徐丹

徐丹：武漢大學，基礎醫學院藥理學系，副教授

學科專業：藥理學

研究方向：藥物發育毒理

學習經歷：

2007/09 -2010/06，武漢大學，基礎醫學院藥理學系，博士

2005/09-2007/06，武漢大學，基礎醫學院藥理學系，碩士

2000/09-2005/06，武漢大學，醫學院臨床醫學專業，學士

主要工作經歷與任職

2013/01-至今，武漢大學，基礎醫學院藥理學系，副教授

2011/01 -2012/12，武漢大學，基礎醫學院藥理學系，講師

2010/07 -2012/06，武漢大學，生命科學學院發育生物學，博士后

2010/07-2010/12，武漢大學，基礎醫學院藥理學系，助教

目前主要科學研究領域和興趣

主要從事外源物發育毒理和胎源性疾病發病機制研究。在前期研究中，系統證實了孕期外源物（咖啡因、尼古丁）暴露所致宮內發育遲緩（IUGR）子代成年下丘腦-垂體-腎上腺（HPA）軸相關疾病（如脂肪肝、抑鬱症）易感的胎兒起源現象，創新性提出咖啡因、尼古丁所致胎HPA軸軸神經內分泌代謝編程改變是引起IUGR仔鼠成年HPA軸相關疾病易感的胎兒起源機制。

教學情況：

承擔研究生、本科生、留學生（全英）的教學; 積極開展教學研究；發表教學論文1篇；參編教材1部。

近5年代表性論文

(1)Xu D, Wu Y, Liu F, Liu YS, Shen L, Lei YY, Liu J, Ping J, Qin J, Zhang C, Chen LB, Magdalou J, Wang H. A hypothalamic–pituitary–adrenal axis-associated neuroendocrine metabolic programmed alteration in offspring rats of IUGR induced by prenatal caffeine ingestion. Toxicol Appl Pharmacol.2012; 64(3): 395-403

(2)Xu D, Zhang BJ, Liang G, Ping J, Kou H, Li XJ, Xiong J, Chen LB, Magdalou J, Wang H*. Caffeine-induced activated glucocorticoid metabolism in hippocampus causes hypothalamic-pituitary-adrenal axis inhibition in fetal rats. PLoS ONE. 2012; 7(9): e44497.

(3)Liu YS, Xu D (co-first author), Feng JH, Kou H, Liang G, Yu H, He XH, Zhang BF, Chen LB, Magdalou J, Wang H*. Fetal rat metabonome alteration by prenatal caffeine ingestion probably due to the increased circulatory glucocorticoid level and altered peripheral glucose and lipid metabolic pathways. Toxicol Appl Pharmacol. 2012; 15; 262(2): 205-16.

(4)Xu D, Liang G, Yan YE, He WW, Liu YS, Chen LB, Magdalou J, Wang H*. Nicotine-induced over-exposure to maternal glucocorticoidand activated glucocorticoid metabolism causes hypothalamic-pituitary-adrenal axis-associated neuroendocrine metabolic alterations in fetal rats. Toxicol Lett. 2012; 209(3): 282-90.

(5)Xu D, Chen M, Pan XL, Xia LP, Wang H*. Dexamethasone induces fetal developmental toxicity through affecting the placental glucocorticoid barrier and depressing fetal adrenal function. Environ Toxicol Pharmacol. 2011; 32(3): 356-63. 被國際生物和醫學論文評價系統“Faculty of 1000”選為“推薦”論文（http://f1000.com/14264021）

(6)Xu D, Chen M, Guo Y, Liang G, Zhang B, Tan J, Magdalou J, Wang H. Synergistic antifibrotic effect of verapamil and interferon-gamma in rats: partially based on enhanced verapamil oral bioavailability. Eur J Gastroenterol Hepatol. 2010; 22(4): 466-73.

(7)Xu D, Zhang BJ, Ping J, Liang G, Liu F, Kou H, Wang H*. Intrauterine Origin of Caffeine-Induced High Susceptibility to Adult Metabolic Syndrome: Alleviated Glucocorticoid Inactivation Alters the Neuroendocrine Metabolic Programming of Fetal Rats. 17th North American Regional ISSX Meeting. Drug Metabol Rev. 2011; 43: S2 146. Abstract.

(8)Xu D, Zhang BJ, Ping J, Wang H*. Synergistic Antifibrotic Effect of Verapamil and Interferon-γ in Rats: A Mechanism Based Partially on Enhanced Verapamil Oral Bioavailability. 2th Asian Pacific Regional ISSX Meeting. Drug Metabol Rev. 2008; 40: 176-7. Abscract.