吳志國

2008/09-2013/06，武漢大學，博士

2004/09-2008/06，武漢大學，學士

主要工作經歷與任職情況：

2015/03-至今：武漢大學生命科學學院；副研究員

2013/09-2015/01：美國辛辛那提兒童醫院醫學中心

真核細胞發育和分化過程中，功能基因組的表達受到精細而廣泛的調控，主要通過相應的調控元件如啟動子增強子等實現。近年來的研究發現，真核細胞內染色體組蛋白的特定修飾與基因調控元件密切相關，如H3K4me3特異性標記啟動子，H3K4me特異性標記增強子，而H3K27ac標記活化的調控原件。通過組蛋白特定修飾相對應的抗體進行高通量的Chip-seq實驗，在全基因組範圍內揭示功能基因組的調控元件，並結合生物信息學的方法統計分析與調控元件相結合的轉錄因子，從而確定真核細胞發育和分化的關鍵基因及其調控網路。系統性的研究生命過程中功能基因組表達和相互之間的調控關係，從而繪製基因調控迴路，全面解析生命過程。

1. Heping Xu, Virendra K Chaudhri, Zhiguo Wu, Konstantinos Biliouris, Krista Dienger-Stambaugh, Yrina Rochman and Harinder Singh*. (2015). Regulation of bifurcating B cell trajectories by mutual antagonism between transcription factors IRF4 and IRF8. Nature Immunology (doi:10.1038/ni.3287).

2. Xiaoming Lu, Erin E. Zoller, Matthew T. Weirauch, Zhiguo Wu, Bahram Namjou, Adrienne H. Williams, Julie T. Ziegler, Mary E. Comeau, Miranda C. Marion, Stuart B. Glenn, Adam Adler, Nan Shen, Swapan K. Nath, Anne M. Stevens, Barry I. Freedman, Betty P. Tsao, Chaim O. Jacob, Diane L. Kamen, Elizabeth E. Brown, Gary S. Gilkeson, Graciela S. Alarcón, John D. Reveille, Juan-Manuel Anaya, Judith A. James, Kathy L. Sivils, Lindsey A. Criswell, Luis M. Vilá, Marta E. Alarcón-Riquelme, Michelle Petri, R Hal Scofield, Robert P. Kimberly, Rosalind Ramsey-Goldman, Young Bin Joo, Jeongim Choi, Sang-Cheol Bae, Susan A. Boackle, Deborah Cunninghame Graham, Timothy J. Vyse, Joel M. Guthridge, Patrick M. Gaffney, Carl D. Langefeld, Jennifer A. Kelly, Kenneth D. Greis, Kenneth M. Kaufman, John B. Harley,* Leah C. Kottyan*. (2015). Lupus risk-variant increases pSTAT1 binding and decreases ETS1 expression. American Journal of Human Genetics 5:731-739.

3. Zhiguo Wu, Xiao Xie, Puzhen Li, Jiayi Zhao, Lili Huang, Xiang Zhou*. (2013). Equilibrious strand exchange promoted by DNA conformational switching. Scientific Reports 3: 1121

4. Zhiguo Wu, Tian Tian, Junping Yu, Xiaocheng Weng, Yi Liu, Xiang Zhou*. (2011). Formation of sequence-independent Z-DNA induced by a ruthenium complex at low salt concentrations. Angew Chem Int Ed Engl. 50: 11962-11967.

5. Zhiguo Wu, Mingliang Tang, Tian Tian, Jianguo Wu, Yuanlin Deng, Xiaohu Dong, Zheng Tan, Xiaocheng Weng, Zhihong Liu, Chunjiang Wang, Xiang Zhou*. (2011). A specific probe for two-photon fluorescence lysosomal imaging. Talanta 87: 216-221

6. Jing Huang, Guorui Li, Zhiguo Wu (co-first author), Zhibin Song, Yangyang Zhou, Liang Shuai, Xiaocheng Weng, Xiang Zhou*, Guang Fu Yang. (2009). Bisbenzimidazole to benzobisimidazole: from binding B-form duplex DNA to recognizing different modes of telomere G-quadruplex . Chem Commun 8: 902-904.

7. Xun Liu, Zhiguo Wu, Tianyou Peng*, Ping Cai, Hongjin Lv, Wenlong Lian. (2009). Fabrication of alumina nanofibers by precipitation reaction combined with heterogeneous azeotropic distillation process. Materials Research Bulletin 44: 160-167.