華躍進

華躍進，1986年浙江農業大學蠶桑專業畢業，獲碩士學位。1994 年畢業於德國馬堡大學醫學院獲理學博士學位， 1999 年回國。浙江大學生物物理學科帶頭人、中國原子核農學會常務副理事長、浙江省原子核農學會理事長、日本東京大學大學院客座教授等職。 Food and Chemical Toxicology 編委、 Science 、 PLoS One 、 Mol. Microbiol. 、 Proteomics 等國際科學雜誌的特邀論文評審專家。在世界上首次從家蠶腦分離鑒定了昆蟲前胸腺抑制肽（PSTP），並克隆了其基因，開闢了昆蟲神經內分泌學的一個新領域。目前的主要研究方向為生物大分子結構和功能、生物信號分子鑒定、耐輻射細菌的基因結構和功能等。近年來，在耐輻射球菌的 DNA 修復機制的研究方面取得重大進展，發現和鑒定了一個通過調控 recA 、 pprA 等基因表達來增強 DNA 修復能力的關鍵因子 PprI 。在國內外重要學術刊物上發表論文 100 余篇，其中 40 余篇為 SCI 收錄。現主持國家自然科學基金重點項目、國家重點基礎研究計劃（ 973 計劃）、國家高科技發展計劃（ 863 計劃）等項目。主持完成的研究成果“ DNA 修復開關基因的發現與鑒定”入選“ 2003 年度中國高校十大科技進展”。

（1）DNA損傷和修復相關的基因組學、轉錄組學和蛋白組學研究；

（2）耐輻射球菌的極端環境適應機理研究；

（3）抗逆性相關功能基因的挖掘和開發利用；

（4）腫瘤細胞耐受性和DNA損傷修復機制研究。

（5）生物大分子結構和功能。

《DNA修復開關基因的發現與鑒定》,2003年度中國高校十大科技進展，2004

《耐輻射奇球菌輻射抗性和DNA修復機制》，浙江省自然科學二等獎，2007

輻射誘導提高耐輻射球菌超氧化物歧化酶產量的方法，CN03116366.1.

提高耐輻射奇球菌類胡蘿蔔素產量的方法，CN101402987B

利用耐輻射球菌生產天然類胡蘿蔔素的生產工藝，

一個感受DNA損傷因子的啟動子及其應用。

一種耐輻射球菌抗逆相關基因及其應用。

一種羥基化類胡蘿蔔素的合成方法。

一個定向突變及遺傳改造的重組質粒及其應用。

1.Nakamura T, Zhao Y, Yamagata Y, Hua Y, Yang W (2012) Watching DNA polymerase η make a phosphodiester bond. Nature, 487(7406):196-201. .(IF=35.248）

2. Zhao Y, Biertumpfel C, Hua Y, Hanaoka F, Yang W. Structural Basis of human DNA Polymeraseη Mediated Chemoresistance to Cisplatin.P Natl Acad Sci USA. 2012, 109 (19): 7269-74.(IF=10.591）

3. Hua X, Xu X, Li M, Wang C, Tian B, Hua Y*. Three nth homologs are all required for efficient repair of spontaneous DNA damage in Deinococcus radiodurans. Extremophiles. 2012 May, 16(3):477-84.

4. Sun H, Li M, Xu G, Chen H, Jiao J, Tian B, Wang L, Hua Y*. Regulation of MntH by a Dual Mn(II)- and Fe(II)-Dependent Transcriptional Repressor (DR2539) in Deinococcus radiodurans. PLoS One. 2012, 7(4):e35057.(IF=4.441)

5. Huiming Lu, Huan Chen, Guangzhi Xu, Amir Miraj-Ul-Hussain Shah, Yuejin Hua,* DNA binding is essential for PprI function in response to radiation damage in the extremely radioresistant Deinococcus radiodurans. DNA Repair. 2012, 11(2):139-45. (IF= 4.293)

6. Jiao J, Wang L, Xia W, Li M, Sun H, Xu G, Tian B, Hua Y*. Function and biochemical characterization of RecJ in Deinococcus radiodurans.DNA Repair (Amst). 2012 Apr, 1;11(4):349-56. (IF= 4.293)

7. Wang H, Wang F, Hua X, Ma T, Chen J, Xu X, Wang L, Tian B, Hua Y*. Genetic and biochemical characteristics of the histone-like protein DR0199 in Deinococcus radiodurans. Microbiology. 2012 Apr,158(Pt 4):936-43.

8. WANG LiangYan, YIN LongFei, XU GuangZhi, LI MingFeng, ZHANG Hui, TIAN Bing, HUA YueJin*. Cooperation of PprI and DrRRA in response to extreme ionizing radiation in Deinococcus radiodurans. Chinese Science Bulletin. 2012, Vol. 57 (1): 98-104.

