吳曉輝

臨床葯代動力學、臨床藥理學、葯事管理學。

臨床藥理學，網路藥理學，中藥標準化。

近5年發表SCI論文20餘篇，涉及藥理學、葯代動力學及植物化學等多個領域和方向，主持科研項目多項。主持了國家自然科學基金、國家留學回國基金、中國博士后基金等科研項目多項。

(1)國家自然科學基金，基於URAT1靶點的牛尾菜總皂苷抗高尿酸血症活性成分及及作用機制研究，No. 81202895，2013.01-2015.12，主持

(2)國家自然科學基金，牛尾菜調控NLRP3/Caspase-1/PDZK1軸抗高尿酸血症的藥效物質及作用機制研究，No. 81974521，2020.01-2023.12，主持

(3)天津市自然科學基金重點項目，牛尾菜總皂苷協同別飄呤醇抗高尿酸血症活性成分及協同機制研究，No. 19JCZDJC33500，2019.04-2022.03，主持

(4)教育部留學回國人員科研啟動基金，雞血蓮抗前列腺增生活性成分及作用機制研究，2015.08-2017.08，主持

(5)中國博士后基金面上項目，基於網路藥理學探索牛尾菜總皂苷多成分多靶點抗高尿酸血症的整合作用機制，No. 2013M530882，2013.06-2015.06，主持

(6)中國博士后特別資助基金，基於網路多靶點的雞血蓮抗前列腺增生活性成分研究，No. 2014T70223，2014.06-2016.06，主持

(7)天津市自然科學基金重點項目，靶向抑制PIK3對前列腺癌轉移的影響及機理研究，No. 12JCZDJC25800，2012.4-2015.3

(1) Xiao-Hui Wu*, Jun Zhang, Shu-Qing Wang, Victor C. Yang, Samantha Anderson, Yan-Wen Zhang. Riparoside B and timosaponin J, two steroidal glycosides from Smilax riparia, resist to hyperuricemia based on URAT1 in hyperuricemic mice. Phytomedicine. 21(2014): 1196–1201. (JCR 一區)

(2) Xiao-Hui Wu,Chun-Hao Yu,Chun-Feng Zhang, Samantha Anderson and Yan-Wen Zhang. Smilax riparia reduces hyperuricemia in mice as a potential treatment of gout. Am J Chin Med. 42(2014): 257–259. (JCR 一區)

(3) Xiao-Hui Wu, Chong-Zhi Wang, Jun Zhang, Shu-Qing Wang, Lide Han, Yan-Wen Zhang and Chun-Su Yuan. Effects of Smilaxchinoside A and Smilaxchinoside C, Two Steroidal Glycosides from Smilax riparia, on Hyperuricemia in a Mouse Model. Phytother Res. 2014, 28(12): 1822–1828. (JCR 一區)

(4) Xiao-Hui Wu*, Jin-LanRuan, Jun Zhang, Shu-QingWang, Yan-Wen Zhang. Pallidifloside D, a saponin glycoside constituent from Smilax riparia, resist to hyperuricemia based on URAT1 and GLUT9 in hyperuricemic mice. J Ethnopharmacol. 157(2014): 201–205. (JCR 一區)

(5) Xiao-Hui Wu*,Chong-Zhi Wang, Shu-Qing Wang, Chao Mi, Jun Zhang, Yan-Wen Zhang, Samantha Anderson, Chun-Su Yuan*. Anti-hyperuricemia effects of allopurinol are improved by Smilax riparia, a traditional Chinese herbal medicine. J Ethnopharmacol. 162(2015): 362–368. (JCR 一區)

(6) Pi-Yong Hou, Chao Mi, Yi He, Jun Zhang, Shu-Qing Wang, Fei Yu, Samantha Anderson,Yan-Wen Zhang, Xiao-Hui Wu*. Pallidifloside D from Smilax riparia enhanced allopurinol effects in hyperuricemia mice. Fitoterapia. 105 (2015) 43–48. (JCR 三區)

(7) Hong-Gang Li, Pi-Yong Hou, Xi Zhang, Yi He, Jun Zhang, Shu-Qing Wang, Samantha Anderson, Yan-Wen Zhang, Xiao-Hui Wu*. Hypouricemic effect of allopurinol are improved by Pallidifloside D based on the uric acid metabolism enzymes PRPS, HGPRT and PRPPAT.Fitoterapia. 113 (2016) 1–5. (JCR 三區)

(8) Ming-Yu Wang, Ming Yang, Pi-Yong Hou, Xiu-Bo Chen, Hong-Gang Li, Jiu-Xing Yan, Jun Zhang, Yan-Wen Zhang, Xiao-Hui Wu*. Intestinal absorption of pallidifloside D are limited by P-glycoprotein in mice.Xenobiotica. 2018, 48(7):739–744. (JCR 三區)

