莫日根

2009年10月回國任內蒙古大學生命科學學院生物化學與分子生物學教授、博士生導師。

現任生命科學學院院長、內蒙古自治區細胞分子調控重點實驗室主任、內蒙古自治區細胞分子工程技術研究中心主任、省部共建草原家畜生殖調控與繁育國家重點實驗室副主任。

研究領域

1.細菌DNA複製、細胞周期及環境適應分子機制與耐藥性。主要以大腸桿菌為模式生物，研究DNA複製與基因組穩定、細胞周期、代謝和基因表達調控分子機制，揭示細胞環境適應性和耐藥性分子機理。

2.癌細胞DNA複製與基因組穩定性。

學術論文

1.Wurihan, Gezi, Brambilla E, Wang S, Sun H, Fan L, Shi Y1, Sclavi B*, Morigen*

DnaA and LexA proteins regulate transcription of the uvrB gene in Escherichia coli: the role of DnaA in the control of the SOS regulon, Front Microbiol, 9:1212, https://doi.org/10.3389/fmicb.2018.01212, 2018.

2.Yao Y, Enkhtsetseg S, Odsbu I, Fan L, Morigen*

Mutations of DnaA-boxes in the oriR region increase replication frequency of the MiniR1–1 plasmid, BMC Microbiol, 18:27,https://doi.org/10.1186/s12866-018-1162-3, 2018.

3.Fan L, Cao X, Yan H, Wang Q, Tian X, Zhang L, He X, Borjihan G, Morigen*

The synthetic antihyperlipidemic drug potassium piperate selectively kills breast cancer cells through inhibiting G1-S-phase transition and inducing apoptosis, Oncotarget, doi:10.18632/oncotarget.16872, 2017.

4.Yao Y, Fan L, Shi Y, Odsbu I, Morigen*

A spatial control for correct timing of gene expression during the Escherichia coli cell cycle, Genes, 8(1), 1: doi:10.3390/genes8010001, 2017.

5.Wurihan, Wunier, Li H, Fan L, Morigen*

Trans-translation ensures timely initiation of DNA replication and DnaA synthesis in Escherichia coli, Gent Mol Res, 15 (3): gmr.15038407, 2016.

6.Yao Y, Wunier, Morigen*

Absence of the BaeR protein leads to the early initiation of DNA replication in Escherichia coli,Gent Mol Res, 14(4):16888-16895, 2015.

7.Fan L, Yan H, Pellegrin S, Morigen*, Mellor H

The Rif GTPase regulates cytoskeletal signaling from plexinA4 to promote neurite retraction, Neurosci Lett, 590(-):178-183, 2015.

8.Dong Q, Dong A, Morigen*

Evaluation of novel antibacterial N-halamine nanoparticles prodrugs towards susceptibility of Escherichia coli induced by DksA protein, Molecules, 21;20(4):7292-308, 2015.

9.Liu F, Qimuge, Hao J, Yan H, Bach T, Fan L, Morigen*

AspC-mediated aspartate metabolism coordinates the Escherichia coli cell cycle, PLoS ONE, 9(3):e92229, 2014.

10.Morigen, Flatten I, Skarstad K

The Escherichia coli datA site promotes proper regulation of cell division, SGM-Microbiol, 160(4):703-710, 2014.

11.Johnsen L, Flatten I, Morigen, Dalhus B, Bjoras M, Waldminghaus T, Skarstad K

TheG157C mutation in the Escherichia coli sliding clamp specifically affects initiation of Replication, Mol Microbiol ,79(2):433-446, 2011.

12.Weatherspoon-Griffin N, Zhao G, Kong W,Kong Y,Morigen,Andrews-Polymenis H,McClelland M, Shi Y

The CpxR/CpxA two-component system up-regulates two Tat-dependent peptidoglycan amidases to confer bacterial resistance to antimicrobial peptide, J Biol Chem, 286(7):5529-39, 2011.

13.Morigen, Odsbu I, Skarstad K

Growthrate dependent numbers of SeqA structures organize the multiple replication forks in rapidly growing Escherichia coli,Genes Cells, 14(5):643-657, 2009.

14.Wang J, Morigen

BayesPI--a new model to study protein-DNA interaction: a case study of condition-specific protein binding parameters for yeast transcription factors, BMC Bioinformatics, 10:345, 2009.

15.Odsbu I., Morigen, Skarstad K

A reductionin ribonucleotide reductase activity slows down the chromo some replication fork but does not change its localization,PLoS ONE, 4(10):e7617, 2009.

16.Flatten I, Morigen, Skarstad K

DnaAprotein interacts with RNA polymerase and protects it from the effect of rifampicin, Mol Microbiol,71(4):1018-1030,2009.

17.Bach T, Morigen, Skarstad K

The initiator protein DnaA contributes to keeping new origins inactivated by promoting the presence of hemi methylated DNA, J Mol Biol, 384(5):1076-85, 2008.

18.Morigen, Molina F, Skarstad K

Deletionof the datA site does not affect once-per-cell-cycle timing but induces rifampin-resistant replication, J Bacteriol, 187(12):3913-20, 2005.

19.Morigen, Lobner-Olesen A, Skarstad K

Titration of the Escherichia coli DnaA protein to excess datAsites causes destabilization of replication forks, delayed replication initiation and delayed cell division, Mol Microbiol, 50:349-362, 2003.

20.Morigen, Boye E, Skarstad K, Lobner-Olesen A

Regulation of chromosomal replication by DnaA protein availability in Escherichia coli: effects of the datA region, Biochim Biophys Acta, 1521: 73-80,2001.

21.Weigel C, Messer W, Preiss S, Welzeck M, Morigen, Boye E

Thesequence requirements for a functional Escherichia coli replication origin are different for the chromosome and a minichromosome, Mol Microbiol, 40(2): 498-507, 2001.