王進

1999年畢業於四川大學，獲材料學博士學位，現為先進材料技術教育部重點實驗室，人工器官表面工程四川省重點實驗室研究成員以及材料科學與工程學院教師。現為中國材料研究學會會員，中國生物材料學會會員。曾在香港城市大學物理及材料科學系從事合作研究工作，擔任副研究員（Associated Researcher）。

本科教學

本科生：有機化學基礎、高分子化學。

碩士研究生：高等高分子化學。

博士研究生：醫用高分子材料。

招生信息

1、生物醫學工程、材料科學與工程、高分子材料與工程、藥學、分子生物學等專業的博士、碩士研究生。

2、生物醫學工程本科畢業設計、大學生科研創新訓練計劃等。

主要研究方向為（1）高分子生物材料及表面改性－抗凝血性高分子材料、抗菌性高分子材料表面構建和性能評價，（2）具有藥物控制釋放功能的高分子材料支架塗層製備與評價的相關研究，（3）等離子體聚合物的製備及生物化構建。

主持二項國家自然科學基金項目，一項國家自然科學基金重點項目子項目及新世紀人才基金。作為主要研究人員參加了1項“973”、2項“863”、3項國家自然科學基金項目、1項教育部骨幹教師項目，其中作為第一作者在國際、國內重要核心期刊、會議上發表論文70餘篇，SCI收錄18篇，EI收錄13篇，ISTP收錄14篇。

主持的科研項目有：

1、等離子體聚氧乙烯功能化薄膜的合成及其抗生物粘附特性研究（51173149）60萬元，國家自然科學基金（主持），2012.1-2015.12.

2、時序功能性血管支架與植入周圍環境的相互作用與調控（81330031）290萬元，國家自然科學基金重點項目（主研），2014.1-2018.12.

3、材料誘導幹細胞定向分化的微環境及其構建（2011CB606204）184萬元，國家重點基礎研究發展（973計劃）（主研），2011.1-2015.12.

已結題的科研項目：

1、醫用金屬器械表面具有生物化功能的等離子體聚合薄膜的構建及生物醫學行為研究（NCET-07-0715）50萬元，教育部新世紀人才支持計劃（主持），2008.1-2010.12.

2、介入器械表面等離子體聚合薄膜的抗凝血結構設計與控制（50673081）28萬元，國家自然科學基金（主持），2007.1-2009.12.

3、滌綸人工心臟瓣膜縫合環的抗菌表面改性及機理研究（50203011）23萬元，國家自然科學基金（主持），2003.1-2005.12.

4、誘導抗凝血生物化表面的設計與構建（2005CB623904）215萬元，國家重點基礎研究發展計劃（973計劃）（主研），2005.10-2010.9.

5、抗凝血、抗感染的表面改性新型人工心臟瓣膜（863計劃，G19990964706），國家高技術研究發展計劃（863計劃）（主研），2006.12-2010.12.

6、藥物塗層/鈦氧薄膜塗層冠狀動脈支架技術1000萬（主研），項目成果轉化， 2007.1-2012.12.

科研團隊：

研究小組在本學科學術帶頭人黃楠教授所領導的研究團隊中從事相關工作，本小組主要成員如下：

1、2009級博士生：楊志祿 陳思；

2、2010級博士生：李欣；

3、2011級博士生：羅日方；

4、2012級博士生：劉慶利；

5、2013級博士生張皓；

6、2010級碩士生：李擁虎、陳瑞、吳婧、溫煦；

7、2011級碩士生：王鑫、湯淋淋、李小靜、鍾司；

8、2012級碩士生：劉玉潔、張江、袁書恆；

9、2013級碩士生：申芳瑜、李文君、羅森。

論文：2014

(1) Zhilu Yang, Kaiqing Xiong, Pengkai Qi, Ying Yang, Qiufen Tu, Jin Wang*, Nan Huang*, Gallic Acid Tailoring Surface Functionalities of Plasma-Polymerized Allylamine-Coated 316L SS to Selectively Direct Vascular Endothelial and Smooth Muscle Cell Fate for Enhanced Endothelialization. ACS Appl. Mater. Interfaces, 2014, DOI: 10.1021/am405124z,

