李建

1982年畢業於北京中醫學院醫療系，

1982年-1986年在北京積水潭醫院任住院醫師。

1987年-1992年在美國紐約州立大學醫學院研究生院 學習並獲細胞生物學碩士學位（1990）和分子生物學博士學位（1992）。

1992年-1996年美國哈佛大學公共衛生學院心血管研究所及哈佛大學醫學院附屬醫院心血管研究中心做博士后研究。

1997-2002年在美國哈佛大學醫學院附屬醫院心血管研究中心任講師，

2002年 起在美國哈佛大學醫學院附屬醫院心血管研究中心任助理教授。北京中醫藥大學教育部心血管內科重點實驗室客座教授。美國心臟學會會員、美國細胞分子生物學學會會員。

運用分子生物學、小鼠心肌缺血模型及轉基因和基因敲除等技術，系統地研究缺血缺氧誘導的血管新生及心肌細胞缺血狀態下誘導的內皮細胞的基因表達及其生物學意義，以及抑制血管生成對於腫瘤發生轉移的分子機理。此外，研究天然葯有效成分對血管生成的影響。

（從40篇中選出）：

Li J, Robertson RD and Lemanski LF. (1990) Abnormalities in myofibril organization and cell shape in developing cardiomyopathic hamster heart cell in culture. Anna. New York Acad. Sci. 588: 412-416.

Li J and Lemanski LF. (1990) Immunofluorescent studies for a-actinin on cultured cardiomyopathic hamster heart cell. Anat. Rec. 228: 46-52.

Li J, Robertson RD and Lemanski LF. (1994) Morphometric analysis of cultured normal and cardiomyopathic hamster heart cells after immunofluorescent staining for tubulin and a-actinin. Acta histochemica. 96: 857-859.

Li J, Perrella M, Tsai JC, Hsieh CM, Yoshizumi M, Patterson C, Endege WO, Zhou F, Lee ME and Haber E. (1995) Induction of vascular endothelial growth factor gene expression by interleukin-1b in rat aortic smooth muscle cells. J. Bio. Chem. 270:308-312

Li J, Brown LF, Hibberd MG, Grossman JD, Morgan JP and Simons M. (1996) VEGF, flk-1, and flt-1 expression in a rat myocardial infarction model of angiogenesis. Am. J. Physiol. 270:H1803-H1811

Li J, Hampton TG, Morgan JP and Simons M. (1997) Stretch-induced VEGF expression in rat heart. J. Clin. Invest. 100 (1): 18-24.

Li J, Brown LF, Laham RL, Volk R and Simons M. (1997) Macrophage-dependent regulation of syndecan gene expression. Circ. Res. 81 (5): 785-796

Metais C, Li J, Li JY, Simons M and Sellke FW. (1999). Serotonin-induced coronary contraction increase after blood cardioplegia-reperfusion. Circulation: 100 [suppl II] II-328-II-334.

Li J, Post M, Volk R, Gao Y, Li M, Metais C, Sato K, Tsai J, Aird W, Rosenberg RD and Simons M. (2000) PR-39, a peptide regulator of angiogenesis. Nature Medicine. Jan. 2000, 49-55.

Li J, Parovian C, Hampton TG, Li JY, Metais C, Tkachenko E, Sellke FW, Simons M (2002) Effect of vascular relaxation by cell surface heparan sulfate and increase of nitric oxide release in response to FGF2 in aMHC-syndecan4 over-expression mice. Microvascular Res. Jul; 64(1): 38-46.

Li J, Shworak NW, and Simons M. (2002) Increased responsiveness of hypoxic endothelial cells to FGF2 is mediated by HIF-1a-dependent regulation of enzymes involved in synthesis of heparan sulfate FGF2 binding sites. J. Cell Science. 115: 1951-1959.

Wu GF, Mannam A, Kirbis S, Wu J, Laham RJ, Sellke FW and Li J. (2003) Hypoxia Induces Myocyte-dependent COX-2 Gene Regulation in Human Vascular Endothelial Cells. Am. J. Physiol 285: H2420-H2429

Wu, JP, Parungo C, Wu GF, Kang PM, Laham RJ, Sellke FW, Simons M and Li J. (2004) PR39 Inhibits Apoptosis in Hypoxic Endothelial Cells-Role of Inhibitor Apoptosis Protein-2. Circulation 109(13): 1660-7.

