葉敏

中藥成分分析與代謝

1.採用HPLC及LC/MS等分析技術，實現中藥化學成分的微量快速分析，建立中藥質量標準。

2.中藥及其復方的多成分代謝及葯代動力學研究。

3.天然產物的質譜裂解途徑研究。

天然產物的生物轉化

1.利用微生物及植物細胞酶體系的催化作用，發現結構新穎的天然產物衍生物。

2.重要類型天然產物的構效關係研究。

1.Cheng Xiang, Xue Qiao, Qing Wang, Rui Li, Wenjuan Miao, Dean Guo, Min Ye*. From single compounds to herbal extract: a strategy to systematically characterize the metabolites of licorice in rats. Drug Metab. Dispos.2011, 39(9), 1597-1608.

2.Yonghong Liang, Min Ye*, Wen zhi Yang, Xue Qiao, Haijun Yang, Xiaoli Wang, Dean Guo*. Flavan-3-ols from the rhizomes of Drynaria fortunei. Phytochemistry2011, 72(14-15), 1876-1882.

3.Rui Li, Xue Qiao, Qingyan Li, Rong He, Min Ye*, Cheng Xiang, Xionghao Lin, Dean Guo*.Metabolic and pharmacokinetic studies of curcumin, demethoxycurcumin and bisdemethoxycurcumin in mice tumor after intragastric administration of nanoparticle formulations by liquid chromatography coupled with tandem mass spectrometry. J. Chromatogr. B2011, 879 (26), 2751-2758.

4.Xue Qiao, Min Ye*, De-lin Pan, Wen-juan Miao, Cheng Xiang, Jian Han, De-an Guo*. Differentiation of various traditional Chinese medicines derived from animal bile and gallstone: simultaneous determination of bile acids by liquid chromatography coupled with triple quadrupole mass spectrometry. J. Chromatogr. A2011, 1218, 107-117.

5.Xue Qiao, Xing Zhang, Min Ye*, Yan-fang Su, Jing Dong, Jian Han, Jun Yin, De-an Guo*. Rapid characterization of triterpene saponins from Conyza bliniibyliquid chromatography coupled with mass spectrometry. Rapid Commun. Mass Spectrom.2010, 24, 3340-3350.

6.Min Ye,Jian Han, Hubiao Chen, Junhua Zheng, Dean Guo. Analysis of phenolic compounds in rhubarbs using liquid chromatography coupled with electrospray ionization mass spectrometry. J. Am. Soc. Mass Spectrom.2007, 18(1), 82-91.

7.Min Ye, Yuning Yan, Dean Guo. Characterization of phenolic compounds in the Chinese herbal drug Tu-Si-Zi by liquid chromatography coupled to electrospray ionization mass spectrometry. Rapid Commun. Mass Spectrom.2005, 19(11), 1469-1484.

8.Min Ye, Jian Han, Dongge An, Guangzhong Tu, Dean Guo.New cytotoxic bufadienolides from the biotransformation of resibufogenin by Mucor polymorphosporus. Tetrahedron2005, 61(37), 8947-8955.

9.Min Ye, Jian Han, Guangzhong Tu, Dongge An, Dean Guo. Microbial hydroxylation of bufalin by Cunninghamella blakesleanaand Mucor spinosus. J. Nat. Prod.2005, 68(4), 626-628.

10.Min Ye, Guiqin Qu, Hongzhu Guo, Dean Guo. Specific 12b-hydroxylation of cinobufagin by filamentous fungi. Appl. Environ. Microbiol.2004, 70(6), 3521-3527.

1.天然抗腫瘤活性化合物的生物轉化研究，2005年教育部自然科學一等獎，第三完成人。

2.中藥複雜體系成分分析及體內過程研究，2007年教育部自然科學一等獎，第二完成人。

3. 2008年獲北京大學青年教師講課比賽(醫學類)三等獎。

4. 2009年入選北京市科技新星計劃。

5.2020年12月21日，入選國家中醫藥管理局公布的青年岐黃學者支持項目人選名單。