李凱

1988年獲首屆中國青年科技獎，94年獲加拿大Sherbrooke大學博士學位。99年任UCLA和C.R. Drew醫學院助理教授，實驗室主任。03年任美國希望城人類遺傳學和臨床分子診斷實驗室訪問科學家。2007年兼任美國希望城國家醫學中心人類遺傳學和臨床分子診斷實驗室客座教授。2007年至今任蘇州大學教授。

主要從事基因診斷和基因治療的研究。

研發了基於高保真酶的突變檢測技術，提出了可治癒HIV感染的基因治療新方案，描述了人類基因突變的規律性現象。已發表英文論文70餘篇，其中SCI收錄52篇；出版基因檢測技術英文專著一部。

國家自然科學青年基金：內皮細胞損傷在心肌缺血再灌注中的意義， 1987-1990

湖南省重大社會發展項目：EGFR基因突變檢測新方法的研發及其在臨床個體化治療中應用，2005-2008

江蘇省“六大人才高峰”項目：肺癌和乳腺癌基因診斷試劑盒的開發，2007-2010

國家863專項：高保真聚合酶介導的突變敏感性分子開關在重大疾病診斷中的應用，2008-2011

國家自然科學基金項目：偶聯連接酶和高保真聚合酶提高核酸分子識別特異性的研究，2009-2012

十二五社會發展項目子課題：CCR5基因敲除技術研發和治療HIV感染的臨床研究，2012-2015

Li K, et al. Superb nucleotide discrimination by a novel on/off switch for DNA polymerization and its applications. Mol Biotechnol. 2005, 29:93-100.

Li K, Xiao L, Liu C, Zhang J, Sirois P. Transforming Viral Sequences to A (H1N1) Flu Diagnosis: The Current Status and Future Prospects of rtPCR Based Assays. Curr Pharm Biotechnol. 2010, 11:113-6

Zhang J, Li K, et al. Proofreading genotyping assays mediated by high fidelity exo+ DNA polymerases. Trends Biotechnol. 2005, 23:92-6.

Pardinas JR, Xiao L, Zhang J, Li K. Re: Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers. J Natl Cancer Inst. 2006, 98:362-3

Youjia Xu, Pierre Sirois, Kai Li：Iron overload plays a unique role in osteoporosis. Blood, 2010，Sept 9，e-letter

Gu D, Scaringe WA, Li K, et al. Database of somatic mutations in EGFR with analyses revealing indel hotspots but no smoking-associated signature. Hum Mutat. 2007, 28:760-70.

Gonzalez KD, Hill KA, Li K, et al. Somatic microindels: analysis in mouse soma and comparison with the human germline. Hum Mutat. 2007, 28:69-80.

Xiao L, Zhang J, Yin YF, Chen CL, Li K, Chang A, Sirois P. Molecular diagnosis of HIV and relevant novel technologies in mutation analysis. Biotechnol Adv. 2008,26:389-97.

Guo J, Shen JK, Wang L, Xiao L, Zhang RJ, Luo WF, Gong ZG, Sun J, Xu H, Sirois P, Li K. In vivo Evaluation of Cerebral Transplantation of Resovist-Labeled Bone Marrow Stromal Cells in Parkinson’s Disease Rats Using Magnetic Resonance Imaging. Appl Biochem Biotech. 2010 [PMID: 20821072 [PubMed]

Zhang J, Xiao L, Yin YF, Sirois P, Gao HL, Li K. A law of mutation: power decay of small insertions and small deletions associated with human diseases. Appl Biochem Biotech. 2010, 162: 321-8.

Zhang ZQ, Lu GM, Zhong Y, Tan Q, Liao W, Wang Z, Wang Z, Li K, Chen H, Liu Y. Altered Spontaneous Neuronal Activity of the Default-Mode Network in Mesial Temporal Lobe Epilepsy. Brain Research 2010，1323:152-60

Xiao L, Saldivar JS, Zhou C, Chen C, Zhang J, Sirois P, Li K. The Updated Concept of Genome and Its Implications in Biotechnological Research and Molecular Diagnostics. Mol Biotechnol. 2009; 41(2):152-6.