9. Huiming Lu, Wenrong Xia, Huan Chen, Longfei Yin, Xiaojun Zhao, Guangzhi Xu and Yuejin Hua*, Characterization of the role of DR0171 in transcriptional response to radiation in the extremely radioresistant bacterium Deinococcus radiodurans. Arch. Microbiol. 2011，193(10 ) :741-750.

10. HUA XiaoTing, WANG Hu, WANG Chao, TIAN Bing, and HUA YueJina*, Global effect of site mutagenesis in the β-subunit of RNA polymerase on gene expression in radiation-resistant bacterium Deinococcus radiodurans. Science in China, 2011, 54 (9): 854-862

1. Naoki Yamanaka, Yue-Jin Hua, Ladislav Roller, Ivana Spalovská-Valachová, Akira Mizoguchi, Hiroshi Kataoka, and Yoshiaki Tanaka, Bombyx prothoracicostatic peptides activate the sex peptide receptor to regulate ecdysteroid biosynthesis. P Natl Acad Sci . 2010, 107(5): 2060-2065. (IF=10.591)

2. Hong Xu, Li Zheng, Huifang Dai, Mian Zhou, Yuejin Hua*, and Binghui Shen*, Chemicals-induced cancer incidence and underlying mechanisms in Fen1 mutant mice.Oncogene. 2010, doi: 10.1038/onc.2010.482 (IF=7.135)

3. Bing Tian and Yuejin Hua*, Carotenoid biosynthesis in the extreme bacteria Deinococcus-Thermus. Trends in Microbiol. 2010, 18(11):512-20 (IF=6.894)

4. Guangzhi Xu, Huiming Lu, Liangyan Wang, Huan Chen, Zhenjian Xu, Yihuai Hu, Bing Tian, Yuejin Hua*, DdrB Stimulates Single-stranded DNA Annealing and Facilitates RecA-independent DNA Repair in Deinococcus radiodurans. DNA Repair. 2010, 9: 805-812. (IF=4.199)

5. Bing Tian, Hu Wang, Xiaoqiong Ma, Yaping Hu, Zongtao Sun, Shaochuan Shen, Fei Wang, and Yuejin Hua*, Proteomic analysis of membrane proteins from a radioresistant and moderate thermophilic bacterium Deinococcus geothermalis. Mol. BioSy. 2010, 6, 2068-2077 (IF=4.015)

6. Duohong Sheng, Mingfeng Li, Jiandong Jiao, Wenqiang Deng, Xiehuang Sheng， Yuejin Hua*, Repression of recA induction by RecX is independent of RecA protein in Deinococcus radiodurans. J. Bacteriol. 2010, 192 (13): 3540-3544, (IF=3.94)

7. Hongxing Sun, Guangzhi Xu, Hongdan Zhan, Zongtao Sun, Huan Chen, Bing Tian, Yuejin Hua*, Identification and evaluation the role of manganese efflux protein in Deinococcus radiodurans. BMC Microbiol. 2010, 10(1):319

8. Chen Huan, Wu Rongrong, Xu Guangzhi, Fang Xu, Qiu Xiao, Guo Hongyin, Tian Bing, Hua Yuejin*, DR2539 is a novel DtxR-like regulator of Mn/Fe ion homeostasis and antioxidant enzyme in Deinococcus radiodurans. Biochem. Bioph. Res. Co. 2010, 396(2): 413-8.

9. Hu Y, Tian B, Xu G, Yin L, Hua X, Lin J, Hua Y*, Characteristics of nuclease activity of the SbcCD complex from Deinococcus radiodurans. J Biochem. 2010, 147(3):307-15.

10. Longfei Yin, Liangyan Wang, Huiming Lu, Guangzhi Xu, Huan Chen, Hongdan Zhan, Bing Tian*, Yuejin Hua*，DRA0336, another OxyR homolog, involved in the antioxidation mechanisms in Deinococcus radiodurans. J. Microbiol. 2010, PMID: 20799089.

11. Xiaoting Hua, Chao Wang, Ye Zhao, Hu Wang, Lifen Huang, Guangzhi Xu, Mingfeng Li, Yuan Wang, Bing Tian, and Yuejin Hua*, Both OB Folds of Single-Stranded DNA-Binding Protein Are Essential for Its ssDNA Binding Activity in Deinococcus radiodurans. Protein & Peptide Lett.2010, 17, 1189-1197.

