基質細胞衍生因子-1

趨化因子CXCL12對淋巴細胞有強烈的趨化作用並在發育中起重要作用。在胚胎髮育中CXCL12引導造血幹細胞從胎兒肝臟到骨髓的遷徙。CXCL12基因敲除的小鼠常常死於胎中或出生后1小時內。SDF-1α/CXCL12a還可以影響神經元的電生理。CXCL12可以在許多組織(包括腦，胸腺，心，肺，肝，腎，骨髓，脾臟)中表達。

趨化因子CXCL12的受體是CXCR4。但是，最近有人認為CXCL12還可以與CXCR7受體結合。

參考文獻

↑ De La Luz Sierra et al. Differential processing of stromal-derived factor-1alpha and beta explains functional diversity. Blood 103:2452-2459, 2004.

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↑ Ara et al. Impaired colonization of the gonads by primordial germ cells in mice lacking a chemokine, stromal cell-derived factor-1 (SDF-1). Proc. Nat. Acad. Sci. 100: 5319-5323, 2003.

↑ Ma et al. Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice. Proc. Nat. Acad. Sci. 95: 9448-9453, 1998.

↑ Bleul et al. The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry. Nature 382: 829-833, 1996.

↑ Balabanian et al. The chemokine SDF-1/CXCl12 binds to and signals through the orphan receptor RDC1 in T lymphocytes. J Biol Chem 280:35760-35766, 2005.