(2) Si Chen, Xin Li, Zhilu Yang, Shuo Zhou, Rifang Luo, Manfred M. Maitz, Yuancong Zhao, Jin Wang*, Kaiqin Xiong, Nan Huang, A simple one-step modification of various materials for introducing effective multi-functional groups. Colloids and Surfaces B: Biointerfaces, 2014; 113: 125-133.

(3) Si Zhong1, Rifang Luo1, Xin Wang,Linlin Tang, Jian Wu*, Jin Wang*, Runbo Huang, Hongsun, Nan Huang, Colloids and Surfaces B: Biointerfaces, 2014, in press,

2013

(4) Zhilu Yang1, Ying Yang1, Wei Yan, Qiufen Tu, Jin Wang*, Nan Huang, Construction of polyfunctional coatings assisted by gallic acid to facilitate co-immobilization of diverse biomolecules. ACS Appl. Mater. Interfaces, 2013; 5: 10495-10501.

(5) Rifang Luo, Linlin Tang, Si Zhong, Zhilu Yang, Jin Wang*, Yajun Weng, Qiufen Tu, Chongxi Jiang, Nan Huang, In Vitro Investigation of Enhanced Hemocompatibility and Endothelial Cell Proliferation Associated with Quinone-Rich Polydopamine Coating. ACS Appl. Mater. Interfaces, 2013; 5: 1704?1714.

(6) Rifang Luo, Linlin Tang, Jin Wang*, Yuancong Zhao, Qiufen Tu, Yajun Weng, Ru Shen, Nan Huang, Improved immobilization of biomolecules to quinone-rich polydopamine for efficient surface functionalization, Colloids and Surfaces B Biointerfaces. 2013; 106: 66-73.

(7) 陳瑞，劉玉潔，李欣，王進*，孫鴻，黃楠，等離子體類聚氧乙烯薄膜的製備及性能研究. 功能材料, 2013; 44: 3255-3260.

2012

(8) Zhilu Yang, Qiufen Tu, Jin Wang*, Nan Huang*, The role ofheparin binding surfaces in the direction of endothelial and smooth muscle cell fate and re-endothelialization. Biomaterials, 2012; 33: 6615-6625.

(9) Zhilu Yang, Qiufen Tu, Ying Zhu, Rifang Luo, Xin Li, Yichu Xie, Manfred F. Maitz, Jin Wang*, Nan Huang, Mussel-Inspired Coating of Polydopamine Directs Endothelial and Smooth Muscle Cell Fate for Re-endothelialization of Vascular Devices. Advanced Healthcare Materials, 2012; 1: 548-559.

(10) Zhilu Yang1, Shuo Zhou1, Lei Lu, Xin Wang, Jin Wang*, Nan Huang*, Construction and hemocompatibility study of highly bioactive heparin-functionalized surface, Journal of Biomedical Material Research part A. 2012; 100A: 3124-3133.

(11) Zhilu Yang, Jin Wu, Xin Wang, Jin Wang*, Nan Huang*, Inspired chemistry for a simple but highly effective immobilization of vascular endothelial growth factor on gallic acid-functionalized plasma polymerized film, Plasma Processes and Polymers. 2012; 9: 718-725.

(12) Tingting He, Zhilu Yang, Rui Chen, Jin Wang*, Yongxiang Leng, Hong Sun, Nan Huang, Enhanced endothelialization guided by fibronectin functionalized plasma polymerized acrylic acid film, Materials Science and Engineering: C. 2012; 32: 1025-1032.

(13) Zhilu Yang, Jin Wang*, Xin Li, Qiufen Tu, Hong Sun, Nan Huang, Interaction of platelets, fibrinogen and endothelial cells with plasma deposited PEO-like films, Applied Surface Science. 2012; 258: 3378-3385.