12. Lu H, Gao G, Xu G, Fan L, Yin L, Shen B, Hua Y. .Deinococcus radiodurans PprI switches on DNA damage-response and cellular survival networks after radiation damage. Mol Cell Proteomics. 2009, 8, 484-491 (IF=8.791)

13. Zongtao Sun, Shaochuan Shen, Chao Wang, Hu Wang, Yaping Hu, Jiandong Jiao, Tingting Ma,Bing Tian and Yuejin Hua. A novel carotenoid 1,2-hydratase (CruF) from two species of the non-photosynthetic bacterium Deinococcus. Microbiology-SGM. 2009, 155: 2775-2783.

14. Zongtao Sun, Shaochuan Shen, Bing Tian, Hu Wang, Zhenjian Xu, Liangyan Wang, Yuejin Hua. Functional analysis of γ-carotene ketolase involved in the carotenoid biosynthesis of Deinococcus radiodurans. FEMS Microbiology Letters. 2009, 301: 21–27

15. Bing Tian, Zongtao Sun, Shaochuan Shen, Hu Wang, Jiandong Jiao, Liangyan Wang, Yihuai Hu, Yuejin Hua. Effects of carotenoids fromDeinococcus radiodurans on protein oxidation. Letters In Applied Microbiology. 2009, 49(6): 689-694

16. Lin J, Hu Y, Tian B, Hua Y. Evolution of double MutT/Nudix domain-containing proteins: similar domain architectures from independent gene duplication-fusion events.J Genet Genomics. 2009, 36(10):603-610.

17. Wu Y, Chen W, Zhao Y, Xu H, Hua Y.Involvement of RecG in H2O2-induced damage repair in Deinococcus radiodurans. Can J Microbiol. 2009, 55(7):841-8.

18. Chen H, Huang L, Hua X, Yin L, Hu Y, Wang C, Chen W, Yu X, Xu Z, Tian B, Hu S, Hua Y. Pleiotropic effects of RecQ in Deinococcus radiodurans. Genomics. 2009 Nov; 94(5):333-340.

19. Ying N., Tachiiri Y, Tsuchiya H, and Hua Y. Responses of tiller growth and related genes expression in rice to red and blue radiation. Biologia Plantarum. 2009, 53(1): 188-190

20. Wang L, Xu G, Chen H, Xu N, Tian B, Hua Y, DrRRA: a novel response regulator essential for the extreme radioresistance of Deinococcus radiodurans. Mol. Microbiol., 2008, 67(6):1211-1222. (IF=5.462)

21. Hua X, Huang L, Tian B, Hua YJ. Involvement of recQ in the ultraviolet damage repair pathway in Deinococcus radiodurans. Mutat Res.-Fund Mol M. 2008, 641(1-2):48-53.

22. Xu G, Wang L, Chen H, Lu H, Ying N, Tian B, and Hua YJ, RecO is essential for DNA damage repair in Deinococcus radiodurans, J. Bacteriol. 2008, 190 (7): 2624–2628. (IF=3.636)

23. Huan Chen, Guangzhi Xu, Ye Zhao, Bing Tian, Huiming Lu, Xiaoming Yu, Songnian Hu, Yuejin Hua, A Novel OxyR Sensor and Regulator of Hydrogen Peroxide Stress with One Cysteine Residue in Deinococcus radiodurans, PloS ONE, 2008, 3 (2): e1602 (IF=4.351)

24. Bing Tian, Zongtao Sun, Zhenjian Xu, Shaochuan Shen, Hu Wang, Yuejin Hua, Carotenoid 3’,4’ desaturase involved in the carotenoid biosynthesis of the extremely radioresistant bacterium Deinococcus radiodurans. Microbiology. 2008,154, 3697-3706.

25. Jun Lin, Yi-Huai Hu, Bing Tian, and Yuejin Hua, Structural and Functional Diversity of Nudix Fold, Protein Pept. Lett. 2008, 15 (1): 108-112.

26. Nanjiao Ying, Zhiguo Zheng, Hong Xu, Bing Tian, Yuejin Hua, Extracellular proteome changes of Deinococcus radiodurans under γ-irradiation stress conditions, Protein Pept. Lett., 2008;15(6):595-599.

27. Donghai Le, Jianfu Shen, Lifen Huang, Guanjun Gao, Huiming Lu, Zhenjian Xu, Bing Tian, Yuejin Hua, Biochemical characterization of two DNA ligases from Deinococcus radiodurans. Protein Pept. Lett. 2008,15(6):600-605.

28. Guanjun Gao, Lu Fan, Huiming Lu, and Yuejin Hua, Engineering Deinococcus radiodurans into biosensor for monitoring radioactivity and genotoxicity in environment. Chin. Sci. Bul. 2008, 53 (11): 1675-1681.

