陳大華
中國科學院動物研究所研究員
陳大華,男,博士,研究員,博士生導師,1965年2月畢業於復旦大學物理系,中國科學院動物研究所計劃生育生殖生物學國家重點實驗室副主任,模式動物與幹細胞生物學研究組組長。國家傑出青年基金獲得者、新世紀百千萬人才工程國家級人選。1999年中國科學院植物研究所獲理學博士學位。
陳大華
國家自然科學基金委資助項目(課題負責人);國家自然科學基金重點項目(2007-2010);“小分子RNA(microRNAs)控制果蠅生殖幹細胞命運的分子機制”
科技部資助項目;科技部生殖發育重大計劃(課題負責人)(2007-2011); “配子發生關鍵基因的功能研究”(2007CB947502)
Xia L, Zheng X, Zheng W, Zhang, Wang H, Tao Y, Chen D. 2012 The Niche-Dependent Feedback Loop Generates a BMP Activity Gradient to Determine the Germline Stem Cell Fate. Current Biology,22, 1–7
Xia L, Jia S, Huang S, Wang H, Zhu Y, Mu Y, Kan L, Zheng W, Wu D, Li X, Sun Q, Meng A, Chen D.* 2010,The Fused/Smurf complex controls the fate of Drosophila germline stem cells by generating a gradient BMP response. Cell, 143(6):978-90
Chen, D-S., Wang, Q., Huang, H., Xia, L., Kan, L., Sun, Q., and Chen D.* 2009, The specific ubiquitin-mediated proteolysis of cyclin A determines the fate of germline stem cells in Drosophila. Development, 136(24):4133-42.
Yang, Y., Xu, S., Xia, L., Wang, J., Jin, P*., and Chen, D.* 2009 The bantam microRNA is associated with Drosophila Fragile X mental retardation protein and regulates the fate of germline stem cells. PLoS Genetics, 5(4):e1000444.
Chang, S., Wen, S., Chen, D* and Jin, P* Small regulatory RNAs in neurodevelopmental Disorders.? Hum Mol Genet,18(R1):R18-26.
Jiang, X., Xia, L., Chen, DS, Yang, Y., Huang, H., Yang, L., Zhao, Q., Sheng, L., Wang, J., and Chen, D.* 2008, Otefin, a nuclear membrane protein, determines the fate of germline stem cells in Drosophila via interaction with Smads complexes. Developmental Cell, 14(4):494-506.
Allan, A., Liang, X., Luo, Y., Pak, C., Li, X., Szulwach, K., Chen, D., Jin, P., Zhao, X. 2008, The loss of methyl-CpG binding protein 1 leads to autism-like behavioral deficits. Hum Mol Genet. 17(13):2047-57.
Yang, L., Chen, D., Duan, R., Xia, L., Wang, J., Qurashi, A., Jin, P*., and Chen, D.* 2007, Argonaute 1 regulates the fate of germline stem cells in Drosophila. Development,134(23):4265-72.
Yang, L., Duan, R., Chen, DS., Wang, J., Chen, D.* and Jin, P* 2007 Fragile X mental retardation protein modulates the fate of germline stem cells in Drosophila. Hum Mol Genet,16(15):1814-20.
獲獎記錄
2016年11月獲得談家楨生命科學創新獎。