Shie JL, Wu GF, Wu JP, Liu FF, Laham RJ, Oettgen P and Li J. (2004) RTEF-1, a Novel Transcriptional Stimulator of VEGF in Hypoxic Endothelial Cells. J. Bio. Chem. 279 (24):25010-6.

Wu GF, Luo JC, Rana J S. Sellke FW, and Li J. (2005) Involvement of COX-2 in VEGF-induced angiogenesis via P38 and JNK pathways in vascular endothelial cells. Cardiovasc. Res. 69: 512-519.

1.

Li J, Robertson RD and Lemanski LF. (1990) Abnormalities in myofibril organization and cell shape in developing cardiomyopathic hamster heart cell in culture. Anna. New York Acad. Sci. 588: 412-416.

2.

Li J and Lemanski LF. (1990) Immunofluorescent studies for a-actinin on cultured cardiomyopathic hamster heart cell. Anat. Rec. 228: 46-52.

3.

Li J, Robertson RD and Lemanski LF. (1994) Morphometric analysis of cultured normal and cardiomyopathic hamster heart cells after immunofluorescent staining for tubulin and a-actinin. Acta histochemica. 96: 857-859.

4.

Li J, Perrella M, Tsai JC, Hsieh CM, Yoshizumi M, Patterson C, Endege WO, Zhou F, Lee ME and Haber E. (1995) Induction of vascular endothelial growth factor gene expression by interleukin-1b in rat aortic smooth muscle cells. J. Bio. Chem. 270:308-312

5.

Li J, Brown LF, Hibberd MG, Grossman JD, Morgan JP and Simons M. (1996) VEGF, flk-1, and flt-1 expression in a rat myocardial infarction model of angiogenesis. Am. J. Physiol. 270:H1803-H1811

6.

Li J, Hampton TG, Morgan JP and Simons M. (1997) Stretch-induced VEGF expression in rat heart. J. Clin. Invest. 100 (1): 18-24.

7.

Li J, Brown LF, Laham RL, Volk R and Simons M. (1997) Macrophage-dependent regulation of syndecan gene expression. Circ. Res. 81 (5): 785-796

8.

Metais C, Li J, Li JY, Simons M and Sellke FW. (1999). Serotonin-induced coronary contraction increase after blood cardioplegia-reperfusion. Circulation: 100 [suppl II] II-328-II-334.

9.

Li J, Post M, Volk R, Gao Y, Li M, Metais C, Sato K, Tsai J, Aird W, Rosenberg RD and Simons M. (2000) PR-39, a peptide regulator of angiogenesis. Nature Medicine. Jan. 2000, 49-55.

10.

Li J, Parovian C, Hampton TG, Li JY, Metais C, Tkachenko E, Sellke FW, Simons M (2002) Effect of vascular relaxation by cell surface heparan sulfate and increase of nitric oxide release in response to FGF2 in aMHC-syndecan4 over-expression mice. Microvascular Res. Jul; 64(1): 38-46.

11.

Li J, Shworak NW, and Simons M. (2002) Increased responsiveness of hypoxic endothelial cells to FGF2 is mediated by HIF-1a-dependent regulation of enzymes involved in synthesis of heparan sulfate FGF2 binding sites. J. Cell Science. 115: 1951-1959.

12.

Wu GF, Mannam A, Kirbis S, Wu J, Laham RJ, Sellke FW and Li J. (2003) Hypoxia Induces Myocyte-dependent COX-2 Gene Regulation in Human Vascular Endothelial Cells. Am. J. Physiol 285: H2420-H2429

13.

Wu, JP, Parungo C, Wu GF, Kang PM, Laham RJ, Sellke FW, Simons M and Li J. (2004) PR39 Inhibits Apoptosis in Hypoxic Endothelial Cells-Role of Inhibitor Apoptosis Protein-2. Circulation 109(13): 1660-7.

14.

Shie JL, Wu GF, Wu JP, Liu FF, Laham RJ, Oettgen P and Li J. (2004) RTEF-1, a Novel Transcriptional Stimulator of VEGF in Hypoxic Endothelial Cells. J. Bio. Chem. 279 (24):25010-6.

15.

Wu GF, Luo JC, Rana J S. Sellke FW, and Li J. (2005) Involvement of COX-2 in VEGF-induced angiogenesis via P38 and JNK pathways in vascular endothelial cells. Cardiovasc. Res. 69: 512-519.