劉景根
劉景根
后在軍事醫學科學院從事博士后研究工作。1998年至2003年先後在美國阿肯色醫科大學疼痛神經生物學實驗室和藥理毒理系從事研究工作。2003年7月應聘到中國科學院上海藥物所工作。新葯研究國家重點實驗室研究員、博士生導師、課題組長。中國科學院“百人計劃”入選者, 2004年獲國家傑出青年科學基金。主要從事阿片類藥物耐受、成癮的細胞和分子機理研究。
現任中國科學院上海藥物研究所研究員,課題組長,博士生導師。美國神經科學學會會員,美國藥理和實驗治療學會會員,上海市生理學會理事、中國神經精神藥理專業委員會委員,中國生化和分子藥理專業委員會委員。中國藥理學通報,中國藥物依賴性雜誌編委。1996年在中國藥科大學獲理學博士學位,專業神經藥理學。后在軍事醫學科學院從事博士后研究工作。1998年至2003年在美國阿肯色醫科大學疼痛神經生物學實驗室和藥理毒理系阿片受體信號轉導實驗室從事研究工作。2003年7月應聘到中國科學院上海藥物所工作。中國科學院“百人計劃”學者,2004年獲國家傑出青年科學基金。主要從事阿片類藥物耐受、成癮的細胞和分子機理研究。已在國際和國內重要學術期刊上發表了二十多篇論文,並應邀為國際學術期刊Brain Research Review 寫綜述一篇。發表的論文已被40多種期刊,200多篇文獻引用。申請發明專利1項。
1979年9月-1983年7月,江西中醫學院,理學學士學位
1990年9月-1993年7月,中國藥科大學,理學碩士學位
1993年9月-1996年9月,中國藥科大學,理學博士學位
1983年8月-1990年8月,江西撫州第一製藥工作,工程師
1996年10月-1998年10月,軍事醫學科學院,博士后
1998年11月-2003年6月,美國阿肯色醫科大學藥理毒理系,研究員
2003年7月至今,中國科學院上海藥物研究所,研究員、課題組長
主要從事阿片類藥物成癮的細胞和分子機理研究及低成癮性阿片類鎮痛葯和戒毒藥研究
1.973,阿片類物質精神依賴的神經生物學機制,課題負責人,2009-2013
2.國家自然科學基金基金重點項目,杏仁核突觸結構重排調節阿片類藥物負性情緒記憶形成的分子機理研究,課題負責人,2012-2016
3.國家自然科學基金基金重大研究計劃(培育)項目,杏仁核和腹內側前額皮層染色質組白乙醯化修飾在嗎啡戒斷引起的負性情感消退學習中的作用研究,課題負責人,2013-2015
4.973,遺忘的功能和機制研究,研究骨幹,2013-2017
6.上海市重點項目,海馬突觸骨架重塑及PICK蛋白表達釺調控嗎啡戒斷負性記憶形成的分子機制研究,課題負責人,2013-2016
現兼任中國神經精神藥理專業委員會常務委員、中國生化和分子藥理專業委員會常務委員,河南省天然藥物與免疫工程重點實驗室學術委員會委員。上海市神經藥理學專業委員會主任委員、上海市生理學會常務理事、上海市藥理學會理事、上海市第二屆禁毒專家委員會委員。浙江大學兼職教授,中國藥科大學兼職博士生導師。中國藥理學報、藥學學報 (英文版)、中國藥學(英文版)、中國藥理學通報、神經藥理學報,中國藥物依賴性雜誌編委。
2004年,中國科學院“百人計劃”、國家傑出青年科學基金
2007年,“上海領軍人才”
2011年,葯明康德生命化學獎三等獎
1. Sun JF, Wang YH, Chai JR, Li FY, Hang A, Lu G, Tao YM, Cheng Y, Chi ZQ, Neumeyer JL, Zhang A, Liu JG, Wang YJ (2014) Pharmacological characterization and therapeutic potential for the treatment of opioid abuse with ATPM-ET, an N-ethyl substituted aminothiazolomorphinan with κ agonist and μ agonist/antagonist activity. Eur J Pharmacol.
2. Wang WS, Chen ZG, Liu WT, Chi ZQ, He L, Liu JG (2014) Dorsal hippocampal NMDA receptor blockade impairs extinction of naloxone-precipitated conditioned place aversion in acute morphine-treated rats by suppressing ERK and CREB phosphorylation in the basolateral amygdala. Br J Pharmacol.