(9) Rui Luo, Xiao-Li Gao, Chang Shi, Yu-Xi Wei, Pi-Yong Hou, Hong-Gang Li, Shu-Qing Wang, Samantha Anderson, Yan-Wen Zhang, Xiao-Hui Wu*. Phytochemical and chemotaxonomic study on the rhizomes of Smilax riparia (Liliaceae). Biochem Syst Ecol.76 (2018): 58–60. (JCR 四區)

(10) Tiantian Zuo, Yuexin Qian, Chunxia Zhang, Yuxi Wei, Xiaoyan Wang, Hongda Wang, Ying Hu, Weiwei Li, Xiaohui Wu*, Wen zhi Yang. Data-Dependent Acquisition and Database-Driven E_cient Peak Annotation for the Comprehensive Profiling and Characterization of the Multicomponents from Compound Xueshuantong Capsule by UHPLC/IM-QTOF-MS. Molecules. 2019, 24, 3431; doi:10.3390/molecules24193431. (JCR 二區)

(11) Lijun An, Jun Ma, Xueyuan Yang, Yue Liang, Huimei Wang, Muhetaer Tuerhong, Namrita Lall, Munira Abudukeremu, Yi Zhang, Dongho Lee, Jing Xu, Xiaohui Wu*, Yuanqiang Guo*. Caseahomopene A, a Ring-Expanded Homotriterpenoid From Casearia Kurzii Showing Anti-Inflammatory Activities in Vitro and in Vivo.Bioorganic Chemistry. 98 (2020) 103758. (JCR 一區)

(12) Dan Wang, Li Tian, Chang Shi, YuXi Wei, Han Wang , TianTian Liu, Ming Gong, YanWen Zhang, RongGuo Yu, XiaoHui Wu*. Network pharmacology-based prediction of the active ingredients and mechanism of Shen Gui capsule for application to coronary heart disease. Comput Biol Med. 2020; 122: 103825. doi: 10.1016/j.compbiomed.2020.103825. (JCR 一區)

(13) Shunming Zhang, Xiaohui Wu*, Shanshan Bian, Qing Zhang, Li Liu, Ge Meng, Zhanxin Yao, Hongmei Wu, Yeqing Gu, Yawen Wang, Shaomei Sun, Xing Wang, Ming Zhou, Qiyu Jia, Kun Song, Kaijun Niu*. Association between consumption frequency of honey and non-alcoholic fatty liver disease: results from a cross-sectional analysis based on the Tianjin Chronic Low-grade Systemic Inflammation and Health (TCLSIH) Cohort Study. Br J Nutr. 2020 Aug 17;1-9. doi: 10.1017/S0007114520003190. (JCR 二區)

(14) Shunming Zhang, Shubham Kumari, Yeqing Gu, Xiaohui Wu*, Xiaoyue Li, Ge Meng, Qing Zhang, Li Liu, Hongmei Wu, Yawen Wang, Tingjing Zhang, Xuena Wang, Xingqi Cao, Huiping Li, Yunyun Liu, Xiaohe Wang, Shaomei Sun, Xing Wang, Ming Zhou, Qiyu Jia, Kun Song, Zhong Sun, Kaijun Niu*. Soy Food Intake Is Inversely Associated with Newly Diagnosed Nonalcoholic Fatty Liver Disease in the TCLSIH Cohort Study. J Nutr. 2020 Oct 23; doi: 10.1093/jn/nxaa297. (JCR 一區)

(15)Huiping Li, Yeqing Gu, Xiaohui Wu*, Sabina Rayamajhi, Shanshan Bian, Qing Zhang, Ge Meng, Li Liu, Hongmei Wu, Shunming Zhang, Yawen Wang, Tingjing Zhang, Xuena Wang, Amrish Thapa, Shaomei Sun, Xing Wang, Qiyu Jia, Kun Song, Kaijun Niu*. Association between consumption of edible seaweeds and newly diagnosed non-alcohol fatty liver disease: the TCLSIH Cohort Study. Liver Int. 2020 Sep 3. doi: 10.1111/liv.14655. (JCR 一區)

《臨床藥物治療學各論》2014版，全國高校臨床藥學專業統編教材，人民衛生出版社.（編委）

國家自然科學基金通訊評審專家

中國博士后基金通訊評審專家

世界中醫藥聯合會中藥分析專業委員會理事

美國藥學家協會（AAPS）會員

中國藥學會會員

《化學通報》《Fitoterapia》《Phytomedicine》《Phytotherapy research》等國內外期刊的審稿專家

世界中醫藥聯合會中藥分析專業委員會理事

天津市藥理學會實驗藥理學專業委員會副主任委員

國家自然科學基金、中國博士后基金、教育部碩博士學位論文等的評審專家

天津市高校“中青年骨幹創新人才”

天津醫科大學卓越教師