熊偉

2006至2013年，在美國國立衛生研究院（NIH）酒精濫用與酒精中毒研究所（NIAAA）做博士后研究工作。

2013年3月，中國科學技術大學生命科學學院教授，博士生導師。

研究領域

長期從事與藥物鎮痛、耐受和成癮有關的神經生物學研究，並運用多種先進的實驗技術對該問題從分子、細胞水平、到動物行為進行了完整的深入系統的研究，並取得了系列重要成果。

研究工作發表在Nature Chemical Biology, Journal of Experimental Medicine, Journal of Neuroscience, Molecular Pharmacology等國際學術期刊上。文章被美國藥物依賴研究所（NIDA）評選為“FEATURED PAPER OF THE MONTH”。曾獲得2011年度美國國立衛生研究院頒發給優秀研究人員的獎項“Fellows Award for Research Excellence”。

研究課題

離子通道受體的調節機制及相關小分子藥物的設計與合成。

配徠體門控型離子通道受體與藥物鎮痛、耐受和成癮的關係。

突觸前離子通道受體的發育與調節機制。

代表論文

1.Wei Xiong, KeJun Chen, Tanxing Cui, Grzegorz Godlewski, Kenner Rice, Yan Xu and Li Zhang. Cannabinoid potentiation of glycine receptors contributes to cannabis-induced analgesia.Nature Chemical Biology, 7: 296-303 (2011).

Also see NEWS AND VIEWS: Receptors: Cannabis medicine without a high. MacDonald J Christie & Christopher E Vaughan. Nature Chemical Biology, 7:249-250 (2011)

Research Highlight: Nature Reviews Neuroscience 12: 306 (2011)

Commented and rated as ‘Must Read” by Faculty of 1000 (2011)

2.Wei Xiong, Tanxing Cui, Kejun Cheng, Fei Yang, Shao-Rui Chen, Dan Willenbring, Yun Guan, Hui-Lin Pan, Ke Ren, Yan Xu and Li Zhang. Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors.Journal of Experimental Medicine, 209 (6): 1121-1134 (2012)

3.Wei Xiong, Xiongwu Wu, David M. Lovinger and Li Zhang. A Common Molecular Basis for Exogenous and Endogenous Cannabinoid Potentiation of Glycine Receptors.Journal of Neuroscience, 32 (15): 5200-5208 (2012)

4.Wei Xiong, Masako Hosoi, Bon-Nyeo Koo, and Li Zhang. Anandamide Inhibition of 5-HT3A Receptors Varies with Receptor Density and Desensitization.Molecular Pharmacology, 73:314-322 (2008)

5.Wei Xiong, Bon-Nyeo Koo, Russell Morton and Li Zhang. Psychotropic and nonpsychotropic cannabis derivatives inhibit human 5-HT3A receptors through a receptor desensitization-dependent mechanism.Neuroscience,184: 28-37 (2011)

6.Wei Xiong, Long-Chuan Yu. Involvement of endogenous cholecystokinin in morphine tolerance in the nucleus accumbens of rats.Behavioural Brain Research(IF≈3.5), 173:116-121 (2006).

7.Yan Zhang,Wei Xiong, Xiaojin Lin, Xiang Ma and Long-Chuan Yu. Receptor trafficking induced by μ-opioid-receptor phosphorylation.Neuroscience & Biobehavioral Reviews, 33: 1192-1197 (2009)

8.Cecilia M. Borghese,Wei Xiong, S. Irene Oh, Angel Ho, John Mihic, Li Zhang, David M. Lovinger and Gregg E. Homanics. Mutations M287L and Q266I in the glycine receptor alpha1 subunit change sensitivity to volatile anesthetics in oocytes and neurons, but Not the minimal alveolar concentration in Knockin Mice.Anesthesiology, 17(4):765-71. (2012)

9.Cecilia M. Borghese, Yuri A. Blednov, Yu Quan, Sangeetha V. Iyer,Wei Xiong, S. John Mihic, Li Zhang, David M. Lovinger, James R. Trudell, Gregg E. Homanics, R. Adron Harris. Characterization of Two Mutations, M287L and Q266I, in the α1 Glycine Receptor Subunit That Modify Sensitivity to Alcohols.Journal of Pharmacology and Experimental Therapeutics, 340: 304-316 (2012)