郭麗

1995年在四川大學化工學院晉陞副教授

2000年～2001年德國Tuebingen大學有機化學研究所,博士后工作

2003年在四川大學華西藥學院晉陞教授,2004年聘為博士生導師

2007～至今華西藥學院藥物化學系主任

社會兼職

四川省學術和技術帶頭人後備人選，四川省衛生廳學術和技術帶頭人，四川省新葯評審委員會、四川省科技計劃項目評審專家

研究領域

1.多官能團分枝狀化合物的研究

2.化合物的合成研究

發表論文

（2012～）在國內外核心期刊上發表科研論文90多篇。

1.Novel Dendritic Naproxen Prodrugs with Poly(aspartic acid) Oligopeptide: Synthesis and Hydroxyapatite Binding In Vitro,Synthetic Communications,2012,42,3441-3451

2.Synthesis and preliminary evaluation of novel amphiphilic Janus dendrimers for bone-targeted drug delivery，Tetrahedron,2012,68,2943-2949

3.Synthesis, antibacterial activity and cytotoxicity of novel Janus peptide dendrimers, synlett，2012, 23,1937-1940

4.Dual-targeting delivery system for bone cancer: synthesis and preliminary biological evaluation, Drug Delivery，2012,19(7),317-326

5.徠Design and synthesis of novel Janus dendrimers as lipophilized antioxidants，synlett. 2013,24(8), 1011-1015

6.Dual-targeting Janus dendrimer based peptides for bone cancer: synthesis and preliminary biological evaluation, Letters in Organic Chemistry，2013,10(8),594-601

7.Design, synthesis and biological evaluation of enzymatically cleavable NSAIDs prodrugs derived from self-immolative dendritic scaffolds for the treatment of inflammatory diseases，Bioorganic Medicinal Chemistry，2013,21(14),4192-4200

8.Molecular Docking, QSAR and Molecular Dynamics Simulation on Spiro-oxindoles as MDM2 Inhibitors，Acta Chimica Sinica，2013,71,1396-1403

9.Multicomplex-Based Pharmacophore and QSAR of Aryl-sulfamides as Pyruvate Kinase M2 Activators, Acta Physico-Chimica Sinica,2013.29,1793-1803

10.Synthesis of cis or trans 4-heteroaromatic substituted furano and pyrano[3,2-c] tetra- hydroquinolines by onepot imino diels-alder reactions, Heterocycles, 2013, 87(12),2495- 2500

11.Synthesis and Intestinal Absorption Evaluation Of oligopeptide Prodrugs Based On PepT1, West China J.Pharm.Sci., 2013,28(3),223-225

12.Preparation and Characterization of Glycyrrhetinic Acid-Modified Poloxamer 188/Chitosan Nanoparticles. NANO: Brief Reports and Reviews, 2013, 8(4), 1350042-1-8

13.Cell-penetrable lysine dendrimers for anti-cancer drug delivery: synthesis and preliminary biological evaluation，Archiv der Pharmazie, 2014, 347, 469-477

14.Dimer and Tetramer of Gallic Acid: Facile Synthesis, Antioxidant and Antiproliferative Activities，Letters in Drug Design & Discovery, 2014, 11, 27-32

15.Diastereoselective，Three-component ，Reaction of Chiral Nickel(II)， Glycinate for Convenient Synthesis of Novel α-amino-β-substituted-γ,γ-disubstituted butyric Acid, Molecules,2014,19,826-845

16.Discovery and in Vivo Evaluation of Novel RGD-Modified Lipid-Polymer Hybrid Nanoparticles for Targeted Drug Delivery, Int. J. Mol. Sci., 2014,15, 17565-17576

17.Design, synthesis and biological evaluation of brain targeting L-ascorbic acid prodrugs of ibuprofen with “lock-in” function, European Journal of Medicinal Chemistry, 2014,82,314-323

18.Efficient Synthesis of Substances Related to Cinacalcet Hydrochloride via Heck Coupling，Synthetic Communications，2014，44，2879-2885

19.A novel and convenient route for the construction of 5-((1H-1,2,4-triazol-1-yl)methyl) -1H-indoles and its application in the synthesis of Rizatriptan, Tetrahedron Letters, 2014,55,3938-3941

20.Preparation and characterization of glycyrrhetinic acid-modified poly(ethylene glycol)-poly(β-benzyl-L-asparate) nanoparticles as liver- targeted delivery system, Colloid Polym Sci. ,2015,293,319-328

21.Synthesis and Preliminary Evaluation of Novel Bone-targeting NSAIDs Prodrugs based on Glutamic Acid Oligopeptides, Letters in Drug Design & Discovery, 2015, 12, 585-590

22.First synthesis of novel 3,30-bipyridazine derivatives as new potent antihepatocellular carcinoma agents, Tetrahedron, 2015, 71,7670-7675

23.First synthesis and characterization for the stereoisomers of Ulipristal acetate, Steroids ,2015,95,7-16

24.First synthesis and characterization of stereoisomers of choleretic drug dihydroxydibutylether, Chin. J. Chem. 2015, 33, 1145-1152

25.Novel naproxen-peptide-conjugated amphiphilic dendrimer self-assembly micelles for targeting Drug delivery to osteosarcoma cells，RSC Adv.,2016, 6,60327-60335

26.Efficient Synthesis of Fully Substituted Pyrrolidine-fused 3-Spirooxindoles via 1,3-Dipolar Cycloaddition of Aziridine and 3-Ylideneoxindole ,Molecules ,2016, 21,1113-1128

27.Copper-γ-cyclodextrin complexes immobilized on hexagonal boron nitride as an efficient catalyst in the multicomponent synthesis of 1,2,3-triazoles，Journal of Catalysis，2016,344，286-292

28.First synthesis of 22-oxa-chenodeoxycholic acid analogue，Steroids， 2016,110,70-76

29.Report on the Synthesis of Isatins via Pyridinum Chlorochromate Catalyzed Intromolecular Cyclization Reactions,Synlett,2016,27,1292-1296

30.Ru(III)-mediated intramolecular ortho-C(sp2)-H activation/oxidative acylation: one-pot synthesis of isatins from α-hydroxy amides，Tetrahedron，2016，72，3193-3197

31.Synthesis Study on the Three Stereoisomers of 4-(3-Hydroxylbutoxy)-2-butanol, Chemical Journal of Chinese Universities-Chinese,2016,37,493-497

32.Synthesis and Preliminary Study of Indole Croconium as Photoacoustic Imaging Contrast Agent[J]. Chinese Journal of Synthetic Chemistry, 2017, 25(4): 287-290

33.Ligand-free C-C coupling reaction promoted by hexagonal boron nitride-supported Palladium(II) catalyst in water,Adv.Synth.Catal.,2017,359,454-466

研究成果

1.教育部留學回國人員啟動基金項目“新型分子酶大分子的合成及初步生物活性的研究”、2003-2004,項目負責人；

2.國家自然科學基金項目“新型樹狀多聚活性肽化合物的合成及初步生物活性的研究”、2005-2007,項目負責人

3.四川大學振興計劃引進人才基金“酶法多肽及樹狀化合物合成研究”,2002-,項目負責人

編寫教材

負責四川省精品課程《藥物化學》，編寫國家級規劃教材《藥物化學》、《有機化學》等。