劉忠

學習經歷：　2003-2008，博士學位，中山大學（2003-2005）/香港理工大學（2005-2008）。

1999-2003，學士學位，中山大學。

工作經歷：

2009至今：暨南大學生命科學技術學院/ 生物醫藥研究院/ 生物醫藥研究開發基地。

《高等生物化學》，《細胞信號傳導與技術》，《生物信息學》。

1. 細胞生物學及化學生物學：靶向抗腫瘤、抗病毒藥物研發及藥物作用機制。

2. 生物信息學及化學信息學：基於重要疾病靶標的計算機輔助藥物設計與應用，藥物虛擬篩選，蛋白質結構預測及分子相互作用預測，生物信息數據分析，量子化學計算。

1.國家自然科學基金青年科學基金項目，基於靶標TrxR 的新型曼宋酮F類似物的抗宮頸癌活性作用機制研究，主持

2.廣東省自然科學基金博士啟動項目，基於靶標TrxR的新型Mansonone F類似物抗宮頸癌作用機制研究，主持

3. 廣東高校優秀青年創新人才培養計劃（育苗工程）項目（LYM10029），主持

4. 廣州市科技計劃應用基礎研究重點項目，基於Akt信號通路的新型Hsp90抑製劑逆轉白血病細胞多葯耐葯的作用機制研究，主持

5. 天然藥物及仿生藥物國家重點實驗室開放課題，南葯余甘子中沒食子醯基多酚成分誘導自噬抗I型皰疹病毒的作用機制與構效關係研究，主持

6.暨南大學引進優秀人才科研啟動基金，硫氧還蛋白還原酶靶向小分子抑製劑抗腫瘤機制研究，主持

7. 十二五國家科技支撐計劃子課題，基於南葯小分子化合物的抗單純皰疹病毒藥靶發現，參與

1. Wang SX, Ju HQ, Liu KS, Zhang JX, Wang X, Xiang YF, Wang R, Liu JY, Liu QY, Xia M, Xing GW, Liu Z*, Wang YF*. SNX -2112, a novel Hsp90 inhibitor, induces G2/M cell cycle arrest and apoptosis in MCF-7 cells. Biosci Biotech Bioch. 2011, 75(8): 1540-1545.

2. Liu JY*, Liu Z*, Wang DM, Li MM, Wang SX, Wang R, Chen JP, Wang YF, Yang DP. Induction of apoptosis in K562 cells by dicyclohexylammonium salt of hyperforin through a mitochondrial-related pathway. Chem Biol Interact. 2011, 190(2-3): 91-101. (*, co-first author)

3. Liu Z, Huang SL, Li MM, Huang ZS, Lee KS, Gu LQ. Inhibition of thioredoxin reductase by mansonone F analogues: implications for anticancer activity. Chem Biol Interact. 2009, 177(1): 48-57.

4. Liu Z, Du ZY, Huang ZS, Lee KS, Gu LQ. Inhibition of thioredoxin reductase by curcumin analogs. Biosci Biotech Bioch. 2008, 72(8): 2214-2218.

5. Qiu X*, Liu Z*, Shao WY, Liu X, Jing DP, Yu YJ, An LK, Huang SL, Bu XZ, Huang ZS, Gu LQ. Synthesis and evaluation of curcumin analogues as potential thioredoxin reductase inhibitors. Bioorg Med Chem. 2008, 16(17): 8035-8041. (*, co-first author)

6. Zhang W, Liu Z, Li S, Yang T, Zhang Q, Ma L, Tian X, Zhang H, Huang C, Zhang S, Ju J, Shen Y, Zhang C. Spiroindimicins A-D: new bisindole alkaloids from a deep-sea-derived actinomycete. Org Lett, 2012, 14 (13), 3364–3367.

7. He F, Liu Z, Yang J, Fu P, Peng J, Zhu WM, Qi SH. A novel antifouling alkaloid from halotolerant fungus Penicillium sp. OUCMDZ-776, Tetrahedron Lett. 2012, 53(18): 2280-2283.

