張勁松

2009.3— 安徽農業大學 茶與食品科技學院

2002.3─2009.2 中國科學技術大學 化學與材料科學學院

2000.3─2002.2 Institute of Food Research, Norwich, UK

1999.8─2000.2 中國科學技術大學 化學與材料科學學院

1988.9─1999.7 國家煙草專賣局 合肥經濟技術學院

學習經歷

2002.9─2004.7 中國科學院 固體物理研究所 博士

1985.9─1988.7 安徽農學院 茶業系 碩士

1981.9─1985.7 安徽農學院 茶業系 學士

全國優秀教師。

第三屆中國優秀青年科技創業獎。

茶與健康、茶與硒生物效應相互影響<3,4>(23,26,28)，硒研究涉及硒毒性、藥效、營養和酶靶。

硒毒性：發明納米硒並闡述其高安全性(1,2,4-6,9,13,20,24,26)，基於納米硒低毒特徵，FDA毒理學研究中心前任主任邀請參編兩部毒理學專著<1,2>，納米硒為衛生部批准的保健食品，屬國家級新產品。

硒藥效：發明硒代硫酸鈉與一線化療葯順鉑聯用治療腫瘤，在肝癌模型上，順鉑至多取得25%治癒率，聯用至少產生75%治癒率(8,15,19,25)，Cancer Weekly三次報道該項研究進展。

硒營養：發現硒與西蘭花中萊菔硫烷協同誘導硫氧還蛋白還原酶，硒與西蘭花可能是防癌伴侶(3)，BBC News, The Times, The Guardian, Genomics and Genetics Weekly, Cancer Weekly等報道此發現。

硒酶靶：基於動物實驗，說明硫氧還蛋白還原酶是抗癌藥的葯靶和毒靶(7,11,12,17,18,21,27)，美國Threshold Pharmaceuticals公司邀請評價抗癌新葯TH-302藥理，發現它抑制該酶活力(22)。

專著章節

<4> Zhang L, Wu S, Wang D, Wan X, Zhang J*. Epigallocatechin-3-gallate (EGCG) in or on nanoparticles: Enhanced stability and bioavailability of EGCG encapsulated in nanoparticles or targeted delivery of gold nanoparticles coated with EGCG. In: Casciano D, Sahu SC (eds) Handbook of Nanotoxicology, Nanomedicine and Stem Cell Use in Toxicology. John Wiley & Sons. Invited chapter in preparation. (* communication author)

<3> Zhang L, Zhang Z, Lu Y, Zhang J, Preedy VR. L-theanine from green tea: Transport and effects on health. In: Preedy VR (ed) Tea in Health and Disease Prevention. Academic Press. pp 425-435, 2012.

<2> Zhang J*, Spallholz J. Toxicity of selenium compounds and nano-selenium particles. In: Casciano D, Sahu SC (eds) Handbook of Systems Toxicology. John Wiley & Sons. pp 787-802, 2011.

<1> Zhang J*. Biological properties of red elemental selenium at nano size (Nano-Se) in vitro and in vivo. In: Sahu SC, Casciano D (eds) Nanotoxicity: From In Vivo and In Vitro Model to Health Risks. John Wiley & Sons. pp 97-114, 2009.

論文評審

第一或通訊作者25篇，第二作者3篇，篇均影響因子4.2，他引超過500次(Web of Science)。Chemical Reviews、Journal of the American Chemical Society、Biomaterials等15種SCI期刊21次邀請論文評審。

(28) Sun K, Wu S, Wang Y, Wan X, Thompson HJ, Zhang J*. High-dose sodium selenite toxicity cannot be prevented by the co-administration of pharmacological levels of epigallocatechin-3-gallate which in turn aggravates the toxicity. Food Chem. Toxicol. 52:36–41, 2013.

(27) Wang Y, Lu H, Wang D, Li S, Sun K, Wan X, Taylor EW, Zhang J*. Inhibition of glutathione synthesis eliminates the adaptive response of ascitic hepatoma 22 cells to nedaplatin that targets thioredoxin reductase. Toxicol. Appl. Pharmacol. 265:342-350, 2012.

(26) Wang D, Taylor EW, Wang Y, Wan X, Zhang J*. Encapsulated nanoepigallocatechin-3-gallate and elemental selenium nanoparticles as paradigms for nanochemoprevention. Int. J. Nanomedicine 7:1711–1721, 2012.

(25) Li J, Sun K, Ni L, Wang X, Wang D, Zhang J*. Sodium selenosulfate at an innocuous dose markedly prevents cisplatin-induced gastrointestinal toxicity. Toxicol. Appl. Pharmacol. 258:376-383, 2012.

(24) Zhang J*, Taylor EW, Wan X, Peng D*. Impact of heat treatment on size, structure, and bioactivity of elemental selenium nanoparticles. Int. J. Nanomedicine 7:815–825, 2012.

(23) Lu Y, Zhang J, Wan X, Long M, Li D, Lei P, Zhang Z. Intestinal transport of pure theanine and theanine in green tea extract: Green tea components inhibit theanine absorption and promote theanine excretion. Food Chem. 125:277-280, 2011.