2011

(14) Zhilu Yang, Qiufen Tu, Jin Wang*, Xingjiang Lei, Tingting He, Hong Sun, Nan Huang. Bioactive Plasma-Polymerized Bipolar Films of Protonated Functionality for Enhanced Endothelial Cellular Mobility. Macromolecular Bioscience. 2011;11:797-805.

(15) Zhilu Yang, Xingjiang Lei, Jin Wang*, Rifang Luo, Tingting He, Hong Sun, Nan Huang. A Novel Technique Toward Bipolar Films Containing Alternating Nano–Layers of Allylamine and Acrylic Acid Plasma Polymers for Biomedical Application. Plasma Processes and Polymers. 2011;8:208-214.

(16) Zhilu Yang, Jin Wang, Rifang Luo, Tingting He, Si Chen, Xingjiang Lei, Hong Sun, Nan Huang. Improved Hemocompatibility Guided by Pulsed Plasma Tailoring the Surface Amino Functionalities of TiO2 Coating for Covalent Immobilization of Heparin. Plasma Processes and Polymers. 2011;8：850-858.

(17) 吳雷剛，吳婧，侯瑞霞，王進*，黃楠. 他克莫司－聚三亞甲基碳酸酯藥物洗脫支架塗層研究。功能材料. 2011; 42(11): 1954-1957.

(18) 俞洪飛，趙元聰，王進*. 磷酸膽鹼表面改性滌綸材料及抗凝血性研究. 功能材料. 2011; 42(7): 1265-1268.

2010

(19) Zhilu Yang, Jin Wang, Rifang Luo, Manfred F. Maitz, Fengjuan Jing, Hong Sun, Nan Huang. The covalent immobilization of heparin to pulsed plasma polymeric allylamine films on 316L stainless steel and the resulting effects on hemocompatibility. Biomaterials. 2010;31:2072-2083.

(20) Xiaona Wang, Jin Wang, Zhilu Yang, Yongxiang Leng, Hong Sun, Nan Huang. Structural characterization and mechanical properties of functionalized pulsed-plasma polymerized allylamine film. Surface and Coatings Technology, 2010; 204(18-19): 3047-3052.

(21) Xiaoqing Xue, Jin Wang*, Ying Zhu, Qiufen Tu, Nan Huang. Biocompatibility of pure titanium modified by human endothelial cell-derived extracellular matrix. Applied Surface Science, 2010; 256: 3866-3873.

(22) Ruixia Hou, Leigang Wu, Jin Wang*, Nan Huang. Investigation on biological properties of tacrolimus-loaded poly(1,3-trimethylene carbonate) in vitro. Applied Surface Science, 2010; 256: 5000-5005.

2004-2009

(23) Zhilu Yang, Xiaona Wang, Jin Wang*, Ye Yao, Hong Sun, Nan Huang. Pulsed-Plasma Polymeric Allylamine Thin Films. Plasma Processes and Polymers. 2009;6:498-505.

(24) 左文瑾，王進，楊志祿，孫鴻，黃楠，聚乙烯吡咯烷酮等離子體接枝改性聚丙烯的親水性及抗凝血性研究. 功能材料. 2009; 40: 667-669, 673.

(25) Ren Jingrun, Wang Jin*, Sun Hong, Huang Nan. Surface modification of polyethylene terephthalate with albumin and gelatin for improvement of anticoagulation and endothelialization. Applied Surface Science, 2008; 255: 263-266.

(26) 楊志祿，王進*，孫鴻，陳俊英，黃楠. 等離子體聚合沉積聚烯丙胺薄膜改性聚酯及體外血小板黏附研究. 功能材料. 2008; 39(9): 1559-1561, 1566.

(27) 任玲，王進*，唐家駒，潘長江，黃楠. 含薑黃素的（丙交酯－乙交酯）共聚物薄膜對血管平滑肌細胞增殖的影響. 生物醫學工程學雜誌. 2008; 25( 4): 874-877.

