李琳

2014年獲電子科技大學學士學位，2014年9月至2019年6月在北京大學攻讀博士學位。

原始生殖細胞產生於胚胎髮育的早期，是發育為成熟的精子和卵細胞的前體細胞，對早期胚胎以及原始生殖細胞發育過程的研究，是進一步深入理解反覆流產、胚胎停止、不孕不育等疾病的重大理論基礎。本人的工作主要是建立了單細胞多組學技術（Single-cell multi-omics sequencing technology，scCOOL-seq），利用該技術在單細胞解析度，系統地解析了小鼠和人類早期胚胎以及原始生殖細胞發育過程中，DNA甲基化組和染色質狀態組的重編程過程，以及染色質狀態與DNA甲基化之間的相互關係等生物學特徵。

1.Fan Guo,Liying Yan,HongshanGuo,Lin Li,Boqiang Hu,Yangyu Zhao,Jun Yong,Yuqiong Hu,Xiaoye Wang, Yuan Wei, Wei Wang,Rong Li,Jie Yan,XuZhi, Yan Zhang,Hongyan Jin,Wenxin Zhang, Yu Hou, Ping Zhu,Jingyun Li, LingZhang,Sirui Liu,YixinRen,Xiaohui Zhu, Lu Wen, Yi Qin Gao, Fuchou Tang,JieQiao, The Transcriptome and DNA Methylome Landscapes of Human Primordial Germ Cells, Cell,2015, 161(6): 1437-1452. (IF=38.64, JCR 1區)

2.Fan Guo, Lin Li, Jingyun Li, Xinglong Wu, Boqiang Hu, Ping Zhu, LuWen, Fuchou Tang, Single-cell multi-omics sequencing of mouse early embryos and embryonic stem cells, Cell Research,2017, 27(8): 967-988. (IF=20.51, JCR 1區)

3.Lin Li, Fan Guo, Yun Gao, YixinRen, Peng Yuan,Liying Yan,Rong Li,Ying Lian,Jingyun Li,Boqiang Hu,JunpengGao, Lu Wen, Fuchou Tang, Qiao J, Single-cell multi-omics sequencing of human early embryos, Nature Cell Biology,2018, 20(7): 847-858. (IF=20.04, JCR 1區)

4.Li Lin, Gao Shuai, Single-cell sequencing: New insights into pre-implantation development, pluripotency, and germ cells, Science Foundation in China,2019, 27(2): 52-65. (非SCI)

5.Baojiang Wu, Lin Li, Bojiang Li, JunpengGao, Yanglin Chen, MengyiWei, Zhiqing Yang, Baojing Zhang, Shudong Li, Kexin Li, Changshan Wang, M. AzimSurani, Xihe Li, Fuchou Tang, SiqinBao, Activin A and BMP4 Signaling Expands Potency of Mouse Embryonic Stem Cells in Serum-Free Media,Stem Cell Reports,2020, 14(2): 241-255. (IF=6.03, JCR 2區)

6.Yun Gao, Lin Li, Peng Yuan, Fan Zhai, YixinRen, Liying Yan, Rong Li, Ying Lian, Xiaohui Zhu, Xinglong Wu, KehkooiKee, Lu Wen, JieQiao, Fuchou Tang, 5-Formylcytosine Landscapes of Human Preimplantation Embryos at Single-cell Resolution, Plos Biology, 2020, Jul 30;18(7):e3000799. (IF=7.08, JCR 1區)

7.Teng Wang, Xianglong Zhang, Zhanguo Liu, Tong Yao, DongyingZheng, JianweiGan, Shuang Yu, Lin Li, Peng Chen, Jian Sun, Single-cell RNA sequencing reveals the sustained immune cell dysfunction in the p athogenesis of sepsis secondary to bacterial pneumonia, Genomics, 2021, 113(3): 1219-1233. (IF=6.21, JCR 2區)

8.Li Li, Lin Li, Qingqing Li, Xixi Liu, Xinyi Ma, Jun Yong, ShuaiGao, Xinglong Wu, Yuan Wei, Xiaoye Wang, Wei Wang, Rong Li, Jie Yan, Xiaohui Zhu, Lu WEN, JieQiao, Liying Yan, Fuchou Tang, Dissecting the epigenomic dynamics of human fetal germ cell development at single-cell resolution, Cell Research, 2021, Apr;31(4):463-477. (IF=20.51, JCR 1區)

1.廣東省重點領域研發計劃，2020/01-2024/12，30萬，在研，項目骨幹

2.國基金面上項目，2021/01-2024/12，58萬，在研，主持

3.國家重點研發計劃，2021/12-2026/06，500萬，在研，主持

4.國基金青年項目，2022/01-2024/12，30萬，在研，主持

5.廣東省自然科學基金傑出青年基金，2022/01-2025/12，100萬，在研，主持

第五屆廣東省青年科學家協會會員、第六屆中國青年科技工作者協會會員。

現代儀器分析與應用、蛋白質組學與質譜數據分析。