李昂

2007-2011為美國賓夕法尼亞大學醫學院生理系訪問學者，主要從事青光眼發病機制的研究，探討非選擇性陽離子通道pannexin-1如何通過調控嘌呤信號傳導進而影響眼內壓。2011-2015就讀於香港大學醫學院內科系，獲得哲學博士學位，期間主要從事運動調控成體海馬神經發生和抗抑鬱機制的研究，提出脂肪細胞因子脂聯素可能通過促進海馬神經前體細胞增殖而在其中起到重要的介導作用。前期研究成果發表在Nature, Proc Natl Acad Sci U S A, J Cell Physiol, Invest Ophthalmol Vis Sci, Am J Physiol Cell Physiol等雜誌上。目前主要研究興趣是代謝相關因子調控海馬可塑性以及心境障礙的機制。

代表性文章：

1. Yau SY*, Li A*, Xu A, So KF. Fat cell-secreted adiponectin mediates physical exercise-induced hippocampal neurogenesis: an alternative anti-depressive treatment? Neural Regen Res. 2015 Jan;10(1):7-9

2. Li A, Banerjee J, Leung CT, Peterson-Yantorno K, Stamer WD, Civan MM. Mechanisms of ATP release, the enabling step in purinergic regulation of aqueous humor dynamics. Cell Physiol Biochem. 2011 Dec 16; 28(6):1135-44

Original Articles

1. Yau SY*, Li A*, Hoo RLC, Ching YP, Christie BR, Lee TMC, Xu A, So KF. Physical exercise-induced hippocampal neurogenesis and antidepressant effect are mediated by adipocyte hormone adiponectin. Proc Natl Acad Sci U S A. 2014 Nov 4;111(44):15810-5.

2. Leung CT, Li A, Banerjee J, Gao ZG, Kambayashi T, Jacobson K, Civan MM. The role of activated adenosine receptors in degranulation of human LAD2 mast cells. Purinergic Signal. 2014 Sep;10(3):465-75

3. Yau SY, Li A, Zhang ED, Christie BR, Xu A, Lee TM, So KF. Sustained running in rats administered corticosterone prevents the development of depressive behaviors and enhances hippocampal neurogenesis and synaptic plasticity without increasing neurotrophic factors’ levels. Cell Transpl. 2014;23(4):481-92.

4. Chen S*, Fan Q*, Li A, Liao D, Ge J, Laties AM, Zhang X. Dynamic Mobilization of PGC-1α Mediates Mitochondrial Biogenesis for the Protection of RGC-5 Cells by Resveratrol during Serum Deprivation. Apoptosis. 2013 Jul;18(7):786-99.

5. Taruno A*, Vingtdeux V*, Ohmoto M, Ma Z, Dvoryanchikov G, Li A, Adrien L, Zhao H, Leung S, Abernethy M, Koppel J, Davies P, Civan MM, Chaudhari N, Matsumoto I, Hellekant G, Tordoff MG, Marambaud P, Foskett JK. CALHM1 ion channel mediates purinergic neurotransmission of sweet, bitter and umami tastes. Nature. 2013 Mar 14;495(7440):223-6.

6. Li A*, Banerjee J*, Peterson-Yantorno K, Stamer WD, Leung CT, Civan MM. Effects of cardiotonic steroids on trabecular meshwork cells: search for mediator of ouabain-enhanced outflow facility. Exp Eye Res. 2012 Mar; 96(1):4-12.

7. Li A, Leung CT, Peterson-Yantorno K, Stamer WD, Mitchell CH, Civan MM. Mechanisms of ATP release by human trabecular meshwork cells, the enabling step in purinergic regulation of aqueous humor outflow. J Cell Physiol. 2012 Jan; 227(1):172-82.

8. Li A, Leung CT, Peterson-Yantorno K, Stamer WD, Civan MM. Cytoskeletal dependence of adenosine triphosphate release by human trabecular meshwork cells. Invest Ophthalmol Vis Sci. 2011 Oct 10; 52(11):7996-8005

9. Li A*, Zhang X*, Zheng DY, Ge Jian, Laties AM, Mitchell CH. Sustained elevation of extracellular ATP in aqueous humor from humans with primary chronic angle-closure glaucoma. Exp Eye Res. 2011 Oct; 93(4):528-33

10. Li A, Leung CT, Peterson-Yantorno K, Mitchell CH, Civan MM. Pathways for ATP release by bovine ciliary epithelial cells, the initial step in purinergic regulation of aqueous humor inflow. Am J Physiol Cell Physiol. 2010 Dec; 299(6):C1308-17.

11. Wang X*, Teng L*, Li A, Ge J, Laties AM, Zhang X. TRPC6 channel protects retinal ganglion cells in a rat model of retinal ischemia/reperfusion-induced cell death. Invest Ophthalmol Vis Sci. 2010 Nov; 51(11):5751-8.