朱孝峰
朱孝峰
2000年，朱孝峰在美國喬治城大學癌症中心結構生物學與抗癌藥物研究實驗室學習。榮獲第六屆中國藥理學會SERVIER青年藥理學工作者獎。《癌症》雜誌常務編務、《防癌報》編委，《中國科學》、《科學通報》、《Acta Pharmacologica Sinica》、《Planta Med》等雜誌特約審稿人。近幾年來先後承擔國家自然科學基金四項，國家高新技術發展計劃（863計劃）分題，廣東省自然科學基金，廣東省科技計劃項目，廣州市科技計劃項目等項目。發表論文40餘篇，其中在國際SCI收錄雜誌發表論文19篇，主編專著二部。申請專利五項，其中二項為國際專利，二項中國發明專利已獲授權。作為主要研究人員之一完成的阿諾寧脂肪乳注射液抗腫瘤作用研究已轉讓企業開發。主要從事研究領域包括：腫瘤信號轉導途徑及靶向腫瘤異常信號轉導途徑的藥物研究。
近年發表的主要論文與專著(*為通訊作者)
1) Deng R, Li W, Guan Z, Zhou JM, Wang Y, Mei YP, Li MT, Feng GK, Huang W, Liu ZC, Han Y, Zeng YX, Zhu XF*. Acetylcholinesterase expression mediated by c-Jun-NH2-terminal kinase pathway during anticancer drug-induced apoptosis. Oncogene, 2006 May 22; [Epub ahead of print]
2) Zhou JM, Zhu XF*, et al. Senescence and telomere shortening induced by novel potent G-quadruplex interactive agents, quindoline derivatives, in human cancer cell lines. Oncogene, 2006, 25, 503-511
3) Zhu XF, et al. Blockade of VEGF receptor signal pathway and antitumor activity of ON-III, a component from Chinese herbal medicine. Mol Pharmacol, 2005, 67(5):1444-1450.
4) Zhu JJ, Li FB, Zhou JM, Liu ZC, Zhu XF*, et al. The Tumor Suppressor p33(ING1b) Enhances Taxol-induced Apoptosis by p53-Dependent Pathway in Human Osteosarcoma U2OS Cells. Cancer Biol Ther, 2005,4(1):39-47.
5) Mei YP, Zhu XF*, et al. siRNA targeting LMP1-induced apoptosis in EBV-positive lymphoma cells is associated with inhibition of telomerase activity and expression. Cancer Letters, 2006, 232, 189-198
6) Zhu JJ, Li FB, Zhu XF*, et al. The p33(ING1b) tumor suppressor cooperates with p53 to induce apoptosis in response to etoposide in human osteosarcoma cells. Life Sciences, 2006, 78(13):1469-77
7) Zhu XF*, et al. SUCI02 inhibits the erbB-2 tyrosine kinase receptor signaling pathway and arrests the cell cycle in G phase in breast cancer cells. Cancer Science, 2006, 97(1): 84-89
8) Zhu XF, et al. Ceramide induces cell cycle arrest and upregulates p27kip in nasopharyngeal carcinoma cells. Cancer Letters, 2003, 193(2):149-155.
9) Zhu XF, et al. EGFR tyrosine kinase inhibitor AG1478 inhibits cell proliferation and arrests cell cycle in nasopharyngeal carcinoma cell line CNE2. Cancer Letters, 2001, 169 (1): 27-32.
10) Wang ZW, Zhou JM, Huang ZS, Yang AP, Liu ZC, Xia YF, Zeng YX, Zhu XF*. Aloe polysaccharides mediated radioprotective effect through the inhibition of apoptosis. J Radiat Res, 2004, 45 (3): 447-454.
11) Zhu XF, et al. Involvement of Caspase-3 Activation in Squamocin-induced Apoptosis in Leukemia Cell line HL-60. Life Sciences, 2002, 70(11):1259-1269.
近年來申請的專利
1) 紫草萘醌類衍生物及其在製備抗癌藥物中的應用。中國專利號：ZL02114973.9
2) Houttuyninum compositions and methods for inhibiting the activity of erbB-2 based thereon. 國際專利申請號：PCT/US01/43123。
3) 脂肪氨基取代喹啉衍生物及其製備方法和製藥用途。中國專利號：ZL200310112457.3；國際專利申請號：PCT/CN2004/000175。
4) 碘化-3，3’-二乙基-9-甲基-硫雜羰花青的抗腫瘤新用途。中國專利申請號：02134263.6。
5) 人表皮生長因子受體2酪氨酸激酶抑製劑。中國專利申請號：200410052496.3