計劍

2000年 第六屆世界生物材料大會傑出博士后旅行獎。

2002年 第十七屆歐洲生物材料大會優秀青年科學家獎

2004年 國家教育部霍英東基金優選資助項目

2005年 國家教育部“新世紀優秀人才支持計劃”

2010年 獲國家傑出青年科學基金資助

主要從事生物醫用材料的應用基礎研究，在生命體系與材料界面的生物相容性和生物功能性方面開展了系統深入的研究，形成了採用過程仿生的自組裝行為製備具有結構和功能仿生的新型生物材料的研究特色，並將該原理應用到現代介入醫用材料和組織工程材料的設計和研發中。

1）心血管醫用材料和微創介入醫用材料

2）醫用材料的組織工程化設計

3）生物治療用智能納米微載體

4）新型固相基因傳遞體系的研究

5）仿生雙親聚合物的溶液和界面組裝

6）層層組裝構建生物相容性和生物功能性納米層狀超薄膜的研究

Dr. Jijian received a bachelor’s degree at Chemistry Department of Zhejiang University in 1992. He joined the department in 1997 after getting his PhD degree in the Institute of Polymer composites of Zhejiang University in 1997, and became an associated professor and full professor in 2000 and 2004, respectively. He teaches two undergraduate courses related to the polymeric composite and functional polymer and one Ph. D course related to polymer surface and interface. He has been doing research work in the polymeric biomaterials and biological interface for over 10 years and has published more than 50 research papers in peer reviewed international Journal.

His main research interest focuses on polymeric biomaterials and biological interface. Based on the biomimic strategy, several supramolecular self-assemble methods were explored to develop biocompatible and biofunctional materials. Electrostatic self –assembly” method, which based on the alternating physisorption of oppositely charged polyelectrolytes, was explored to develop several functional multilayer coating onto biomaterial to represent the desirable properties, such as anti-coagulation, promote cytocompatibility and control release of DNA. In following the biological perspective of glycocalyx, the poly(ethylene oxide) comb-like copolymers were explored to engineer glycocalyx-mimic surfaces, which reduce the non-specific interaction and end-tethered ligand to trigger biomolecules self-assemble. Get inspiration of the cell membrane structure, a kind of cell membrane biomimetic micelles were developed via supramolecular aggregation of a biomimetic amphiphilies. The biomimetic nano-carriers show low toxicity and high cell uptake ratio, which might be suitable as a carrier vehicle for delivering bioactive agents.

1.

在包括Advanced Materials, Biomaterials, Langmuir等核心期刊發表SCI, EI收錄論文90餘篇，影響因子大於6.0的10篇，大於3.0的36篇，獲國家發明專利12項。是我國具有自主知識產權的心動系列細胞膜仿生藥物塗層支架的主要發明人。

Quankui Lin , Xin Ding , Fuyu Qiu , Xiaoxiao Song , Guosheng Fu , Jian Ji*, In situ endothelialization of intravascular stents coated with an anti-CD34 antibody functionalized heparin–collagen multilayer, Biomaterials, 2010,31, 4017-4025 (2010 IF: 7.882)

2. Lan Jia, Jian-Ping Xu,* Di Li, Shao-Peng Pang, Yuan Fang, Zhe-Gang Song, Jian Ji*, Fluorescence detection of alkaline phosphatase activity with β-cyclodextrin-modified quantum dots, Chem. Commun., 46,7166-7168 (2010 IF: 5.787)

3. Wenbo Zhou, Jinyan Shao, Qiao Jin, Qingshan Wei, Jianguo Tang, Jian Ji*, Zwitterionic phosphorylcholine as a better ligand for gold nanorods cell uptake and selective photothermal ablation of cancer cells, Chem. Commun., 2010, 46, 1479-1481 (2010 IF: 5.787)

4. Gongyan Liu, Qiao Jin, Xiangsheng Liu, Liping Lv, Chaojian Chen, Jian Ji*， Biocompatible Vesicles Based on PEO-b-PMPC/α-Cyclodextrin Inclusion Complexes for Drug Delivery. Soft Matter, in press, (2010 IF: 4.457)

5. Fang-Ming Xu, Jian-Ping Xu*, Li-Ping Lv and Jian Ji*， Bowl- and porous sphere-shaped supramolecular assemblies and their application as templates for confined assembly of gold nanoparticles, Soft Matter, in press, (2010 IF: 4.457)

6. Leize Zhu, Yonggang Shangguan, Yixin Sun, Jian Ji*, Qiang Zheng, Rheological properties of redox-responsive, associative ferrocene-modified branched poly(ethylene imine) and its modulation by β-cyclodextrin and hydrogen peroxide, Soft Matter, 2010, 6, 5541-5546 (2010 IF: 4.457)

