劉波

1994-1998 在西南師範大學化學化工學院學習，環境學專業；獲理學學士學位。

1998-2001 在中科院成都有機化學研究所學習，有機合成專業，主要從事不對稱催化反應研究；獲理學碩士學位。

2001-2004 在中科院上海有機化學研究所學習，有機合成專業，主要從事天然產物全合成研究；獲理學博士學位。

2004-2007 在美國德克薩斯大學西南醫學中心作博士后研究，主要從事過渡金屬催化的反應研究及天然產物全合成。

2007 年 3 月至今四川大學化學學院教授。

1. 具有重要生物活性的複雜天然產物全合成。

2. 天然產物分子探針的生物學功能開發。

3. 合成導向的反應方法學研究。

4. 藥物合成。

1．具有重要藥用價值的多環天然產物的高效合成，國家自然科學基金重大項目（2013-2017）。

2．瑞香烷型二萜Trigoxyphin A的全合成研究，國家自然科學基金面上項目（2012-2015），項目負責人。

3．具有重要生物活性的天然產物的化學合成，國家重點基礎研究計劃（科技部973計劃， 2010-2014）。

4．四川大學優秀青年學者科研基金（B類），2011-2014。

5．天然產物Chlorahololide A（鉀離子通道抑製劑）的全合成研究，國家自然科學基金面上項目（2009-2011），項目負責人。

6．教育部新世紀優秀人才支持計劃（2009-2011）, 項目負責人。

7．抗真菌天然產物金粟蘭內酯 A 的全合成研究，教育部留學回國人員基金（2009-2011），項目負責人。

8．抗結核天然產物 Hirsutellones A-F 的全合成研究，國家自然科學基金青年基金項目（2008-2010），項目負責人。

完成了orostanal、palmerolide A、heliespirones A & C、cuevaene A、金粟蘭內酯A&D、銀線草內酯E、leucosceptroid B、bolivianine和crotobarin等天然產物在國際上的首次合成；完成了海洋天然產物Phorboxazoles的片段合成及Peloruside A的大環骨架的合成；同時，發展了貴金屬催化炔烴的碳-雜原子鍵形成反應，以及鹼性條件下縮酮的脫保護方法。

目前運用機理和構象分析為工具，結合前沿的串聯反應、原子經濟性、氧化-還原經濟性、步驟經濟性、無保護基合成、集合合成和可放大合成等高效策略，重點圍繞以萜類為主的多環複雜天然產物開展工作。

截止2015年10月，在J. Am. Chem. Soc., Angew. Chem. Int. Ed., Org. Lett.,Chem. Commun., Eur. J. Chem.等專業期刊上發表近四十篇論文，均為SCI收錄。一些研究成果被評選為Org. Lett.和J. Am. Chem. Soc.的most read articles, 被收錄進入化學專業網站 Organic Chemistry Highlights，被化學博客brsmbog.com和chemblogs.net以及專業評述性雜誌Synfacts收錄和正面評價。

（獲獎成果、專著、論文、專利）

1 ． Total Synthesis and Structure Revision of the Marine Metabolite Palmerolide A Xin Jiang, Bo Liu , Sylvain Lebreton, Jef K. De Brabander J. Am. Chem. Soc. 2007 , 129 , 6386. （ Most-Accessed Articles: April-June, 2007 ）

2 . Metal-Catalyzed Regioselective Oxy-Functionalization of Internal Alkynes: An Entry into Ketones, Acetals, and Spiroketals Bo Liu , Jef K. De Brabander Org. Lett. 2006 , 8 , 4907 .

3 ． Total Synthesis of Phorboxazole B De-Run Li, Dong-Hui Zhang, Cai-Yun Sun, Ji-Wen Zhang, Li Yang, Jian Chen, Bo Liu , Ce Su, Wei-Sh an Zhou, Guo-Qiang Lin Chem. Eur. J. 2006 , 12 , 1185.

4. Towards the total synthesis of natural peloruside A: stereoselective synthesis of the backbone of the core Bo Liu ; Wei-Shan Zhou Org. Lett. 2004 , 6 , 71.

5. Stereoselective synthesis of the C21-C27 fragment of the phorboxazoles Bo Liu, ; Wei-Shan Zhou Tetrahedron Lett. 2003 , 44 , 4933.

