劉來華
劉來華
劉來華,中國農業大學教授,博導。
劉來華,男,英國劍橋大學(Cambridge Uni.)植物科學系,博士后研究員
中國農業大學特殊引進人才, 資源與環境學院植物營養(分子生物)學教授, 博士生導師
簡 歷2004.10-今 中國農業大學特殊引進人才, 資源與環境學院植物營養(分子生物)學教授, 博士導師2004.11-2006.01 英國劍橋大學(Cambridge Uni.)植物科學系,兼(獨立性)博士后研究員2003.03-2004.10 英國劍橋大學(Cambridge Uni.)植物科學系,博士后研究員1998.10-2002.12 德國蒂賓根大學植物分子生物學中心(ZMBP),理學(生物學)博士1996.08—1998.09 德國霍因海姆大學(Hohenheim Uni.)、蒂賓根大學(Tuebingen Uni.)工作 學 習1994.09—1996.06 中國農大資環學院,博士生1991.09—1994.07 中國農大資環學院,碩士 主要學術任職1) 現任國際學術刊物 《Plant Signaling & Behavior》的編委 (http://www.landesbioscience.com/journals/psb/index.php)2) 現任國際學術刊物《植物學研究》期刊的主編 (http://www.hanspub.org/Journal/br.html)3) 中南民族大學(生物學院)兼職教授(2011.1-2013.1)4) 湖南農業大學“神農學者講座教授”(2013.3-2016.3)5) 科技部國際項目評審專家6) 教育部學位中心評審專家7) 國家留學基金委項目評審專家8) 教育部國家科技計劃項目評審專家9) 北京市自然科學基金項目評審專家10) 浙江省自然科學基金項目外省評審專家11) 江蘇省科技諮詢專家12) 德國學術交流中心 (DAAD)-中國留學生項目評審專家
/Course Provided for PhD & Master Student1) Molecular Biology of Plant and Environment (In English), 碩士/博士生必修課2) Molecular Membrane Transport of nutrients and solutes in higher plants (in English), 碩士/博士生選修課受教育、論文、研究經歷/Education, Thesis and Research CareerFull professor (specially introduced/qualified professor) for Molecular Plant Physiology & Nutrition at the College of Resources and Environmental Sciences, China Agricultural University,Beijing, China, since 2004.11. Postdoctoral research associate at the Department of Plant Sciences, University of Cambridge, UK. “Novel Ion Channel In Plants: Functional characterization of glutamate receptors in Arabidopsis”, 2003.03-2006.01. Worked with Prof. Mark Tester and senior lecture Dr. Julia Davies.Dissertation (PhD) “Molecular cloning and biochemical characterization of urea transporters in Arabidopsis” at the ZMBP-Center for Plant Molecular Biology, University of Tuebingen, Germany, 1998.10-2002.12. Worked with Prof. Wolf B. Frommer and prof. Nicolaus von Wirén. Study of biology required for PhD-student qualification at the University of Tuebingen, Germany (exams in genetics, molecular biology, plant physiology and plant nutrition; exam in German language-“PNDS level” at Hohenheim University, 1996.08-1998.09.PhD study (not finished) at the College of Resources and Environmental Sciences, China Agricultural University, Beijing, China, 1994.09-1996.05. Supervisor: prof. Yuan-Chun Shi. Master thesis (M.Sc.) at the College of Resources and Environmental Sciences, China Agricultural University, Beijing, China “Modeling of nitrogen uptake and water use efficiency in winter wheat”, 1991-1994. Worked with Prof. Yun-Zhu Li.Bachelor thesis (B. Agr.) at the College of Agriculture, Hunan Agricultural University, Changsha, China “Effect of rare elements on the yield and quality of hemp”, 1982-1986. Worked with Prof. Xi-Zhi Wang.