7. Qiao Jin, Gongyan Liu, Xiangsheng Liu, Jian Ji*, Photo-responsive supramolecular self-assembly and disassembly of an azobenzene-containing block copolymer, Soft Matter, 2010, 6, 5589-5595 (2010 IF: 4.457)

8. Jianping Xu, Xi Yang, Liping Lv, Yu Wei, Fangmin Xu, Jian Ji*, Gold Nanoparticles Stabilized Pluronic Micelles Exhibiting Glutathione Triggered Morphology Evolution Properties, Langmuir, 2010, DOI: 10.1021/la102929k. (2010 IF: 4.268)

9. Liyan Shen, Jinhong Fu, Ke Fu, Catherine Picart, Jian Ji*, Humidity Responsive Asymmetric Free-Standing Multilayered Film, Langmuir, 2010, DOI: 10.1021/la102928g (2010 IF: 4.268)

10. Wei Sun, Liyan Shen, Jiaming Wang, Ke Fu, Jian Ji*, Netlike Knitting of Polyelectrolyte Multilayers on Honeycomb-Patterned Substrate, Langmuir, 2010, 26(17),14236–14240 (2010 IF: 4.268)

11. Xiaofen Hu, Jian Ji*, Construction of Multifunctional Coatings via Layer-by-Layer Assembly of Sulfonated Hyperbranched Polyether and Chitosan, Langmuir, 2010, 26 (4), 2624-2629 (2010 IF: 4.268)

12. Qiao Jin, Gongyan Liu, Jian Ji*, Micelles and Reverse Micelles with a Photo and ThermoDouble-Responsive Block Copolymer, J. Polym. Sci.: Part A: Polym. Chem., 2010, 48, 2855–2861 (2010 IF: 3.894)

13. Jinhong Fu, Jian Ji*, Liyan Shen, Alexander Ku¨ller, Axe Rosenhahn, Jiacong Shen, and Michae Grunze*,pH-Amplified Exponential Growth Multilayers: A Facile Method to Develop Hierarchical Micro- and Nanostructured Surfaces, Langmuir, 2009, 25 (2), 672-675 (2010 IF: 4.268)

14. Xuefei Wang and Jian Ji*, Postdiffusion of Oligo-Peptide within Exponential Growth Multilayer Films for Localized Peptide Delivery, Langmuir, 2009, 25(19), 11664–11671 (2010 IF: 4.268)

15. 孫婕衎, 王雪飛, 計劍*, 層狀組裝：先進藥物控釋塗層材料的新選擇, 化學進展, 2009, 21, 2682-2688. (2010 IF: 0.56)

16. Qiao Jin, Jianping Xu, Jian Ji*, Jiacong Shen, Zwitterionic phosphorylcholine as a better ligand for stabilizing large biocompatible gold nanoparticles, Chem. Commun., 2008: 3058-3060 (2010 IF: 5.787)

17. Qingshan Wei, Jian Ji*, Jiacong Shen, Synthesis of near-infrared responsive gold nanorod/PNIPAAm core/shell nanohybrids via surface initiated ATRP for smart drug delivery, Macromol. Rapid Commun., 2008, 29: 645-650 (2010 IF: 4.365)

18. Wei Sun, Jian Ji*, Jiacong Shen, Rings of Nanoparticle-Decorated Honeycomb-Structured Polymeric Film: The Combination of Pickering Emulsions and Capillary Flow in the Breath Figures Method, Langmuir, 2008, 24: 11338-11341 (2010 IF: 4.268)

19. Liyan Shen, Jian Ji*, Jiacong Shen, Silver mirror reaction as an approach to construct superhydrophobic surfaces with high reflectivity, Langmuir, 2008, 24: 9962-9965 (2010 IF: 4.268)

20. Xiaolin Li, Jian Ji*, XiaoliWang , Youxiang Wang, Jiacong Shen, Stability and Drug Loading of the Spontaneous Vesicles of Comb-like PEG Derivates, Macromol. Rapid Commun., 2007, 28 (5): 660-665 (2010 IF: 4.365)

21. Ji Jian, Fu Jin-Hong, Shen Jia-Cong, Fabrication of a Superhydrophobic Surface from the Amplified Exponential Growth of a Multilayer, Adv. Mater., 2006, 18: 1441-1444 (2010 IF: 10.857)

22. Ren Ke-Feng, Ji Jian*, Shen Jia-Cong, Construction and enzymatic degradation of multilayered poly-l-lysine/DNA films, Biomaterials, 2006, 27(7): 1152-1159 (2010 IF: 7.882)

