理念灌輸到團隊精神當中,形成我們自己的特色。還是那句話,我們可能不是最好的科學家,但要做最好的合作者”。
作為導師,金大勇帶學生也秉承 “合作”的理念。他有句話常掛在嘴邊,那就是“不做老闆做教練”。“對於我的學生,我不想他們因為要為我、為團隊完成什麼而去做研究,而是反過來,他們有什麼想法,我儘力幫助他們去實現”。
金大勇常對學生說:“做研究就像學車一樣,你是駕駛員,你來掌握方向,決定要加速還是減速,我頂多坐在副駕駛的位置上,幫你看看地圖、指指方向。你相對可以獨立的時候,我可能就坐到後排去了。”
金大勇從不喜歡被叫作“老闆”。“我也不像‘老闆’。”他笑著說。作為教練的金大勇,在每年年初都會幫學生樹立一個清楚明確的目標,每一周給學生分配任務,“沒勁了就給他們鼓鼓勁”。“前幾年我們資源比較少,做項目比較節省,不是什麼想法都能放手去做。這幾年情況好轉,學生有好的想法,我們會好好討論,制定計劃,我負責給你他們提供‘槍和彈藥’,他們去做。給他們好的方向、好的裝備和條件,必要的時候做做心理疏導,這就是我的作用。”金大勇說道。
金大勇並不是特別在意學生究竟對團隊作出了什麼貢獻,而是更期待通過研究項目和科研工作把他們的能力培養出來。“我常對學生講,我最希望的是,你從實驗室出去之後,我們能成為朋友和合作夥伴。換句話說,我更像是為自己培養未來的合作夥伴”。
如今,金大勇的研究團隊的合作夥伴既有來自澳大利亞本土的其他高校和企業,也有中國、美國、新加坡、法國、德國等的科研機構和人員,他們的合作跨校、跨國、跨學科。尤其近些年,金大勇與國內研究團隊的合作越來越多,越來越密切。
“現在,我們有70%~80%的合作來自國內,包括與北京大學、復旦大學、中山大學和中國科學院長春應用化學研究所等建立的密切合作。”金大勇說,新的國家重點研究基地成立后,他還要尋找更多的合作夥伴,期待未來能與國內的研究者建立更為密切的合作交流。

獲得榮譽


2015年獲澳大利亞科研最高獎“尤里卡獎交叉學科創新獎”;
2016年當選澳大利亞百名科技創新領軍人物;
2017年獲澳大利亞科學院工程科學獎並在同年成為首位獲得澳大利亞總理獎“馬爾科姆·麥金托什”年度物理學家獎的華人科學家;
2021年7月獲得澳大利亞桂冠教授。
2021年11月26日,金大勇當選澳大利亞工程院院士。