(28) 王海波，王進*，王曉娜，孫鴻，黃楠，等離子體聚合薄膜改性醫用不鏽鋼及內皮細胞黏附行為研究。功能材料. 2008; 39(7): 1193-1196.

(29) 唐家駒，王進*，潘長江，任玲，黃楠。薑黃素/聚乳酸—乙醇酸共聚物複合薄膜的製備及抗凝血研究. 生物醫學工程學雜誌. 2008; 25(1): 113-116.

(30) 閆峰，王進，楊志祿，張釗，孫鴻，黃楠.白蛋白固定等離子體聚烯丙胺薄膜及體外血小板粘附行為. 生物醫學工程研究. 2008; 27(4): 268-271.

(31) J. X. Li, J. Wang*, L. R. Shen, Z. J. Xu, P. Li, G. J. Wan, N. Huang. The influence of polyethylene terephthalate surfaces modified by silver ion implantation on bacterial adhesion behavior. Surface & Coatings Technology, 2007; 201: 8155-8159.

(32) 侯瑞霞，翁亞軍，王進*，王志浩，冷永祥，黃楠. Ti-O－N表面肝素分子的共價固定及抗凝血性研究。無機材料學報, 2007; 22(5): 996-1000.

(33) Jin Wang, Jianxin Li, Ling Ren, Ansha Zhao, Peng Li, Yongxiang Leng, Hong Sun, Nan Huang. Antibacterial activity of silver surface modified polyethylene terephthalate by filtered cathodic vacuum arc method, Surf. Coat. Tech.. 2007; 201: 6893-6896.

(34) Wang Jin, Li Jianxin, Shen Liru, Ren Ling, Xu Zejin, Zhao Ansha, Leng Yongxiang, Huang Nan. The biomedical properties of polyethylene terephthalate surface modified by silver ion implantation, Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms. 2007; 257: 141-1456.

(35) J. Wang, J.Y. Chen, P. Yang, Y.X. Lenga, G.J. Wan, H. Sun, A.S. Zhao, N. Huang, P.K. Chu. In vitro platelet adhesion and activation of polyethylene terephthalate modified by acetylene plasma immersion ion implantation and deposition. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms. 2007; 242:12-14.

(36) Wang Jin, Tang Jiaju, Ren ling, Pan Changjiang, Huang Nan, Effect of rapamycin/curcumin co-loaded poly(Lactide-Co-Glycolide) films on blood compatibility and vascular smooth muscle cell proliferation. Key Engineering Materials. 2007; 342-343: 317-320.

(37) Tang Jiaju, Wang Jin*, Pan Changjiang, Weng Yajun, Huang Nan, Anticoagulation and drug release behavior of curcumin-loaded PLGA films. Key Engineering Materials. 2007; 342-343: 481-484.

(38) L. Ren, J. Wang*, J.J. Tang, Ch.J. Pang, M. Maitz, N. Huang, Biological evaluation of sirolimus-loaded PLGA films. Key Engineering Materials. 2007; 342-343:837-840.

(39) Jianxin Li, Jin Wang,* Peng Li, Yajun Weng, Ling Ren, Xueling Fei,Hong Sun, Nan Huang, Ozone-induced immobilization of chitosan and heparin on polyethylene terephthalate films to improve antithrombogenic properties. Key Engineering Materials. 2007; 342-343:809-812.

(40) J. Wang, J.Y. Chen, P. Yang, Y.X. Lenga, G.J. Wan, H. Sun, A.S. Zhao, N. Huang, P.K. Chu. In vitro platelet adhesion and activation of polyethylene terephthalate modified by acetylene plasma immersion ion implantation and deposition. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms. 2006; 242:12-14.