23. Ren Ke-Feng, Ji Jian*, Shen Jia-Cong, Tunable DNA release from cross-linked ultrathin DNA/PLL multilayered films, Bioconj. Chem.,2006, 17 (1): 77-83 (2010 IF: 5.002)

24. Li Xiao-Lin, Ji Jian*, Shen Jia-Cong, Spontaneous vesicle formation in aqueous solutions of comb-like PEG, Macromol. Rapid Commun., 2006, 27 (3): 214-218 (2010 IF: 4.365)

25. Ren Ke-Feng, Ji Jian*, Shen Jia-Cong, Construction of Polycation-based non-viral DNA Nanoparticles and Polyanion Multilayers via Layer-by-layer Self-assembly. Macromol. Rapid Commun., 2005, 26, 1633-1638 (2010 IF: 4.365)

26. Fu Jin-Hong, Ji Jian*, Shen Jia-Cong, Construction of Anti-adhesive and Antibacterial Multilayer Films Via Layer-by-layer Assembly of Heparin and Chitosan, Biomaterials, 2005, 26 (33): 6684-6692 (2010 IF: 7.882)

27. XuJian-Ping, Ji Jian*, Chen Wei-Dong , Shen Jia-Cong, Novel biomimetic polymersomes as polymer therapeutics for drug delivery, J. Control. Release, 2005, 107( 3): 502-512 (2010 IF: 7.164)

28. Ji Jian*, Zhu Hui-Guang, Shen Jia-Cong, Surface tailoring of poly(DL-lactic acid) by ligand-tethered amphiphilic polymer for promoting chondrocyte attachment and growth, Biomaterials, 2004, 25 (10): 1859-1867 (2010 IF: 7.882)

29. Zhu Hui-Guang, Ji Jian*, Shen Jia-Cong, Biomacromolecules Electrostatic Self-assembly on 3-Dimensional Tissue Engineering Scaffold, Biomacromolecules, 2004, 5(5):1933-1939 (2010 IF: 5.325)

30. Zhu Hui-Guang, Ji Jian*, Shen Jia-Cong, Construction of multilayer coating onto poly-(dl-lactide) to promote cytocompatibility, Biomaterials, 2004, 25:109-117 (2010 IF: 7.882)

31. Ji Jian*, Feng Lin-Xian, Shen Jia-Cong, ‘Loop’ or ‘Tail’? Self-assembly and Surface Architecture of Polystyrene-graft-w-stearyl-poly(ethylene oxide), Langmuir, 2003, 19, 2643-2648 (2010 IF: 4.268)

32. Tang Qing-Ging, Ji Jian*, Barbosa MA, Fonseca C., Shen Jia-Cong, Construction thromboresistant surface on biomedical stainless steel via layer-by-layer deposition antocoagulant, Biomaterials, 2003, 24, 4699-4705 (2010 IF: 7.882)

33. Zhu Hui-Guang, Ji Jian*, Tan Qing-Guang, M. A. Barbosa, Shen Jia-Cong, Surface Engineering of Poly (DL-lactide) via Electrostatic Self-assembly of Extracellular Matrix-like Molecules, Biomacromolecules, 2003, 4: 378-386 (2010 IF: 5.325)

34. Zhu Hui-Guang, Ji Jian*, Shen Jia-Cong, surface engineering of poly (DL-lactic acid) by entrapment of biomacromolecules, Macromol. Rapid Commun., 2002, 23, 819-823 (2010 IF: 4.365)

35. Zhu Hui-Guang, Ji Jian*, Lin Rong-Yi, Gao Chang-You, Feng Lin-Xian, Shen Jia-Cong, Surface engineering of poly(DL-lactic acid) by entrapment of alginate-amino acid derivatives for promotion of chondrogenesis, Biomaterials, 2002, 23 (15): 3141-3148 (2010 IF: 7.882)

36. Ji Jian*, Feng Lin-Xian, M. A. Barbosa, Stearyl poly(ethylene oxide) grafted surfaces as albumin preferential material, Biomaterials, 2001, 22(22): 3015-23 (2010 IF: 7.882)

37. Ji Jian*, Feng Lin-Xian, Qiu Yong-Xin, Yu Xiao-Jie, Stearyl poly(ethylene oxide) grafted surface as an albumin preferential materials 2 The effect of the molecule mobility onto protein adsorption, Polymer, 2000, 41, 3713-3718 (2010 IF: 3.828)

38. Ji Jian*, Feng Lin-Xian, Qiu Yong-Xin, Yu Xiao-Jie, ESR Spectroscopy as a probe of the molecular mobility of poly(ethylene oxide) amphiphilic graft copolymer Macromol. Rapid Commun., 1998, 19, 473-477 (2010 IF: 4.365)