6. The first stereoselective synthesis of orostanal, a novel abeo-sterol inducing apoptosis in leukemia cells Bo Liu , Wei-Shan Zhou Tetrahedron 2003 , 59 , 3379.

7 ． Enantioselective Strecker reactions between aldimines and trimethylsilyl cyanide promoted by chiral N,N -dioxides Zhigang Jiao, Xiaoming Feng , Bo Liu , Fuxue Chen, Guolin Zhang, Yaozhong Jiang Eur. J. Org. Chem. 2003 , 3818.

8. The first stereoselective synthesis of orostanal, a novel abeo-sterol inducing apoptosis in leukemia cells Bo Liu , Wei-Shan Zhou Tetrahedron Lett. 2002 , 43 , 4187.

9. Enantioselective Strecker reaction promoted by chiral N -oxides Bo Liu , Xiaoming Feng, Fuxue Chen, Guolin Zhang, Xin Cui, Yaozhong Jiang SYNLETT 2001 , 1551.

Biao Du, Changchun Yuan, Tianzi Yu, Li Yang, Yang Yang, Bo Liu*, Song Qin* Asymmetric Total Synthesis of Onoseriolide, Bolivianine and Isobolivianine, Chem. Eur. J. 2014, 20, 2613-2622.

11.Guizhou Yue, Xuan Huang, Bo Liu* Progress in the Total Synthesis of trans-Hydrindane- Containing Terpenoids, Chin. J. Org. Chem. 2013, 33, 1167-1185.

12.Changchun Yuan, Biao Du, Li Yang, Bo Liu* Bioinspired Total Synthesis of Bolivianine: A Diels-Alder/ Intramolecular Hetero-Diels-Alder Cascade Approach, J. Am. Chem. Soc. 2013, 135, 9291-9294.

13.Xuan Huang, Liqiang Song, Jiao Xu, Guili Zhu, Bo Liu* Asymmetric Total Synthesis of Leucosceptroid B, Angew. Chem. Int. Ed. 2013, 52, 952-955.

14.Jing Feng, Guili Zhu, Bo Liu*, Xiangdong Zhou* Expedient Synthesis of (R)-Curcuphenol: A Chiral Pool Strategy, Chin, J. Chem. 2013, 31, 23-26.

15.Guizhou Yue, Li Yang, Changchun Yuan, Biao Du, Bo Liu* Progress in Total Syntheses of Lindenane-type Sesquiterpenoids and Their Dimers, Chin. J. Org. Chem. 2013, 33, 90-100.

16.Hang Su, Ting Zhou, Bo Liu* Total Synthesis of (±)-Spirobenzofuran, Synlett 2013, 615-618.

17.Biao Du, Changchun Yuan, Langzhong Zhang, Li Yang, Bo Liu* Deprotection of 1,3-Oxathiolanes to Ketones Promoted by Base, Tetrahedron Lett. 2013, 54, 2217-2220.

18.Changchun Yuan, Li Yang, Biao Du, Bo Liu* A Base-promoted deprotection of 1,3-dioxolanes to ketones, Tetrahedron Lett. 2012, 53, 6972-6976.

19.Guizhou Yue, Li Yang, Changchun Yuan, Biao Du, Bo Liu* Total Syntheses of Lindenane- type Sesquiterpenoids: (±)-Chloranthalactones A, B, F, (±)-9-Hydroxy Heterogorgiolide and (±)-Shizukanolide E, Tetrahedron, 2012, 68, 9624-9637.

20.Ting Zhou, Guili Zhu, Xuan Huang, Bo Liu* Zeise’s dimmer-catalyzed regioselective hydration of homopropargyl tertiary ether, Tetrahedron Lett. 2012, 53, 4955-4958

21.Guizhou Yue, Li Yang, Changchun Yuan, Xiaoling Jiang, Bo Liu* Total synthesis of chloranthalactone A, Org. Lett. 2011, 13, 5406-5408. (one of Most Read Articles of OL in September, 2011)

22.Yongjiang Liu, Chong Huang, Bo Liu* Asymmetric total syntheses of heliannuol E and epi-heliannuol E, Tetrahedron Lett. 2011, 52, 5802-5804.

23.Chong Huang, Wenhan Zhang, Bo Liu* Racemic and enantioselective total synthesis of heliespirones A & C, Sci. China. Chem. 2011, 54, 43-55.