3. Li M, Liu WJ, Lu B, Wang YH, Liu JG* (2013) Differential expression of Arc in the mesocorticolimbic system is involved in drug and natural rewarding behavior in rats. Acta Pharmacol Sin
4. Kang S, Ling QL, Liu WT, Lu B, Liu Y, He L, Liu JG* (2013) Down-regulation of dorsal striatal RhoA activity and impairment of working memory in middle-aged rats. Neurobiol Learn Mem
5. Wang J, Wang YH, Hou YY, Xi T, Liu Y, Liu JG* (2013) The small GTPase RhoA, but not Rac1, is essential for conditioned aversive memory formation through regulation of actin rearrangements in rat dorsal hippocampus. Acta Pharmacol Si
6. Liu Y, Zhou QX, Hou YY, Lu B, Yu C, Chen J, Ling QL, Cao J, Chi ZQ, Xu L*, Liu JG* (2012) Actin polymerization-dependent increase in synaptic Arc/Arg3.1 expression in the amygdala is crucial for the expression of aversive memory associated with drug withdrawal. J Neurosci
7. Wang WS, Kang S, Liu WT, Li M, Liu Y, Yu C, Chen J, Zhi-Qiang Ch ZQ, He L, and Jing-Gen Liu JG* (2012) Extinction of aversive memories associated with morphine withdrawal requires ERK-mediated epigenetic regulation of brain-derived neurotrophic factor transcription in the rat ventromedial prefrontal cortex. J Neurosci
8. Lu G, Zhou QX, Kang S, Li QL, Zhao LC, Chen JD, Sun JF, Cao J, Wang YJ, Chen J, Chen XY, Zhong DF, Chi ZQ, Xu L*, Liu JG* (2010) Chronic morphine treatment impaired hippocampal LTP and spatial memory via accumulation of extracellular adenosine acting on adenosine A1 receptors. J Neurosci
9. Xu C, Hong MH, Zhang LS, Hou YY, Wang FF, Chen YJ, Xu XJ, Chen J, Xie X, Ma L, Chi ZQ, Liu JG* (2010) Serine 363 Residue of δ-Opioid Receptor is Crucial for Adopting Distinct Pathways to Activate ERK1/2. J Cell Sci
10. Sun JF, Wang YH, Li FY, Lu G, Tao YM, Cheng Y, Chen J, Xu XJ, Chi ZQ, John L Neumeyer JL, Zhang A, Liu JG* (2010) Effects of ATPM-ET, a novel κ agonist with partial μ activity on morphine physical dependence and expression of morphine sensitization. Acta Pharmacol Sin
11. Lu B, Li M, Hou YY, Chen J, Chi ZQ, Liu JG* (2010) Initial experience of heroin use under a two-chained operant schedule influences drug-seeking behavior after one month of abstinence. Acta Pharmacol Sinica
12. Wang YH, Sun JF, Tao YM, Chi ZQ, Liu JG* (2010) The role of kappa-opioid receptor activation in mediating antinociception and addiction. Acta Pharmacol Sin
13. Wang YH, Sun JF, Tao YM, Xu XJ, Chi ZQ, Liu JG, * (2010) Paradoxical relationship between RAVE (relative activity versus endocytosis) values of several opioid receptor agonists and their liability to cause dependence. Acta Pharmacol Sinica
14. Cheng Y, Tao YM, Sun JF, Wang YH, Xu XJ, Chen J, Chi ZQ, Jing-gen Liu JG* (2010)Adenosine A1 receptor agonist CHA induced phosphorylation of delta opioid receptor and desensitization of its signaling. Acta Pharmacol Sinica
15. Hou YY, Lu B, Li M, Liu Y, Chen J, Chi ZQ, and Liu JG* (2009) Involvement of actin rearrangements within the amygdala and the dorsal hippocampus in aversive memories of drug withdrawal in acute morphine dependent rats. J Neurosc
16. Hong MH, Xu C, Wang YJ, Ji JL, Tao YM, Xu XJ, Chen J, Xie X, Zhi-Qiang Chi ZQ, Liu JG* (2009) Role of Src in Ligand-specific Regulation of δ-opioid Receptor Desensitization and Internalization. J Neurochem
17. Wang YJ, Tao YM, Xu XJ, Chen J, Cao YL, Chi ZQ, Liu JG* (2009) Pharmacological Characterization of ATPM-AZ, a Novel Mixed κ Agonist and μ Agonist/Antagonist That Attenuates Morphine Antinociceptive Tolerance and Heroin Self-Administration Behavior. J Pharmacol Exp Ther
18. Lin X, Wang YJ, Huo YY, Li Q, Chi ZQ, Liu JG* (2009) Morphine promotes SH-SY5Y cell apoptosis through c-Jun N-terminal kinase-mediated activation of mitochondria-dependent apoptosis pathway. FEBS J
19. Li F, Gao L, Yin C, Chen J, Chi ZQ, Liu JG, Xie X,, Zhang A (2009) Synthesis and opioid receptor activity of indolopropellanes. Bioorg Med Chem Lett
20. Li W, Tao YM, Ang Y, Xu XJ Chen J, Wang XH, Chao B, Sheng W, Chi ZQ, Qiu ZB*, Liu JG* (2010) Unexpected potent and highly selective μ-opioid agonists discovered by substituting an omitted region of 4, 5-epoxymorphinanes. Bioorg Med Chem Let
21. Li F, Yin C, Chen J, Liu JG, Xie X, Zhang A (2009) Synthesis and SAR study of opioid receptor ligands: mono- and bis-Indolomorphinans. Chem Biol Drug Des
22. Li M, Hou YY, Lu B, Chen J, Chi ZQ, Liu JG* (2009) Neural synaptic plasticity marker-Arc expression pattern in different brain regions induced by conditioned drug withdrawal from acute morphine dependent rats. Acta Pharmacol Sinic
23. Hou YY, Liu Y, Kang S, Yu C, Chi ZQ, Liu JG* (2009)Glutamate receptors within the dorsal hippocampus mediate the acquisition, but not the expression, of conditioned place aversion induce induced by acute morphine withdrawal. Acta Pharmacol Sinica
24. Li F, Yin C, Chen J, Liu JG*, Xie X*, Zhang A* (2009) [6,7]-Heterocycle-Fused 14-Hydroxymorphinan derivatives: design, synthesis, and opioid receptor activity ChemMedChem.