張曉兵

1989-1993 湖南大學 有機化工 學士；

1995-1998 湖南大學 有機化學 碩士；

1998-2001 湖南大學 分析化學 博士。 

2001年獲分析化學博士學位后留校任教。2003-2005年在法國里昂高等師範學校、瑞典皇家工學院從事生物有機化學方向博士后研究，2005年3月加入湖南大學化學生物感測與計量學國家重點實驗室，2006年起任湖南大學教授。分別於2008年6-9月以邀請教授的身份到法國里昂高等師範學校，2009年2-8月以高級訪問學者的身份到美國伊利諾伊大學香檳分校從事生物分析領域的科研合作。 

現任《分析化學》及《中國科學-化學》編委。 

新型有機小分子熒光探針的設計與合成；熒光生物探針在生物分析中的應用。 

主持國家傑出青年科學基金項目，國家自然科學基金面上項目以及國家“973”計劃課題等。 

代表性論文：

1. H. Liu, K. Li, X.-X. Hu, L. Zhu, Q. Rong, Y. Liu, X.-B. Zhang*, J. Hasserodt, F.-L. Qu, W. Tan, In situ localization of enzyme activity in live cells by a molecular probe releasing a precipitating fluorochrome, Angew. Chem. Int. Ed. 2017, 56, 11788-11792.

2. Y. Wu, L. Zhang, C. Cui, S. Cansiz, H. Liang, C. Wu, I.-T. Teng, W. Chen, Y. Liu, W. Hou, X.-B. Zhang*, W. Tan*, Enhanced targeted gene transduction: AAV2 vectors conjugated to multiple aptamers via reducible disulfide linkages, J. Am. Chem. Soc. 2018, 140, 2-5. 

3. Hong-Min Meng, Hui Liu, Hailan Kuai, Ruizi Peng, Liuting Mo and Xiao-Bing Zhang*, Aptamer-integrated DNA nanostructures for biosensing, bioimaging and cancer therapy, Chem. Soc. Rev., 2016, 45, 2583-2602.

4. Huanhuan Fan, Guobei Yan, Zilong Zhao, Xiaoxiao Hu, Wenhan Zhang, Hui Liu, Xiaoyi Fu, Ting Fu, Xiao-Bing Zhang* and Weihong Tan*, A Smart Photosensitizer-MnO2 Nanosystem for Enhanced Photodynamic Therapy via Reducing Glutathione Levels in Cancer Cells, Angew. Chem. Int. Ed., 2016, 55, 5477-5482.

5. Yifan Lv, Rong Hu, Guizhi Zhu, Xiao-Bing Zhang*, Lei Mei, Qiaoling Liu, Liping Qiu, Cuichen Wu, Weihong Tan*, Preparation and biomedical applications of programmable and multifunctional DNA nanoflowers, Nature Protocols, 2015, 10, 1508-1524.

6. Zhi-Ling Song, Zhuo Chen*, Xia Bian, Li-Yi Zhou, Ding Ding, Hao Liang, Yu-Xiu Zou, Shan-Shan Wang, Long Chen, Chao Yang, Xiao-Bing Zhang*, and Weihong Tan*, Alkyne-Functionalized Superstable Graphitic Silver Nanoparticles for Raman Imaging, J. Am. Chem. Soc., 2014, 136, 13558-13561.

7. Hao Liang, Xiao-Bing Zhang*, Yifan Lv, Liang Gong, Ruowen Wang, Xiaoyan Zhu,Ronghua Yang* and Weihong Tan*. Functional DNA-Containing Nanomaterials: Cellular Applications in Biosensing, Imaging, and Targeted Therapy, Acc. Chem. Res., 2014, 47, 1891-1901.

8. Zilong Zhao, Hongmin Meng, Nannan Wang, Michael J. Donovan, Ting Fu, Mingxu You, Xiao-Bing Zhang*, Weihong Tan*, A Controlled-release Nanocarrier with pHe-driven Targeting and Translocation for Drug Delivery, Angew. Chem. Int. Ed., 2013, 52, 7487-7491.

9. Tao Chen, Cuichen Sam Wu, Elizabeth Jimenez, Zhi Zhu, Joshua G. Dajac, Mingxu You, Da Han, Xiao-Bing Zhang*, and Weihong Tan*, DNA Micelle Flares for Intracellular mRNA Imaging and Gene Therapy, Angew. Chem. Int. Ed., 2013, 52, 2012-2016.

10. Cuichen Wu, Da Han, Tao Chen, Lu Peng, Guizhi Zhu, Mingxu You, Liping Qiu, Kwame Sefah, Xiaobing Zhang*, Weihong Tan*, Building a Multifunctional Aptamer-Based DNA Nanoassembly for Targeted Cancer Therapy. J. Am. Chem. Soc., 2013, 135, 18644-18650.

11. Mingxu You, Yan Chen, Xiao-Bing Zhang*, Haipeng Liu, Ruowen Wang, Kelong Wang, KathrynR.Williams, and Weihong Tan*, An Autonomous and Controllable Light-Driven DNA Walking Device. Angew. Chem. Int. Ed., 2012, 51, 2457-2460.

12. Tao Chen, Ismail Oecsoy, Quan Yuan, Ruowen Wang, Mingxu You, Zilong Zhao, Erqun Song, Xiao-Bing Zhang*, Weihong Tan,* One-Step Facile Surface Engineering of Hydrophobic Nanocrystals with Designer Molecular Recognition, J. Am. Chem. Soc., 2012, 134, 13164-13167.

13. Liu Yang, Ling Meng, Xiao-Bing Zhang*, Yan Chen, Guizhi Zhu, Haipeng Liu, Kwame Sefah and Weihong Tan*, Engineering Polymeric Aptamers for Selective Cytotoxicity. J. Am. Chem. Soc., 2011, 133, 13380-13386.

14. Li-Min Lu, Xiao-Bing Zhang*, Rong-Mei Kong, Bin Yang, Weihong Tan*, Ligation-triggered DNAzyme Cascade for Amplified Fluorescence Detection of Biological Small Molecules with Zero-Background Signal. J. Am. Chem. Soc., 2011, 133, 11686-11691.

2007年入選教育部新世紀優秀人才計劃項目，

2011年獲湖南省傑出青年科學基金資助，

2013年獲國家傑出青年科學基金資助，

2015年入選湖南省芙蓉學者特聘教授，

2016年入選湖南省科技領軍人才、國家中青年科技創新領軍人才

2017年入選國家“萬人計劃”科技創新領軍人才、國家百千萬人才工程，並被授予“有突出貢獻中青年專家稱號”。

2018年獲湖南省自然科學一等獎、教育部自然科學一等獎。