24.Mingzheng Huang, Liqiang Song, Bo Liu* Construction of the Cyclophane Core of the Hirsutellones via a RCM Strategy, Org. Lett. 2010, 12, 2504-2507.

25.Chong Huang, Bo Liu* Asymmetric total synthesis ent-heliespirones A & C, Chem. Commun. 2010, 46, 5280-5282

26.Daxing Yang, Jianfeng Huang, Bo Liu* Platinum-Catalyzed Regioselective Formation of β-Alkoxy Ketones from Internal Alkynes, Eur. J. Org. Chem. 2010, 4185-4188.

27.Jianfeng Huang, Xuan Huang, Bo Liu* Gold-catalyzed synthesis of nitrogen-containing heterocycles from ε-N-protected propargylic esters, Org. Biomol. Chem. 2010, 8, 2697-2699.

28.Yunxiu Chen, Jianfeng Huang, Bo Liu* Total syntheses of the proposed structures of cuevaene A, Tetrahedron Lett. 2010, 51, 4655-4657.

29.Mingzheng Huang, Chong Huang, Bo Liu* Studies toward the total synthesis of the hirsutellones, Tetrahedron Lett. 2009, 50, 2797-2800.

30.Jef K. De Brabander*, Bo Liu, Mingxing Qian Au(I)- and Pt(II)-Catalyzed Cycloetherification of ω-Hydroxy Propargylic Esters, Org. Lett. 2008, 10, 2533.

31.Xin Jiang, Bo Liu, Sylvain Lebreton, Jef K. De Brabander* Total Synthesis and Structure Revision of the Marine Metabolite Palmerolide A, J. Am. Chem. Soc. 2007, 129, 6386. (One of the Most-Accessed Articles in 2007）

32.Bo Liu, Jef K. De Brabander* Metal-Catalyzed Regioselective Oxy-Functionalization of Internal Alkynes: An Entry into Ketones, Acetals, and Spiroketals, Org. Lett. 2006, 8, 4907.

33.De-Run Li, Dong-Hui Zhang, Cai-Yun Sun, Ji-Wen Zhang, Li Yang, Jian Chen, Bo Liu, Ce Su, Wei-Shan Zhou*, Guo-Qiang Lin* Total Synthesis of Phorboxazole B, Chem. Eur. J. 2006, 12, 1185.

34.Bo Liu, Wei-Shan Zhou* Towards the total synthesis of natural peloruside A: stereoselective synthesis of the backbone of the core, Org. Lett. 2004, 6, 71.

35.Bo Liu, Wei-Shan Zhou*, Stereoselective synthesis of the C21-C27 fragment of the phorboxazoles, Tetrahedron Lett. 2003, 44, 4933.

36.Bo Liu, Wei-Shan Zhou* The first stereoselective synthesis of orostanal, a novel abeo-sterol inducing apoptosis in leukemia cells, Tetrahedron 2003, 59, 3379.

37.Zhigang Jiao, Xiaoming Feng * , Bo Liu , Fuxue Chen, Guolin Zhang, Yaozhong Jiang, Enantioselective Strecker reactions between aldimines and trimethylsilyl cyanide promoted by chiral N,N’-dioxides, Eur. J. Org. Chem. 2003 , 3818.

38.Bo Liu, Wei-Shan Zhou* The first stereoselective synthesis of orostanal, a novel abeo-sterol inducing apoptosis in leukemia cells, Tetrahedron Lett. 2002, 43, 4187.

39.Bo Liu, Xiaoming Feng*, Fuxue Chen, Guolin Zhang, Xin Cui, Yaozhong Jiang, Enantioselective Strecker reaction promoted by chiral N –oxides, SYNLETT 2001, 1551.

40. 獲准美國專利一項：Jef K. De Brabander, Xin Jiang, Bo Liu，Palmerolides: Methods of preparation and derivatives thereof, US patent, US2008249162-A1; WO2008124072-A1; TW200906387-A; US7838691-B2.

教育部新世紀優秀人才支持計劃（2009）。

國家自然科學基金委優秀青年基金（2013）。

Thieme Chemistry Journal Award 2014。

ACP Lectureship Awards to Japan & Malaysia (2014)。

ACP Lectureship Awards to Taiwan (2015)。

中國化學會維善天然產物合成獎（2015）。