主要研究領域與項目 主要研究領域a) 生物膜蛋白基因在植物(氮素)養分吸收、抗逆生長及信號傳遞過程中的分子功能。b) 氮素吸收/轉運的分子生理機理c) 根系的分子發育與感應環境信號d) 植物矮生性生長發育的分子遺傳基礎 目前主要的研究課題/ Research Interest1) 氮素(如尿素、氨、氨基酸等)跨膜轉運的分子機理與提高作物的氮素利用率/ Molecular Physiology of Plant Nitrogen (e.g. urea, NH4+, NO3-, amino acids) Transport.2) 高等植物谷氨酸受體離子通道基因(GLR)的分子生物學功能 (e.g. 可能涉及到根系發生及形成、陽離子吸收與平衡、植物抗逆機制、鈣通道與信號傳遞等) / Biological Function of Glutamate Receptors (GLRs) in Plant e.g. Arabidopsis.3) 氮信號與根系形態形成及功能的分子機理/ Nitrogen Signaling (e.g. amino acids) -Directed Root Growth and Function.4) 高等植物水通道基因(Aquaporin)的分子生物學功能 (e.g. 植物的水分衡與抗旱機制、對生物小分子如尿素和氨等的運輸)/ Function of Water Channels in Plant Draught Stress Resistance and Small Molecule Movement (e.g. urea, ammonium, ect.) 5) 植物矮生性生長發育的分子生物學機理/ Molecular Mechanism of Plant Dwarfism 近新研究成果曾首次克隆並鑒定出高等植物(擬南芥)中主動及被動運輸尿素分子的基 (AtDUR3,TIP1;2/2;1/4;1) (2003),為高等植物特別是農作物高效吸收、利用尿素氮肥提供了新的分子生物學理論基礎。曾首次(合作)發現外源谷氨酸作為信號分子調控根系形態形成的特殊生物功能(2006)。曾首次(合作)發現、闡明高等植物谷氨酸受體蛋白的鈣通道功能並控制花粉管生長與發育(2011)。在研/已完成的科研項目/ Research Grants Awarded 中國農業大學引進人才基金課題,100萬,執行年限2005.1-2007.12。教育部高等學校博士學科點專項科研基金,主持,項目編號20060019040,題目"谷氨酸信號傳遞與根系形態形成的分子機理",執行年限2006.7-2009.6。科技部"863"專項課題基金,主持,項目編號2006AA10Z166, 題目"水稻有效吸收和同化尿素的基因分離、克隆及其功能鑒定",執行年限2006.12-2010.10。國家自然科學基金項目,主要參加,項目編號40671096, 題目"莠去津降解與污染土壤原位生物修復",執行年限2007.1-2009.12。國家自然科學基金項目,主持,項目編號30771288, 題目"谷氨酸作為信號分子調控根系生長發育的分子生物學機理研究",執行年限2008.1-2010.12。科技部(中國生物技術發展中心,CNCBD)與德國學術交流中心(DAAD)的“青年科學家德-中小組計劃項目”,中方主持人(德方負責人 Dr. Claus-Peter Witte ,伯林自由大學生物系),國科生便字[2009]004 號,“Improving nirtrogen use efficiency of rice by biotechnological modification of urea uptake and metabolism”,2009.1-2013.12。德方獲135 萬歐元,其中部分將用於中方科研人員前往德國開展合作研究的費用。http://www.fu-berlin.de/en/presse/fup/2009/fup_09_043/index.html。國家自然科學基金項目,主持,項目編號31070223, 題目“發掘水稻轉運和同化尿素的功能基因以探索氮肥高效利用的新途徑”。執行年限2011.01-2013.12。國家自然科學基金項目,主持,項目編號31270881, 題目“谷氨酸受體基因參與擬南芥根系生長響應外源氨基酸的分子功能研究”。執行年限2013.01-2013.12。橫向技術研發基金項目(湖南),主持,項目編號…, 題目“發掘控制基因在根細胞特異性表達的啟動子”。執行年限2013. 06-2016.5.31。主要學術論文與專利 主要代表性論文/Selected Publications23. G-Y. Shi, L-D. Zhang, Y. Huang, X-Y. Guo, X-W. Wang, D. Wang, L-H. Liu, Z-H. Li, and J-P. Hua (2013). Full-length cDNA libraries reveal gibberellins-DELLAs-mediated ROS signaling during salt stress in Upland Cotton (Gossypium hirsutum L.). Plant Science, under revision. (影響因子-IF 2.92)22. G-W. Liu, A-L. Sun, and L-H. Liu* (2013, *通訊作者/Corresponding author). Identification and functional analysis of maize DUR3 homolog in urea transport. J. Exp.Bot., in submission. (IF 5.35)21. Y-Y. Gong, Y-K. Feng, W-C. Nie, H-M. Shu, S-Q. Guo, and L-H. Liu* (2013). Construction and Verification of s Plant Expression Vector pCAMBIA2300-35S-GUS-CaMVterm. China Biotechnology, 33(3): 86-91. (In Chinese with the abstract in English). 