8. Li MM, Wu S, Liu Z, Zhang W, Xu J, Wang Y, Liu JS, Zhang DM, Tian HY, Li YL, Ye WC. Arenobufagin, a bufadienolide compound from toad venom, inhibits VEGF-mediated angiogenesis through suppression of VEGFR-2 signaling pathway. Biochem Pharmacol. 2012, 83(9): 1251-1260.

9. Liu KS, Ding WC, Wang SX, Liu Z, Xing GW, Wang Y, Wang YF. The heat shock protein 90 inhibitor SNX-2112 inhibits B16 melanoma cell growth in vitro and in vivo. Oncol Rep. 2012, 27(6):1904-1910.

10. Liu KS, Liu H, Qi JH, Liu QY, Liu Z, Xia M, Xing GW, Wang SX, Wang YF. SNX-2112, an Hsp90 inhibitor, induces apoptosis and autophagy via degradation of Hsp90 client proteins in human melanoma A-375 cells. Cancer Lett. 2012, 318(2): 66-74.

11. Zhang XQ, Xu FF, Wang L, Huang MY, Liu Z, Zhang DM, Wang GC, Li YL, Ye WC, Two pairs of new diastereoisomeric flavonolignans from the seeds of Hovenia acerba. Phytochem Lett. 2012, 5(2): 292-296.

12. Liu XT, Schwan WR, Volk TJ, Rott M, Liu M, Huang P, Liu Z, Wang Y, Zitomer NC, Sleger C, Hartsel S, Monte A, Zhang L. Antibacterial Spirobisnaphthalenes from the North American Cup Fungus Urnula craterium. J Nat Prod. 2012, DOI: 10.1021/np300221a

13. Zhai QQ, Gong GQ, Liu Z, Luo Y, Xia M, Xing GW, You XF, Wang YF. Preclinical pharmacokinetic analysis of SNX-2112, a novel Hsp90 inhibitor, in rats. Biomed Pharmacother. 2011, 65(2): 132-136.

14. Sun F, Liu JY, He F, Liu Z, Wang R, Wang DM, Wang YF, Yang DP. In-vitro antitumor activity evaluation of hyperforin derivatives. J Asian Nat Prod Res. 2011, 13(8): 688-699.

15. Ju HQ, Wang SX, Xiang YF, Liu Z, Liu JY, Chen ZP, Zeng FL, Xia M, Liu ZH, Xing GW, Wang SY, Wang YF. BJ-B11, a novel Hsp90 inhibitor, induces apoptosis in human chronic myeloid leukemia K562 cells through the mitochondria-dependent pathway. Eur J Pharmacol. 2011, 666: 26-34.

16. Shao M, Wang Y, Liu Z, Zhang DM, Cao HH, Jiang RW, Fan CL, Zhang XQ, Chen HR, Yao XS, Ye WC. Psiguadials A and B, two novel meroterpenoids with unusual skeletons from the leaves of Psidium guajava. Org Lett. 2010, 12(21):5040-5043.

17. Zhou GX, Mo SY, He HX, Shi JG, Ye WC, Liu Z. Jiang RW, Molecular structure and tautomerization of the 1:1 complex of luteoskyrin and rugulosin J Mol Struct. 2010, 979(1): 86-91.

18. Tian HY, Wang L, Zhang XQ, Wang Y, Zhang DM, Jiang RW, Liu Z, Liu JS, Li YL, Ye WC. Bufogargarizins A and B two novel 19-norbufadienolides with unprecedented skeletons from the venom of bufo bufo gargarizans. Chem Eur J. 2010, 16(36): 10989-10993.

19. Zhai QQ, Gong GQ, Luo Y, Wang QD, Xia M, Xing GW, Li YC, Jiang JH, Liu Z, Liu QY, Wang YF. Determination of SNX-2112, a selective Hsp90 inhibitor in plasma samples by high-performance liquid chromatography and its application to pharmacokinetics in rats. J Pharm Biomed Anal. 2010, 53(4): 1048-1052.