劉鑫

學習經歷： 1994-1998年畢業於武漢大學生命科學學院94級生物基地班，本科

2000-2005年在武漢大學生命科學學院病毒系，研究生

2005-2008年在哈佛大學醫學院，博士后

工作經歷：2009年至今，武漢大學藥學院

研究領域：

1.與腫瘤相關的血管生成機理研究；

2.抗腫瘤藥物及相關作用機制研究；

3.抗病毒藥物的機理研究

研究興趣與方向：主要方向為治療腫瘤，抗病毒的蛋白質藥物研發

教學課題：

生物工程製藥雙學位（本科）

生理生化技術及藥學進展（研究生）

承擔課題：主持和參與國家自然科學基金，973課題等。

代表性論文：

1.Ai S, Duan J, Liu X, Bock S, Tian Y, Huang Z.Biological Evaluation of a Novel Doxorubicin-Peptide Conjugate for Targeted Delivery to EGF Receptor-Overexpressing Tumor Cells. Mol Pharm. 2011 Feb 2.

2. Liu X*, Zhao D*, James L, Li J, Zeng H.Requirement of the nuclear localization oftranscription enhancer factor 3 for proliferation, migration, tube formation, and angiogenesis induced by vascular endothelial growth factor. FASEB J. 2010 Dec 17.( *Co-first author)

3. Huang Y*, Liu X*, Dong LL, Liu ZC, He XH, and Liu WH “Development of Viral Vectors for Gene Therapy for Chronic Pain,” Pain Research and Treatment,2011(*Co-first author)

4. Liu X, Zhao D, Qin L, Li J, Zeng H Transcription Enhancer Factor 3 (TEF3) Mediates the Expression of Down Syndrome Candidate Region 1 Isoform 1 (DSCR1-1L) in Endothelial Cells. J Biol Chem. 2008 Dec 5;283(49):34159-67. Epub 2008 Oct 7

5.徠 Qin L, Zhao D, Liu X, Nagy JA, Hoang MV, Brown LF, Dvorak HF, Zeng H.Down syndrome candidate region 1 isoform 1 mediates angiogenesis through the calcineurin-NFAT pathway. Mol Cancer Res. 2006 Nov;4(11):811-20.

6．Liu X*, Zhou W*., Qi Y., et al. Expression of SLAM (CDw150) on SF9 cell surface mediates Measles Viral infection in the nonpermissive cells through SLAM/MVH interaction Microbes Infect. 2005 Aug-Sep;7(11-12):1235-45. (*Co-first author)

7.Xu Q, Zhang P, Hu C, Liu X, Qi Y Identification of amino acid residues involved in the interaction between measles virus Haemagglutin (MVH) and its human cell receptor (signaling lymphocyte activation molecule, SLAM).J Biochem Mol Biol. 2006 Jul 31;39(4):406-11.

8. Xu H, Zhou Q, Liu X, Qi Y Co-involvement of the mitochondria and endoplasmic reticulum in cell death induced by the novel ER-targeted protein HAP. Cell Mol Biol Lett. 2006;11(2):249-55.

9. Hu C, Zhang P, Liu X, et al. “Characterization of a region involved in binding of Measles virus H protein and its receptor SLAM (CD150).” Biochemical and Biophysical Research Communications. 2004,31:698-704.

10. Hu C., Qi Y., Zhang P., Liu X., Xu Q., Chen X. Is mRNA and protein level of CD46 altered in measles virus vaccine strain S191-infected cells? Biochemical and Biophysical Research Communications. 2004, 322:794-802.

11. Gan M., Qi Y.,Wan Q.,Kuang E.S.,Liu Q.Z.., Liu X. , Mammalian apoptosis-inducing protein, HAP, induces bacterial cell death Molecular Biology Reports , 2004,31:159-164