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徐峰

南開大學藥學院副教授

徠徐峰,男,南開大學藥學院副教授。

學科方向


徐峰[南開大學藥學院副教授]
徐峰[南開大學藥學院副教授]
藥物篩選和設計

招生方向


藥物化學,藥物分析,生物信息學,結構生物學

教師簡介


2002年在清華大學生命科學學院獲得理學學士學位,2007年在清華大學醫學院獲得理學博士學位,2009年在美國國立衛生研究院完成博士后工作,從事膜蛋白結構與功能研究,包括信號傳導中的GPCR受體蛋白及其相關蛋白複合物,GPCR和Agonist/Antagonist的相互作用等。在研究工作中共測定了11個蛋白質及其複合物的晶體結構,在SCI收錄的國外期刊上發表論文17篇,參與編寫清華大學教科書1本。2009年12月回國工作,主要研究方向為靶向藥物篩選與設計,計算生物學和結構生物學,通過測定藥物靶點蛋白的結構,分析蛋白與小分子配體的結合機制,進而設計優化潛在的藥物分子,參與具有自主知識產權的新葯研究。

代表性作品


B徠ell SG, Xu F†, Johnson EO, Forward IM, Bartlam M, Rao Z, Wong LL.
Protein Recognition in Ferredoxin–P450 Electron Transfer in the Class I CYP199A2 System from Rhodopseudomonas palustris. Journal of Biological Inorganic Chemistry; 2009 Nov 11.
Xu F, Bell SG, Peng Y, Johnson EO, Bartlam M, Rao Z, Wong LL. Crystal structure of a ferredoxin reductase for the CYP199A2 system from Rhodopseudomonas palustris. Proteins. 2009 Dec; 77(4):867-80.
Bell SG, Xu F†, Forward I, Bartlam M, Rao Z, Wong LL. Crystal structure of CYP199A2, a para-substituted benzoic acid oxidizing cytochrome P450 from Rhodopseudomonas palustris. J. Mol. Biol. 2008 Nov 14; 383(3):561-74.
Li L, Liu X, Yang W, Xu F, Wang W, Feng L, Bartlam M, Wang L, Rao Z. Crystal structure of long-chain alkane monooxygenase (LadA) in complex with coenzyme FMN: unveiling the long-chain alkane hydroxylase. J Mol Biol. 2008 Feb 15; 376(2):453-65.
Guo D, Xu F, Bell SG, Pang X, Bartlam M, Wong LL. Purification, crystallization and preliminary crystallographic analysis of CYP 195A2, a P450 enzyme from Rhodopseudomonas palustris. Protein Pept Lett. 2008; 15(4):423-6.
Xu F, Bell SG, Rao Z, Wong LL. Structure–activity correlations in pentachlorobenzene oxidation by engineered cytochrome P450cam. Protein Eng. Des. Sel. 2007 Oct; 20(10):473-80.
Peng Y, Xu F‡, Bell SG, Wong LL, Rao Z. Crystallization and preliminary X-ray diffraction studies of a ferredoxin reductase from Rhodopseudomonas palustris CGA009. Acta Crystallographica Section F. 2007; 63(Pt5):422-5.
Pang X, Xu F‡, Bell SG, Guo D, Wong LL, Rao Z. Preliminary Crystallographic Analysis of Cytochrome P450 203A1 from Rhodopseudomonas palustris. Acta Crystallographica Section F. 2007; 63(Pt4):342-5.
Zhao Q, Qin L, Jiang F, Wu B, Yue W, Xu F, Rong Z, Yuan H, Xie X, Gao Y, Bai C, Bartlam M, Pei X, Rao Z. Structure of human spindlin1: tandem tudor-like domains for cell cycle regulation. J Biol Chem. 2007 Jan 5; 282(1):647-56.
Bell SG, Hoskins N, Xu F, Caprotti D, Rao Z, Wong LL. Cytochrome P450 enzymes from the metabolically diverse bacterium. Rhodopseudomonas palustris. Biochem Biophys Res Commun. 2006 Mar 31; 342(1):191-6.
Dong X, Xu F, Gong Y, Gao J, Lin P, Chen T, Pen Y, Qiang B, Yuan J, Peng X, Rao Z. Crystal structure of the V domain of human Nectin-like molecule-1/SynCAM3 /TSLL1/IGSF4B, a neural tissue-specific immunoglobulin-like cell-cell adhesion molecule. J Biol Chem. 2006 Apr 14; 281(15):10610-7.
Xu F, Bell SG, Lednik J, Insley A, Rao Z, Wong LL. The heme monooxygenase cytochrome P450cam can be engineered to oxidize ethane to ethanol. Angew Chem Int Ed Engl. 2005 Jun 27; 44(26):4029-32.
Dong X, Peng Y, Peng Y, Xu F, He X, Wang F, Peng X, Qiang B, Yuan J, Rao Z. Characterization and crystallization of human DPY-30-like protein, an essential component of dosage compensation complex.Biochim Biophys Acta. 2005 Dec 1; 1753(2):257-62.
Wang YY, Zhou GB, Yin T, Chen B, Shi JY, Liang WX, Jin XL, You JH, Yang G, Shen ZX, Chen J, Xiong SM, Chen GQ, Xu F, Liu YW, Chen Z, Chen SJ. AML1-ETO and C-KIT mutation/overexpression in t(8;21) leukemia: implycation in stepwise leukemogenesis and response to Gleevec. Proc Natl Acad Sci U S A. 2005 Jan 25; 102(4):1104-9.
Yu B, Duan M, Zhou G, Chen J, Xu F. Practice of Experimental Biochemistry. Tsinghua University Press, 2004, ISBN 7-302-07519-0/Q.35
Bell SG, Chen X, Xu F, Rao Z, Wong LL. Engineering substrate recognition in catalysis by cytochrome P450cam. Biochem Soc Trans. 2003 Jun; 31(Pt 3):558-62.
Bell SG, Chen X, Sowden RJ, Xu F, Williams JN, Wong LL, Rao Z. Molecular recognition in (+)-alpha-pinene oxidation by cytochrome P450cam. J Am Chem Soc. 2003 Jan 22; 125(3):705-14.
Chen X, Christopher A, Jones JP, Bell SG, Guo Q, Xu F, Rao Z, Wong LL. Crystal structure of the F87W/Y96F/V247L mutant of cytochrome P-450cam with 1,3,5-trichlorobenzene bound and further protein engineering for the oxidation of pentachlorobenzene and hexachlorobenzene. J Biol Chem. 2002 Oct 4; 277(40):37519-26.