(41) 王進，潘長江，李鵬，冷永祥，陳俊英，萬國江，楊蘋，孫鴻，黃楠. 醫用滌綸材料表面類金剛石塗層的表面自由能參數對細菌粘附的影響. 生物醫學工程學雜誌. 2006; 23(2): 342-345.

(42) 李建新，王進*，沈麗如，許澤金，陳燕，李鵬，黃楠. 銀離子注入表面改性滌綸材料的抗菌性能研究. 真空科學與技術學報. 2006; 26(5): 408-411.

(43) 唐家駒，潘長江，洪瑋，王進*，黃楠. 大黃素/聚乳酸物複合薄膜的製備及抗凝血研究. 功能材料. 2006; 37(8): 1312-1313, 1317.

(44) Wang, J., Pan C.J., Huang, N., Sun, H., Yang, P., Leng, Y.X., Chen, J.Y., Wan, G.J., Chu, P.K., Surface characterization and blood compatibility of poly(ethylene terephthalate) modified by plasma surface grafting.Surface & Coatings Technology.2005; 196: 307-11.

(45) Wang J., Li P., Sun H., Yang P., Leng Y. X., Chen J.Y., Huang N.. Blood Compatibility of Chitosan Immobilized on Poly(Ethylene Terephthalate) Surface Modified by Plasma and Ultraviolet Grafting. Key Engineering Materials. 2005; 288-289: 327-330.

(46) 王進，Kwok S.C.H.，陳俊英，楊萍，黃楠，Chu P. K..磷摻雜類金剛石薄膜的製備與性能研究。真空科學與技術學報. 2005; 25(2):123-126.

(47) Wang J., Huan, N., Yang P., Leng Y.X., Sun H., Liu Z.Y., Chu, P.K.. The effects of amorphous carbon films deposited on polyethylene terephthalate on bacterial adhesion. Biomaterials. 2004; 25: 3163-70.

(48) Wang J., Huang, N., Pan, C.J., Kwok, S.C.H., Yang, P., Leng, Y.X., Chen, J.Y., Sun H., Wan G.J., Liu Z.Y., Chu P.K.. Bacterial repellence from polyethylene terephthalate surface modified by acetylene plasma immersion ion implantation-deposition. Surface & Coatings Technology. 2004; 186: 299-304.

(49) Wang J., Pan C.J., Kwok S.C.H., Yang P., Chen J.Y., Wan G.J., Huang N., Chu P.K.. Characteristics and anticoagulation behavior of polyethylene terephthalate modified by C2H2 plasma immersion ion implantation-deposition. Journal of Vacuum Science & Technology A (Vacuum, Surfaces, and Films). 2004; 22: 170-5.

1. 王進，楊志祿，黃楠，冷永祥，趙元聰，一種具有高生物功能性的肝素化界面材料製備方法，中國發明專利ZL201110195704.5，授權時間2013年7月31日；

2. 王進，楊志祿，冷永祥，孫鴻，黃楠，基於類聚乙二醇的可回收下腔靜脈濾器表面膜製備方法，中國發明專利ZL201110277736.X，授權時間2013年6月12日；

3. 王進，黃楠，楊蘋，孫鴻，冷永祥，陳俊英，萬國江，趙安莎，游天雪，吳熹，一種具有抗菌功能的人工心臟瓣膜縫合環滌綸材料，中國發明專利ZL200810046050.8，授權日2011年12月；

4. 黃楠，侯瑞霞，王進，吳雷剛，一種具有防再狹窄塗層的血管支架及其製備方法，2012.5，中國發明專利ZL200910216008.0，授權日2012年5月。

黃楠，王進譯《生物材料科學：醫用材料導論》（顧中偉，劉偉、俞耀庭等譯校）第7章第3節--- “心血管醫療器械”，科學出版社，2011.06。

1、 2013年獲批四川省有突出貢獻的優秀專家；

2、四川省科技進步一等獎（2007，排名第五）：鈦基抗凝血薄膜材料研究；

3、 2007年入選教育部新世紀人才培養計劃。