29. Huang L, Hua X, Lu H, Gao G, Tian B, Shen B, Hua Y. Three tandem HRDC domains have synergistic effect on the RecQ functions inDeinococcus radiodurans. DNA Repair. 2007, 6(2):167-76. (IF=5.018)

30. Bing Tian, Zhenjian Xu, Zongtao Sun, Jun Lin, Yuejin Hua. Evaluation of the antioxidant effects of carotenoids from Deinococcus radioduransthrough targeted mutagenesis, chemiluminescence, and DNA damage analyses. Biochimica et Biophysica Acta- General Subjects. 2007, 1770: 902-911.

31. Bing Tian, Zongtao Sun, Zhenjian Xu, Yuejin Hua. Chemiluminescence analysis of the prooxidant and antioxidant effects of epigallocatechin-3-gallate. Asia Pacific Journal of Clinical Nutrition. 2007,16 (Suppl 1):153-157.

32. Zhenjian Xu,Bing Tian,Zongtao Sun, Jun Lin, Yuejin Hua, Identification and functional analysis of a phytoene desaturase gene from the extremely radioresistant bacterium Deinococcus radiodurans. Microbiology-SGM. 2007, 153: 1642-1652 .

33. Wu Yuanyuan, TIAN Bing, HUA Yuejin. Dr1127: A novel gene of Deinococcus radiodurans responsible for oxidative stress. Chinese Science Bulletin. 2007, 52(15): 2081-2087.

34. Jun Lin, Zhong-Zhong Chen, Bing tian, Yue-Jin Hua. Origin and Evolutionary Pathways of RecX. GENE. 2007, 387(1-2): 15-20

35. Hu Yihuai, Ma Chenyu, Tian Bing, Lin Jun, Hua Yuejin. Function analysis of the sbcD (dr1921) gene of the extremely radioresistant bacteriumDeinococcus radiodurans. Chinese Science Bulletin. 2007, 52(18): 2506-2513.

36. Chen Huan, Xu Zhenjian, Tian Bing, Chen Weiwei, Hu Songnian and Hua Yuejin. Transcriptional profile in response to ionizing radiation at low dose in Deinococcus radiodurans. Progress in Natural Science. 2007, 17(5): 529-536.

37. Gao G, Lu H, Yin L, Hua Y. Ring-like nucleoid does not play a key role in radioresistance of Deinococcus radiodurans. Science in China, Series C: Life Sciences. 2007,50(4):525-9.

38. Zhou Q, Zhang X, Xu H, Xu B, Hua Y. A new role of Deinococcus radiodurans RecD in antioxidant pathway. FEMS Microbiology Letters. 2007,271(1):118-25.

39. Zhou Q, Chen W, Zhang X, Xu H, Xu B, Hua Y. Characterization of the double mutant of Deinococcus radiodurans lexA1 and lexA2. Chinese Science Bulletin. 2007;52(8):1046-52.

40. Zhou Q, Zhang X, Xu H, Xu B, Hua Y. RadA: A protein involved in DNA damage repair processes of Deinococcus radiodurans R1. Chinese Science Bulletin. 2006;51(24):2993-9.

41. Gao G, Le D, Huang L, Lu H, Narumi I, Hua Y. Internal promoter characterization and expression of the Deinococcus radiodurans pprI-folP gene cluster. FEMS Microbiology Letters. 2006, 257(2):195-201.

42. Chunchao Zhang, Jianfeng Wei, Zhiguo Zheng, Nanjiao Ying, and Yuejin Hua * . Proteomic analysis of Deinococcus radiodurans recovering from γ -radiation. Proteomics. 2005, Vol. 5, 138–143.

43. Duohong Sheng, Zhiguo Zheng, Bing Tian, Binghui Shen, and Yuejin Hua *. Dual negative regulatory mechanisms of RecX on RecA functions in radiation resistance, DNA recombination and consequent genome instability in Deinococcus radiodurans. DNA Repair. 2005, 4(6): 671-678. (IF= 4.293)

44. Duohong Sheng; Bing Tian, Zhenjian Xu, Zhiguo Zheng, and Yuejin Hua *. RecX is involved in antioxidant mechanisms of the radioresistant bacterium Deinococcus radiodurans . FEMS Microbiol. Let. 2005, 244(2): 251-257.

45. Bing Tian and Y.J. Hua *. Concentration dependence of prooxidant and antioxidant effects of aloin and aloe emodin on DNA. Food Chem. 2005, 91(3): 413-418.

46. Lili Liu, Jianjun Shi, Xiyue Zhao, Yuejin Hua *. Dynamics of transfer and distribution of 95Zr in the broadbean-soil ecosystem. J. Environ. Radioactiv. 2005, 80(2):217-223.

47. Guanjun Gao, Huiming Lu, Lifeng Huang & Yuejin Hua *. Construction of DNA damage response gene pprI function- deficient and function-com- plementary mutants in Deinococcus radiodurans. Chin. Sci. Bul. 2005, 50(1): 1-6.