(22) Li S, Zhang J*, Li J, Chen D, Matteucci M, Curd J, Duan J. Inhibition of both thioredoxin reductase and glutathione reductase may contribute to the anticancer mechanism of TH-302. Biol. Trace Elem. Res. 136:294-301, 2010.

(21) Wang X, Zhang J*, Xu T. Cyclophosphamide-evoked heart failure involves pronounced co-suppression of cytoplasmic thioredoxin reductase activity and non-protein free thiol level. Eur. J. Heart Failure 11:154-162, 2009.

(20) Zhang J*, Wang X, Xu T. Elemental selenium at nano size (Nano-Se) as a potential chemopreventive agent with reduced risk of selenium toxicity: comparison with se-methylselenocysteine in mice. Toxicol. Sci. 101:22-31, 2008.

(19) Zhang J*,Peng D, Lu H, Liu Q. Attenuating the toxicity of cisplatin by using selenosulfate with reduced risk of selenium toxicity as compared with selenite. Toxicol. Appl. Pharmacol. 226:251-259, 2008.

(18) Zhang J*, Wang X, Lu H. Amifostine increases cure rate of cisplatin on ascites hepatoma 22 via selectively protecting renal thioredoxin reductase. Cancer Lett. 260:127-136, 2008.

(17) Wang X, Zhang J*, Xu T. Thioredoxin reductase inactivation as a pivotal mechanism of ifosfamide in cancer therapy. Eur. J. Pharmacol. 579:66-73, 2008.

(16) Zhang J*, Wang H, Peng D, Taylor EW. Further insight into the impact of sodium selenite on selenoenzymes: High-dose selenite enhances hepatic thioredoxin reductase 1 activity as a consequence of liver injury. Toxicol. Lett. 176:223-229, 2008.

(15) Zhang J*, Lu H, Wang X. Sodium selenosulfate synthesis and demonstration of its in vitro cytotoxic activity against HepG2, Caco2 and three kinds of leukemia cells. Biol. Trace Elem. Res. 125:13-21, 2008.

(14) Li H, Zhang J, Wang T, Luo W, Zhou Q, Jiang G. Elemental selenium particles at nano size (Nano-Se) are more toxic to Medaka (Oryzias latipes) as a consequence of hyper-accumulation of selenium: A comparison with sodium selenite. Aquat. Toxicol. 89:251-256, 2008.

(13) Wang H, Zhang J*, Yu H. Elemental selenium at nano size possesses lower toxicity without compromising the fundamental effect on selenoenzymes: comparison with selenomethionine in mice. Free Radic. Biol. Med. 42:1524-1533, 2007.

(12) Zhang J*, Lu H. Ifosfamide induces acute renal failure via inhibition of the thioredoxin reductase activity. Free Radic. Biol. Med. 43:1574-1583, 2007.

(11) Wang X, Zhang J*, Xu T. Cyclophosphamide as a potent inhibitor of tumor thioredoxin reductase in vivo. Toxicol. Appl. Pharmacol. 218:88-95, 2007.

(10) Zhang J*, Wang H, Yu H. Thioacetamide-induced cirrhosis in selenium-adequate mice displays rapid and persistent abnormity of hepatic selenoenzymes which are mute to selenium supplementation. Toxicol. Appl. Pharmacol. 224:81-88, 2007.

(9) Peng D, Zhang J*, Liu Q, Taylor EW. Size effect of elemental selenium nanoparticles (Nano-Se) at supranutritional levels on selenium accumulation and glutathione S-transferase activity. J. Inorg. Biochem. 101:1457-1463, 2007.

徠(8) Peng D, Zhang J*, Liu Q. Effect of sodium selenosulfate on restoring activities of selenium-dependent enzymes and selenium retention compared with sodium selenite in vitro and in vivo. Biol. Trace Elem. Res. 117:77-88, 2007.

(7) Zhang J*, Ma K, Wang H. Cyclophosphamide suppresses thioredoxin reductase in bladder tissue and its adaptive response via inductions of thioredoxin reductase and glutathione peroxidase. Chem Biol. Interact. 162:24-30, 2006.

(6) Zhang J*, Wang H, Yan X, Zhang L. Comparison of short-term toxicity between Nano-Se and selenite in mice. Life Sci. 76:1099-1109, 2005.

(5) Zhang J*, Wang H, BaoY, Zhang L. Nano red elemental selenium has no size effect in the induction of seleno-enzymes in both cultured cells and mice. Life Sci. 75:237-244, 2004.

(4) Huang B#, Zhang J#, Hou J, Chen C. Free radical scavenging efficiency of Nano-Se in vitro. Free Radic. Biol. Med. 35:805-813, 2003. (# contributed equally)

(3) Zhang J, Svehlíková V, Bao Y, Howie AF, Beckett GJ, Williamson G. Synergy between sulforaphane and selenium in the induction of thioredoxin reductase 1 requires both transcriptional and translational modulation. Carcinogenesis 24:497-503, 2003.

(2) Gao X, Zhang J, Zhang L. Hollow sphere selenium nanoparticles: their in-vitro anti hydroxyl radical effect. Adv. Mater. 14:290-293, 2002.

(1) Zhang J, Gao X, Zhang L, Bao Y. Biological effects of a nano red elemental selenium. Biofactors 15:27-38, 2001.