鞏元勇,馮永坤,倪萬潮,束紅梅,郭書巧,劉來華* (2013)。植物表達載體pCAMBIA2300-35S-GUS-CaMVterm的構建及驗證。中國生物工程雜誌, 33(3): 86-91.20. D. Tapken, U. Anschütz, L-H. Liu, T. Huelsken, G. Seebohm, D. Becker and M. Hollmann (2013). A Plant Homolog of Animal Glutamate Receptors Is an Ion Channel Gated by Multiple Hydrophobic Amino Acids. Science Signaling, Vol 6 Issue 279 ra47 (DOI: 10.1126/scisignal.2003762). (IF 7.50 )19. W-H. Wang, G-W. Liu, F-Q. Cao, X-Y. Cheng, B-W. Liu, L-H. Liu* (2013). Inadequate root absorption may represent a major component limiting rice to use urease sole nitrogen source for growth. Plant & Soil, 363:191–200. (IF 2.64)18. Q-C. Song, F-Q. Cao, Y-Y. Gong, X-Y. Cheng, X-Y. Bi, L-H. Liu* (2012. *corresponding author). Current research progresses of amino acids uptake, transport and their biological roles in higher plants. Plant Nutrition & Fertilizer Science, 18(6):1507-1717. (In Chinese with the abstract in English) 宋奇超,曹鳳秋,鞏元勇, 程曉園,畢昕媛,劉來華* (2012). 高等植物氨基酸吸收與轉運及生物學功能的研究進展。植物營養與肥料學報,18(6):1507-1717. (國內核心期刊)17. W-H. Wang, B. Köhler, F-Q. Cao, G-W. Liu, Y-Y. Gong, S. Sheng, Q-C. Song, X-Y. Cheng, T. Garnett, M. Okamoto, R. Qin, B. Mueller-Roeber, M. Tester, and L-H. Liu* (2012). Rice DUR3 mediates high-affinity urea transport and plays an effective role in improvement of urea acquisition and utilization when expressed in Arabidopsis. New Phytologist, 193(2): 432-444. (IF 6.73)16. E. Michard, P.T. Lima, F. Borges, A.C. Silva, J.E. Carvalho, M. Gilliham, L-H. Liu, G. Obermeyer and J.A. Feijó (2011). Glutamate-Like-Receptors function as Ca2+ channels in pollen tubes and are regulated by D-serine produced by the pistil. Science, Vol. 332 (6028): 434-437. (IF 31.02)15. Y-Y. Gong, X-Q. Qu, Q-C. Song, Z-R. Zeng, S. Sheng, and L-H. Liu* (2011). Research progress on formation of Regulation root system morphology by glutamate. J. Agricul. Sci. & Tech., 13(1): 34-43. (In Chinese with the abstract in English) 鞏元勇,瞿小青,宋奇超,曾子芮,盛崧,劉來華* (2011). 谷氨酸調節根系形態建成的研究進展. 中國農業科技導報,13(1):34-43. (國內核心期刊)14. F-Q. Cao, AK. Werner, K. Dahncke, T. Romeis, L-H. Liu, and C-P. Witte (2010). Identification and Characterization of Proteins Involved in Rice Urea and Arginine Catabolism. Plant Physiology, 154(1): 98-108. (IF 6.55)13. 鞏元勇,瞿小青,程曉園,劉來華*(2010). 擬南芥超矮生型突變體的發現及其生長表型的鑒定,中國科技論文在線精品論文, 3(19):1974-1977.12. 鞏元勇,瞿小青,劉來華*(2010). 