龔濤

四川大學華西藥學院教授

龔濤,男,四川大學華西藥學院,教授,博士生導師學術兼職:四川省葯監局新葯評審專家、國家葯監局新葯評審專家。

單位


四川大學華西藥學院

個人履歷


1987~1992 華西醫科大學藥學院藥學專業,本科。
1992~1995 華西醫科大學藥學院藥劑學專業,碩士研究生。
1995~2001 華西醫科大學製藥廠,工作。
2001~2004 博士研究生。
2004~至今 四川大學華西藥學院,講師,副教授。

研究方向


1. 藥物新劑型及其應用研究
主要研究課題及成果
近年作為主研人員先後參與國家自然科學基金面上項目“腦靶向前體藥物的研究”、863計劃課題“藥物及治療基因納米粒製劑的研究與開發”等課題研究。目前在研項目三項,作為負責人主持“注射用穿心蓮內酯凍乾粉針(運用分子包合技術)的研製”和“注射用羥基喜樹鹼磷脂複合物脂質納米粒凍乾粉針的研製”兩項課題,作為主研人員參與國家自然科學基金重點項目“血管內注射藥用高分子材料PELGE及其肝靶向納米粒研究”。研製開發新葯近10個,申請專利5項。
主要研究課題及成果
《Drug Development and Industrial Pharmacy》、《Acta Pharmacologica Sinica》、《Molecular Pharmaceutics》、《International Journal of Pharmaceutics》、《International Journal of Nanomedicine》和《中藥新葯與臨床藥理》等國內外專業雜誌的審稿人。主要研究課題及成果有PEPT2介導的以調控肺癌基因的miRNA為靶點的載寡聚核苷酸的肺部給葯系統研究等5項。發表的主要論著有有,《靶向治療分子基礎與靶向藥物設計》等3部(章節)
近年作為主研人員先後參與國家自然科學基金面上項目“腦靶向前體藥物的研究”、863計劃課題“藥物及治療基因納米粒製劑
的研究與開發”等課題研究。目前在研項目三項,作為負責人主持“注射用穿心蓮內酯凍乾粉針(運用分子包合技術)的研製”和
“注射用羥基喜樹鹼磷脂複合物脂質納米粒凍乾粉針的研製”兩項課題,作為主研人員參與國家自然科學基金重點項目“血管內注射
藥用高分子材料PELGE及其肝靶向納米粒研究”。研製開發新葯近10個,申請專利5項。

專利:


1.腎靶向前體藥物、製劑及其製備方法與應用。發明專利授權號:ZL 200610020167.X,發明人:張志榮,龔濤,孫遜鄭強
2. 一種腎靶向藥物載體材料及與其形成的前葯、製法和應用。發明專利授權號:ZL 200610020991.5,發明人:張志榮,龔濤,孫遜,袁志翔。
3.一種穿琥寧脂質體凍乾粉製劑及其製備方法。發明專利授權號:ZL 200610022665.8,發明人:張志榮,龔濤
4.喜樹鹼衍生物磷脂複合物脂質納米粒製劑及其製備方法。發明專利授權號:ZL 200710048481.3,發明人:張志榮,龔濤,衛薇。
5. 丹參酚酸B磷脂複合物及其製備方法 發明專利授權號:ZL 200710051038.1,發明人:張志榮,龔濤,彭強
6. 一種細辛腦注射劑及其製備方法, 發明專利授權號:ZL 200910164296.X,發明人:許玉瓊,龔濤,張志榮,梁臻
7. 一種α-細辛腦混合膠束注射劑及其製備方法、應用及其凍乾粉針製劑, 發明專利授權號:ZL 200910059924.8,發明人:張志榮,龔濤,任春娟
有機胺衍生物作為小分子藥物腦靶向修飾基團的用途,發明專利授權號:ZL 201010144446.3,發明人:張志榮,龔濤,孫遜、張宣、趙棟劉興
醋酸艾塞那肽多囊脂質體及其製備方法,申請號:201110112974.5,發明人:張志榮,龔濤,陳麗宇
一種提高桑色素口服生物利用度的藥物組合物,申請號:201110275082.7,發明人:張志榮、龔濤、張金潔、孫遜
氨基葡萄糖衍生物作為小分子藥物腎靶向修飾基團的用途,申請號:201110262847.3,發明人:張志榮 林燕 龔濤 孫遜 王曉虹
一種9-硝基喜樹鹼混合膠束凍乾粉針及其製備方法,申請號:201210035050.4,發明人:龔濤、張志榮、孫遜、黃蕊