擬南芥根生長發育與應答外源谷氨酸機理中的重要遺傳因子的發現,中國科技論文在線精品論文, 3(7):660-664.11. F-Q. Cao, G-W. Liu, W-H. Wang, X-M. Wu, L-H. Liu* (2009). Molecular processes of urea metabolism and transport in higher plants. Chinese Bulletin of Botany, 44(3): 273-282. ((In Chinese with the abstract in English) 曹鳳秋,劉國偉,王偉紅,吳學民,劉來華* (2009). 高等植物尿素代謝及轉運的分子機理. 植物學報,44(3):273-282. (國內核心期刊)10. W-H. Wang, B. Köhler, F-Q. Cao and L-H. Liu* (2008). Molecular and Physiological Aspects of Urea Transport in Higher Plants. Plant Science, 175:467-477. (IF 2.95)9. S.J. Roy, M. Gilliham, B. Berger, P.A. Essah, C. Cheffings, A.J. Miller, L. Widdowson, R.J. Davenport, L-H. Liu, M.J. Skynner, J.M. Davies, P. Richardson, R.A. Leigh, and M. Tester (2008). Investigating glutamate receptor-like gene co-expression in Arabidopsis thaliana. Plant, Cell and Environment,31: 861-871. (IF 5.14)8. P. Walch-Liu, L-H. Liu, T. Remans, M. Tester, and B.G. Forde (2006). Evidence that L-glutamate can act as an exogenous signal to modulate root growth and branching in Arabidopsis thaliana. Plant Cell Physiology,47(8): 1045-1057. (IF 4.13)7. L-H. Liu, Y. Nakagawa-Yokoi, M. Gilliham, T. Fujiwara, J. Davies and M. Tester (2005). Molecular identification of the first crop urea transporter OsDUR3 in rice (Oryza sativa). C.J. Li et al. (Eds), Plant nutrition for food security, human health and environmental protection. pp. 106-107. Tsinghua University Press. Printed in Beijing, China.6. P.A. Essah, L-H. Liu, R. Davenport, R. Leigh, M.Tester (2005). Using the chemical-inducible RNA interference (RNAi) system to elucidate the function(s) of glutamate receptor homologues in Arabidopsis thaliana. C.J. Li et al. (Eds), Plant nutrition for food security, human health and environmental protection. pp. 122-123. Tsinghua University Press. Printed in Beijing, China.5. L-H. Liu, U. Ludewig, B. Gassert, WB. Frommer and N. von Wirén (2003). Urea transport by nitrogen regulated tonoplast intrinsic proteins in Arabidopsis. Plant Physiology. Vol.133: 1220-1228. (IF 6.55)4. L-H. Liu, U. Ludewig, WB. Frommer and N. von Wirén. (2003). AtDUR3 encodes a new type of high-affinity urea/H+ symporter in Arabidopsis. The Plant Cell, Vol.15: 790-800. (IF 9.25)3. Lai-Hua Liu and Nicolaus von Wirén N. (2001). Identification of members of the MIP family as urea transporters in Arabidopsis thaliana. WJ. Horst et al. (Eds.) Plant nutrition- Food security and sustainability of agro-ecosystems, pp. 26-27. Kluwer Academic Publishers, Netherlands.2. 李韻珠,王鳳仙,劉來華 (1999). 土壤水氮資源的利用與管理. 植物營養與肥料,5(3):206-213.1. 劉來華,李韻珠,綦雪梅,黃元仿, (1996). 冬小麥水氮有效利用的研究. 中國農業大學學報,1(5):67-73. 發明專利/Patents《與尿素吸收相關的蛋白及其編碼基因與應用》,中國,申請/授權號: 201010276055.7。