代表性論著


1. 張志榮主編,《靶向治療分子基礎與靶向藥物設計》(第三章 腦靶向藥物設計,共約4萬字),科學出版社 2005.12
1. Tao Gong, Yuan Huang, Zhi-Rong Zhang*, Li-li Li. Synthesis and Characterization of Tacrine’s Derivative 9-[P-(N, N-dipropylsulfamide)] benzoylamino-1,2,3,4-4H- acridine. Journal of Drug Targeting, 2004;12(3):177-182.
2.Hai-Tao SHI, Tao GONG, Shi-Wei LIU, Shu CHEN and Zhi-Rong ZHANG*. Adsorption and Desorption of Insulin on Porous Hydroxyapatite Microspheres. Journal of the Ceramic Society of Japan, 113(2005),No.1321(9):579-583.
3.Duan YR, Sun X, Gong T, Wang Q, Zhang ZR*. Preparation of DHAQ-loaded mPEG-PLGA-mPEG nanoparticles and evaluation of drug release behaviors in vitro/in vivo. Journal of Materal Sciences- Materals in Medicine. 2006;17 (6): 509-516. IF=1.562
4. Duan YR, Nie Y, Gong T, Wang Q, Zhang ZR*. Evaluation of blood compatibility of MeO-PEG-poly (D,L-lactic-co-glycolic acid)-PEG-OMe triblock copolymer. Journal of Applied Polymer Science. 2006;100 (2): 1019-1023. IF=1.306
5. L.L.Li, Z.R.Zhang, T.Gong*. L.L.He, L.Deng. Simultaneous determination of Gastrodin and Ligustrazine hydrochloride in dog plasma by gradient high- performance liquid chromatography. Journal of Pharmaceutical and Biomedical Analysis. 2006;41(4):1083-1087. IF=2.032
6. Lili He, Tao Gong, Zhi-Rong Zhang*, Lili Li. A Novel Controlled Porosity Osmotic Pump System of Sodium Ferulate. Pharmazie, 2006,61:1022-1027. IF=0.606
7. Qiang Zheng, Tao Gong and Zhi-Rong Zhang?. Synthesis, Characterization and in vitro Evaluation of Triptolide-lysozyme Conjugate for Renal Targeting Delivery of Triptolide. Archives of Pharmacal Researchs, 2006,29(12):1164-1170. IF=0.929
8.Rong Gao, Qiang Zheng, Tao Gong, Yao Fu, Li Deng, and Zhirong Zhang*. Gradient high-performance liquid chromatography for the simultaneous determination of Chlorogenic Acid and Baicalin in plasma and its application in the study of pharmacokinetics in rats. Journal of Pharmaceutical and Biomedical Analysis. 2007;43:335-340. IF=2.032
9. Juan Huang, Tao Gong, Zhi-Rong Zhang*. Synthesis and Characterization of Insulin- 5-Fu Conjugate, Enabling Insulin as Multi-drug Carrier via a Dendritic Approach. Chinese Chemical Letters. 2007;18:247-250. IF=0.266
10. Zhi-xiang Yuan, Xun Sun*, Tao Gong, Hong Ding, Fu Chen, Zhi-rong Zhang*. Randomly 50% N-acetylated low molecular weight chitosan as a novel renal targeting carrier. Journal of Drug Targeting.2007,15(4):269-278. IF=1.699
11. Jie Liu, Tao Gong, Changguang Wang, Zhirong Zhong, Zhirong Zhang?. Solid lipid nanoparticles loaded with insulin-sodium cholate complex: preparation and characterization. International Journal of Pharmaceutics, 2007;340(8):153-162. IF=2.212
12. Zheng Qiang, Ye Limin, Gao Rong, Xiong Meijin, Han Jing, Gong Tao, Zhang Zhirong*. Kinetic release of triptolide after injection of renal targeting 14-succinyl triptolide-lysozyme in rat kidney study by liquid chromatography/mass spectrometry. Biomedical Chromatography, 2007,21:724-729 IF=1.611
13. Xiuli Wang, Zhirong Zhang, Hualin Fu, Qian Chen, Liu Jie, Yu Nie, Li Deng,Tao Gong*. Simultaneous determination and pharmacokinetics study of water-soluble and lipid-soluble components of Danshen in rat plasma using HPLC-UV method. Biomedical Chromatography, 2007.21:1180-1185 . IF=1.611
14. Yu Nie, Wen-min YUAN, Tao Gong, Jiao Lu, Yao Fu, Zhi-rong Zhang Investigation on characterization ang transfection of a novel multi-polyplex gene delivery system. Journal of Applied Polymer Science. 2007,106(2):1028-1033 IF=1.306
15. Qing-yu Xiang, Min-ting Wang, Fu Chen, Tao Gong, Yan-lin Jian, Zhi-rong Zhang, Yuan Huang*. Lung-Targeting Delivery of Dexamethasone Acetate Loaded Solid Lipid Nanoparticles. Archives of Pharmacal Research, 2007;30(4):519-525. IF=0.929
16. Yourong Duan, Yan Zhang, Tao Gong, Zhirong Zhang*. Synthesis and Characterization of MeO-PEG-PLGA- PEG-OMe Copolymers as Drug Carriers and Their Degradation Behavior in Vitro. Journal of Materal Sciences-Materals in Medicine.2007,18:2067-2073